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Frederic T Billings
This is a general discussion of the "toxic terrors" (1) Love Canal and Hinkley, California, and a more specific, in depth, evaluation of the extent and the significance of the industrial and petrochemical cancer risks to the people of Louisiana in the so-called "Cancer Alley" between Baton Rouge and New Orleans. Has the birthright been exchanged for a mess of "chemical pottage?" "...and a great star fell from heaven, blazing like a torch, and it fell on a third of the rivers and on the springs of water. The name of the star is Wormwood...
2005: Transactions of the American Clinical and Climatological Association
Donald R Yance, Stephen M Sagar
An integrative approach for managing a patient with cancer should target the multiple biochemical and physiological pathways that support tumor development while minimizing normal tissue toxicity. Angiogenesis is a key process in the promotion of cancer. Many natural health products that inhibit angiogenesis also manifest other anticancer activities. The authors will focus on natural health products (NHPs) that have a high degree of antiangiogenic activity but also describe some of their many other interactions that can inhibit tumor progression and reduce the risk of metastasis...
March 2006: Integrative Cancer Therapies
Henry Lai, Narendra P Singh
Artemisinin, a compound isolated from the sweet wormwood Artemisia annua L., has previously been shown to have selective toxicity towards cancer cells in vitro. In the present experiment, we studied the potential of artemisinin to prevent breast cancer development in rats treated with a single oral dose (50mg/kg) of 7,12-dimethylbenz[a]anthracene (DMBA), known to induce multiple breast tumors. Starting from the day immediately after DMBA treatment, one group of rats was provided with a powdered rat-chow containing 0...
January 8, 2006: Cancer Letters
Narendra P Singh, Henry C Lai
BACKGROUND: Butyric acid is a short chain fatty acid produced by large bowel bacterial flora. It serves as an antiinflammatory agent and nutrient for normal colon cells. Butyric acid has also been shown to induce apoptosis in colon and many other cancer cells. Artemisinin is a compound extracted from the wormwood Artemisia annua L. It has been shown to selectively kill cancer cells in vitro and to be effective in treating animal and human cancer. We and others have found that the artemisinin analog, dihydroartemisinin (DHA), kills cancer cells by apoptosis...
November 2005: Anticancer Research
Wei Li, Weike Mo, Dan Shen, Libo Sun, Juan Wang, Shan Lu, Jane M Gitschier, Bing Zhou
Artemisinins, derived from the wormwood herb Artemisia annua, are the most potent antimalarial drugs currently available. Despite extensive research, the exact mode of action of artemisinins has not been established. Here we use yeast, Saccharamyces cerevisiae, to probe the core working mechanism of this class of antimalarial agents. We demonstrate that artemisinin's inhibitory effect is mediated by disrupting the normal function of mitochondria through depolarizing their membrane potential. Moreover, in a genetic study, we identify the electron transport chain as an important player in artemisinin's action: Deletion of NDE1 or NDI1, which encode mitochondrial NADH dehydrogenases, confers resistance to artemisinin, whereas overexpression of NDE1 or NDI1 dramatically increases sensitivity to artemisinin...
September 2005: PLoS Genetics
Róbert Góra, Milan Hutta
Newly developed method for characterisation and analysis of humic substances (HS) and humic-like substances (HULIS) in air dust particles was tested for potential interferences caused by abundant co-sampled pollens (common dandelion, common wormwood-absinth, apple tree). RP-HPLC using 10-step gradient of dimethylformamide (DMF) in a buffered aqueous mobile phase and a wide-pore (30 nm) octadecylsilica column has been applied to the analysis of HS and HULIS using tandem of spectrophotometric (DAD) and fluorimetric detection (FLD)...
August 19, 2005: Journal of Chromatography. A
Dirk W Lachenmeier, J Emmert, T Kuballa, G Sartor
Habitual abuse of the wormwood spirit absinthe was described in the 19th and 20th centuries as a cause for the mental disorder "absinthism" including the symptoms hallucinations, sleeplessness and convulsions. A controversial discussion is going on if thujone, a characteristic component of the essential oil of the wormwood plant Artemisia absinthium L., is responsible for absinthism, or if it was merely caused by chronic alcohol intoxication or by other reasons such as food adulterations. To ascertain if thujone may have caused absinthism, absinthes were produced according to historic recipes of the 19th century...
April 20, 2006: Forensic Science International
H Van der Meersch
This article reviews the development of the artemisinins used in the treatment of drug-resistant Plasmodium falciparum malaria. The story starts in China with Artemisia annua L., a plant that was traditionally used as an antipyretic. The activity of Annual wormwood can be explained by the presence of the active substance artemisinin. Soon, artemether, artemotil, artenimol, artesunate and sodium artesunate, derivatives of artemisinin, have been developed. Each has its own physical and pharmaceutical properties, dosage and dosage forms...
