Fabio Santanelli Di Pompeo, Demosthenes Panagiotakos, Guido Firmani, Michail Sorotos
BACKGROUND: The epidemiologic picture of Breast Implant Associated-Anaplastic Large Cell Lymphoma (BIA-ALCL) is unclear, with no high-level evidence, as only case reports and series are available. OBJECTIVES: We aimed at updating the BIA-ALCL epidemiology by using all available data through a systematic review of scientific literature. METHODS: A search on PubMed, Scopus, and Web of Science was conducted between October 2021 and April 2022...
November 29, 2022: Aesthetic Surgery Journal
Haijun Gu, Jia He, Yuzhan Li, Dazhao Mi, Tian Guan, Weikai Guo, Bo Liu, Yihua Chen
B-cell lymphoma 6 (BCL6) is a transcriptional repressor that regulates the differentiation of B lymphocytes and mediates the formation of germinal centers (GCs) by recruiting corepressors through the BTB domain of BCL6. Physiological processes regulated by BCL6 involve cell activation, differentiation, DNA damage, and apoptosis. BCL6 is highly expressed when the gene is mutated, leading to the malignant proliferation of cells and drives tumorigenesis. BCL6 overexpression is closely correlated with tumorigenesis in diffuse large B-cell lymphoma (DLBCL) and other lymphomas, and BCL6 inhibitors can effectively inhibit some lymphomas and overcome resistance...
November 28, 2022: Journal of Medicinal Chemistry
Daniel J Landsburg, Jennifer J D Morrissette, Stephen J Schuster, Sunita D Nasta, James N Gerson, Stefan K Barta, Jakub Svoboda, Elise A Chong, Megan S Lim
Comprehensive genomic analyses of tumor biopsies from patients with newly-diagnosed germinal center B cell (GCB) diffuse large B cell/high grade B cell lymphoma (DLBCL/HGBL) have identified molecular subtypes predictive of inferior survival, which are characterized by somatic mutations that can be detected through clinical laboratory mutation analysis (CLMA). To determine the frequency and predictive value of individual genetic mutations associated with these experimentally-defined poor-risk subgroups, we reviewed the findings from CLMA performed on tumors from patients with newly-diagnosed GCB DLBCL/HGBL who were previously treated at our institution...
November 17, 2022: Oncotarget
Jason Gurney, James Stanley, Andrea Teng, Jeremy Krebs, Jonathan Koea, Chunhuan Lao, Ross Lawrenson, Ineke Meredith, Dianne Sika-Paotonu, Diana Sarfati
The number of new cases of cancer is increasing each year, and rates of diabetes mellitus are also increasing dramatically over time. It is not an unusual occurrence for an individual to have both cancer and diabetes at the same time, given they are both individually common, and that one condition can increase the risk of the other. In this manuscript, we use national-level diabetes (Virtual Diabetes Register) and cancer (New Zealand Cancer Registry) data on nearly five million individuals over 44 million person-years of follow-up to examine the occurrence of cancer amongst a national prevalent cohort of patients with diabetes...
2022: PloS One
Alen Zabotti, Enrico Pegolo, Ivan Giovannini, Valeria Manfrè, Michele Lorenzon, Alojzija Hocevar, Sara Zandonella Callegher, Christian Dejaco, Luca Quartuccio, Carla Di Loreto, Chiara Zuiani, Salvatore De Vita
OBJECTIVES: The diagnosis and classification of primary Sjögren's syndrome (pSS) relies on labial biopsy, whereas the role of open parotid biopsy is mainly reserved to evaluate the lymphoproliferative complications. Recently ultrasound-guided core needle biopsy (US-guided CNB) appeared as a novel and safe technique useful in lymphoma assessment, however, its potential role in the diagnosis of pSS has never been assessed.The main aim of this study was to evaluate the diagnostic value of US-guided CNB of the parotid glands in patients affected by pSS...
November 21, 2022: Clinical and Experimental Rheumatology
Sidsel J Juul, Sára Rossetti, Michal Kicinski, Marleen A E van der Kaaij, Francesco Giusti, Paul Meijnders, Berthe M P Aleman, John M M Raemaekers, Hanneke C Kluin-Nelemans, Michele Spina, Christophe Fermé, Loïc Renaud, Olivier Casasnovas, Aspasia Stamatoullas, Marc André, Fabien Le Bras, Wouter J Plattel, Michel Henry-Amar, Martin Hutchings, Maja V Maraldo
PURPOSE: Little is known about the employment situation of long-term Hodgkin lymphoma (HL) survivors despite their young age at diagnosis and the favorable prognosis of the disease. In this cross-sectional study, we aim to describe the employment situation in a cohort of long-term HL survivors compared to the general population and investigate the associations with disease characteristics and treatment exposure. METHODS: HL survivors > 25 years (n = 1961) were matched 1:25 to controls (n = 49,025) from the European Union Labour Force Survey...
