prescription corticosteroids

John Mackowiak, John T Jones, Vinod Dasa
OBJECTIVES: To compare the medical costs associated with treatments for knee osteoarthritis (OA): intra-articular corticosteroids (ICS) and intra-articular hyaluronic acid (IHA) primarily, and ICS/IHA vs knee arthroplasty (TKA) secondarily. METHODS: This was a retrospective analysis of an insurance claims database. Eligible members had diagnosed OA and no claims for ICS, IHA, or TKA during the 6-18-month look-back period. Cohorts of interest over the 4-year observation period were: patients who received ICS only, those who received IHA only, and those who received TKA only...
January 17, 2020: Seminars in Arthritis and Rheumatism
Aida Moure-Fernandez, Sandra Hollinghurst, Fran E Carroll, Harriet Downing, Grace Young, Sara Brookes, Margaret May, Magdy El-Gohary, Anthony Harnden, Denise Kendrick, Natasher Lafond, Paul Little, Michael Moore, Elizabeth Orton, Matthew Thompson, David Timmins, Kay Wang, Alastair D Hay
OBJECTIVE: To estimate the costs and outcomes associated with treating non-asthmatic adults (nor suffering from other lung-disease) presenting to primary care with acute lower respiratory tract infection (ALRTI) with oral corticosteroids compared with placebo. DESIGN: Cost-consequence analysis alongside a randomised controlled trial. Perspectives included the healthcare provider, patients and productivity losses associated with time off work. SETTING: Fifty-four National Health Service (NHS) general practices in England...
February 18, 2020: BMJ Open
Valérie Johnson Girard, Ashley Hill, Emma Glaser, Marie-Thérèse Lussier
BACKGROUND: Patients are often non-adherent to topical corticosteroids (TCS). This may be in part due to poor communication between patients and dermatologists. OBJECTIVES: This quality improvement (QI) study aims to describe dermatologist-patient communication about TCS treatments and to compare communication before and after the implementation of an educational intervention. METHODS: This QI study assesses the communication between dermatologists and new dermatology outpatients receiving a TCS prescription in a tertiary care center...
February 19, 2020: Journal of Cutaneous Medicine and Surgery
Svanhildur Haflidadottir, Iren Lindbak Matthews, Runar Almaas
BACKGROUND: LTX in children is associated with increased risk of food allergy, and the mechanisms underlying this are unknown. We wanted to study whether plasma cytokine profile differed in liver transplanted children, with and without food allergy, and whether it differed from untransplanted children with CLD. METHODS: Plasma cytokines, total and specific IgE in nine patients with food allergy were compared with 13 patients without food allergy following LTX, and also with seven untransplanted patients with CLD...
March 2020: Pediatric Transplantation
Gráinne d'Ancona, Joanne Kavanagh, Cris Roxas, Linda Green, Mariana Fernandes, Louise Thomson, Jaideep Dhariwal, Alexandra M Nanzer, David J Jackson, Brian D Kent
INTRODUCTION: Inhaled corticosteroids (ICS) achieve disease control in the majority of asthmatics, although adherence to prescribed ICS is often poor. Patients with severe eosinophilic asthma (SEA) may require treatment with oral corticosteroids (OCS) and/or biologic agents such as mepolizumab. It is unknown if ICS adherence changes on, or alters clinical response to, biologic therapy. METHODS: We examined ICS adherence and clinical outcomes in OCS-dependent SEA patients who completed 1 year of mepolizumab therapy...
February 14, 2020: European Respiratory Journal
Michael C Kwa, Kyle Tegtmeyer, Leah J Welty, Sam G Raney, Markham C Luke, Shuai Xu, Betty Kong
The cost of prescription drugs has increased at rates far exceeding general inflation in recent history, with topical drugs increasing at a disproportionate rate compared to other routes of administration. We assessed the relationship between net changes in the number of therapeutic options, defined as any approved drug or therapeutic equivalent on the market, and prescription topical drug spending. Drugs were divided based on the category of use through pairing of Medicare Part D Prescriber Public Use and Food and Drug Administration (FDA) approved drug products databases...
February 13, 2020: Archives of Dermatological Research
Christos V Chalitsios, Dominick E Shaw, Tricia M McKeever
Exposure to oral corticosteroids (OCS) is associated with an increased risk of osteoporosis and fragility fractures. Guidelines suggest bisphosphonate (BP) therapy as the first-line treatment of glucocorticoid-induced osteoporosis (GIOP). This population study used publicly available data, including prescription annual cost analysis and monthly practice-level data. Our aim was to examine the prescribing of OCS and BP at practice level and investigate reasons for variation using a mixed-effect negative binomial regression analysis...
