Yin Huang, Dehong Cao, Zeyu Chen, Bo Chen, Jin Li, Jianbing Guo, Qiang Dong, Liangren Liu, Qiang Wei
The purpose of this umbrella review was to evaluate the quality of evidence, validity and biases of the associations between red and processed meat consumption and multiple cancer outcomes according to existing systematic reviews and meta-analyses. The umbrella review identified 72 meta-analyses with 20 unique outcomes for red meat and 19 unique outcomes for processed meat. Red meat consumption was associated with increased risk of overall cancer mortality, non-Hodgkin lymphoma (NHL), bladder, breast, colorectal, endometrial, esophageal, gastric, lung and nasopharyngeal cancer...
March 27, 2021: Food Chemistry
K Chaker, M Beghdad, M A Mennouni, A Mkhatri, Y Oukessou, M Mahtar
INTRODUCTION: Primary lymphoma of the larynx is extremely rare, representing less than 1% of all primary laryngeal neoplasms. It consists mainly of non-Hodgkin lymphomas (NHLs), represented particularly by diffuse large B-cell. Extranodal natural killer/T-cell lymphoma, presented in larynx is a rare condition that accounts for less than 11% of all lymphomas without distinctive clinicopathologic features, as well as challenging pathologic diagnosis. CASE REPORT: We report here a case of a 64-years-old man who presented with primary lymphoma type T of the subglottic larynx...
April 2, 2021: International Journal of Surgery Case Reports
Jessica Katherine Cameron, Peter Baade
BACKGROUND: Accurate forecasts of cancer incidence, with appropriate estimates of uncertainty, are crucial for planners and policy makers to ensure resource availability and prioritize interventions. We used Bayesian age-period-cohort (APC) models to project the future incidence of cancer in Australia. METHODS: Bayesian APC models were fitted to counts of cancer diagnoses in Australia from 1982 to 2016 and projected to 2031 for seven key cancer types: breast, colorectal, liver, lung, non-Hodgkin lymphoma, melanoma and stomach...
April 7, 2021: Cancer Epidemiology
Zhaoqiang Zhang, Xiao Sun, Kun Wang, Yang Yu, Li Zhang, Keping Zhang, Jinglongfei Gu, Xiaofan Yuan, Guohua Song
Some cardiovascular symptoms in the early stage of Parkinson's disease (PD) were related to degeneration of the rostral ventrolateral medulla (RVLM) catecholaminergic neurons. To date, little is known about the effects of hydrogen water on early stage of PD. Here, protective actions of hydrogen-saturated saline (HS) on rotenone-induced PD rats, as well as its underlying mechanisms were investigated. HS was used to treat PD rats at three general stages; early, medium and late, which were represented by rotenone induced rats for 0, 7 and 14 days...
April 7, 2021: Brain Research Bulletin
Maurizio Bruno Nava, Paolo Chiodini, Giuseppe Catanuto, Nicola Rocco
Breast Implant Associated-Anaplastic Large Cell Lymphoma (BIA-ALCL) is a distinctive type of T-cell lymphoma arising around breast implants. We performed a review of the existing literature with the aim of providing an evidence-based overview of the available data on BIA-ALCL with a standardized evaluation of the quality of the studies and investigating the potential association between textured breast implants and BIA-ALCL.We analyzed the literature reporting estimates of relative or absolute risks of BIA-ALCL in case-control, cohort studies and case series studies...
April 9, 2021: Aesthetic Plastic Surgery
Rebecca Caeser, Jie Gao, Miriam Di Re, Chun Gong, Daniel J Hodson
Next-generation sequencing has transformed our knowledge of the genetics of lymphoid malignancies. However, limited experimental systems are available to model the functional effects of these genetic changes and their implications for therapy. The majority of mature B-cell malignancies arise from the germinal center (GC) stage of B-cell differentiation. Here we describe a detailed protocol for the purification and ex vivo expansion of primary, nonmalignant human GC B cells. We present methodology for the high-efficiency transduction of these cells to enable combinatorial expression of putative oncogenes...
April 9, 2021: Nature Protocols
Ruoning Ni, Mahmoud Amr, Abhishek Kalla
BACKGROUND Hodgkin lymphoma (HL) is a relatively rare etiology of superior vena cava (SVC) syndrome, with only 24 cases reported in the literature. The characteristics, management, and prognosis of HL-associated SVC syndrome remain unclear. This case report describes nodular sclerosis classical HL and the associated clinical manifestations presenting as SVC syndrome in a middle-aged patient, and it summarizes the characteristics of HL-associated SVC syndrome. CASE REPORT In this case report, we present a 53-year-old Hispanic man with progressively worsening dyspnea, dry cough, facial and neck edema, and dysphagia...
