Musab Ali Kutluhan, Selman Ünal, Emrah Özsoy, Aytaç Şahin, Asım Özayar, Emrah Okulu, Önder Kayıgil
BACKGROUND: Biochemical recurrence (BCR) can be seen in the early or late period after radical prostatectomy (RP). Various models have been developed to predict BCR. OBJECTIVE: In our study we evaluated accuracy of four pre-operative models (GP score, PRIX, D'Amico risk classification, CAPRA) in predicting BCR after RP in Turkish patients. METHODS: Age, preoperative total prostate specific antigen (PSA) values, clinical stages, total number of cores taken in biopsy, number of positive cores, preoperative biopsy Gleason score (GS), follow-up time and presence of BCR after RP were recorded...
July 31, 2021: International Journal of Clinical Practice
Mohammad Bagherniya, Gholamreza Askari, Babak Alikiaii, Saeed Abbasi, Davood Soleimani, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar
Prostate cancer is one of the significant causes of morbidity and mortality worldwide. Benign prostatic hyperplasia is another condition of the prostate which, like prostate cancer, is more common among ageing men and is linked to inflammation. In this study, a systematic review was undertaken to estimate the effect of turmeric or curcumin supplementation on prostate diseases. A comprehensive search was conducted in PubMed, Scopus, ISI Web of Science and Google Scholar up to 15 April 2020 to identify clinical trials assessing the effects of curcumin/turmeric alone or in combination with other herbs on prostate diseases...
2021: Advances in Experimental Medicine and Biology
Jin Li, Yiming Lai, Yi Cao, Tao Du, Lexiang Zeng, Ganping Wang, Xianju Chen, Jieqing Chen, Yongsheng Yu, Simin Zhang, Yiming Zhang, Hai Huang, Zhenghui Guo
No abstract text is available yet for this article.
July 31, 2021: Medical Oncology
Renaud Ciappuccini, Virginie Saguet-Rysanek, Florence Giffard, Idlir Licaj, Marine Dorbeau, Bénédicte Clarisse, Laurent Poulain, Stéphane Bardet
CONTEXT: Little is known about prostate-specific membrane antigen (PSMA) expression in patients with cervical involvement of differentiated thyroid cancer (DTC). OBJECTIVE: We investigated PSMA expression in neck persistent/recurrent disease (PRD) using immunohistochemistry and the association with radioiodine (RAI) or 18Fluorodeoxyglucose ( 18FDG) uptake, and patient outcome. DESIGN, SETTING AND PATIENTS: Data from 44 consecutive DTC patients who underwent neck reoperation from 2006 to 2018 in a comprehensive cancer center...
July 31, 2021: Journal of Clinical Endocrinology and Metabolism
Cassandra L Clift, Anand Mehta, Richard R Drake, Peggi M Angel
We describe a multiplexed imaging mass spectrometry approach especially suitable for fibrosis research. Fibrosis is a process characterized by excessive extracellular matrix (ECM) secretion. Buildup of ECM impairs tissue and organ function to promote further progression of disease. It is an ongoing analytical challenge to access ECM for diagnosis and therapeutic treatment of fibrosis. Recently, we reported the use of the enzyme collagenase type III to target the ECM proteome in thin histological tissue sections of fibrotic diseases including hepatocellular carcinoma, breast cancer, prostate cancer, lung cancer and aortic valve stenosis...
2021: Methods in Molecular Biology
Demet Cansaran-Duman, Gamze Guney Eskiler, Betul Colak, Elif Sozen Kucukkara
BACKGROUND: Lichen secondary metabolites have drawn considerable attention in recent years due to the limitations of current treatment options. Vulpinic acid (VA) obtained from Letharia vulpina lichen species exerts a remarkable cytotoxic effect on different cancer types. However, the therapeutic efficacy of VA in metastatic prostate cancer (mPC) cells has not been investigated. In the present study, we aimed to identify VA-mediated cytotoxicity in PC-3 mPC cells compared with control cells...
July 30, 2021: Molecular Biology Reports
Masaki Makise, Ryota Uchimura, Kumiko Higashi, Yasumi Mashiki, Rikako Shiraishi, Yuumi Shutoku, Akihiko Kuniyasu
Elevated expression of the nucleoporin Nup88, a constituent of the nuclear pore complex, is seen in various types of malignant tumors, but whether this overexpression contributes to the malignant phenotype has yet to be determined. Here, we investigated the effect of the overexpression of Nup88 on the migration and invasion of cervical cancer HeLa cells. The overexpression of Nup88 promoted a slight but significant increase in both migration and invasion, whereas knockdown of Nup88 by RNA interference suppressed these phenotypes...
