Francisco V Gaspar, Soraya Marques Ribeiro, Júlio C F Barcellos, Samuel Monteiro, Jorge L O Domingos, Maria Claudia Dos Santos Luciano, Carlos R K Paier, Cláudia Pessoa, Paulo R R Costa
Natural pterocarpans and synthetic 5-carba-pterocarpans are isosteres in which the oxygen atom at position 5 in the pyran-ring of pterocarpans is replaced by a methylene group. These 5-carba-analogues were obtained in good yields through the palladium-catalyzed oxyarylation of alcoxy-1,2-dihydronaphthalens with o-iodophenols in PEG-400. They were evaluated on human cancer cell lineages derived respectively from prostate tumor (PC3, IC50  = 11.84 μmol L-1 , SI > 12)) and acute myeloid leukemia (HL-60, IC50  = 8...
January 1, 2021: Bioorganic Chemistry
Danielle Rodin, Bouchra Tawk, Osama Mohamad, Surbhi Grover, Fabio Y Moraes, Mei Ling Yap, Eduardo Zubizarreta, Yolande Lievens
BACKGROUND AND PURPOSE: Multiple large trials have established the non-inferiority of hypofractionated radiotherapy compared to conventional fractionation. This study will determine real-world hypofractionation adoption across different geographic regions for breast, prostate, cervical cancer, and bone metastases, and identify barriers and facilitators to its use. MATERIALS AND METHODS: An anonymous, electronic survey was distributed from January 2018 through January 2019 to radiation oncologists through the ESTRO-GIRO initiative...
January 13, 2021: Radiotherapy and Oncology
Ronald C Chen, Sabrina G Prime, Ramsankar Basak, Dominic Himchan Moon, Claire Liang, Deborah S Usinger, Aaron J Katz
Prospective clinical trials have demonstrated the safety and efficacy of active surveillance for men with localized prostate cancer, but also suggested that inadequate surveillance may risk missing an opportunity for cure. We used data from a population-based cohort of active surveillance patients to examine the rigor of surveillance monitoring in the general population. Among 1,419 patients enrolled from 2011-2013 throughout the State of XXXXX in collaboration with the state cancer registry and followed prospectively, 346 pursued active surveillance...
January 13, 2021: International Journal of Radiation Oncology, Biology, Physics
K Liang Zeng, Arjun Sahgal, Zain A Husain, Sten Myrehaug, Chia-Lin Tseng, Jay Detsky, Arman Sarfehnia, Mark Ruschin, Mikki Campbell, Monica Foster, Sunit Das, Nir Lipsman, Georg A Bjarnason, Eshetu G Atenafu, Pejman Jabehdar Maralani, Hany Soliman
PURPOSE: The concept of a radioresistant (RR) phenotype has been challenged with use of stereotactic body radiotherapy (SBRT). We compared outcomes following SBRT to RR spinal metastases to a radiosensitive cohort. METHODS: Renal cell, melanoma, sarcoma, gastro-intestinal, and thyroid spinal metastases were identified as RR and prostate cancer (PCA) as radiosensitive. The primary endpoint was MRI-based local failure (LF). Secondary endpoints included overall survival (OS) and vertebral compression fracture (VCF)...
January 16, 2021: Journal of Neuro-oncology
Soichiro Yoshida, Taro Takahara, Yuki Arita, Kazuma Toda, Ichiro Yamada, Hajime Tanaka, Minato Yokoyama, Yoh Matsuoka, Ryoichi Yoshimura, Yasuhisa Fujii
PURPOSE: To evaluate the clinical characteristics of genuine- and induced-oligometastatic castration-resistant prostate cancer (OM-CRPC) and assess the therapeutic effect of progressive-site directed therapy (PSDT). METHODS: We performed a retrospective analysis of 45 patients with OM-CRPC. Whole-body diffusion-weighted MRI (WB-DWI) was used to diagnose oligo-progressive disease. Based on the clinical and radiological findings, the OM-CRPCs were classified as genuine or induced...
January 16, 2021: International Urology and Nephrology
B Valentin, L Schimmöller, T Ullrich, M Klingebiel, D Demetrescu, L M Sawicki, J Lakes, D Mally, M Quentin, I Esposito, P Albers, G Antoch, C Arsov
OBJECTIVES: The aim of this study was to investigate 3 Tesla multiparametric magnetic resonance imaging (mpMRI)-based predictors for the pretherapeutic T staging of prostate cancer and their accuracy. METHODS: Consecutive patients with 3 Tesla mpMRI, positive systematic and MR-targeted biopsy, and subsequent radical prostatectomy (RPE) between 01/2016 and 12/2017 were included. MRI parameters such as measurable extraprostatic extension (EPE) (≥ 3 mm), length of (pseudo)capsular contact (LCC), invasion of neurovascular bundle (NVBI), and/or seminal vesicles lesion contact (SVC) or infiltration (SVI) were assessed and correlated to clinical and histopathological results...