November 28, 2022: Journal of Cancer Survivorship: Research and Practice
Jinrong Zhao, Yan Zhang, Wei Wang, Wei Zhang, Dao-Bin Zhou
OBJECTIVES: To analyse the clinical features, outcomes, and risk factors of patients with diffuse large B-cell lymphoma (DLBCL) in China, with the aim to establish a new prognostic model based on risk factors. METHODS: Clinical features and outcomes of 564 patients newly diagnosed with DLBCL from Jan 2009 to May 2017 were analyzed retrospectively. Variables were screened by LASSO regression and nomogram was constructed. RESULTS: The 5-year overall survival (OS) of the cohort was 75%...
2022: Journal of Oncology
Benjamin J McCormick, Razvan M Chirila
Gordonia species are gram-positive, partially acid-fast bacteria recognized as pathogens associated with medical devices and catheter-related infections in immunocompetent and immunocompromised hosts. We describe a rare case of Gordonia bronchialis bacteremia due to central venous catheter infection in a patient undergoing active chemotherapy for Burkitt lymphoma. We review the diagnosis, treatment, and extent of infections reported throughout medical literature about this rare and emerging pathogen.
October 2022: Curēus
Yuan Chen, Hu Zhao, Jing Luo, Youping Liao, Xu Dan, Guoyu Hu, Weiyue Gu
UNLABELLED: Peripheral T-cell lymphoma (PTCL) is a type of highly heterogeneous non-Hodgkin lymphoma with a poor prognosis and lack of effective targeted therapies. Adoptive T-cell therapy has been successfully used in the treatment of B-cell malignancies. We first used adoptive transfer of haploidentical T cells activated by patient-specific neoantigens in vitro to treat an elderly patient with refractory angioimmunoblastic T-cell lymphoma (AITL) in 2017, and the patient achieved long-term complete remission (CR)...
2022: Frontiers in Oncology
Zhiwei Peng, Li Yi, Yahong Tao, Zhiyong Chen, Ze Lin, Anjing He, Mengni Jin, Fanrong Liu, Minjing Zuo
BACKGROUND: The risk of gastrointestinal stromal tumor (GIST) in combination with other primary malignancies is high, which occurs before and after the diagnosis of GIST. Primary pulmonary T-cell lymphoma is a rare type of non-Hodgkin lymphoma. CASE PRESENTATION: We report a 53-year-old male patient who was admitted to our hospital with fever, cough, and expectoration for 2 weeks. Chest computed tomography (CT) showed a cavitary mass in the left lower lobe with multiple nodules in the upper lobes of both lungs...
2022: Frontiers in Oncology
Miri Michaeli, Emanuela Carlotti, Helena Hazanov, John G Gribben, Ramit Mehr
Follicular lymphoma (FL) is an indolent disease, characterized by a median life expectancy of 18-20 years and by intermittent periods of relapse and remission. FL frequently transforms into the more aggressive diffuse large B cell lymphoma (t-FL). In previous studies, the analysis of immunoglobulin heavy chain variable region (IgHV) genes in sequential biopsies from the same patient revealed two different patterns of tumor clonal evolution: direct evolution, through acquisition of additional IgHV mutations over time, or divergent evolution, in which lymphoma clones from serial biopsies independently develop from a less-mutated common progenitor cell (CPC)...
2022: Frontiers in Oncology
Ashes Rijal, Anish Shrestha, Sharmila Chaudhary, Anisha Shrestha
Facial puffiness as a consequence of superior vena cava syndrome (SVCS) can be a presentation from which the physician would have to conjecture a diagnosis of a mediastinal mass including lymphomas. Pediatric SVCS can rapidly progress and pose a greater challenge for airway protection as was in our case.
November 2022: Clinical Case Reports
Shengjie Li, Zuguang Xia, Jiazhen Cao, Jinsen Zhang, Bobin Chen, Tong Chen, Xin Zhang, Wei Zhu, Danhui Li, Wei Hua, Ying Mao
PURPOSE: The systemic immune-inflammation index (SII) has been considered a novel prognostic biomarker in several types of lymphoma. Our aims were to determine the best statistical relationship between pretreatment SII and survival and to combination of SII and the Memorial Sloan Kettering Cancer Center model (MSKCC) to derive the best prognostic mode in primary central nervous system lymphoma (PCNSL). METHODS: Pretreatment SII and clinical data in 174 newly diagnosed PCNSL patients were included from two retrospective discovery cohorts (n = 128) and one prospective validation cohort (n = 46)...
2022: Frontiers in Immunology
Madeline J Hooper, Gail L Enriquez, Francesca L Veon, Tessa M LeWitt, Dagmar Sweeney, Stefan J Green, Patrick C Seed, Jaehyuk Choi, Joan Guitart, Michael B Burns, Xiaolong A Zhou
Skin microbiota have been linked to disease activity in cutaneous T-cell lymphoma (CTCL). As the skin microbiome has been shown to change after exposure to narrowband ultraviolet B (nbUVB) phototherapy, a common treatment modality used for CTCL, we performed a longitudinal analysis of the skin microbiome in CTCL patients treated with nbUVB. 16S V4 rRNA gene amplicon sequencing for genus-level taxonomic resolution, tuf2 amplicon next generation sequencing for staphylococcal speciation, and bioinformatics were performed on DNA extracted from skin swabs taken from lesional and non-lesional skin of 25 CTCL patients receiving nbUVB and 15 CTCL patients not receiving nbUVB from the same geographical region...