July 31, 2021: Histochemistry and Cell Biology
Jan-Henning Schierz, Ismet Sarikaya, Ahmed N Albatineh, Ali Sarikaya
Aim: 68 Ga -PSMA ligands are used for prostate cancer but also show high renal cortical uptake. In this study, we aimed to assess if there is any correlation between renal PSMA PET parameters and renal function tests using the images of prostate cancer patients. Methods: 68 Ga-PSMA-11 PET/CT images of the patients with prostate cancer were retrospectively evaluated. The following PET parameters were obtained: SUVmax , SUVmean, SULmax, SULmean, volume, TLGSUL and counts of both kidneys as well as SUVmean of liver, blood pool and spleen...
July 30, 2021: Journal of Nuclear Medicine Technology
Else A Aalbersberg, Desiree Verwoerd, Chelvi Mylvaganan-Young, Hilda A de Barros, Pim J van Leeuwen, Mariska Sonneborn-Bols, Maarten L Donswijk
Aim: The aim of this study was to estimate and subsequently measure the occupational radiation exposure for all personnel involved in the production, administration, imaging, or surgery with [99m Tc]Tc-PSMA-I&S, which has been introduced for identification of tumor-positive lymph nodes during salvage prostate cancer surgery Materials and Methods: The effective dose was estimated and subsequently measured with electronic personal dosimeters for the following procedures and personnel: labeling and quality control by the radiopharmacy technician, syringe preparation by the nuclear medicine laboratory technician, patient administration by the nuclear medicine physician, patient imaging by the nuclear medicine imaging technician, and robot-assisted laparoscopic salvage lymph node dissection attended by an anesthesiology technician, scrub nurse, surgical nurse, and surgeon...
July 30, 2021: Journal of Nuclear Medicine Technology
Joshua Tulk, Joshua A Rash, John Thoms, Richard Wassersug, Brian Gonzalez, Sheila N Garland
OBJECTIVES: This paper (1) sought to compare sleep, mood and physical symptom profiles of men with prostate cancer (PCa) who experienced subjective and objective cancer-related cognitive impairment (CRCI) during the first year of treatment and (2) examine if fluctuations in mood and physical symptoms are associated with change in subjective or objective CRCI. METHODS: This prospective observational cohort study examined 24 new patients with PCa receiving androgen deprivation therapy (ADT) and radiation therapy (RT) during the first 12 months of treatment...
July 30, 2021: BMJ Supportive & Palliative Care
(no author information available yet)
No abstract text is available yet for this article.
August 1, 2021: Journal of Nuclear Medicine
(no author information available yet)
No abstract text is available yet for this article.
August 1, 2021: Journal of Nuclear Medicine
Mohamed A Abu El Maaty, Elise Grelet, Céline Keime, Anna-Isavella Rerra, Justine Gantzer, Camille Emprou, Julie Terzic, Régis Lutzing, Jean-Marc Bornert, Gilles Laverny, Daniel Metzger
Epidemiological data have linked vitamin D deficiency to the onset and severity of various cancers, including prostate cancer, and although in vitro studies have demonstrated anticancer activities for vitamin D, clinical trials provided conflicting results. To determine the impact of vitamin D signaling on prostatic precancerous lesions, we treated genetically engineered Pten(i)pe-/- mice harboring prostatic intraepithelial neoplasia (PIN) with Gemini-72, a vitamin D analog with reported anticancer activities...
July 2021: Science Advances
M Alvarez-Maestro, J Gomez Rivas, M Moschini
No abstract text is available yet for this article.
July 27, 2021: Actas urologicas españolas
Xingyu Xiong, Shi Qiu, Xianyanling Yi, Hang Xu, Dazhou Liao, Haoran Lei, Shengjiang Bai, Ge Peng, Jianzhong Ai, Lu Yang
BACKGROUND: Emerging evidence indicates that patients with metastatic castration-resistant prostate cancer could respond to steroid switch from prednisone (P) to dexamethasone (D) following progression on abiraterone acetate plus prednisone (AA+P). OBJECTIVES: Conducting a systematic review to evaluate the efficacy, safety, and prognostic factors of steroid switch. MATERIALS AND METHODS: We systematically searched Pubmed, Web of Science, and American Society of Clinical Oncology annual meeting abstracts published up to October 2020...
