keyword
https://read.qxmd.com/read/33857768/tatme-approach-as-a-rescue-during-a-laparoscopic-tme-for-high-rectal-cancer-a-case-report
#1
F Carannante, G Bianco, S Lauricella, G Mascianà, M Caricato, G T Capolupo
INTRODUCTION AND IMPORTANCE: In the last years, transanal total mesorectal excision (TaTME) has been described in rectal cancer treatment, especially in challenging patients, difficulties in pelvic exposure and limitations of instrumentation improving not only dissection but also the preservation of autonomic pelvic nerves and the achievement of a restorative procedure. Here we report a case report of anterior laparoscopic rectal resection for adenocarcinoma of the high-mid rectum converted to transanal approach...
April 7, 2021: International Journal of Surgery Case Reports
https://read.qxmd.com/read/33857756/targeted-nanomedicine-modalities-for-prostate-cancer-treatment
#2
Lital Cohen, Yoav D Livney, Yehuda G Assaraf
Prostate cancer (PC) is the second most common cause of death amongst men in the USA. Therapy of PC has been transformed in the past decade by introducing novel therapeutics, advanced functional imaging and diagnostic approaches, next generation sequencing, as well as improved application of existing therapies in localized PC. Treatment of PC at the different stages of the disease may include surgery, androgen deprivation therapy (ADT), chemotherapy and radiation therapy. However, although ADT has proven efficacious in PC treatment, its effectiveness may be temporary, as these tumors frequently develop molecular mechanisms of therapy resistance, which allow them to survive and proliferate even under conditions of testosterone deprivation, inhibition of androgen receptor signaling, or cytotoxic drug treatment...
March 19, 2021: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://read.qxmd.com/read/33857629/fda-approves-ga-68-psma-11-for-prostate-cancer-imaging
#3
Shane C Masters, A Alex Hofling, Alex Gorovets, Libero Marzella
No abstract text is available yet for this article.
April 12, 2021: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/33857498/pmepa1-stimulates-the-proliferation-colony-formation-of-pancreatic-cancer-cells-via-the-mapk-signaling-pathway
#4
Mengqi Song, Bin Zhou, Bilu Li, Lantian Tian
BACKGROUND: Prostate transmembrane protein androgen-induced 1 (PMEPA1) is reportedly highly expressed in pancreatic cancer (PC). However, its biological role and associated mechanisms have not been addressed in PC progression. METHODS: PMEPA1 mRNA expression and survival outcome of PC patients were evaluated via the GEPIA website. Lentiviral-mediated shRNA knockdown and ectopic expression of PMEPA1 were implemented in the pancreatic cancer cell line PANC1 cells...
April 12, 2021: American Journal of the Medical Sciences
https://read.qxmd.com/read/33857006/the-use-of-multiple-correspondence-analysis-to-explore-associations-between-categories-of-qualitative-variables-and-cancer-incidence
#5
Didac Florensa, Pere Godoy, Jordi Mateo, Francesc Solsona, Tere Pedrol, Miquel Mesas, Ramon Pinol
BACKGROUND: Previous works have shown that risk factors for some kinds of cancer depend on people's lifestyle (e.g. rural or urban residence). This article looks into this, seeking relationships between cancer, age group, gender and population in the region of Lleida (Catalonia, Spain) using Multiple Correspondence Analysis (MCA). METHODS: The dataset analysed was made up of 3,408 cancer episodes between 2012 and 2014, extracted from the Population-based Cancer Registry (PCR) for Lleida province...
April 15, 2021: IEEE Journal of Biomedical and Health Informatics
https://read.qxmd.com/read/33856522/the-influence-of-digital-pet-ct-on-diagnostic-certainty-and-interrater-reliability-in-68-ga-ga-psma-11-pet-ct-for-recurrent-prostate-cancer
#6
Ian Alberts, Jan-Niklas Hünermund, Christos Sachpekidis, Clemens Mingels, Viktor Fech, Karl Peter Bohn, Axel Rominger, Ali Afshar-Oromieh
OBJECTIVE: To investigate the impact of digital PET/CT on diagnostic certainty, patient-based sensitivity and interrater reliability. METHODS: Four physicians retrospectively evaluated two matched cohorts of patients undergoing [68 Ga]Ga-PSMA-11 PET/CT on a digital (dPET/CT n = 65) or an analogue scanner (aPET/CT n = 65) for recurrent prostate cancer between 11/2018 and 03/2019. The number of equivocal and pathological lesions as well as the frequency of discrepant findings and the interrater reliability for the two scanners were compared...