February 13, 2020: NPJ Primary Care Respiratory Medicine
Taisuke Jo, Hideo Yasunaga, Yasuhiro Yamauchi, Akihisa Mitani, Yoshihisa Hiraishi, Wakae Hasegawa, Yukiyo Sakamoto, Hiroki Matsui, Kiyohide Fushimi, Takahide Nagase
Background: Inhaled corticosteroids (ICSs) are used for advanced-stage chronic obstructive pulmonary disease (COPD). The application and safety of ICS withdrawal remain controversial.This study aimed to evaluate the association between ICS withdrawal and outcomes in elderly patients with COPD with or without comorbid bronchial asthma, who were hospitalised for exacerbation. Patients and methods: We conducted a retrospective cohort study using the Japanese Diagnosis Procedure Combination database from July 2010 to March 2016 ...
January 2020: ERJ Open Research
Daniel Dedman, Sonia J Coton, Rebecca E Ghosh, Wilhelmine Meeraus, Courtney Crim, Catherine Harvey, Justyna Amelio, Sarah H Landis
INTRODUCTION: This retrospective database study explored treatment patterns and potential off-label prescribing among patients newly prescribed fluticasone furoate/vilanterol (FF/VI) in a UK primary care setting. METHODS: In Europe, FF/VI is approved in two strengths: 100/25 µg for adults with chronic obstructive pulmonary disease (COPD) and 100/25 µg or 200/25 µg for treatment of asthma in patients aged 12 or older. Using electronic health records from the Clinical Practice Research Datalink, new users of FF/VI or other inhaled corticosteroid/long-acting beta-agonist fixed-dose combination products were identified and classified into one of three groups: COPD diagnosis, asthma diagnosis, and other diagnosis (not COPD or asthma)...
June 2019: Pulmonary Therapy
Mario Cazzola, Luigino Calzetta, Paola Rogliani, Maria Gabriella Matera
Guidelines are mainly based on evidence of well-designed randomized controlled trials (RCTs), but there are limitations to the transferability of conclusions of RCTs to usual care mainly because the patients enrolled in RCTs are selected and not representative of the population encountered in daily practice; moreover, the research environment is substantially different from that of the real world. Because of the scarcity of data generated in large unselected populations in everyday clinical practice, the possibility of using meta-analyses can be considered...
December 2019: Pulmonary Therapy
Mandeep Singh, Alexander G Duarte, En-Shuo Hsu, Yong-Fang Kuo, Gulshan Sharma
Background: Medical management of patients with chronic obstructive pulmonary disease (COPD) includes nebulized therapy as an option for inhalational drug delivery. A broad variety of short- and long-acting bronchodilators and inhaled corticosteroids in the nebulized form are available. Despite this, limited information exists on the pattern and predictors of nebulized prescription. We examined the trend and factors associated with prescription of nebulized therapy among Medicare beneficiaries with COPD. Methods: A retrospective cross-sectional study of 5% Medicare beneficiaries with COPD ( n  = 66,032) who were enrolled in parts A, B, and D and received nebulized prescription from 2008 to 2015 was conducted...
February 4, 2020: Journal of Aerosol Medicine and Pulmonary Drug Delivery
Shih-Wei Lai, Cheng-Li Lin, Kuan-Fu Liao
The aim of this study was to assess a correlation between avascular necrosis of femoral head and oral corticosteroids use in the general population in Taiwan. A population-based case-control study was performed to analyze the database of Taiwan National Health Insurance Program. The study consisted of 3002 subjects aged 20 to 84 with newly diagnosed avascular necrosis of femoral head between 2000 and 2013 as the cases and 11279 sex-matched and age-matched subjects without avascular necrosis of femoral head as the matched controls...
January 2020: Medicine (Baltimore)
Patrick Doiron-Cadrin, Simon Lafrance, Marie Saulnier, Émie Cournoyer, Jean-Sébastien Roy, Joseph-Omer Dyer, Pierre Frémont, Clermont Dionne, Joy C MacDermid, Michel Tousignant, Annie Rochette, Véronique Lowry, Nathalie J Bureau, Martin Lamontagne, Marie-France Coutu Psy, Patrick Lavigne, François Desmeules
OBJECTIVES: To perform a systematic review of clinical practice guidelines (CPGs) and semantic analysis of specific clinical recommendations for the management of rotator cuff disorders in adults. DATA SOURCES: A systematic bibliographic search was conducted up until May 2018 in Medline, Embase and PeDro databases, in addition to twelve clinical guidelines search engines listed on the AGREE Thrust website. STUDY SELECTION: Nine CPGs on the management of rotator cuff disorders in adults and/or workers, available in English or French and published from January 2008 onward, were included and screened by two independent reviewers...
