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REVIEW
Fraser Henderson, Theodore H Schwartz
PURPOSE/INTRODUCTION: Craniopharyngiomas are locally-aggressive tumors arising along the hypothalamic-pituitary axis. Treatment is nuanced as a result of their proximity and adherence to vital neurovascular structures and responsiveness to surgery, radiation and, in some cases, chemotherapy. METHODS: We reviewed the literature discussing the current state of knowledge regarding craniopharyngioma biology and therapy. RESULTS: Recent advances in endoscopic endonasal surgery (EEA) have made surgery a safer and more effective option...
January 2022: Journal of Neuro-oncology
#22
Kenji Hanamura, Halley R Washburn, Sean I Sheffler-Collins, Nan L Xia, Nathan Henderson, Dipti V Tillu, Shayne Hassler, Daniel S Spellman, Guoan Zhang, Thomas A Neubert, Theodore J Price, Matthew B Dalva
[This corrects the article DOI: 10.1371/journal.pbio.2002457.].
November 2021: PLoS Biology
#23
JOURNAL ARTICLE
Daniel Kerr, Zhiliang Gong, Tiffany Suwatthee, Adrienne Luoma, Sobhan Roy, Renee Scarpaci, Hyeondo Luke Hwang, J Michael Henderson, Kathleen D Cao, Wei Bu, Binhua Lin, Gregory T Tietjen, Theodore L Steck, Erin J Adams, Ka Yee C Lee
Immune surveillance cells such as T cells and phagocytes utilize integral plasma membrane receptors to recognize surface signatures on triggered and activated cells such as those in apoptosis. One such family of plasma membrane sensors, the transmembrane immunoglobulin and mucin domain (Tim) proteins, specifically recognize phosphatidylserine (PS) but elicit distinct immunological responses. The molecular basis for the recognition of lipid signals on target cell surfaces is not well understood. Previous results suggest that basic side chains present at the membrane interface on the Tim proteins might facilitate association with additional anionic lipids including but not necessarily limited to PS...
November 2, 2021: Biophysical Journal
#24
JOURNAL ARTICLE
Joanne McPeake, Theodore J Iwashyna, Philip Henderson, Alastair H Leyland, Daniel Mackay, Tara Quasim, Matthew Walters, Michael Harhay, Martin Shaw
BACKGROUND: : This study aimed to understand the impact of a critical care admission on long-term outcomes, compared to other hospitalised patients without a critical care encounter. A secondary aim was to examine the interrelationship between emotional, physical, and social problems during recovery. METHODS: : We utilised data from the UK Biobank, an on-going, prospective population-based cohort study. We employed propensity score matching to assess differences in outcomes between patients with a critical care encounter and patients admitted to the hospital (first admission to hospital available) without critical care...
July 2021: The Lancet regional health. Europe
#25
JOURNAL ARTICLE
Joanne McPeake, Tara Quasim, Philip Henderson, Alastair H Leyland, Nazir I Lone, Matthew Walters, Theodore J Iwashyna, Martin Shaw
BACKGROUND: Survivors of critical illness have poor long-term outcomes with subsequent increases in healthcare utilisation. Less is known about the interplay between multimorbidity and long-term outcomes. RESEARCH QUESTION: How do baseline patient demographics impact mortality and healthcare utilisation in the year following discharge from critical care? STUDY DESIGN AND METHODS: Using data from a prospectively collected cohort, we employed propensity score matching to assess differences in outcomes between patients with a critical care encounter and patients admitted to the hospital without critical care...
June 18, 2021: Chest
#26
JOURNAL ARTICLE
Anthony Jerant, Tonya Fancher, Mark C Henderson, Erin J Griffin, Theodore R Hall, Carolyn J Kelly, Ellena M Peterson, Peter Franks
Studies employing data collected over 15 years ago suggested salutary effects of postbaccalaureate (PB) premedical coursework on medical school class diversity, academic performance, and primary care training. The studies may have limited current applicability given changes in medical school admissions paradigms and population demographics. Using data from interviewees at >1 of 5 California public medical schools between 2011-2013 (N=3805), we examined associations of PB premedical coursework with underrepresented race/ethnicity; academic performance (United States Medical Licensing Examination Step 1 and Step 2 scores, clerkship Honors); and primary care residency...
