keyword
https://read.qxmd.com/read/38534076/clinical-evaluation-and-surgical-management-of-ocular-malakoplakia-of-the-caruncle-and-periorbital-region-a-report-of-two-case-and-literature-review
#21
JOURNAL ARTICLE
Chinmayee J Thrishulamurthy, H Shafeeq Ahmed, Mohammed Sohail J, Dayananda S Biligi
Ocular malakoplakia, a rare inflammatory disorder characterized by Michaelis-Gutmann bodies, is presented in 2 unique cases involving uncommon anatomical sites-the orbit and caruncle. The first case describes a 10-year-old girl with localized subconjunctival swelling near the caruncle, prompting surgical excision, and revealing characteristic malakoplakia features. Despite medical management, surgical intervention provided symptom relief. The second case involves a painless swelling below the lower lid in a 23-year-old female, initially suggestive of lymphoma...
March 21, 2024: Ophthalmic Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38533980/diagnostic-utility-of-cytology-in-a-patient-with-epstein-barr-virus-positive-mucocutaneous-ulcer-in-palatine-tonsils-a-case-report
#22
JOURNAL ARTICLE
Mieko Doi, Mei Hamada, Keisuke Ishizawa, Naoki Fushimi, Yasuhiro Kase, Tetsuo Ikezono, Jun-Ichi Tamaru, Taketo Yamada
Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a newly established immunodeficiency-related disease. Herein, we report a case of EBVMCU and focus on its cytological usefulness for diagnosis. An 82-year-old man manifested pharyngalgia, dysphagia, and oral pain. His medical history included rheumatoid arthritis that had been treated with methotrexate. Clinically, peritonsillar abscess was suspected, but since neoplastic lesions, including malignant lymphoma (ML), could not be excluded, a series of cytohistological examination was attempted...
March 27, 2024: Diagnostic Cytopathology
https://read.qxmd.com/read/38533933/data-mining-and-safety-analysis-of-traditional-immunosuppressive-drugs-a-pharmacovigilance-investigation-based-on-the-faers-database
#23
JOURNAL ARTICLE
Juan-Juan Li, Li Chen, Yang Zhao, Xue-Qin Yang, Fa-Bin Hu, Li Wang
OBJECTIVE: The purpose of this study aimed to explore the new and serious adverse events(AEs) of Tacrolimus(FK506), cyclosporine(CsA), azathioprine(AZA), mycophenolate mofetil(MMF), cyclophosphamide(CTX) and methotrexate(MTX), which have not been concerned. METHODS: The FAERS data from January 2016 and December 2022 were selected for disproportionality analysis to discover the potential risks of traditional immunosuppressive drugs. RESULTS: Compared with CsA, FK506 has more frequent transplant rejection, and is more related to renal impairment, COVID-19, cytomegalovirus infection and aspergillus infection...
March 27, 2024: Expert Opinion on Drug Safety
https://read.qxmd.com/read/38533681/lymphomatoid-papulosis-with-t-cell-receptor-gamma-delta-expression-a-clinicopathologic-case-series-of-26-patients-of-an-underrecognized-immunophenotypic-variant-of-lymphomatoid-papulosis
#24
JOURNAL ARTICLE
Erica Mark, Werner Kempf, Joan Guitart, Melissa Pulitzer, Christina Mitteldorf, Alexandra Hristov, Carlos Torres-Cabala, Enrica Marchi, Thomas Cropley, Socorro Maria Rodriguez Pinilla, Teresa Griffin, Rony Fernandez, Stefano Pileri, Alessandro Pileri, Valentina Tabanelli, Lisa Borretta, Antonio Subtil, Jose Antonio Plaza, Jose A Miguel Angel Piris, Andrew L Feldman, Lorenzo Cerroni, Alejandro A Gru
Lymphomatoid papulosis (LyP) has several histopathologic presentations. LyP featuring gamma-delta (γδ) T-cell receptor expression may masquerade as and may be misdiagnosed as aggressive cutaneous T-cell lymphoma, particularly primary cutaneous γδ T-cell lymphoma (PCGDTL) or γδ mycosis fungoides. We performed a clinicopathologic analysis of the largest series of LyP featuring γδ T-cell expression. We identified 26 patients with a diagnosis of LyP with γδ T cells from our institutions, as well as through a comprehensive review of the literature, and characterized these cases...