January 30, 2020: Archives of Physical Medicine and Rehabilitation
Daniel Spinosa, Annalisa Post, Jeffrey A Kuller, Sarah Dotters-Katz
Importance: Hyperemesis gravidarum (HEG) affects 0.3% to 3% of pregnancies and requires additional therapies beyond those commonly used for less severe instances of nausea and vomiting of pregnancy (NVP). Differentiating between NVP and HEG is a vital yet challenging function for any obstetrician. The literature for management of HEG is lacking compared with that of NVP. Objective: Review etiology of NVP/HEG highlights key considerations in the workup of HEG as they compare to NVP and explore management options for recalcitrant HEG focusing principally on how they affect maternal and fetal outcomes and secondarily on where data are nonprescriptive...
January 2020: Obstetrical & Gynecological Survey
A-S Darrigade
Atopic dermatitis is a chronic disease with an alteration of the skin barrier and an abnormal immune response. The European guidelines for treatment of atopic dermatitis in children and adults recommend basic hygiene rules including daily use of emollient. Then in the first therapeutic line, for mild or acute atopic dermatitis, the prescription of local care by topical corticosteroids or topical calcineurin inhibitors is recommended. A proactive treatment is now recommended. If the atopic dermatitis is moderate or recurrent, the use of phototherapy in addition to topical treatment is recommended...
December 2019: Annales de Dermatologie et de Vénéréologie
Luca Pasina, Alessio Novella, Chiara Elli, Alessandro Nobili, Aladar Ianes
PURPOSE: To examine the prevalence of residents receiving proton pump inhibitors (PPIs) for evidence-based indications in a large sample of Italian nursing homes (NHs) and to assess the predictors of potentially inappropriate prescriptions. METHODS: This study was conducted in a sample of Italian long-term care NHs. Information on drug prescription, diseases, and socio-demographic characteristics of NH residents was collected three times during 2018. Appropriate use of PPI was defined in accordance with the strongest evidence-based indications and the Italian criteria for PPI prescription...
January 27, 2020: Pharmacoepidemiology and Drug Safety
C Vasilakis-Scaramozza, R Persson, K W Hagberg, S Jick
BACKGROUND: Anxiety and depression are common among psoriasis and psoriatic arthritis (PsA) patients, but rates may differ by treatment OBJECTIVE: To quantify the risk of incident treated anxiety, depression and mixed anxiety+depression in users of apremilast compared to users of other treatments for psoriasis and PsA. METHODS: We conducted two separate cohort studies of psoriasis and PsA patients treated with apremilast, tumor necrosis factor inhibitor biologics, interleukin-17, -23 or -12/23 inhibitor biologics, conventional DMARDs, or systemic corticosteroids in the United States MarketScan database...
January 25, 2020: Journal of the European Academy of Dermatology and Venereology: JEADV
Christer Janson, Andrew Menzies-Gow, Cassandra Nan, Javier Nuevo, Alberto Papi, Jennifer K Quint, Santiago Quirce, Claus F Vogelmeier
INTRODUCTION: Globally, individuals with asthma tend to overrely on short-acting β2 -agonists (SABAs) and underuse inhaled corticosteroids, thereby undertreating the underlying inflammation. Such relief-seeking behavior has been reinforced by long-standing treatment guidelines, which until recently recommended SABA-only use for immediate symptom relief. We aimed to describe the current burden of SABA use among European individuals with asthma within the SABA use IN Asthma (SABINA) program...
January 24, 2020: Advances in Therapy
Zahra Nikbakht, Mehdi Rajabi, Abdolali Shahrasbi, Elnaz Roohi, Farshad Hashemian
The present study evaluated adherence to antiemetic guidelines for prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) in four tertiary university teaching hospitals in Tehran. This prospective observational study enrolled 382 adult patients on chemotherapy at oncology centers affiliated to medical universities located in Tehran. Patients were followed up during their chemotherapy cycles. Risk factors related to CINV were evaluated, and information on antiemetic prescribing patterns was gathered using direct interview and patient medical records...
January 19, 2020: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Ruth Brauer, Ian Chi Kei Wong, Kenneth Kc Man, Nicole L Pratt, Rae Woong Park, Soo-Yeon Cho, Yu-Chuan Jack Li, Usman Iqbal, Phung-Anh Alex Nguyen, Martijn Schuemie
OBJECTIVE: To measure the paediatric user and prescription prevalence in inpatient and ambulatory settings in South Korea, Hong Kong, Taiwan, Japan and Australia by age and gender. A further objective was to list the most commonly used drugs per drug class, per country. DESIGN AND SETTING: Hospital inpatient and insurance paediatric healthcare data from the following databases were used to conduct this descriptive drug utilisation study: (i) the South Korean Ajou University School of Medicine database; (ii) the Hong Kong Clinical Data Analysis and Reporting System; (iii) the Japan Medical Data Center; (iv) Taiwan's National Health Insurance Research Database and (v) the Australian Pharmaceutical Benefits Scheme...
January 13, 2020: BMJ Open
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