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Martha M Moore, Lynn H Pottenger, Tamara House-Knight
Styrene is an important high production volume chemical used to manufacture polymeric products. In 2018, IARC classified styrene as probably carcinogenic to humans; NTP lists styrene as reasonably anticipated to be a human carcinogen. The genotoxicity literature for styrene and its primary metabolite, styrene 7,8-oxide (SO), begins in the 1970s. OECD recently updated most genotoxicity test guidelines (TGs), making substantial new recommendations for assay conduct and data evaluation for the standard mutagenicity/clastogenicity assays...
February 20, 2019: Environmental and Molecular Mutagenesis
Daniel Caldeira, Daniela Alves, João Costa, Joaquim J Ferreira, Fausto J Pinto
INTRODUCTION: Ibrutinib is an oral covalent inhibitor of Bruton's tyrosine kinase approved for the treatment of patients with chronic lymphocytic leukemia (CLL), mantle cell lymphoma and Waldenstrӧm's macroglobulinemia. Ibrutinib has an increased risk of atrial fibrillation but the mechanism is unknown, and hypertension may play a role in the pathogenesis of this adverse drug reaction. METHODS: We aimed to review the risk of hypertension and atrial fibrillation as adverse events associated with ibrutinib through a systematic review with meta-analysis of randomized controlled trials (RCTs) retrieved in December 2018 on MEDLINE, EMBASE, CENTRAL and ClinicalTrials...
2019: PloS One
Caroline Houillier, Luc Taillandier, Sylvain Dureau, Thierry Lamy, Mouna Laadhari, Olivier Chinot, Cecile Moluçon-Chabrot, Pierre Soubeyran, Remy Gressin, Sylvain Choquet, Gandhi Damaj, Antoine Thyss, Julie Abraham, Vincent Delwail, Emmanuel Gyan, Laurence Sanhes, Jérôme Cornillon, Reda Garidi, Alain Delmer, Marie-Laure Tanguy, Ahmad Al Jijakli, Pierre Morel, Pascal Bourquard, Marie-Pierre Moles, Adrien Chauchet, Thomas Gastinne, Jean-Marc Constans, Adriana Langer, Antoine Martin, Patricia Moisson, Lucette Lacomblez, Nadine Martin-Duverneuil, Daniel Delgadillo, Isabelle Turbiez, Loïc Feuvret, Nathalie Cassoux, Valérie Touitou, Damien Ricard, Khê Hoang-Xuan, Carole Soussain
PURPOSE: To determine the efficacy and toxicity of chemoimmunotherapy followed by either whole-brain radiotherapy (WBRT) or intensive chemotherapy and autologous stem-cell transplantation (ASCT) as a first-line treatment of primary CNS lymphoma (PCNSL). PATIENTS AND METHODS: Immunocompetent patients (18 to 60 years of age) with untreated PCNSL were randomly assigned to receive WBRT or ASCT as consolidation treatment after induction chemotherapy consisting of two cycles of R-MBVP (rituximab 375 mg/m2 day (D) 1, methotrexate 3 g/m2 D1; D15, VP16 100 mg/m2 D2, BCNU 100 mg/m2 D3, prednisone 60 mg/kg/d D1-D5) followed by two cycles of R-AraC (rituximab 375 mg/m2 D1, cytarabine 3 g/m2 D1 to D2)...
February 20, 2019: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Zhi-Zhang Yang, Hyo Jin Kim, Jose C Villasboas, Tammy Price-Troska, Shahrzad Jalali, Hongyan Wu, Rebecca A Luchtel, Mei-Yin C Polley, Anne J Novak, Stephen M Ansell
Follicular lymphoma (FL) is an indolent B cell malignancy characterized by an extensive but poorly functional T cell infiltrate in the tumor microenvironment. Using mass cytometry, we identified at least 12 subsets of intratumoral CD4+ T cells, 3 of which were unique to FL biopsies versus control tissues. Of these subsets, the frequency of naive T cells correlated with improved patient survival. Although total PD-1+ T cell numbers were not associated with patient outcome, specific PD-1+ T cell subpopulations were associated with poor survival...
