Mohamed J Saadh, Amera Bekhatroh Rashed, Azfar Jamal, Roxana Yolanda Castillo-Acobo, Mohammad Azhar Kamal, Juan Carlos Cotrina-Aliaga, José Luis Arias Gonzáles, Abdulaziz S Alothaim, Wardah A Alhoqail, Fuzail Ahmad, Natrayan Lakshmaiya, Ali H Amin, Dhuha Ghassan Younus, Gregorio Gilmer Rosales Rojas, Abolfazl Bahrami, Reza Akhavan-Sigari
AIMS: Pain is a profoundly debilitating symptom in cancer patients, leading to disability, immobility, and a marked decline in their quality of life. This study aimed to investigate the potential roles of miR-199a-3p in a murine model of bone cancer pain induced by tumor cell implantation in the medullary cavity of the femur. MATERIALS AND METHODS: We assessed pain-related behaviors, including the paw withdrawal mechanical threshold (PWMT) and the number of spontaneous flinches (NSF)...
September 30, 2023: Life Sciences