July 27, 2021: Urologic Oncology
Sarah L Ullevig, Dean J Bacich, Jose M Gutierrez, Ashton Balarin, C Austin Lobitz, Denise S O'Keefe, Michael A Liss
BACKGROUND & AIMS: Fortification of the US food supply has increased folic acid intake and resulted in a concomitant decrease in neural tube defects in women. However, a body evidence supports the hypothesis that increased circulating folate levels due to excessive dietary or supplemental folic acid may be harmful for men with prostate cancer. Therefore, this pilot study aimed to investigate the feasibility of a reduced folic acid dietary intervention in men on an active surveillance monitoring program for prostate cancer...
August 2021: Clinical Nutrition ESPEN
Thenmozhi Rajarathinam, Minho Kwon, Dinakaran Thirumalai, Seonghye Kim, Seulah Lee, Jang-Hee Yoon, Hyun-Jong Paik, Suhkmann Kim, Jaewon Lee, Hong Koo Ha, Seung-Cheol Chang
A new disposable amperometric biosensor for sarcosine (Sar, a biomarker for prostate cancer) was designed based on screen-printed carbon electrodes, Prussian blue, polymer dispersed reduced graphene oxide (P-rGO) nanosheets, and sarcosine oxidase (SOx). Poly(sodium 4-styrenesulfonate-r-LAHEMA) denoted as PSSL was newly synthesized as dispersant for rGO. The P-rGO was utilized for SOx immobilization, the sulfonate and disulfide functionalities in PSSL enable physical adsorption of SOx and its bioactivity and stability properties were improved...
August 29, 2021: Analytica Chimica Acta
N Peters, P Wohlfahrt, C V Dahlgren, L de Marzi, M Ellerbrock, F Fracchiolla, J Freeh, C Gomà, J Góra, M F Jensen, T Kajdrowicz, R Mackay, S Molinelli, I Rinaldi, V Rompokos, D Siewert, P van der Tol, X Vermeren, H Nyström, A Lomax, C Richter
PURPOSE: Experimental assessment of inter-centre variation and absolute accuracy of stopping-power-ratio (SPR) prediction within 17 particle therapy centres of the European Particle Therapy Network. MATERIAL AND METHODS: A head and body phantom with seventeen tissue-equivalent materials were scanned consecutively at the participating centres using their individual clinical CT scan protocol and translated into SPR with their in-house CT-number-to-SPR conversion. Inter-centre variation and absolute accuracy in SPR prediction were quantified for three tissue groups: lung, soft tissues and bones...
July 27, 2021: Radiotherapy and Oncology
Taher Abbasiasl, Hande Eda Sutova, Soroush Niazi, Gizem Celebi, Zeynep Karavelioglu, Ufuk Gorkem Kirabali, Abdurrahim Yilmaz, Huseyin Uvet, Ozlem Kutlu, Sinan Ekici, Morteza Ghorbani, Ali Kosar
Hydrodynamic cavitation involves the formation of bubbles inside a flow due to local reduction of pressure below the saturation vapor pressure. The resulting growth and violent collapse of bubbles lead to a huge amount of released energy. This energy can be implemented in different fields such as heat transfer enhancement, wastewater treatment and chemical reactions. In this study, a cystoscope based on small scale hydrodynamic cavitation was designed and fabricated to exploit the destructive energy of cavitation bubbles for treatment of tumor tissues...
July 30, 2021: IEEE Transactions on Bio-medical Engineering
Donia E Hafez, Eman Hafez, Islam Eddiasty, Shou-Ping Shih, Leng-Chiang Chien, Yi-Jia Hong, Hung-Yu Lin, Adam B Keeton, Gary A Piazza, Mohammad Abdel-Halim, Ashraf H Abadi
A series of 2-arylthiazolidine-4-carboxylic acid amide derivatives were synthesized and their cytotoxic activity against three cancer cell lines (PC-3, SKOV3 and MDA-MB231) was evaluated. Various structural modifications were tried including modifications of the length of the amide chain and modifications of the 2-aryl part using disubstituted phenyl and thiophene derivatives. The structure activity relationship was evaluated based on the in vitro biological evaluation against the above mentioned three cancer cell lines...
July 7, 2021: Bioorganic Chemistry
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