April 10, 2021: American Journal of Case Reports
Luca Castagna, Anna Dodero, Francesca Patriarca, Francesco Onida, Attilio Olivieri, Domenico Russo, Laura Giordano, Ignazio Majolino, Stefania Bramanti, Jacopo Mariotti, Barbara Sarina, Chiara De Philippis, Lucia Farina, Carmelo Carlo-Stella, Paolo Corradini, Armando Santoro
Allogeneic stem cell transplantation from haploidentical donors using unmanipulated bone marrow and posttransplantation cyclophosphamide has been largely employed to cure high-risk lymphomas. However, the increased incidence of relapse associated with the use of a nonmyeloablative conditioning regimen is still considered a concerning issue. The aim of our study was to prospectively evaluate the efficacy and feasibility of a reduced-intensity conditioning regimen, including thiotepa, cyclophosphamide, and fludarabine, in high-risk lymphoma patients...
April 2021: Transplantation and cellular therapy
Aimee M Merino, Rohtesh S Mehta, Xianghua Luo, Hansol Kim, Todd De For, Murali Janakiram, Sarah Cooley, Rose Wangen, Frank Cichocki, Daniel J Weisdorf, Jeffrey S Miller, Veronika Bachanova
Adaptive natural killer (NK) cells are long-lived and exhibit properties of immunologic memory against cytomegalovirus (CMV). We previously reported that expansion of adaptive NK cells after CMV reactivation in recipients of allogeneic hematopoietic cell transplantation (HCT) was associated with a lower rate of relapse of acute myelogenous leukemia. In the present study, we examined the impact of adaptive NK cell expansion in a cohort of 110 individuals who underwent autologous HCT (AHCT) for a lymphoid malignancy (lymphoma or multiple myeloma [MM])...
April 2021: Transplantation and cellular therapy
Jiasheng Wang, Changsu Park, Raul Arroyo-Suarez
It is unknown if daratumumab could affect venous thromboembolism (VTE) risks in patients with multiple myeloma (MM). In this study, individual participant data from three trials comparing daratumumab (DARA) and non-DARA regimens, the CASTOR, PULLOX and MAIA trial, were pooled into two groups. A total of 896 and 899 patients received DARA and non-DARA regimens, respectively. After a median follow-up of 13.9 and 13.5 months, there was no significant difference in VTE incidence between the two groups (hazard ratio 0...
April 9, 2021: Leukemia & Lymphoma
Jessica Alvarez-Lesmes, Jennifer R Chapman, Daniel Cassidy, Yi Zhou, Monica Garcia-Buitrago, Elizabeth A Montgomery, Izidore S Lossos, Daniel Sussman, Julio Poveda
CONTEXT.—: The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin lymphoma, accounting for 20% to 40% of all extranodal lymphomas. The majority of these are systemic processes secondarily involving the GI tract. Primary GI lymphomas are less common, accounting for approximately 10% to 15% of all non-Hodgkin lymphoma. Most non-Hodgkin lymphoma involving the GI tract are of B-cell lineage, of which diffuse large B-cell lymphoma is the most common subtype, irrespective of location...
April 9, 2021: Archives of Pathology & Laboratory Medicine
Jia-Qi Qin, Hua Yin, Jia-Zhu Wu, Rui-Ze Chen, Yi Xia, Li Wang, Hua-Yuan Zhu, Lei Fan, Jian-Yong Li, Jin-Hua Liang, Wei Xu
The study investigated serum 25-Hydroxy vitamin D (25-(OH)D) deficiency and its prognostic values of patients newly diagnosed Hodgkin lymphoma (HL). With seventy-seven patients enrolled, the median level of 25-(OH)D was 44.5 nmol/L (range, 15.5-100.9 nmol/L) and 16 (20.8 %) of them were considered as 25-(OH)D deficiency. With a median follow-up of 28 months (range, 4-56 months), the 2-year progression-free survival (PFS) and overall survival (OS) rate were 75.3 %±5.5 % and 94.7 %±3.0 %, respectively. Patients with deficient 25-(OH)D level had inferior PFS (P<0...
March 29, 2021: Leukemia Research
Mohamed A El-Emam, Samar El Achy, Dalaal M Abdallah, Hanan S El-Abhar, Mennatallah A Gowayed
AIMS: The fact that physical activity besides central cholinergic enhancement contributes in improving neuronal function and spastic plasticity, recommends the use of the anticholinesterase and cholinergic drug galantamine with/without exercise in the management of the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). MATERIALS AND METHODS: Sedentary and 14 days exercised male Sprague Dawley rats were subjected to EAE. Hereafter, exercised rats continued on rotarod for 30 min for 17 consecutive days...