April 15, 2021: European Radiology
https://read.qxmd.com/read/33856508/prostate-cancer-detection-by-targeted-prostate-biopsy-using-the-3d-navigo-system-a-prospective-study
#7
Alexandre Magnier, Cosmina Nedelcu, Samuel Chelly, Marie-Christine Rousselet-Chapeau, Abdel Rahmene Azzouzi, Souhil Lebdai
PURPOSE: The 3D Navigo™ system is a magnetic resonance imaging (MRI) and transrectal ultrasound (TRUS) fusion device for prostate targeted biopsies (TB). Our aim was to evaluate the clinically significant prostate cancer (CSC) detection rate of TB using the 3D Navigo™ system. METHODS: Patients who underwent TB with the 3D Navigo™ system in our center between June 2014 and May 2018 were prospectively included, excluding those who have previously received treatment for prostate cancer...
April 15, 2021: Abdominal Radiology
https://read.qxmd.com/read/33854977/gastrin-releasing-peptide-receptor-in-low-grade-prostate-cancer-can-it-be-a-better-predictor-than-prostate-specific-membrane-antigen
#8
Pinuccia Faviana, Laura Boldrini, Paola Anna Erba, Iosè Di Stefano, Francesca Manassero, Riccardo Bartoletti, Luca Galli, Carlo Gentile, Massimo Bardi
The aim of the present study was to evaluate whether prostate cancer (PC) patients can be accurately classified on the bases of tissue expression of gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA). This retrospective study included 28 patients with PC. Formalin-fixed paraffin-embedded samples were used for diagnosis. Immunohistochemistry staining techniques were used to evaluate PSMA and GRPR expression (both number of cells expressed and % of area stained). To assess the independent associations among selected variables, a multi-dimensional scaling (MDS) analysis was used...
2021: Frontiers in Oncology
https://read.qxmd.com/read/33854618/protein-kinase-pim2-a-simple-pim-family-kinase-with-complex-functions-in-cancer-metabolism-and-therapeutics
#9
REVIEW
Yixin Wang, Jing Xiu, Chune Ren, Zhenhai Yu
PIM2 (proviral integration site for Moloney murine leukemia virus 2) kinase plays an important role as an oncogene in multiple cancers, such as leukemia, liver, lung, myeloma, prostate and breast cancers. PIM2 is largely expressed in both leukemia and solid tumors, and it promotes the transcriptional activation of genes involved in cell survival, cell proliferation, and cell-cycle progression. Many tumorigenic signaling molecules have been identified as substrates for PIM2 kinase, and a variety of inhibitors have been developed for its kinase activity, including SMI-4a, SMI-16a, SGI-1776, JP11646 and DHPCC-9...
2021: Journal of Cancer
https://read.qxmd.com/read/33854607/consumption-of-sugar-sweetened-beverages-and-fruit-juice-and-human-cancer-a-systematic-review-and-dose-response-meta-analysis-of-observational-studies
#10
Yuting Li, Lilianagzi Guo, Kaiyin He, Changbing Huang, Shaohui Tang
Background: Several epidemiological studies have assessed the association of sugary drinks consumption with cancer, but the results remain controversial. Objective: We performed this analysis to evaluate possible causal relationship between sugary drinks consumption and cancer risk and mortality. Methods: We searched PubMed, Embase, and Web of Science databases in English. Observational studies evaluating the association of sugary drinks intake with cancer were included. Random-effects meta-analysis was used to calculate the risk estimates...
2021: Journal of Cancer
https://read.qxmd.com/read/33854590/changes-in-phospholipid-metabolism-in-exosomes-of-hormone-sensitive-and-hormone-resistant-prostate-cancer-cells
#11
Xianlin Yi, You Li, XiaoGang Hu, FuBing Wang, Tiangang Liu
Background: To explore the changes in lipids in exosomes of hormone-sensitive and hormone-resistant prostate cancer cells and develop an inexpensive and rapid technique for screening lipid-based biomarkers of prostate cancer. Methods: Exosomes were extracted from LnCap, PC3 and DU-145 cells, and their lipid composition was analyzed quantitatively using high-throughput mass spectrometry. Exosomes released by LnCap prostate cancer cells were also purified using a modified procedure based on polyethylene glycol (PEG) precipitation...
