Fernando Echegaray, Peter Laing, Samantha Hernandez, Sully Marquez, Amanda Harris, Ian Laing, Adam Chambers, Neil McLennan, Victor A Sugiharto, Hua-Wei Chen, Sandra Vivero Villagran, Abigail Collingwood, Magelda Montoya, Fausto Bustos Carrillo, Mark P Simons, Philip J Cooper, Andrea Lopez, Gabriel Trueba, Joseph Eisenberg, Shuenn-Jue Wu, William Messer, Eva Harris, Josefina Coloma, Leah C Katzelnick
The only licensed dengue vaccine, Dengvaxia® , increases risk of severe dengue when given to individuals without prior dengue virus (DENV) infection but is protective against future disease in those with prior DENV immunity. The World Health Organization has recommended using rapid diagnostic tests (RDT) to determine history of prior DENV infection and suitability for vaccination. Dengue experts recommend that these assays be highly specific (≥98%) to avoid erroneously vaccinating individuals without prior DENV infection, as well as be sensitive enough (≥95%) to detect individuals with a single prior DENV infection...
2021: Frontiers in Immunology