Mohamed A Alfaleh, Reem M Alsulaiman, Sarah A Almahboub, Leena Nezamuldeen, Ayat Zawawi, Najwa D Aljehani, Muhammad Yasir, Rwaa H Abdulal, Rami Alkhaldi, Assala Helal, Sawsan S Alamri, Jana Malki, Rowa Y Alhabbab, Turki S Abujamel, Nabil A Alhakamy, Aisha Alnami, Abdullah Algaissi, Mazen Hassanain, Anwar M Hashem
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the Middle East respiratory syndrome coronavirus (MERS-CoV) are highly pathogenic human coronaviruses (CoVs). Anti-CoVs mAbs and vaccines may be effective, but the emergence of neutralization escape variants is inevitable. Angiotensin-converting enzyme 2 and dipeptidyl peptidase 4 enzyme are the getaway receptors for SARS-CoV-2 and MERS-CoV, respectively. Thus, we reformatted these receptors as Fc-fusion decoy receptors. Then, we tested them in parallel with anti-SARS-CoV (ab1-IgG) and anti-MERS-CoV (M336-IgG) mAbs against several variants using pseudovirus neutralization assay...
January 2024: Antibody Therapeutics