2021: Journal of Health Care for the Poor and Underserved
#27
JOURNAL ARTICLE
Theodore A Henderson, Simon DeBruin, Philippe Briandet
No abstract text is available yet for this article.
May 10, 2021: Journal of Nuclear Medicine
#28
JOURNAL ARTICLE
Shuoyan Xiong, Manar M Shoshani, Xinglong Zhang, Heather A Spinney, Alex J Nett, Briana S Henderson, Thomas F Miller, Theodor Agapie
The efficient copolymerization of acrylates with ethylene using Ni catalysts remains a challenge. Herein, we report two neutral Ni(II) catalysts (POP-Ni-py ( 1 ) and PONap-Ni-py ( 2 )) that exhibit high thermal stability and significantly higher incorporation of polar monomer (for 1 ) or improved resistance to tert -butylacrylate (tBA)-induced chain transfer (for 2 ), in comparison to previously reported catalysts. Nickel alkyl complexes generated after tBA insertion, POP-Ni-CCO(py) ( 3 ) and PONap-Ni-CCO(py) ( 4 ), were isolated and, for the first time, characterized by crystallography...
April 22, 2021: Journal of the American Chemical Society
#29
JOURNAL ARTICLE
Philip Henderson, Tara Quasim, Annette Asher, Lucy Campbell, Malcolm Daniel, Lisa Davey, Helen Devine, Martyn Gall, Pamela Mactavish, Karen Mcgroarty, Fiona Nolan, Colin Purdie, Isma Quasim, John Sharp, Martin Shaw, Theodore J Iwashyna, Joanne McPeake
OBJECTIVES: To describe the long-term outcomes of cardiac intensive care unit patients and their primary caregivers, and to explore the feasibility of implementing a complex intervention, designed to support problems associated with post-intensive care syndrome and post-intensive care syndrome-family, in the year following discharge from the cardiac intensive care unit. DESIGN: A complex multidisciplinary rehabilitation programme, delivered as a quality improvement initiative, in a single centre in the West of Scotland...
April 15, 2021: Journal of Rehabilitation Medicine
#30
JOURNAL ARTICLE
Mark P Breazzano, Archana A Nair, J Fernando Arevalo, Mark R Barakat, Audina M Berrocal, Jonathan S Chang, Andrew Chen, Dean Eliott, Sunir J Garg, Quraish Ghadiali, Dan Gong, Dilraj S Grewal, James T Handa, Matthew Henderson, Yannek I Leiderman, Theodore Leng, Amar Mannina, Thomas A Mendel, Debarshi Mustafi, Lisa C Olmos de Koo, Shriji N Patel, Tapan P Patel, Jonathan Prenner, Paige Richards, Rishi P Singh, Charles C Wykoff, Nicolas A Yannuzzi, Hannah Yu, Yasha S Modi, Stanley Chang
Importance: The American Academy of Ophthalmology (AAO) indicated that urgent or emergent vitreoretinal surgical procedures should continue during the coronavirus disease 2019 (COVID-19) pandemic. Although decreases in the frequency of critical procedures have been reported outside the field of ophthalmology, analyses are limited by volume, geography, and time. Objective: To evaluate whether the frequency of ophthalmic surgical procedures deemed urgent or emergent by the AAO changed across the United States during the COVID-19 pandemic...
April 1, 2021: JAMA Ophthalmology
#31
MULTICENTER STUDY
(no author information available yet)
BACKGROUND: CRANIAL (CSF Rhinorrhoea After Endonasal Intervention to the Skull Base) is a prospective multicenter observational study seeking to determine 1) the scope of skull base repair methods used and 2) corresponding rates of postoperative cerebrospinal fluid (CSF) rhinorrhea in the endonasal transsphenoidal approach (TSA) and the expanded endonasal approach (EEA) for skull base tumors. We sought to pilot the project, assessing the feasibility and acceptability by gathering preliminary data...
