Jean de la Rosette, Jose Dominguez-Escrig, Kai Zhang, Jeremy Teoh, Eric Barret, Juan Casanova Ramon-Borja, Gordon Muir, Julia Bohr, Theo de Reijke, Chi-Fai Ng, Chi-Ho Leung, Rafael Sanchez-Salas, Pilar Laguna
PURPOSE: Our goal was to evaluate the effect of focal vs extended irreversible electroporation on side effects, patient-reported quality of life, and early oncologic control for localized low-intermediate risk prostate cancer patients. MATERIALS AND METHODS: Men with localized low-intermediate risk prostate cancer were randomized to receive focal or extended irreversible electroporation ablation. Quality of life was measured by International Index of Erectile Function, Expanded Prostate Cancer Index Composite questionnaire, and International Prostate Symptom Score...
November 28, 2022: Journal of Urology
S Swathi Krishna, Beena Briget Kuriakose, P K Lakshmi
Phytoestrogens are non-steroidal, polyphenolic compounds that are derived from plants and have biological properties similar to those of human estrogens. Their bioactivity, which is based on the core ring system, is caused by their structural resemblance to estrogen. Flavonoids, coumestans, lignans, and stilbenes are the four major categories into which they can be divided. They are structurally and functionally related to ovarian and placental estrogens, which are essential in female reproductive processes...
November 28, 2022: Archives of Pharmacal Research
Gaurav Pahouja, Hiten D Patel, Shalin Desai, Goran Rac, Teresa Cheng, Yudai Okabe, Alexander Gorbonos, Marcus L Quek, Robert C Flanigan, Maria M Picken, Gopal N Gupta
INTRODUCTION: Ductal adenocarcinoma (DA) and intraductal carcinoma (IDC) of the prostate are associated with higher stage disease at radical prostatectomy (RP). We evaluated diagnostic accuracy of biopsy, MRI-visibility, and outcomes for patients undergoing RP with DA/IDC histology compared to pure acinar adenocarcinoma (AA) of the prostate. MATERIALS AND METHODS: A retrospective cohort study of men receiving RP between 2014 and 2021 revealing AA, DA, or IDC on final pathology was conducted...
January 2023: Urologic Oncology
Diederik J H Baas, Willem Vreuls, J P M Michiel Sedelaar, H J E J Eric Vrijhof, Robert J Hoekstra, Saskia F Zomer, G J L H Geert van Leenders, Jean-Paul A van Basten, Diederik M Somford
OBJECTIVE: To evaluate the feasibility of confocal laser microscopy (CLM) for intraoperative margin assessment as faster alternative to NeuroSAFE during robot-assisted radical prostatectomy (RARP). PATIENTS AND METHODS: Surgical margins were assessed during 50 RARP procedures in patients scheduled for NeuroSAFE. Posterolateral sections were cut and imaged with CLM and further processed conform the NeuroSAFE protocol. Secondary resection (SR) was performed in case a positive surgical margin (PSM) was observed with NeuroSAFE...
November 28, 2022: BJU International
Shirong Peng, Xinyu Zhang, Hao Huang, Bisheng Cheng, Zhi Xiong, Tao Du, Jun Wu, Hai Huang
Prostate cancer (PCa) is the second most common malignant tumor among males. Traditional treatments for PCa, which include surgery and endocrine therapy, have shown limited success, and more effective therapies are needed. Cisplatin (DDP) is an approved chemotherapeutic drug that causes DNA damage in cancer, whereas AZD7762, an inhibitor of CHK1, can significantly inhibit DNA repair. The effective therapeutic combination of cisplatin and the DNA damage response inhibitor AZD7762 has been considered to be a potential solution to the resistance to cisplatin and the adverse reactions that occur in many cancers...
December 2022: APL Bioengineering
Tianqing Sang, Tengfei Zhang, Juntao Wang, Yuling Zheng
PURPOSE: To explore the active compounds of the Chinese medicine prescriptions of Bushen Hugu Decoction (BHD) and demonstrate its mechanisms against malignant tumor bone metastasis (BM) through network pharmacology and molecular docking analysis. METHODS: The main components and targets of BHD were retrieved from the TCMSP database, and the targets were normalized by UniProt. The Herbs-Components-Targets network of BHD was established by Cytoscape. The main BM targets were obtained from GeneCards, TTD, DrugBank, and OMIM...
2022: BioMed Research International
Tarana Arman, Peter S Nelson
Prostate cancer is a common malignancy affecting men worldwide. While the vast majority of newly diagnosed prostate cancers are categorized as adenocarcinomas, a spectrum of uncommon tumor types occur including those with small cell and neuroendocrine cell features. Benign neuroendocrine cells exist in the normal prostate microenvironment, and these cells may give rise to primary neuroendocrine carcinomas. However, the more common development of neuroendocrine prostate cancer is observed after therapeutics designed to repress the signaling program regulated by the androgen receptor which is active in the majority of localized and metastatic adenocarcinomas...