March 27, 2024: American Journal of Surgical Pathology
https://read.qxmd.com/read/38533514/single-cell-transcriptome-sequencing-provides-insight-into-multiple-chemotherapy-resistance-in-a-patient-with-refractory-dlbcl-a-case-report
#25
Kewei Zhao, Qiuhui Li, Pengye Li, Tao Liu, Xinxiu Liu, Fang Zhu, Liling Zhang
Relapsed and refractory diffuse large B-cell lymphoma (DLBCL) is associated with poor prognosis. As such, a comprehensive analysis of intratumoral components, intratumoral heterogeneity, and the immune microenvironment is essential to elucidate the mechanisms driving the progression of DLBCL and to develop new therapeutics. Here, we used single-cell transcriptome sequencing and conventional bulk next-generation sequencing (NGS) to understand the composite tumor landscape of a single patient who had experienced multiple tumor recurrences following several chemotherapy treatments...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38532849/multimodal-imaging-in-a-case-of-presumed-secondary-vitreoretinal-lymphoma-presenting-with-inner-retina-and-optic-nerve-head-infiltration
#26
Emily S Levine, Nikhil N Batra
PURPOSE: To report the findings supported by multimodal imaging in a case of secondary vitreoretinal lymphoma presenting with inner retina and optic nerve head infiltration. OBSERVATIONS: A 64-year-old man with systemic diffuse large B-cell lymphoma presented with reduced visual acuity. Moderate anterior chamber and vitreous cell were present. Fundus exam showed bilateral disc edema and diffuse opaque macular infiltrates with a pseudo cherry-red spot in the left eye...
June 2024: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/38532751/gelatinous-bone-marrow-with-vivid-fatty-cells
#27
Osamu Imataki, Makiko Uemura
We treated a 78-year-old Japanese man with gastric diffuse large B cell lymphoma. The patient received three courses of chemotherapy and involved-field local radiation therapy to the stomach. Three years after chemotherapy, the patient become sick with anorexia and pancytopenia. He was cachexic, however, levels of vitamin B12, folate, zinc, and copper were normal. His bone marrow revealed focal eosinophilic deposit characterized by mixture of vivid atrophic fatty cells, which was pathologically diagnosed as gelatinous bone marrow...
March 2024: Oxford Medical Case Reports
https://read.qxmd.com/read/38532575/long-term-outcome-of-peripheral-t-cell-lymphomas-ten-year-follow-up-of-the-international-prospective-t-cell-project
#28
JOURNAL ARTICLE
M Civallero, J G Schroers-Martin, S Horwitz, M Manni, Y Stepanishyna, M E Cabrera, J Vose, M Spina, F Hitz, A Nagler, S Montoto, C Chiattone, T Skrypets, M A Perez Saenz, G Priolo, S Luminari, A Lymboussaki, A Pavlovsky, D Marino, M Liberati, J Trotman, D Mannina, M Federico, R Advani
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of haematological cancers with generally poor clinical outcomes. However, a subset of patients experience durable disease control, and little is known regarding long-term outcomes. The International T-cell Lymphoma Project (ITCLP) is the largest prospectively collected cohort of patients with PTCLs, providing insight into clinical outcomes at academic medical centres globally. We performed a long-term outcome analysis on patients from the ITCLP with available 10-year follow-up data (n = 735)...
March 26, 2024: British Journal of Haematology
https://read.qxmd.com/read/38532527/management-of-vaccinations-in-patients-with-non-hodgkin-lymphoma
#29
REVIEW
Michele Merli, Andrea Costantini, Silvio Tafuri, Davide Fiore Bavaro, Carla Minoia, Erika Meli, Stefano Luminari, Guido Gini
Vaccinations are fundamental tools in preventing infectious diseases, especially in immunocompromised patients like those affected by non-Hodgkin lymphomas (NHLs). The COVID-19 pandemic made clinicians increasingly aware of the importance of vaccinations in preventing potential life-threatening SARS-CoV-2-related complications in NHL patients. However, several studies have confirmed a significant reduction in vaccine-induced immune responses after anti-CD20 monoclonal antibody treatment, thus underscoring the need for refined immunization strategies in NHL patients...
March 26, 2024: British Journal of Haematology
https://read.qxmd.com/read/38532323/neuro-protective-effect-of-acetyl-11-keto-%C3%AE-boswellic-acid-in-a-rat-model-of-scopolamine-induced-cholinergic-dysfunction
#30
JOURNAL ARTICLE
Amir Hossein Assaran, Mahmoud Hosseini, Matin Shirazinia, Mohammad Hosein Eshaghi Ghalibaf, Farimah Beheshti, Leila Mobasheri, Farshad Mirzavi, Arezoo Rajabian
BACKGROUND: Acetyl-11-keto-β-boswellic acid (AKBA) is a major component of the oleo-gum resin of B. serrata with multiple pharmacological activities. The objective of this study was to explore the underlying mechanisms of neuroprotective potential of AKBA against scopolamine-mediated cholinergic dysfunction and memory deficits in rats. METHODS: The rats received AKBA (2.5, 5, and 10 mg/kg, oral) for 21 days. In the third week, scopolamine was administered 30 min before the Morris water maze and passive avoidance tests...