2005: Journal de Pharmacie de Belgique
Zhao-Bin Chen
Disinfection means killing or removing pathogenic microorganisms in media to realize a harmless process. A disinfectant, which is also referred to as a disinfection medicine in relevant regulations, is the medicine used to kill microorganisms for the purpose of disinfection. The disinfectants prepared from plants (including traditional Chinese herbal medicines) and the extracts thereof are called herbal disinfectants. China has a long history of using herbal disinfectants. As early as in 533 A.D., the use of Cornel to sterilize well water was recorded in Necessary Techniques for Qi People by Jia Enxie of the Beiwei Dynasty...
December 2004: Biomedical and Environmental Sciences: BES
Narendra P Singh, Henry C Lai
BACKGROUND: Artemisinin is a chemical compound extracted from the wormwood plant, Artemisia annua L. It has been shown to selectively kill cancer cells in vitro and retard the growth of implanted fibrosarcoma tumors in rats. In the present research, we investigated its mechanism of cytotoxicity to cancer cells. MATERIALS AND METHODS: Molt-4 cells, in complete RPMI-1640 medium, were first incubated with 12 microM of human holotransferrin at 37 degrees C in a humid atmosphere of 5% CO2 for one hour...
July 2004: Anticancer Research
Markus S Mueller, Nyabuhanga Runyambo, Irmela Wagner, Steffen Borrmann, Klaus Dietz, Lutz Heide
The Chinese medicinal plant Artemisia annua L. (Annual Wormwood) contains the antimalarial compound artemisinin. The locally grown herb may offer an additional tool for the control of malaria, especially in poor countries where modern antimalarial drugs are often unavailable. In an open, randomized, controlled pilot trial, we investigated the efficacy and safety of traditional tea preparations of Artemisia annua in the treatment of uncomplicated malaria. Treatment resulted in a quick resolution of parasitaemia and of clinical symptoms...
May 2004: Transactions of the Royal Society of Tropical Medicine and Hygiene
I G Akhapkina, T M Zheltikova
The cross reactivity of the pollen allergens of birch (Betula pendula), hazel (Corylus avelana), alder (Alnus glutinosa), wormwood (Artemisia absinthium), oak (Quercus robur) and ashtree (Fraxinus excelsior) was studied by the methods of the enzyme immunoassay and gel diffusion with the use of rabbit polyclonal antisera (PAS) prepared against birch pollen allergen. PAS was shown to be greatly related to all above-mentioned allergens with the exception of oak pollen allergen. PAS was found capable of forming precipitates in the layer of agar gel only with birch pollen allergen...
January 2004: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
Karin Räth, Katja Taxis, Gitta Walz, Christoph H Gleiter, Shu-Ming Li, Lutz Heide
Artemisia annua L. (annual wormwood) contains the antimalarial artemisinin. Aqueous preparations of the dried herb are included in the pharmacopoeia of the People's Republic of China for treatment of fever and malaria. Fourteen healthy male volunteers received one liter of tea prepared from nine grams of Artemisia annua leaves. Blood samples were taken and artemisinin was detected by reversed phase high-performance liquid chromatography. The mean +/- SD maximum plasma concentration of artemisinin was 240 +/- 75 ng/mL and the mean +/- SD area under the plasma concentration-time curve was 336 +/- 71 ng/mL x hr...
February 2004: American Journal of Tropical Medicine and Hygiene
Amy J Skyles, Burgunda V Sweet
No abstract text is available yet for this article.
February 1, 2004: American Journal of Health-system Pharmacy: AJHP
(no author information available yet)
No abstract text is available yet for this article.
May 1951: Cancer Bulletin
No abstract text is available yet for this article.
January 1951: Die Pharmazie
Tomoko Muto, Takao Watanabe, Miwa Okamura, Mitsuyoshi Moto, Yoko Kashida, Kunitoshi Mitsumori
Wormwood, Artemisia absinthium, is a very bitter plant, and its extract has been used as food additives such as seasonings for food and drinks. A 13-week repeated dose toxicity study of wormwood extract was performed in both sexes of Wistar Hannover (GALAS) rats. Rats were divided into 4 groups consisting of 10 males and 10 females each, and were given water containing 0, 0.125, 0.5, or 2% wormwood extract. All rats had survived at the end of the study, and no changes indicating obvious toxicities that are attributable to the treatment of wormwood extract were observed in the body weights, hematological and serum biochemical examinations, organ weights, and histopathological examinations...
December 2003: Journal of Toxicological Sciences
Véronique Masotti, Fabien Juteau, Jean Marie Bessière, Josette Viano
The volatile components of the aerial parts of Artemisia molinieri, an endemic wormwood of southern France, were analyzed by GC and GC-MS. Among the 69 compounds identified, major components were ascaridole (19-76%), alpha-terpinene (traces-36%), p-cymene (1-17%), 1,8-cineole (0.3-8%), and germacrene D (0.6-15%). Quantitative variations have been characterized following the season, the phenological cycle, and the aging of the plants. Bioassays have been performed on a sample of essential oil, which has shown a strong inhibition of the growth of both tested yeasts (Candida albicans and Saccharomyces cerevisiae var...
November 19, 2003: Journal of Agricultural and Food Chemistry
No abstract text is available yet for this article.
September 1959: [Shandong Yi Kan] [Shantung Medical Publication]
No abstract text is available yet for this article.
April 1956: Die Pharmazie
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