Lingyan Zhu, Chao Qiu, Lili Dai, Linxia Zhang, Meiqi Feng, Yu Yang, Chenli Qiu, Anli Zhang, Jun Huang, Ying Wang, Ying Wan, Chen Zhao, Hao Wu, Jianxin Lyu, Xiaoyan Zhang, Jianqing Xu
It remains poorly defined whether any human miRNAs play protective roles during HIV infection. Here, focusing on a unique cohort of HIV-infected former blood donors, we identified miR-31 (hsa-miR-31) by comparative miRNA profiling as the only miRNA inversely correlating with disease progression. We further validated this association in two prospective cohort studies. Despite conservation during evolution, hsa-miR-31, unlike its mouse counterpart (mmu-miR-31), was downregulated in human T cell upon activation...
2021: Frontiers in Immunology