2021: Journal of Cancer
https://read.qxmd.com/read/33854206/male-sexual-dysfunction-and-rehabilitation-strategies-in-the-settings-of-salvage-prostate-cancer-treatment
#12
REVIEW
Eric Chung
Male sexual dysfunction, a common sequela following primary prostate cancer (PC) treatment, is likely to be more significant following salvage PC therapy. In general, these impairments in sexual domains can be divided into three groups, namely (1) sexual desire, sexuality and masculinity; (2) erectile function (EF); and (3) ejaculation and orgasm. However, there is considerable overlap between these sexual domains and male sexual response cycle, and various factors such as cancer status, mental well-being, medical conditions and social circumstances can adversely impact on the male sexual function...
April 14, 2021: International Journal of Impotence Research
https://read.qxmd.com/read/33853867/interleukin-4-receptor-inhibition-targeting-metastasis-independent-of-macrophages
#13
Megan M Cleary, Narendra Bharathy, Jinu Abraham, Erin R Rudzinski, Joel E Michalek, Charles Keller
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma occurring in children and carries a dismal prognosis when metastatic disease is detected. Our previous work has suggested the cytokine receptor IL4Rα may play a role in contributing to metastasis in the alveolar subtype of rhabdomyosarcoma (aRMS), and thus could present a therapeutic target. The IL4 signaling axis has been characterized in various adult cancers as well; however, pediatric trials often follow similar adult trials and the role of the IL4Rα receptor has not been explored in the context of a mediator of metastasis in adult disease...
April 14, 2021: Molecular Cancer Therapeutics
https://read.qxmd.com/read/33853754/overall-survival-after-systemic-treatment-in-high-volume-versus-low-volume-metastatic-hormone-sensitive-prostate-cancer-systematic-review-and-network-meta-analysis
#14
REVIEW
Mike Wenzel, Christoph Würnschimmel, Luigi Nocera, Claudia Collà Ruvolo, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Derya Tilki, Markus Graefen, Luis A Kluth, Frederik C Roos, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz
CONTEXT: Novel prospective randomized controlled observations addressing combination therapy in metastatic hormone-sensitive prostate cancer (mHSPC) have demonstrated promising overall survival (OS) outcomes. OBJECTIVE: To compare these novel findings and systematically review and address them within formal network meta-analyses (NMAs) that include observations from other prospective randomized controlled trials (RCTs). EVIDENCE ACQUISITION: First, we focused on abiraterone, enzalutamide, apalutamide, and docetaxel effects on OS in mHSPC using the PRISMA methodology...
April 11, 2021: European Urology Focus
https://read.qxmd.com/read/33852571/mapping-expanded-prostate-cancer-index-composite-to-eq5d-utilities-to-inform-economic-evaluations-in-prostate-cancer-secondary-analysis-of-nrg-rtog-0415
#15
Rahul Khairnar, Stephanie L Pugh, Howard M Sandler, W Robert Lee, Ester Villalonga Olives, C Daniel Mullins, Francis B Palumbo, Deborah W Bruner, Fadia T Shaya, Soren M Bentzen, Amit B Shah, Shawn C Malone, Jeff M Michalski, Ian S Dayes, Samantha A Seaward, Michele Albert, Adam D Currey, Thomas M Pisansky, Yuhchyau Chen, Eric M Horwitz, Albert S DeNittis, Felix Y Feng, Mark V Mishra
PURPOSE: The Expanded Prostate Cancer Index Composite (EPIC) is the most commonly used patient reported outcome (PRO) tool in prostate cancer (PC) clinical trials, but health utilities associated with the different health states assessed with this tool are unknown, limiting our ability to perform cost-utility analyses. This study aimed to map EPIC tool to EuroQoL-5D-3L (EQ5D) to generate EQ5D health utilities. METHODS AND MATERIALS: This is a secondary analysis of a prospective, randomized non-inferiority clinical trial, conducted between 04/2006 and 12/2009 at cancer centers across the United States, Canada, and Switzerland...
2021: PloS One
https://read.qxmd.com/read/33852531/efficacy-and-safety-of-177lu-dotmp-in-palliative-treatment-of-symptomatic-skeletal-metastases-a-prospective-study
#16
Neeraja Bollampally, Jaya Shukla, Bhagwant Rai Mittal, Ashwani Sood, Manju Mohanty, Rakesh Kapoor, Rakhee Vatsa, Swayamjeet Satapathy, Rubel Chakravarty, Sudipta Chakraborty, And Ashutosh K Dash
AIMS: Bone-seeking radiopharmaceutical 177Lu-DOTMP with favorable pharmacokinetics in the preclinical studies has been evaluated for its role in reducing bone pain and improving quality of life (QOL) in patients with symptomatic skeletal metastases. METHOD: Patients with painful widespread skeletal metastases documented on 99mTc-MDP bone scintigraphy were intravenously administered 37 MBq/kg of 177Lu-DOTMP. Visual analogue score (VAS), analgesic score, European Cooperative Group of Oncology (ECOG) and the European Organization of Research and Treatment of Cancer QLQ-C30 of all the patients were assessed at baseline and posttherapy follow-up...