April 6, 2021: Life Sciences
Anadil Faqah, Summaiya Asif, Suleyman Yasin Goksu, Hassan S Sheikh
PURPOSE: CNS relapse in patients with diffuse large B-cell lymphoma (DLBCL) is associated with poor prognosis with a median survival of about 2.5 months. Data demonstrating best prophylactic strategy remain controversial and need further definition. PATIENTS AND METHODS: We present data of 110 patients with DLBCL treated with standard systemic therapy divided into four groups based on primary CNS prophylaxis strategy and CNS International Prognostic Index (IPI) risk categories...
April 2021: JCO global oncology
Marina Silveira Cucco, Laise Eduarda Paixão de Moraes, Felipe de Oliveira Andrade, Ricardo Khouri, Bernardo Galvão-Castro, Thessika Hialla Araujo, Filipe Ferreira de Almeida Rego, Luana Leandro Gois, Fernanda Khouri Barreto, Luciane Amorim Santos
The Human T-Cell Lymphotropic Virus Type-1 (HTLV-1) is associated with severe pathologies as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult T-cell leukemia-lymphoma (ATLL) and infective dermatitis associated with the HTLV-1 (IDH). Interestingly, HTLV-1 infection does not necessarily imply in the development of pathological processes and it is unknown why some patients remains as asymptomatic carriers (AC). Despite some mutations in HTLV-1 genome appear to influence the outcome of HTLV-1, there are few studies that characterizes molecularly the hbz region...
April 9, 2021: Journal of Medical Virology
Natalia Rendón-Serna, Luis A Correa-Londoño, Margarita M Velásquez-Lopera, Maria Bermudez-Muñoz
Cutaneous T-cell lymphomas (CTCL) result from the infiltration and proliferation of a population of T cells in the skin, inducing changes in the activity of both T cells and surrounding skin cells. In the CTCL microenvironment, cell interactions mediated by cell signaling pathways are altered. Defining changes in cell signaling enables to understand T-cell deregulations in the CTCL microenvironment and thus the progression of the disease. Moreover, characterizing signaling networks activated in CTCL stages can lead to consider new molecular biomarkers and therapeutic targets...
April 9, 2021: International Journal of Dermatology
Atef Abdel-Moneem Ali, Ehab Abdel-Raouf Essawy, Heba Salah El-Din Fathy Hamed, Ahmed E Abdel Moneim, Fawzy Ali Attaby
Neuropathy is considered a critical complication of diabetes mellitus (DM). Scientific studies are needed to relieve these painful complications. The current study aims to estimate the ameliorative role of Physalis juice (PJ) against neurological impairment in streptozotocin (STZ)-induced diabetic rats. Type 1 DM was induced after one week of injecting rats with 55 mg STZ/kg body weight. PJ-treated rats were orally administered 5 ml PJ/kg body weight per day for 28 days after induction of diabetes. A small piece of the cerebral cortex of rats was fixed and used for histopathological investigations...
April 9, 2021: Metabolic Brain Disease
Ziv Frankenstein, Naohiro Uraoka, Umut Aypar, Ruth Aryeequaye, Mamta Rao, Meera Hameed, Yanming Zhang, Yukako Yagi
Fluorescence in situ hybridization (FISH) is a technique to visualize specific DNA/RNA sequences within the cell nuclei and provide the presence, location and structural integrity of genes on chromosomes. A confocal Whole Slide Imaging (WSI) scanner technology has superior depth resolution compared to wide-field fluorescence imaging. Confocal WSI has the ability to perform serial optical sections with specimen imaging, which is critical for 3D tissue reconstruction for volumetric spatial analysis. The standard clinical manual scoring for FISH is labor-intensive, time-consuming and subjective...
April 9, 2021: Applied Microscopy
Kyle P D'mello, Lei Zhao, Erin C Kaser, Ziwen Zhu, Huaping Xiao, Mark R Wakefield, Qian Bai, Yujiang Fang
Non-Hodgkin's lymphoma is a relatively common cancer with malignant tendencies. Although there is no current cure for the disease, research has been successful in figuring out the mechanisms of how the disease progresses, however, there is still a lot of unknowns, and more research must be done to find the ultimate cause of the disease. Interleukins and various cytokines play unique roles in the development of cancer. This review article summarizes the pathophysiology between certain interleukins and non-Hodgkin's lymphoma...
April 9, 2021: Medical Oncology
Angela Steineck, Eric J Chow, David R Doody, Beth A Mueller
PURPOSE: Children with cancer are frequently hospitalized. However, hospitalization and death by disease category are not well defined < 5 years from diagnosis. METHODS: We conducted a retrospective cohort study using linked cancer registry-hospital discharge-vital records to identify cancer cases < 20 years at diagnosis during 1987-2012 (n = 4,567) and comparison children without cancer, matched on birth year and sex (n = 45,582). Data linkage identified serious morbidities resulting in cancer- and non-cancer-related hospitalizations or deaths < 5 years from diagnosis...
April 9, 2021: Cancer Causes & Control: CCC
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