2022: Frontiers in Immunology
Harjeet Singh, Samer A Srour, Denái R Milton, Jessica McCarty, Cuiping Dai, Mahmoud R Gaballa, Mariam Ammari, Simon Olivares, Helen Huls, Eleanor De Groot, David Marin, Demetrios Petropoulos, Amanda L Olson, Paolo Anderlini, Jin S Im, Issa Khouri, Chitra M Hosing, Katayoun Rezvani, Richard E Champlin, Elizabeth J Shpall, Laurence J N Cooper, Partow Kebriaei
Chimeric antigen receptor (CAR) T-cell therapy has emerged recently as a standard of care treatment for patients with relapsed or refractory acute lymphoblastic leukemia (ALL) and several subtypes of B-cell non-Hodgkin lymphoma (NHL). However, its use remains limited to highly specialized centers, given the complexity of its administration and its associated toxicities. We previously reported our experience in using a novel Sleeping Beauty (SB) CD19-specific CAR T-cell therapy in the peri-transplant setting, where it exhibited an excellent safety profile with encouraging survival outcomes...
2022: Frontiers in Immunology
Jinjin Wang, Hui Zhou, Mingchun Mu, Ailin Zhao, Zhaolun Cai, Linfeng Li, Mengyao Wang, Ting Niu
BACKGROUND: Copanlisib is an intravenously administered pan-class I PI3K inhibitor that has been demonstrated to have appreciable effects in the treatment of patients with lymphoma. The purpose of this meta-analysis was to evaluate the efficacy and safety of copanlisib for treating patients with relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL). METHODS: PubMed, Web of Science, EMBASE, and the Cochrane Central Register of Controlled Trials were searched for relevant studies published prior to July 2022...
2022: Frontiers in Immunology
Renjie Xu, Jiahui Yu, Shangjin Song, Dazhi Sun, Lijuan Xiu, Jinyu Xu, Jing Zhao, Xuan Liu, Qing Ji, Xiaoqiang Yue
Objective: To determine the effect and mechanism of the long non-coding RNA (lncRNA) ncRuPAR (non-protein coding RNA, upstream of coagulation factor II thrombin receptor [F2R]/protease-activated receptor-1 [PAR-1]) in human gastric cancer. Methods: HGC-27-ncRuPAR overexpression and MGC-803-ncRuPAR-RNAi knockdown gastric cancer cell lines were established. We assessed the effect of ncRuPAR on cell proliferation, apoptosis, migration, and invasion using Cell Counting Kit 8, flow cytometry, scratch and transwell assays, respectively...
2022: International Journal of Medical Sciences
Qing Wan, Qiang Li, Xin Lai, Tiantian Xu, Jinfang Hu, Hongwei Peng
Objective: The introduction of Bruton's tyrosine kinase (BTK) inhibitors was a milestone in the treatment of B-cell malignancies in recent years owing to its desired efficacy against chronic lymphocytic leukaemia and small cell lymphocytic lymphoma. However, safety issues have hindered its application in clinical practice. The current study aimed to explore the safety warning signals of BTK inhibitors in a real-world setting using the FDA Adverse Event Reporting System (FAERS) to provide reference for clinical rational drug use...
2022: Frontiers in Pharmacology
TingTing Liu, RenZhi Hu, Jing Lv, Qin Luo, LuXiang Xu, ChaoYu Wang, Jun Liu, ZaiLin Yang, LingLi Xu, Yao Liu
OBJECTIVE: To investigate the predictive value of nutritional status on the prognosis of patients with human immunodeficiency virus (HIV) infection-related lymphoma. MATERIALS AND METHODS: A total of 149 patients with HIV infection-related lymphoma who were admitted to our hospital from August 2012 to May 2022 were selected as research subjects. Based on the patient prognosis, they were divided into a poor prognosis group ( n = 30) and a good prognosis group ( n = 119)...
2022: Frontiers in Nutrition
Abdul Saad Bissessur, Ji-Chun Zhou, Ling Xu, Zhao-Qing Li, Si-Wei Ju, Yun-Lu Jia, Lin-Bo Wang
BACKGROUND: Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare and rapidly progressive intestinal T-cell non-Hodgkin lymphoma associated with a very poor prognosis and a median survival of 7 mo. Advances in the identification of MEITL over the last two decades have led to its recognition as a separate entity. MEITL patients, predominantly male, typically present with vague and nonspecific symptoms and diagnosis is predominantly confirmed at laparotomy. Currently, there are no standardized treatment protocols, and the optimal therapy remains unclear...
November 15, 2022: World Journal of Gastrointestinal Oncology
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