April 12, 2021: Nuclear Medicine Communications
https://read.qxmd.com/read/33852421/genomic-alterations-impact-cell-cycle-related-genes-during-prostate-cancer-progression
#17
Salma Ben-Salem, Varadha Balaji Venkadakrishnan, Hannelore V Heemers
The recent genomic characterization of patient specimens has started to reveal the landscape of somatic alterations in clinical prostate cancer (CaP) and its association with disease progression and treatment resistance. The extent to which such alterations impact hallmarks of cancer is still unclear. Here, we interrogate genomic data from thousands of clinical CaP specimens that reflect progression from treatment-naïve, to castration-recurrent, and in some cases, neuroendocrine CaP for alterations in cell cycle-associated and -regulated genes, which are central to cancer initiation and progression...
April 1, 2021: Endocrine-related Cancer
https://read.qxmd.com/read/33852174/phosphorylated-lass2-inhibits-prostate-carcinogenesis-via-negative-regulation-of-wnt-%C3%AE-catenin-signaling
#18
Kuangen Zhang, Rui Wu, Fang Mei, Yuhe Zhou, Lin He, Yanhua Liu, Xuyang Zhao, Jiangfeng You, Beiying Liu, Qingyang Meng, Fei Pei
LASS2 is a novel tumor-suppressor gene and has been characterized as a ceramide synthase, which synthesizes very-long acyl chain ceramides. However, LASS2 function and pathway-related activity in prostate carcinogenesis are still largely unexplored. Here, we firstly report that LASS2 promotes β-catenin degradation through physical interaction with STK38, SCYL2, and ATP6V0C via the ubiquitin-proteasome pathway, phosphorylation of LASS2 is essential for β-catenin degradation, and serine residue 248 of LASS2 is illustrated to be a key phosphorylation site...
April 14, 2021: Journal of Cellular Biochemistry
https://read.qxmd.com/read/33852165/the-interaction-between-inflammation-urinary-symptoms-and-erectile-dysfunction-in-early-stage-prostate-cancer-treated-with-brachytherapy
#19
Alexandre Alcaidinho, David-Dan Nguyen, Guila Delouya, Kevin C Zorn, Fred Saad, Daniel Taussky, Daniel Liberman
Erectile function has been shown to decline as a function of increasing peripheral blood inflammatory markers, namely the neutrophil-to-lymphocyte ratio (NLR). We evaluated if the association between NLR and erectile dysfunction (ED) applies to patients with localised prostate cancer. We included 1,282 patients who underwent brachytherapy. ED was classified before treatment according to the Terminology Criteria for Adverse Event Scale version 3.0. ED was defined as the need for the use of oral pharmacologic or mechanical assistance to have satisfactory sexual function...
April 14, 2021: Andrologia
https://read.qxmd.com/read/33852051/patterns-of-disease-detection-using-18-f-dcfpyl-pet-ct-imaging-in-patients-with-detectable-psa-post-prostatectomy-being-considered-for-salvage-radiotherapy-a-prospective-trial
#20
Samantha Koschel, Kim Taubman, Thomas Sutherland, Kelvin Yap, Michael Chao, Mario Guerrieri, Angela Benson, Michelle Starmans, Graeme Byrne, Grace Ong, Craig Macleod, Marcus Foo, Lih Ming Wong, Dennis Gyomber, Michael Ng
PURPOSE: Prostate-specific membrane antigen (PSMA) PET/CT is increasingly used in patients with biochemical recurrence post prostatectomy to detect local recurrence and metastatic disease at low PSA levels. The aim of this study was to assess patterns of disease detection, predictive factors and safety using [18 F]DCFPyL PET/CT versus diagnostic CT in patients being considered for salvage radiotherapy with biochemical recurrence post prostatectomy. METHODS: We conducted a prospective trial recruiting 100 patients with detectable PSA post prostatectomy (PSA 0...
April 14, 2021: European Journal of Nuclear Medicine and Molecular Imaging
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