January 16, 2021: Abdominal Radiology
Tânia Lima, Rui Henrique, Rui Vitorino, Margarida Fardilha
Prostate cancer (PCa) is one of the most common cancer types among men. The quantification of prostate-specific antigen used for PCa detection has revealed limited applicability. Thus, it is crucial to identify new minimally invasive biomarkers for PCa. It is believed that the integration of proteomics data from different studies is vital for identifying new biomarkers for PCa, but studies carried out in this regard have few converging results. Using a different approach, this study aimed to unveil molecular features consistently dysregulated in PCa and potential urinary biomarkers for PCa...
January 16, 2021: Medical Oncology
Cedric Curt Cappel, Denise Dopcke, Jürgen Dunst
No abstract text is available yet for this article.
January 15, 2021: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Po-I Liu, An-Chen Chang, Jiun-Lin Lai, Tien-Huang Lin, Chun-Hao Tsai, Po-Chun Chen, Ya-Jing Jiang, Liang-Wei Lin, Wei-Chien Huang, Shun-Fa Yang, Chih-Hsin Tang
Cancer-related bone erosion occurs frequently in bone metastasis and is associated with severe complications such as chronic bone pain, fractures, and lower survival rates. In recognition of the fact that the darkness hormone melatonin is capable of regulating bone homeostasis, we explored its therapeutic potential in bone metastasis. We found that melatonin directly reduces osteoclast differentiation, bone resorption activity and promotes apoptosis of mature osteoclasts. We also observed that melatonin inhibits RANKL production in lung and prostate cancer cells by downregulating the p38 MAPK pathway, which in turn prevents cancer-associated osteoclast differentiation...
January 15, 2021: Oncogene
Takayuki Sumiyoshi, Kim N Chi, Alexander W Wyatt
There has been a rapid expansion in treatment options for the management of metastatic prostate cancer, but individual patient outcomes can be variable due to inter-patient tumor heterogeneity. Fortunately, the disease can be stratified on the basis of common somatic features, providing potential for the development of clinically useful prognostic and predictive biomarkers. Tissue biopsy programs and studies leveraging circulating tumor DNA (ctDNA) have revealed specific genomic alterations that are associated with aggressive disease biology...
January 15, 2021: Prostate Cancer and Prostatic Diseases
Ayesha A Shafi, Chris M McNair, Jennifer J McCann, Mohammed Alshalalfa, Anton Shostak, Tesa M Severson, Yanyun Zhu, Andre Bergman, Nicolas Gordon, Amy C Mandigo, Saswati N Chand, Peter Gallagher, Emanuela Dylgjeri, Talya S Laufer, Irina A Vasilevskaya, Matthew J Schiewer, Michael Brunner, Felix Y Feng, Wilbert Zwart, Karen E Knudsen
Mechanisms regulating DNA repair processes remain incompletely defined. Here, the circadian factor CRY1, an evolutionally conserved transcriptional coregulator, is identified as a tumor specific regulator of DNA repair. Key findings demonstrate that CRY1 expression is androgen-responsive and associates with poor outcome in prostate cancer. Functional studies and first-in-field mapping of the CRY1 cistrome and transcriptome reveal that CRY1 regulates DNA repair and the G2/M transition. DNA damage stabilizes CRY1 in cancer (in vitro, in vivo, and human tumors ex vivo), which proves critical for efficient DNA repair...
January 15, 2021: Nature Communications
Dinesh Keerty, Kevin C Eaton, Karina Trejo, Carolina Strosberg, Elizabeth J Haynes
No abstract text is available yet for this article.
January 15, 2021: Postgraduate Medical Journal
Mark C Markowski, Pedro Isaacsson Velho, Mario A Eisenberger, Martin G Pomper, Kenneth J Pienta, Michael A Gorin, Emmanuel S Antonarakis, Samuel R Denmeade, Steven P Rowe
Rationale: Bipolar androgen therapy (BAT) is an emerging treatment for metastatic castration resistant prostate cancer (mCRPC). 18 F-DCFPyL is a small-molecule positron emission tomography (PET) radiotracer targeting prostate-specific membrane antigen (PSMA). We analyzed the utility of 18 F-DCFPyL PET/CT in determining clinical response to BAT. Methods: Six men with mCRPC receiving BAT were imaged with 18 F-DCFPyL PET/CT at baseline and after 3 months of treatment. Progression by PSMA-targeted PET/CT was defined as the appearance of any new 18 F-DCFPyL-avid lesion...
January 15, 2021: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Catherine H Marshall, Wei Fu, Hao Wang, Jong Chul Park, Theodore L DeWeese, Phuoc T Tran, Daniel Y Song, Serina King, Michaella Afful, Julia Hurrelbrink, Charlotte E Manogue, Patrick Cotogno, Nancy P Moldawer, Pedro Barata, Charles G Drake, Edwin M Posadas, Andrew J Armstrong, Oliver Sartor, Emmanuel S Antonarakis
PURPOSE: To investigate if radium-223 increases peripheral immune responses to sipuleucel-T in men with bone-predominant, minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). METHODS: 32 patients were randomized 1:1 in this open label, phase 2 multicenter trial. Patients in the control arm received 3 sipuleucel-T treatments, 2 weeks apart. Those in the combination arm received 6 doses of radium-223 monthly, with sipuleucel-T intercalated between the second and fourth doses of radium-223...