February 19, 2019: Cell Reports
Masayoshi Harigai, Tsutomu Takeuchi, Josef S Smolen, Kevin L Winthrop, Atsushi Nishikawa, Terence P Rooney, Chadi G Saifan, Maher Issa, Yoshitaka Isaka, Naotsugu Akashi, Taeko Ishii, Yoshiya Tanaka
OBJECTIVES: Baricitinib is a selective oral inhibitor of JAK1/JAK2 for patients with moderately-to-severely active rheumatoid arthritis (RA). Baricitinib's safety profile in Japanese patients was evaluated using 6 studies (5 Ph2/Ph3 trials, 1 long-term extension study thru 01-Sept-2016) from an integrated database (9 RA studies). METHODS: Incidence rates (IRs) or exposure-adjusted IRs (EAIRs) of adverse events (AEs) per 100 patient-years (PY) were calculated using data which included RA patients exposed to any baricitinib dose...
February 20, 2019: Modern Rheumatology
Michael Geylis, Guy Bec, Dana Danino, Ruth Schreiber, Dima Hassan, Karen Nalbandyan, Amit Nahum
We present a 5-year-old female with minimal change nephrotic syndrome (MCNS). Within several months, she became steroid-dependent with progression of edema and ascites. Imaging studies revealed abnormal solid mass and liver cysts and she was diagnosed with both abdominal Hodgkin's lymphoma (cHD) and large hepatic cystic echinococcosis (CE). Association between MCNS and cHL or with CE has been described in the literature in adults and rarely in the pediatric population. We report, for the first time, a simultaneous occurrence of all three: MCNS, cHL, and CE...
February 20, 2019: Pediatric Hematology and Oncology
Christopher R Lamb, James Whitlock, Andrew T L Foster-Yeow
In order to estimate the prevalence of pulmonary nodules in dogs with nonpulmonary malignant neoplasia, medical record descriptions of CT findings in dogs diagnosed with nonpulmonary malignant neoplasia were reviewed retrospectively. A total of 536 dogs were sampled from a single hospital. For malignant neoplasms with >10 affected individuals, prevalence of multiple pulmonary nodules at first CT was hemangiosarcoma 24 of 58 (41%), osteosarcoma 14 of 55 (26%), carcinoma 20 of 80 (25%), histiocytic sarcoma five of twenty-one (24%), soft tissue sarcoma 13 of 57 (23%), adenocarcinoma 11 of 60 (18%), melanoma five of thirty-seven (14%), lymphoma 10 of 76 (13%), mast cell tumor two of forty-seven (4%), and squamous cell carcinoma zero of seventeen (0%)...
February 19, 2019: Veterinary Radiology & Ultrasound
Khoirun Nisa, Sue Yee Lim, Masayoshi Shinohara, Tatsuyuki Osuga, Nozomu Yokoyama, Masahiro Tamura, Noriyuki Nagata, Kazuyoshi Sasaoka, Angkhana Dermlim, Rommaneeya Leela-Arporn, Tomoya Morita, Noboru Sasaki, Keitaro Morishita, Kensuke Nakamura, Hiroshi Ohta, Mitsuyoshi Takiguchi
BACKGROUND: Contrast-enhanced ultrasonography (CEUS) can be used to evaluate intestinal perfusion in healthy dogs. It is helpful for diagnosing and monitoring inflammatory bowel disease in humans and could be useful for dogs with chronic intestinal diseases. OBJECTIVES: To examine duodenal perfusion in dogs with chronic inflammatory enteropathy (CIE) and intestinal lymphoma. ANIMALS: Client-owned dogs with CIE (n = 26) or intestinal lymphoma (n = 7) and dogs with gastrointestinal signs but histopathologically normal duodenum (controls, n = 14)...
