Emmanuelle Charrin, Emeline Aufradet, Aymeric Douillard, Aymen Romdhani, Genevieve De Souza, Amine Bessaad, Camille Faes, Erica N Chirico, Vincent Pialoux, Cyril Martin
Oxidative stress plays a crucial role in sickle cell disease (SCD) physiopathology. Given that chronic physical activity is known to decrease reactive oxygen species (ROS) and increase nitric oxide (NO) bioavailability in healthy subjects and in patients with cardiovascular or inflammatory pathologies, modulating these factors involved in the severity of the pathology could also be beneficial in SCD. This study aimed to determine if 8 weeks of increased physical activity (PA) by voluntary wheel running affects the hypoxia/reoxygenation (H/R) responses by reducing oxidative stress and increasing NO synthesis in sickle SAD mice...
March 2015: British Journal of Haematology