prescription corticosteroids | Page 2

Daniel Dedman, Sonia J Coton, Rebecca E Ghosh, Wilhelmine Meeraus, Courtney Crim, Catherine Harvey, Justyna Amelio, Sarah H Landis
INTRODUCTION: This retrospective database study explored treatment patterns and potential off-label prescribing among patients newly prescribed fluticasone furoate/vilanterol (FF/VI) in a UK primary care setting. METHODS: In Europe, FF/VI is approved in two strengths: 100/25 µg for adults with chronic obstructive pulmonary disease (COPD) and 100/25 µg or 200/25 µg for treatment of asthma in patients aged 12 or older. Using electronic health records from the Clinical Practice Research Datalink, new users of FF/VI or other inhaled corticosteroid/long-acting beta-agonist fixed-dose combination products were identified and classified into one of three groups: COPD diagnosis, asthma diagnosis, and other diagnosis (not COPD or asthma)...
June 2019: Pulmonary Therapy
Mario Cazzola, Luigino Calzetta, Paola Rogliani, Maria Gabriella Matera
Guidelines are mainly based on evidence of well-designed randomized controlled trials (RCTs), but there are limitations to the transferability of conclusions of RCTs to usual care mainly because the patients enrolled in RCTs are selected and not representative of the population encountered in daily practice; moreover, the research environment is substantially different from that of the real world. Because of the scarcity of data generated in large unselected populations in everyday clinical practice, the possibility of using meta-analyses can be considered...
December 2019: Pulmonary Therapy
Mandeep Singh, Alexander G Duarte, En-Shuo Hsu, Yong-Fang Kuo, Gulshan Sharma
Background: Medical management of patients with chronic obstructive pulmonary disease (COPD) includes nebulized therapy as an option for inhalational drug delivery. A broad variety of short- and long-acting bronchodilators and inhaled corticosteroids in the nebulized form are available. Despite this, limited information exists on the pattern and predictors of nebulized prescription. We examined the trend and factors associated with prescription of nebulized therapy among Medicare beneficiaries with COPD. Methods: A retrospective cross-sectional study of 5% Medicare beneficiaries with COPD ( n  = 66,032) who were enrolled in parts A, B, and D and received nebulized prescription from 2008 to 2015 was conducted...
February 4, 2020: Journal of Aerosol Medicine and Pulmonary Drug Delivery
Shih-Wei Lai, Cheng-Li Lin, Kuan-Fu Liao
The aim of this study was to assess a correlation between avascular necrosis of femoral head and oral corticosteroids use in the general population in Taiwan. A population-based case-control study was performed to analyze the database of Taiwan National Health Insurance Program. The study consisted of 3002 subjects aged 20 to 84 with newly diagnosed avascular necrosis of femoral head between 2000 and 2013 as the cases and 11279 sex-matched and age-matched subjects without avascular necrosis of femoral head as the matched controls...
January 2020: Medicine (Baltimore)
Patrick Doiron-Cadrin, Simon Lafrance, Marie Saulnier, Émie Cournoyer, Jean-Sébastien Roy, Joseph-Omer Dyer, Pierre Frémont, Clermont Dionne, Joy C MacDermid, Michel Tousignant, Annie Rochette, Véronique Lowry, Nathalie J Bureau, Martin Lamontagne, Marie-France Coutu Psy, Patrick Lavigne, François Desmeules
OBJECTIVES: To perform a systematic review of clinical practice guidelines (CPGs) and semantic analysis of specific clinical recommendations for the management of rotator cuff disorders in adults. DATA SOURCES: A systematic bibliographic search was conducted up until May 2018 in Medline, Embase and PeDro databases, in addition to twelve clinical guidelines search engines listed on the AGREE Thrust website. STUDY SELECTION: Nine CPGs on the management of rotator cuff disorders in adults and/or workers, available in English or French and published from January 2008 onward, were included and screened by two independent reviewers...
January 30, 2020: Archives of Physical Medicine and Rehabilitation
Daniel Spinosa, Annalisa Post, Jeffrey A Kuller, Sarah Dotters-Katz
Importance: Hyperemesis gravidarum (HEG) affects 0.3% to 3% of pregnancies and requires additional therapies beyond those commonly used for less severe instances of nausea and vomiting of pregnancy (NVP). Differentiating between NVP and HEG is a vital yet challenging function for any obstetrician. The literature for management of HEG is lacking compared with that of NVP. Objective: Review etiology of NVP/HEG highlights key considerations in the workup of HEG as they compare to NVP and explore management options for recalcitrant HEG focusing principally on how they affect maternal and fetal outcomes and secondarily on where data are nonprescriptive...