2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38532234/stigma-risks-and-benefits-of-medicinal-cannabis-use-among-australians-with-cancer
#31
JOURNAL ARTICLE
Julia N Morris, Jessica Loyer, Jason Blunt
PURPOSE: People with cancer who use medicinal cannabis do so despite risks associated with limited clinical evidence, legalities, and stigma. This study investigated how Australians with cancer rationalise their medicinal cannabis use despite its risks. METHODS: Ten adults (5 males and 5 females; mean age of 53.3) who used cannabis medicinally for their cancer were interviewed in 2021-2022 about how they used and accessed the substance, attitudes and beliefs underpinning their use, and conversations with others about medicinal cannabis...
March 27, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38532079/allogeneic-hematopoietic-stem-cell-transplantation-after-mogamulizumab-in-t-cell-lymphoma-patients-a-retrospective-analysis
#32
JOURNAL ARTICLE
Mary Jo Lechowicz, Christy Smith, Robert Ristuccia, Karen Dwyer
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important therapy for patients with T-cell lymphomas, including cutaneous T-cell lymphoma (CTCL), adult T-cell lymphoma (ATL), and peripheral T-cell lymphoma (PTCL). Mogamulizumab is an anti-CCR4 antibody that has been associated with an increased risk of transplant-related complications in retrospective analyses of ATL, particularly when administered within 50 days before transplantation. This post hoc analysis of 3 clinical trials examined safety and outcome data for 32 patients with CTCL (n = 23), ATL (n = 7), or PTCL (n = 2) who underwent allo-HSCT after mogamulizumab treatment...
March 27, 2024: International Journal of Hematology
https://read.qxmd.com/read/38532075/miliary-tuberculosis-diagnosed-by-diffuse-hepatic-uptake-on-pet-ct-and-transjugular-liver-biopsy
#33
JOURNAL ARTICLE
Ren Ueta, Akiko Saito, Yuka Yanai, Yuki Otake, Chizu Yokoi, Jun-Ichi Akiyama, Mikio Yanase, Tsuyoshi Tajima
The patient was an 81-year-old man. In his 20s, he had been treated with pharmacotherapy for pulmonary tuberculosis for 1 year. He presented to the Department of Respiratory Medicine with a chief complaint of dyspnea. The possibility of respiratory disease appeared to be low, but hepatic impairment was detected. The patient was thus referred to our department. Though the cause of hepatic impairment was unknown, the soluble interleukin-2 receptor level was elevated, suggesting malignant lymphoma. 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) revealed diffuse, homogenous, intense FDG uptake in the entire liver, and transjugular liver biopsy confirmed the diagnosis...
March 26, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38531903/cancer-incidence-trends-in-new-york-state-and-associations-with-common-population-level-exposures-2010-2018-an-ecological-study
#34
JOURNAL ARTICLE
Haokun Yuan, Rebecca D Kehm, Josephine M Daaboul, Susan E Lloyd, Jasmine A McDonald, Lina Mu, Parisa Tehranifar, Kai Zhang, Mary Beth Terry, Wan Yang
The impact of common environmental exposures in combinations with socioeconomic and lifestyle factors on cancer development, particularly for young adults, remains understudied. Here, we leveraged environmental and cancer incidence data collected in New York State at the county level to examine the association between 31 exposures and 10 common cancers (i.e., lung and bronchus, thyroid, colorectal, kidney and renal pelvis, melanoma, non-Hodgkin lymphoma, and leukemia for both sexes; corpus uteri and female breast cancer; prostate cancer), for three age groups (25-49, 50-69, and 70-84 year-olds)...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531863/how-comparable-are-patient-outcomes-in-the-real-world-with-populations-studied-in-pivotal-aml-trials
#35
JOURNAL ARTICLE
Ing Soo Tiong, Meaghan Wall, Ashish Bajel, Akash Kalro, Shaun Fleming, Andrew W Roberts, Nisha Thiagarajah, Chong Chyn Chua, Maya Latimer, David Yeung, Paula Marlton, Amanda Johnston, Anoop Enjeti, Chun Yew Fong, Gavin Cull, Stephen Larsen, Glen Kennedy, Anthony Schwarer, David Kipp, Sundra Ramanathan, Emma Verner, Campbell Tiley, Edward Morris, Uwe Hahn, John Moore, John Taper, Duncan Purtill, Pauline Warburton, William Stevenson, Nicholas Murphy, Peter Tan, Ashanka Beligaswatte, Howard Mutsando, Mark Hertzberg, Jake Shortt, Ferenc Szabo, Karin Dunne, Andrew H Wei
Despite an increasing desire to use historical cohorts as "synthetic" controls for new drug evaluation, limited data exist regarding the comparability of real-world outcomes to those in clinical trials. Governmental cancer data often lacks details on treatment, response, and molecular characterization of disease sub-groups. The Australasian Leukaemia and Lymphoma Group National Blood Cancer Registry (ALLG NBCR) includes source information on morphology, cytogenetics, flow cytometry, and molecular features linked to treatment received (including transplantation), response to treatment, relapse, and survival outcome...