February 19, 2019: Journal of Veterinary Internal Medicine
Juan Pablo Alderuccio, Wei Zhao, Amrita Desai, Jeremy Ramdial, Nicolas Gallastegui, Erik Kimble, Macarena I de la Fuente, Muhammad Husnain, Joseph D Rosenblatt, Alvaro J Alencar, Jonathan H Schatz, Craig H Moskowitz, Jennifer R Chapman, Francisco Vega, Isildinha M Reis, Izidore S Lossos
Between 11-37% of extranodal marginal zone lymphoma (EMZL) patients present with disease involvement in multiple mucosal sites (MMS). We analyzed 405 EMZL patients seen between 1995 and 2017. 265 (65.4%) presented with stage I disease, 49 of 309 (15.8%) with bone marrow involvement and 35 of 328 (10.7%) with monoclonal gammopathy (MG). 43 (10.6%) patients had MMS presentation, which was more frequently seen in patients aged >60 years (55.8%). 5(17.9%) of 28 MMS patients had MG. MMS patients commonly exhibited an IPI >2 (79...
February 19, 2019: American Journal of Hematology
Jun Shao, Xubin Pan, Xiaowen Yin, Guangming Fan, Chengye Tan, Yong Yao, Yu Xin, Chao Sun
Long noncoding RNAs have been reported to play important roles in the pathogenesis of diabetic retinopathy (DR), which has been considered as the most common disease leading to vision loss. However, it is still unclear whether KCNQ1 overlapping transcript 1 (KCNQ1OT1) could affect DR. In this study, regarding quantitative reverse transcription polymerase chain reaction assay, KCNQ1OT1 level was upregulated while microRNA-1470 (miR-1470) was decreased in DR patients and human retinal endothelial cells. High KCNQ1OT1 expression was correlated with DR stage and low visual function...
February 19, 2019: Journal of Cellular Physiology
Takako Miyamura, Hiroshi Moritake, Hideki Nakayama, Shiro Tanaka, Daisuke Tomizawa, Norio Shiba, Akiko M Saito, Akio Tawa, Akira Shimada, Shotaro Iwamoto, Yasuhide Hayashi, Takashi Koike, Keizo Horibe, Atsushi Manabe, Shuki Mizutani, Takashi Taga, Souichi Adachi
The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19.0%. High leucocyte count, M7 morphology, and unfavourable genetic aberrations, such as FLT3-internal tandem duplication, NUP98-NSD1 and high MECOM or PRDM16 expression, were risk factors for PIF...
February 19, 2019: British Journal of Haematology
Paul J Galardy, Tibor Bedekovics, Elizabeth Macintyre, Rodney R Miles
In the modern era, clinicians and pathologists increasingly make challenging diagnoses in patients with suspected lymphoma using minimal amounts of diagnostic material. The increase in utilization of minimally invasive procedures, such as fine needle aspiration or needle core biopsies, lead to challenges in our ability to make accurate histopathological assessments of disease, including the integration of new diagnostic and prognostic testing, with smaller amounts of material. The trend towards minimally invasive diagnostics is also often in conflicting interest with researchers seeking to study tissue specimens to better understand the biology and genetics of these diseases to move the field forward...
February 19, 2019: British Journal of Haematology
Edward A Copelan
No abstract text is available yet for this article.
February 15, 2019: Oncology (Williston Park, NY)
Alexios-Fotios A Mentis, Marina Boziki, Nikolaos Grigoriadis, Athanasios G Papavassiliou
Helicobacter pylori (H. pylori) infection affects an estimated 4.4 billion people globally. Moreover, H. pylori presents the most significant risk factor for gastric cancer and low-grade mucosa-associated lymphoid tissue (MALT) lymphoma, and it is the first example of bacterial infection linked to carcinogenesis. Here, we contend that H. pylori research, which focuses on a cancer-causing pathogen resident in a relatively accessible organ, the stomach, could constitute an exemplar for microbial-related carcinogenesis in less tractable organs, such as the pancreas and lung...
February 19, 2019: Cellular and Molecular Life Sciences: CMLS
Jintao Liu, Jinquan Liu, Xinyi Lu
Breast cancer (BC) is the most commonly diagnosed cancer and the second leading cause of cancer-associated mortality among females worldwide. As a member of the homeobox (HOX) gene family, HOXA1 is involved in tumor progression and prognosis in several types of human cancer. However, the clinical significance and biological functions of HOXA1 in BC remains unknown. The current study assessed the expression of HOXA1 in BC tissues and cells via western blotting and reverse transcription-quantitative polymerase chain reaction...