January 2020: Obstetrical & Gynecological Survey
A-S Darrigade
Atopic dermatitis is a chronic disease with an alteration of the skin barrier and an abnormal immune response. The European guidelines for treatment of atopic dermatitis in children and adults recommend basic hygiene rules including daily use of emollient. Then in the first therapeutic line, for mild or acute atopic dermatitis, the prescription of local care by topical corticosteroids or topical calcineurin inhibitors is recommended. A proactive treatment is now recommended. If the atopic dermatitis is moderate or recurrent, the use of phototherapy in addition to topical treatment is recommended...
December 2019: Annales de Dermatologie et de Vénéréologie
Luca Pasina, Alessio Novella, Chiara Elli, Alessandro Nobili, Aladar Ianes
PURPOSE: To examine the prevalence of residents receiving proton pump inhibitors (PPIs) for evidence-based indications in a large sample of Italian nursing homes (NHs) and to assess the predictors of potentially inappropriate prescriptions. METHODS: This study was conducted in a sample of Italian long-term care NHs. Information on drug prescription, diseases, and socio-demographic characteristics of NH residents was collected three times during 2018. Appropriate use of PPI was defined in accordance with the strongest evidence-based indications and the Italian criteria for PPI prescription...
January 27, 2020: Pharmacoepidemiology and Drug Safety
C Vasilakis-Scaramozza, R Persson, K W Hagberg, S Jick
BACKGROUND: Anxiety and depression are common among psoriasis and psoriatic arthritis (PsA) patients, but rates may differ by treatment OBJECTIVE: To quantify the risk of incident treated anxiety, depression and mixed anxiety+depression in users of apremilast compared to users of other treatments for psoriasis and PsA. METHODS: We conducted two separate cohort studies of psoriasis and PsA patients treated with apremilast, tumor necrosis factor inhibitor biologics, interleukin-17, -23 or -12/23 inhibitor biologics, conventional DMARDs, or systemic corticosteroids in the United States MarketScan database...
January 25, 2020: Journal of the European Academy of Dermatology and Venereology: JEADV
Christer Janson, Andrew Menzies-Gow, Cassandra Nan, Javier Nuevo, Alberto Papi, Jennifer K Quint, Santiago Quirce, Claus F Vogelmeier
INTRODUCTION: Globally, individuals with asthma tend to overrely on short-acting β2 -agonists (SABAs) and underuse inhaled corticosteroids, thereby undertreating the underlying inflammation. Such relief-seeking behavior has been reinforced by long-standing treatment guidelines, which until recently recommended SABA-only use for immediate symptom relief. We aimed to describe the current burden of SABA use among European individuals with asthma within the SABA use IN Asthma (SABINA) program...
January 24, 2020: Advances in Therapy
Zahra Nikbakht, Mehdi Rajabi, Abdolali Shahrasbi, Elnaz Roohi, Farshad Hashemian
The present study evaluated adherence to antiemetic guidelines for prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) in four tertiary university teaching hospitals in Tehran. This prospective observational study enrolled 382 adult patients on chemotherapy at oncology centers affiliated to medical universities located in Tehran. Patients were followed up during their chemotherapy cycles. Risk factors related to CINV were evaluated, and information on antiemetic prescribing patterns was gathered using direct interview and patient medical records...
January 19, 2020: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Ruth Brauer, Ian Chi Kei Wong, Kenneth Kc Man, Nicole L Pratt, Rae Woong Park, Soo-Yeon Cho, Yu-Chuan Jack Li, Usman Iqbal, Phung-Anh Alex Nguyen, Martijn Schuemie
OBJECTIVE: To measure the paediatric user and prescription prevalence in inpatient and ambulatory settings in South Korea, Hong Kong, Taiwan, Japan and Australia by age and gender. A further objective was to list the most commonly used drugs per drug class, per country. DESIGN AND SETTING: Hospital inpatient and insurance paediatric healthcare data from the following databases were used to conduct this descriptive drug utilisation study: (i) the South Korean Ajou University School of Medicine database; (ii) the Hong Kong Clinical Data Analysis and Reporting System; (iii) the Japan Medical Data Center; (iv) Taiwan's National Health Insurance Research Database and (v) the Australian Pharmaceutical Benefits Scheme...
January 13, 2020: BMJ Open
Doran Ksienski, Elaine S Wai, Nicole S Croteau, Ashley T Freeman, Angela Chan, Leathia Fiorino, Zia Poonja, David Fenton, Tiffany Patterson, Sarah Irons, Mary Lesperance
OBJECTIVES: To explore the association of age with development of immune related adverse events (irAE) and survival in patients with advanced nonsmall cell lung cancer (aNSCLC) receiving programmed cell death 1 antibodies (PD-1 Ab) outside of clinical trials. METHODS: A multicenter retrospective study of PD-1 Ab prescription for patients with aNSCLC between 06/2015-11/2018 at BC Cancer. Multivariable (MVA) logistic regression identified baseline variables associated with irAE manifested within 3 months of PD-1 Ab initiation...