2022: Frontiers in Endocrinology
Ming Chang, Yu He, Cong Liu, Risheng Lin, Xin Huang, Dongcuan Liang, Jian Zhang, Yi Lu
Background: Prostate cancer (PCa) is one of the most common carcinomas in men, and aberrant expression of SEPTIN5 (SEPT5) has been detected in PCa tissues. However, the role of SEPT5 in PCa is still unclear. In this study, we attempted to explore the expression changes, clinical relevance and immunomodulatory function of SEPT5 in PCa. Methods: The expression and clinical significance of SEPT5 were evaluated based on bioinformatic analysis and were verified by western blotting, real time PCR and IHC. Allograft mouse models were used to assess the role of SEPT5 on PCa tumour formation and immunomodulatory function...
2022: International Journal of Biological Sciences
Peizhang Li, Yuanping Shi, Dajun Gao, Huan Xu, Yun Zou, Zhong Wang, Wenzhi Li
Background : N6-methyladenosine (m6A) is one of the most prevalent mRNA modifications in mammals, and it regulates the fate of modified RNA transcripts. In the current study, we aimed to elucidate the role of YTH m6A RNA-binding protein 1 (YTHDF1), a "reader" of m6A modification, in prostate cancer tumorigenesis. Methods : We employed a multi-omics approach to detect the direct target of YTHDF1 upon manipulation of YTHDF1 expression in prostate cancer cells. Expression of YTHDF1 was also evaluated in human prostate tumors and either adjacent or paired normal tissues...
2022: International Journal of Biological Sciences
Fei Shi, Meng-Hao Sun, Zheng Zhou, Lei Wu, Zheng Zhu, Shu-Jie Xia, Bang-Min Han, Yu-Yang Zhao, Yi-Feng Jing, Di Cui
Background: M2 macrophages are well accepted to promote cancer progression in the prostate cancer (PCa). Paracrine is the principally studied mode of communication between M2 macrophages and tumor cells. In addition to this, we present here a novel model to demonstrate these cellular communications. Methods: PCa cells were co-cultured with THP-1/ human peripheral blood mononuclear cells derived M2 macrophages in direct contact manner. Cancer cell proliferation and invasion were examined to explain how direct contact communicates...
2022: International Journal of Biological Sciences
Huijun Lei, Min Zhang, Luyao Zhang, Kari Hemminki, Xiao-Jia Wang, Tianhui Chen
Carriers with BRCA1/2 germline pathogenic variants are associated with a high risk of breast and ovarian cancers (also pancreatic and prostate cancers). While the spectrum on germline BRCA mutations among the Chinese population shows ethnic specificity, the identification of carriers with germline BRCA mutation before cancer onset is the most effective approach to protect them. This review focused on the current status of BRCA1/2 screening, the surveillance and prevention measures, and discussed the issues and potential impact of BRCA1/2 population screening in China...
2022: Frontiers in Oncology
Aoyu Fan, Yunyan Zhang, Jiangting Cheng, Yunpeng Li, Wei Chen
Prostate cancer (PCa) is one of the most common malignancies in males globally, and its pathogenesis is significantly related to androgen. As one of the important treatments for prostate cancer, androgen deprivation therapy (ADT) inhibits tumor proliferation by controlling androgen levels, either surgically or pharmacologically. However, patients treated with ADT inevitably develop biochemical recurrence and advance to castration-resistant prostate cancer which has been reported to be associated with androgen biosynthetic and catabolic pathways...
2022: Frontiers in Oncology
Hua Lu, Tingliang Han, Fangcun Li, Jiali Yang, Zhaomeng Hou
BACKGROUND: With the development of robotic surgery in the field of oncology, an increasing number of relevant research papers have been published. In order to explore the research hotspots and trends in this field, a bibliometric and visual analysis was performed for the first time. METHODS: The literature records related to oncology robotic surgery were obtained from the Web of Science Core Collection database and imported into the software VOSviewer 1.6.18, CiteSpace 6...
2022: Frontiers in Oncology
Edmond M Kwan, Alexander W Wyatt, Kim N Chi
Plasma circulating tumor DNA (ctDNA) represents short fragments of tumor-derived DNA released into the bloodstream primarily from cancer cells undergoing apoptosis. In metastatic castration-resistant prostate cancer (mCRPC), characterizing genomic alterations in ctDNA identifies mutations, copy number alterations, and structural rearrangements with predictive and prognostic biomarker utility. These associations with clinical outcomes have resulted in ctDNA increasingly incorporated into routine clinical care...