January 15, 2021: Clinical Cancer Research
Justin N Drobish, Mark D Bevill, Chad R Tracy, Shawn M Sexton, Maheen Rajput, Catherine M Metz, Paul T Gellhaus
INTRODUCTION: Magnetic Resonance Imaging (MRI)-targeted prostate biopsy (MRI-TB) improves the detection of prostate cancer. These biopsies typically involve both a 12-core systematic biopsy (SB) and MRI-TB of the lesion. Since the majority of PI-RADS 5 lesions represent clinically significant cancers, the utility of SB in addition to MRI-TB is unclear. We evaluate the utility of SB in the setting of PI-RADS 5 lesions in biopsy naïve and active surveillance patients. METHODS: Patients undergoing MRI-TB+SB with a PI-RADS 5 lesion were retrospectively reviewed in a prospectively collected database...
January 12, 2021: Urologic Oncology
Shuchi Gulati, Ramya Muddasani, Paulo Gustavo Bergerot, Sumanta K Pal
As the novel severe acute respiratory syndrome coronavirus-2 related pandemic - Corona Virus Disease 2019 (COVID-19) has emerged, decision making in the context of cancer treatment has become more complex. The apprehension of using drugs that could adversely affect infected patients, the risk of not using life-saving treatments and the complexities related to the type of cancer itself, all must be taken into consideration before proceeding with treatment. Data from large registries such as COVID-19 and Cancer Consortium, Thoracic Cancers International COVID-19 Collaboration (TERAVOLT) and NCI COVID-19 in Cancer Patients Study will hopefully provide granularity on the outcomes of patients with cancer who are infected with COVID-19...
December 26, 2020: Urologic Oncology
Viviana M Bimonte, Francesco Marampon, Ambra Antonioni, Simona Fittipaldi, Elisabetta Ferretti, Richard G Pestell, Mariaignazia Curreli, Andrea Lenzi, Giovanni Vitale, Antonio Brunetti, Silvia Migliaccio, Antonio Aversa
BACKGROUND: The androgen receptor (AR) plays a key role in normal prostate homeostasis and in prostate cancer (PCa) development, while the role of aromatase (Cyp19a1) is still unclear. We evaluated the effects of a treatment with Tadalafil (TAD) on both these proteins. METHODS: Androgen-sensitive human PCa cell line (LnCAP) was incubated with/without TAD (10-6 M) and bicalutamide (BCT) (10-4 M) to evaluate a potential modulation on cell proliferation, protein and mRNA expression of Cyp19a, AR and estrogen receptor-β (ERβ), respectively...
January 13, 2021: International Journal of Molecular Sciences
Andra Piciu, Doina Piciu, Narcis Polocoser, Anita A Kovendi, Iulia Almasan, Alexandru Mester, Dragos-Stefan Morariu, Calin Cainap, Simona Sorana Cainap
INTRODUCTION: F18-FDG PET/CT is the most important hybrid imaging used in the diagnostic, staging, follow-up, and treatment evaluation response in cancer patients. However, it is well-known that in breast cancer the use of F18-FDG is not included in the first line protocol of initial diagnostic, both in female and male breast cancer patients. F18-FDG PET/CT is a valuable tool to provide information on extra-axillary lymph node involvement, distant metastases, and other occult primary cancers...
January 13, 2021: Diagnostics
Gilberto Ruiz-Deya, Jaime Matta, Jarline Encarnación-Medina, Carmen Ortiz-Sanchéz, Julie Dutil, Ryan Putney, Anders Berglund, Jasreman Dhillon, Youngchul Kim, Jong Y Park
In 2020, approximately 191,930 new prostate cancer (PCa) cases are estimated in the United States (US). Hispanic/Latinos (H/L) are the second largest racial/ethnic group in the US. This study aims to assess methylation patterns between aggressive and indolent PCa including DNA repair genes along with ancestry proportions. Prostate tumors classified as aggressive ( n = 11) and indolent ( n = 13) on the basis of the Gleason score were collected. Tumor and adjacent normal tissue were annotated on H&E (Haemotoxylin and Eosin) slides and extracted by macro-dissection...
January 13, 2021: International Journal of Molecular Sciences
Daniel E Hagaman, Jossana A Damasco, Joy Vanessa D Perez, Raniv D Rojo, Marites P Melancon
Patients with advanced prostate cancer can develop painful and debilitating bone metastases. Currently available interventions for prostate cancer bone metastases, including chemotherapy, bisphosphonates, and radiopharmaceuticals, are only palliative. They can relieve pain, reduce complications (e.g., bone fractures), and improve quality of life, but they do not significantly improve survival times. Therefore, additional strategies to enhance the diagnosis and treatment of prostate cancer bone metastases are needed...
January 13, 2021: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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