May 2021: World Neurosurgery
#32
JOURNAL ARTICLE
Soham Bandyopadhyay, Danyal Z Khan, Hani J Marcus, Benjamin E Schroeder, Vikesh Patel, Alice O'Donnell, Shahzada Ahmed, Andrew F Alalade, Ahmad Ms Ali, Callum Allison, Sinan Al-Barazi, Rafid Al-Mahfoudh, Meriem Amarouche, Anuj Bahl, David Bennett, Raj Bhalla, Pragnesh Bhatt, Alexandros Boukas, Ivan Cabrilo, Annabel Chadwick, Yasir A Chowdhury, David Choi, Simon A Cudlip, Neil Donnelly, Neil L Dorward, Graham Dow, Daniel M Fountain, Joan Grieve, Anastasios Giamouriadis, Catherine Gilkes, Kanna Gnanalingham, Jane Halliday, Brendan Hanna, Caroline Hayhurst, Jonathan Hempenstall, Duncan Henderson, Kismet Hossain-Ibrahim, Theodore Hirst, Mark Hughes, Mohsen Javadpour, Alistair Jenkins, Mahmoud Kamel, Richard J Mannion, Angelos G Kolias, Habibullah Khan, Mohammad Saud Khan, Peter Lacy, Shumail Mahmood, Eleni Maratos, Andrew Martin, Nijaguna Mathad, Patrick McAleavey, Nigel Mendoza, Christopher P Millward, Showkat Mirza, Sam Muquit, Daniel Murray, Paresh P Naik, Ramesh Nair, Claire Nicholson, Alex Paluzzi, Omar Pathmanaban, Dimitris Paraskevopoulos, Jonathan Pollock, Nick Phillips, Rory J Piper, Bhaskar Ram, Iain Robertson, Elena Roman, Peter Ross, Thomas Santarius, Parag Sayal, Jonathan Shapey, Rishi Sharma, Simon Shaw, Alireza Shoakazemi, Saurabh Sinha, Georgios Solomou, Simon Stapleton, Patrick Statham, Benjamin Stew, Syed Shumon, Wai Cheong Soon, Nick Thomas, Georgios Tsermoulas, James R Tysome, Adithya Varma, Philip Weir, Adam Williams, Mohamed Youssef
BACKGROUND: During the pandemic, there has been a concern about the increased risk of perioperative mortality for patients with COVID-19, and the transmission risk to healthcare workers, particularly during endonasal neurosurgical operations. The Pituitary Society produced recommendations to guide management during this era. We sought to assess contemporary neurosurgical practice and the impact of COVID-19. METHODS: A multicentre, prospective, observational cohort study was conducted at twelve tertiary neurosurgical units (UK and Ireland)...
January 11, 2021: World Neurosurgery
#33
JOURNAL ARTICLE
Pamela MacTavish, Tara Quasim, Colin Purdie, Morna Ball, Lesley Barker, Sarah Connelly, Helen Devine, Philip Henderson, Lucy A Hogg, Rakesh Kishore, Phil Lucie, Jennifer Murphy, Peter O'Brien, Martin Shaw, Laura Strachan, Alan Timmins, Theodore J Iwashyna, Joanne McPeake
No abstract text is available yet for this article.
July 27, 2020: Annals of the American Thoracic Society
#34
REVIEW
Theodore A Henderson, Muriel J van Lierop, Mary McLean, John Michael Uszler, John F Thornton, Yin-Hui Siow, Dan G Pavel, Joe Cardaci, Phil Cohen
While early efforts in psychiatry were focused on uncovering the neurobiological basis of psychiatric symptoms, they made little progress due to limited ability to observe the living brain. Today, we know a great deal about the workings of the brain; yet, none of this neurobiological awareness has translated into the practice of psychiatry. The categorical system which dominates psychiatric diagnosis and thinking fails to match up to the real world of genetics, sophisticated psychological testing, and neuroimaging...
