Hector R Wong, Natalie Z Cvijanovich, Mark Hall, Geoffrey L Allen, Neal J Thomas, Robert J Freishtat, Nick Anas, Keith Meyer, Paul A Checchia, Richard Lin, Michael T Bigham, Anita Sen, Jeffrey Nowak, Michael Quasney, Jared W Henricksen, Arun Chopra, Sharon Banschbach, Eileen Beckman, Kelli Harmon, Patrick Lahni, Thomas P Shanley
INTRODUCTION: Differentiating between sterile inflammation and bacterial infection in critically ill patients with fever and other signs of the systemic inflammatory response syndrome (SIRS) remains a clinical challenge. The objective of our study was to mine an existing genome-wide expression database for the discovery of candidate diagnostic biomarkers to predict the presence of bacterial infection in critically ill children. METHODS: Genome-wide expression data were compared between patients with SIRS having negative bacterial cultures (n = 21) and patients with sepsis having positive bacterial cultures (n = 60)...
October 29, 2012: Critical Care: the Official Journal of the Critical Care Forum