2022: Frontiers in Oncology
Xi Cao, Xian-Shu Gao, Wei Li, Peilin Liu, Shang-Bin Qin, Yan-Bin Dou, Hong-Zhen Li, Shiyu Shang, Xiao-Bin Gu, Ming-Wei Ma, Xin Qi, Mu Xie, Dian Wang
PURPOSE: It is difficult to contour nerve structures with the naked eye due to poor differentiation between the nerve structures with other soft tissues on CT images. Magnetic resonance neurography (MRN) has the advantage in nerve visualization. The purpose of this study is to identify one MRN sequence to better assist the delineation of the lumbosacral plexus (LSP) nerves to assess the radiation dose to the LSP using the magnetic resonance (MR)/CT deformable coregistration technique...
2022: Frontiers in Oncology
Mingyue Xia, Shuyan Wang, Yannan Qi, Kaili Long, Enjie Li, Lingfeng He, Feiyan Pan, Zhigang Guo, Zhigang Hu
The expression of O-GlcNAc transferase (OGT) and its catalytic product, O-GlcNAcylation (O-GlcNAc), are elevated in many types of cancers, including prostate cancer (PC). Inhibition of OGT serves as a potential strategy for PC treatment alone or combinational therapy. PC is the second common cancer type in male worldwide, for which chemotherapy is still the first-line treatment. However, the function of inhibition of OGT on chemotherapeutic response in PC cells is still unknown. In this study, we show that inhibition of OGT by genetic knockdown using shRNA or by chemical inhibition using OGT inhibitors sensitize PC cells to docetaxel, which is the most common chemotherapeutic agent in PC chemotherapy...
2022: Frontiers in Oncology
Tamara Panajotović, Nikola Panajotović, Milos Vukcević, Aleksandra Dragicevic, Iva Vojinović, Sladjana Kovacević, Mina Dimitrijević
Prostate cancer is the second most commonly occurring cancer in men. Regardless of statistics, screening for prostate cancer is an individual decision and most male patients come for their first examination with an already developed disease, as they are not adequately informed. The study aimed to emphasize the importance of preventive tests for urological diseases in the Republic of Serbia, raise awareness about urinary problems, and present social marketing strategies for prevention. The results confirm the generally lower awareness of respondents under the age of 30, followed by those who finished university, go to the doctor two or three times a year, and receive information other than by watching TV...
2022: Journal of Environmental and Public Health
Yvonne Benatzy, Megan A Palmer, Bernhard Brüne
As a lipoxygenase (LOX), arachidonate 15-lipoxygenase type B (ALOX15B) peroxidizes polyenoic fatty acids (PUFAs) including arachidonic acid (AA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and linoleic acid (LA) to their corresponding fatty acid hydroperoxides. Distinctive to ALOX15B, fatty acid oxygenation occurs with positional specificity, catalyzed by the non-heme iron containing active site, and in addition to free PUFAs, membrane-esterified fatty acids serve as substrates for ALOX15B. Like other LOX enzymes, ALOX15B is linked to the formation of specialized pro-resolving lipid mediators (SPMs), and altered expression is apparent in various inflammatory diseases such as asthma, psoriasis, and atherosclerosis...
2022: Frontiers in Pharmacology
Ze Yang, Xiang Wang, Wei Hong, Shiyi Zhang, Yang Yang, Yongliang Xia, Ruiwen Yang
Background: Advanced ovarian cancer (AOC) develops rapidly, adding to difficulties in treatment. Traditional Chinese medicine (TCM) plays a significant role in the treatment of AOC, and so to explore the efficacy and safety of TCM in the treatment of AOC and its effective targets, we performed the following review. Methods: The major databases were searched for randomized controlled trials of TCM for the treatment of AOC. A meta-analysis of the efficacy of Chinese herbs on AOC was conducted using RevMan 5.4 software...
2022: Frontiers in Pharmacology
Wei Mi, Zhi Zheng, Jiong-Di Lu, Shu-Quan Duan, Jie Zhang, Hai-Qiao Zhang, Yi-Xuan Ding, Jie Yin, Feng Cao, Jun Zhang, Fei Li
BACKGROUND: Pancreatic adenocarcinoma (PAAD) is a cancerous tumor with an extremely poor 5-year survival rate. The exploration of biomarkers for the diagnosis and treatment of PAAD is crucial in clinical practice. Krüppel-like factors (KLFs) are involved in a variety of biological functions in cells. According to multiple studies, KLF16 behave as an oncogene in prostate, breast and gastric cancers. However, no research has been done on the significance of KLF16 in PAAD. AIM: To explore the molecular mechanisms of KLF16 in PAAD...
November 15, 2022: World Journal of Gastrointestinal Oncology
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