2020: Frontiers in Psychiatry
#35
JOURNAL ARTICLE
W Brian Simison, James F Parham, Theodore J Papenfuss, Athena W Lam, James B Henderson
Among vertebrates, turtles have many unique characteristics providing biologists with opportunities to study novel evolutionary innovations and processes. We present here a high quality, partially phased, and chromosome level Red-Eared Slider (Trachemys scripta elegans, TSE) genome as a reference for future research on turtle and tetrapod evolution. This TSE assembly is 2.269 Gb in length, has one of the highest scaffold N50 and N90 values of any published turtle genome to date (N50=129.68 Mb and N90=19 Mb) and has a total of 28,415 annotated genes...
March 30, 2020: Genome Biology and Evolution
#36
LETTER
Theodore A Henderson, Larry D Morries
No abstract text is available yet for this article.
February 2019: Photobiomodulation, photomedicine, and laser surgery
#37
JOURNAL ARTICLE
Anthony Jerant, Mark C Henderson, Erin Griffin, Theodore R Hall, Carolyn J Kelly, Ellena M Peterson, David Wofsy, Daniel J Tancredi, Francis J Sousa, Peter Franks
PURPOSE: To compare the predictive validities of medical school admissions multiple mini-interviews (MMIs) and traditional interviews (TIs). METHOD: This longitudinal observational study of 2011-2013 matriculants to five California public medical schools examined the associations of MMI scores (two schools) and TI scores (three schools) with subsequent academic performance. Regression models adjusted for socio-demographics and undergraduate academic metrics examined associations of standardized mean MMI and TI scores with United States Medical Licensing Examination Step 1 and Step 2 Clinical Knowledge (CK) scores, and, for required clerkships, with mean National Board of Medical Examiners Clinical Science subject (shelf) exam score and number of honors grades...
September 4, 2018: Academic Medicine
#38
JOURNAL ARTICLE
Anthony Jerant, Mark C Henderson, Erin Griffin, Theodore R Hall, Carolyn J Kelly, Ellena M Peterson, David Wofsy, Peter Franks
PURPOSE: In single-school studies, multiple mini-interview (MMI) and traditional interview (TI) scores are associated with acceptance offers. Unexamined is whether scores at one school are associated with acceptance at other schools; such analyses would mitigate single-school design biases and better estimate how well interviews capture desired applicant attributes. Using data from the 5 California Longitudinal Evaluation of Admissions Practices (CA-LEAP) medical schools, the authors examined associations of MMI and TI scores with acceptance offers within and across schools...
August 2018: Academic Medicine
#39
REVIEW
Cyrus A Raji, Theodore A Henderson
This article offers an overview of the application of PET and single photon emission computed tomography brain imaging to concussion, a type of mild traumatic brain injury and traumatic brain injury, in general. The article reviews the application of these neuronuclear imaging modalities in cross-sectional and longitudinal studies. Additionally, this article frames the current literature with an overview of the basic physics and radiation exposure risks of each modality.
February 2018: Neuroimaging Clinics of North America
#40
JOURNAL ARTICLE
Anthony Jerant, Mark C Henderson, Erin Griffin, Julie A Rainwater, Theodore R Hall, Carolyn J Kelly, Ellena M Peterson, David Wofsy, Peter Franks
BACKGROUND: Many medical schools use admissions Multiple Mini-Interviews (MMIs) rather than traditional interviews (TIs), partly because MMIs are thought to be more reliable. Yet prior studies examined single-school samples of candidates completing either an MMI or TI (not both). Using data from five California public medical schools, the authors examined the within- and between-school reliabilities of TIs and MMIs. METHODS: The analyses included applicants interviewing at ≥1 of the five schools during 2011-2013...
November 6, 2017: BMC Medical Education
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