March 26, 2024: Blood Cancer Journal
https://read.qxmd.com/read/38531816/simultaneous-determination-of-ibrutinib-dihydroxydiol-ibrutinib-and-zanubrutinib-in-human-plasma-by-liquid-chromatography-mass-spectrometry-mass-spectrometry
#36
JOURNAL ARTICLE
Yu-Jiao Guo, Tian-Tian Du, Yan-Ling Yang, Yang Zhao, Xiang-Long Chen, Hong Ma, Lu-Ning Sun, Yong-Qing Wang
BACKGROUND: Ibrutinib and zanubrutinib are Bruton tyrosine kinase inhibitors used to treat mantle cell lymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma. Dihydroxydiol ibrutinib (DHI) is an active metabolite of the drug. A liquid chromatography-tandem mass spectrometry method was developed to detect ibrutinib, DHI, and zanubrutinib in human plasma. METHODS: The method involved a protein precipitation step, followed by chromatographic separation using a gradient of 10 mM ammonium acetate (containing 0...
March 21, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38531803/analysis-and-investigation-of-bioinformatics-and-epigenetics-reveal-the-underlying-mechanisms-by-which-flot2-modulates-the-progression-of-diffuse-large-b-cell-lymphoma
#37
JOURNAL ARTICLE
Yujing Zhang, Yao Chen, Qiang Guo, Ying Zhang, Aichun Liu
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) poses a significant threat to the quality of life for people worldwide. Regrettably, effective treatment strategies for this disease remain elusive in clinical practice due to the unclear understanding of its molecular mechanisms. Therefore, this study was devised to address these issues and identify novel diagnostic, therapeutic, and prognostic biomarkers for DLBCL. METHODS: Gene expression and clinical data for DLBCL patients were retrieved from The Cancer Genome Atlas (TCGA) database, and relevant clinical data, tumor mutational burden (TMB), and gene expression levels were extracted...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531760/car-t-cell-therapy-a-collaboration-between-authorized-treatment-centers-and-community-oncologists
#38
REVIEW
Michael R Bishop, Gary E Kay
With the approval of the first CAR T-cell products for hematological malignancies in 2017, these autologous cell therapies have changed the treatment paradigm for patients with relapsed or refractory (r/r) non-Hodgkin lymphoma (NHL), who have a poor prognosis and few effective treatment options. Despite the demonstrated clinical benefit in patients with r/r diffuse large B-cell lymphoma, mantle cell lymphoma, and follicular lymphoma, many patients who are eligible for CAR T-cell therapies do not receive them or are treated with CAR T cells as a later line of therapy at advanced stages of disease...
February 22, 2024: Seminars in Oncology
https://read.qxmd.com/read/38531551/treating-anaplastic-lymphoma-kinase-alk-fusion-driven-metastatic-non-small-cell-lung-cancer-nsclc-with-alectinib-through-pregnancy
#39
JOURNAL ARTICLE
Florence Wu, Rebekah Rittberg, Kenneth Lim, Cheryl Ho
Management of cancer during pregnancy requires careful consideration of risks and benefits from maternal and fetal perspectives. For advanced lung adenocarcinomas, with no targetable driver mutations, there is evidence-based guidance on the use of carboplatin-paclitaxel chemotherapy after first trimester. In contrast, for epidermal growth factor receptor (EGFR)-mutated or anaplastic lymphoma kinase (ALK)-rearranged metastatic lung adenocarcinomas, there is a paucity of clinical data on the safety of EGFR and ALK tyrosine kinase inhibitors to mother and fetus for official guidelines to recommend the use of these otherwise-first-line therapies in pregnancy...
March 25, 2024: BMJ Case Reports
https://read.qxmd.com/read/38531062/nivolumab-plus-brentuximab-vedotin-for-relapsed-refractory-peripheral-t-cell-lymphoma-and-cutaneous-t-cell-lymphoma
#40
JOURNAL ARTICLE
Pier Luigi Zinzani, Gilles A Salles, Alison J Moskowitz, Armando Santoro, Amitkumar Mehta, Paul M Barr, Neha Mehta-Shah, Graham P Collins, Stephen M Ansell, Joshua D Brody, Eva Domingo-Domenech, Nathalie A Johnson, David Cunningham, Silvia Ferrari, Julie M Lisano, Jennifer Krajewski, Rachael Wen, Alev Akyol, Russell Crowe, Kerry J Savage
No abstract text is available yet for this article.
March 26, 2024: Blood Advances
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