January 11, 2020: Journal of Geriatric Oncology
Kenichi Arai, Ko-Hei Yamamoto, Takaaki Suzuki, Nobuyuki Mitsukawa, Itsuko Ishii
Treatment of pressure ulcers requires removing the cause as well as eliminating factors that interfere with healing. There are no reports on the effect of medications prescribed for underlying diseases on pressure ulcers. Accordingly, the aim of this study was to investigate whether medications prescribed to patients with pressure ulcers could be a factor that influences pressure ulcer healing. We retrospectively reviewed the records of patients with pressure ulcer who were admitted to Chiba University Hospital between June 2009 and June 2015...
January 8, 2020: Wound Repair and Regeneration
Yong Suk Jo, Junsu Choe, Sun Hye Shin, Hyeon Kyoung Koo, Won Yeon Lee, Yu Il Kim, Seung Won Ra, Kwang Ha Yoo, Ki Suck Jung, Hye Yun Park, Yong Bum Park
BACKGROUND: Fractional exhaled nitric oxide (FeNO) is regarded as a potential biomarker for identifying eosinophilic inflammation. We aimed to evaluate the clinical implication of FeNO and its influence on inhaled corticosteroids (ICS) prescription rate in Korean chronic obstructive pulmonary disease (COPD) patients. METHODS: FeNO level and its association with clinical features were analyzed. Changes in the prescription rate of ICS before and after FeNO measurement were identified...
January 2020: Tuberculosis and Respiratory Diseases
Timothy H Harries, Victoria Rowland, Christopher J Corrigan, Iain J Marshall, Lucy McDonnell, Vibhore Prasad, Peter Schofield, David Armstrong, Patrick White
BACKGROUND: Blood eosinophil count has been proposed as a predictor of response to inhaled corticosteroid (ICS) in the prevention of acute exacerbations of COPD. An optimal threshold of blood eosinophil count for prescribing ICS has not been agreed. Doubt has been cast on the role by observational studies. The role of inhaled corticosteroids in this relationship, independent of long-acting bronchodilators, has not been examined. METHODS: We conducted a systematic review of post-hoc analyses of randomised controlled trials (RCTs) and observational studies examining three blood eosinophil thresholds and the independent role of ICS...
January 3, 2020: Respiratory Research
Laura J Spece, Lucas M Donovan, Matthew F Griffith, Thomas Keller, Laura C Feemster, Nicholas L Smith, David H Au
RATIONALE: Decreasing medication overuse represents an opportunity to avoid harm and costs in the era of value-based purchasing. Studies of inhaled corticosteroids (ICS) overuse in COPD has examined prevalent use. Understanding initiation of low-value ICS among complex patients with COPD may help shape de-adoption efforts. OBJECTIVES: Examine ICS initiation among a cohort with low exacerbation risk COPD and test for associations with markers of patient and health system complexity...
January 3, 2020: Annals of the American Thoracic Society
Luke J Pasick, William L Valentino, Hassan Paknezhad, Robert T Sataloff
OBJECTIVES: There are no widely accepted guidelines for the use of peri- and postoperative antibiotics for microdirect laryngoscopy (MDL) to prevent postoperative surgical site infection (SSI). This study examines the incidence of not only SSI, but also respiratory and oropharyngeal infections among patients who underwent MDL. STUDY DESIGN: Retrospective cohort. METHODS: Medical records from a quaternary laryngology practice were reviewed retrospectively for patients who underwent MDL between October 2015 and December 2018...
December 20, 2019: Journal of Voice: Official Journal of the Voice Foundation
Onuma Sattayalertyanyong, Premrutai Thitilertdecha, Chonticha Auesomwang
Background Proton pump inhibitors are often inappropriately prescribed during hospital admission and after discharge. The inappropriate prescription may be associated with increased and unnecessary healthcare costs. Objective To determine the prevalence of inappropriate prescription of proton pump inhibitors during hospital admission and after discharge at Thailand's largest national tertiary referral center. Setting Medicine wards at Siriraj Hospital (Bangkok, Thailand) during September 2016 to September 2017...
December 21, 2019: International Journal of Clinical Pharmacy
Raj Gill, E Mark Williams
Background: The National Review of Asthma Deaths UK highlighted that 46% of deaths could be avoided and recommended that all sufferers receive a structured asthma annual review which assess asthma control. In primary care this is commonly achieved using symptom-based questionnaires such as the Asthma Control Test (ACT). A newer method of assessing asthma control is Fractional Exhaled Nitric Oxide (FeNO) testing, which is currently recommended for the diagnosis of asthma, but not for monitoring of asthma control...
2019: Allergy, Asthma, and Clinical Immunology
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