March 2019: Experimental and Therapeutic Medicine
Zhixue Wang, Jifeng Fang, Jizhou Xiao
Correlation of the expression of inflammatory factors with expression of apoptosis-related genes, B-cell lymphoma 2 ( Bcl-2 ) and Bcl-2 associated X protein ( Bax ), in burned rats was investigated. Forty healthy Sprague-Dawley rats were selected and randomly divided into SHAM group (n=10), I° burn group (n=10), II° burn group (n=10) and III° burn group (n=10). Changes in tumor necrosis factor-α (TNF-α), Bax messenger ribonucleic acid (mRNA), Bcl-2 mRNA, Bax protein and Bcl-2 protein expression levels were detected...
March 2019: Experimental and Therapeutic Medicine
Xiaoping Yang, Wei Wang, Xiong Zhang, Qi Zou, Lei Cai, Bo Yu
Pancreatic cancer (PC) is a common malignancy with a poorly understood pathogenesis. Currently, the efficacy of anti-PC therapies is insufficient, partially due to the chemoresistance of cancer cells. The present study aimed to elucidate the role of miR-183 in the proliferation, apoptosis, and chemosensitivity to 5-fluorouracil and gemcitabine of human PC cells and the associated mechanisms. PANC-1 cells were transfected with microRNA (miR)-183 inhibitors, and the effect of miR-183 on cell proliferation was evaluated via MTT assay...
March 2019: Experimental and Therapeutic Medicine
Yuyan Qi, Zhaoxia Ding, Yushuang Yao, Dehua Ma, Feifei Ren, Hongjuan Yang, Aiping Chen
Ovarian cancer is one of the main causes of cancer-associated mortality across the world. Currently, ovarian cancer is mainly treated with chemotherapy. However, ovarian cancer is detected at advanced stages and chemotherapy has numerous side effects. In addition, the results of current chemotherapy on the treatment of ovarian cancer are less than satisfactory. Therefore, there is an urgent need to develop novel and more viable chemotherapeutic agents that can be used to treat ovarian cancer. The present study was designed to synthesize a series of novel triazole analogs of the bioactive apigenin-7-methyl ether to evaluate its anticancer activity against three human ovarian cancer cell lines...
March 2019: Experimental and Therapeutic Medicine
Haitao Zhang, Ling Qin, Chaolu Li, Jianyi Jiang, Libo Sun, Xiaofei Zhao, Ning Li
The present study aimed to examine the apoptotic effects of adenovirus (ADV)-mediated herpes simplex virus thymidine kinase (ADV-TK) combined with ganciclovir (GCV) in tissues obtained from patients with hepatocellular carcinoma in order to provide a theoretical basis for the development of this gene therapy program. Apoptosis detection was conducted using the terminal deoxynucleotidyl-transferase-mediated dUTP nick end labelling assay and the apoptosis index was compared between the experimental; and control groups...
March 2019: Experimental and Therapeutic Medicine
Carlota Recio, Borja Guerra, Miguel Guerra-Rodríguez, Haidée Aranda-Tavío, Patricia Martín-Rodríguez, Mercedes de Mirecki-Garrido, Yeray Brito-Casillas, José M García-Castellano, Ana Estévez-Braun, Leandro Fernández-Pérez
The signal transducer and activator of transcription (STAT) are transcription factors that work via JAK/STAT pathway regulating the expression of genes involved in cell survival, proliferation, differentiation, development, immune response, and, among other essential biological functions, hematopoiesis. JAK/STAT signaling is strictly regulated under normal physiological conditions. However, a large group of diverse diseases has been associated to an aberrant regulation of STAT factors. Erroneous modulation of the pathway leads to constitutive STAT activation, thereby driving proliferation, inflammation, and an uncontrolled immune response...
February 19, 2019: Oncogene
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