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JOURNAL ARTICLE
Ahmad Nassr, Domagoj Coric, Zachariah W Pinter, Arjun S Sebastian, Brett A Freedman, Donald Whiting, Ali Chahlavi, Stephen Pirris, Nicolas Phan, Scott A Meyer, A David Tahernia, Faheem Sandhu, Harel Deutsch, Eric A Potts, Joseph Cheng, John H Chi, Michael Groff, Yoram Anekstein, Michael P Steinmetz, William C Welch
BACKGROUND: The comparative effectiveness of decompression plus lumbar facet arthroplasty versus decompression plus instrumented lumbar spinal fusion in patients with lumbar spinal stenosis and grade-I degenerative spondylolisthesis is unknown. METHODS: In this randomized, controlled, Food and Drug Administration Investigational Device Exemption trial, we assigned patients who had single-level lumbar spinal stenosis and grade-I degenerative spondylolisthesis to undergo decompression plus lumbar facet arthroplasty (arthroplasty group) or decompression plus fusion (fusion group)...
May 7, 2024: Journal of Bone and Joint Surgery. American Volume
#2
REVIEW
Davendra Ramkumar, Aileen Marty, Japhia Ramkumar, Holly Rosencranz, Radhika Vedantham, Modan Goldman, Erin Meyer, Jasia Steinmetz, Amy Weckle, Kelly Bloedorn, Carl Rosier
Non-communicable diseases (NCDs) pose a global health challenge, leading to substantial morbidity, mortality, and economic strain. Our review underscores the escalating incidence of NCDs worldwide and highlights the potential of regenerative agriculture (RA) products in mitigating these diseases. We also explore the efficacy of dietary interventions in NCD management and prevention, emphasizing the superiority of plant-based diets over those high in processed foods and red meat. Examining the role of the gut microbiome in various diseases, including liver disorders, allergies, metabolic syndrome, inflammatory bowel disease, and colon cancer, we find compelling evidence implicating its influence on disease development...
June 2024: One Health
#3
JOURNAL ARTICLE
Yann Le Teurnier, Bertrand Rozec, Cecile Degryse, François Levy, Youcef Miliani, Gilles Godet, George Daccache, Cyrille Truc, Eric Steinmetz, Alexandre Ouattara, Bernard Cholley, Jean-Marc Malinovsky, Denis Portier, Gregory Dupont, Darius Liutkus, Pierre Viard, Morgane Pere, Benjamin Daumas-Duport, Pierre-Aubin Magras, Mickael Vourc'h
BACKGROUND: Whether the optimization of cerebral oxygenation based on regional cerebral oxygen saturation (rSO2 ) monitoring reduces the occurrence of cerebral ischemic lesions is unknown. METHODS: This multicenter, randomized, controlled trial recruited adults admitted for scheduled carotid endarterectomy. Patients were randomized between the standard of care or optimization of cerebral oxygenation based on rSO2 monitoring using near-infrared spectroscopy. In the intervention group, in case of a decrease in rSO2 in the intervention, the following treatments were sequentially recommended: (1) increasing oxygenotherapy, (2) reducing the tidal volume, (3) legs up-raising, (4) performing a fluid challenge and (5) initiating vasopressor support...
May 4, 2024: Anaesthesia, Critical Care & Pain Medicine
#4
JOURNAL ARTICLE
Sweta Karan, Ana Luisa Durán-Meza, Abigail Chapman, Cheylene Tanimoto, Soo Khim Chan, Charles M Knobler, William M Gelbart, Nicole F Steinmetz
The dramatic effectiveness of recent mRNA (mRNA)-based COVID vaccines delivered in lipid nanoparticles has highlighted the promise of mRNA therapeutics in general. In this report, we extend our earlier work on self-amplifying mRNAs delivered in spherical in vitro reconstituted virus-like particles (VLPs), and on drug delivery using cylindrical virus particles. In particular, we carry out separate in vitro assemblies of a self-amplifying mRNA gene in two different virus-like particles: one spherical, formed with the capsid protein of cowpea chlorotic mottle virus (CCMV), and the other cylindrical, formed from the capsid protein of tobacco mosaic virus (TMV)...
May 6, 2024: Molecular Pharmaceutics
#5
JOURNAL ARTICLE
Arpan A Patel, Jacob K Greenberg, Michael P Steinmetz, Sarel Vorster, Edin Nevzati, Alexander Spiessberger
OBJECTIVE: The authors present a finite element analysis (FEA) evaluating the mechanical impact of C1-2 hypermobility on the spinal cord. METHODS: The Code_Aster program was used to perform an FEA to determine the mechanical impact of C1-2 hypermobility on the spinal cord. Normative values of Young's modulus were applied to the various components of the model, including bone, ligaments, and gray and white matter. Two models were created: 25° and 50° of C1-on-C2 rotation, and 2...
May 3, 2024: Journal of Neurosurgery. Spine
#6
JOURNAL ARTICLE
Lorena Cecilia López Steinmetz, Margarita Sison, Rustam Zhumagambetov, Juan Carlos Godoy, Stefan Haufe
INTRODUCTION: The COVID-19 pandemic has exacerbated mental health challenges, particularly depression among college students. Detecting at-risk students early is crucial but remains challenging, particularly in developing countries. Utilizing data-driven predictive models presents a viable solution to address this pressing need. AIMS: 1) To develop and compare machine learning (ML) models for predicting depression in Argentinean students during the pandemic. 2) To assess the performance of classification and regression models using appropriate metrics...
2024: Frontiers in Psychiatry
#7
JOURNAL ARTICLE
Christoph Leineweber, Maike Lücht, Christine Gohl, Hanspeter W Steinmetz, Rachel E Marschang
Electrophoresis is a useful diagnostic tool for detecting inflammation, including inflammation associated with infectious diseases (eg, aspergillosis in penguins). To our knowledge, reference intervals are not available for plasma proteins via electrophoresis in Humboldt penguins ( Spheniscus humboldti ). Therefore, preliminary reference intervals for blood plasma proteins measured by capillary zone electrophoresis were calculated for Humboldt penguins from a single zoological collection, and possible differences between the sexes and the ages of the birds were evaluated...
April 2024: Journal of Avian Medicine and Surgery
#8
JOURNAL ARTICLE
Ashley Anzet van Niekerk, Sara Maluck, Patrik Mag, Csaba Kővágó, Ádám Kerek, Ákos Jerzsele, Torsten Steinmetzer, Erzsébet Pászti-Gere
The increasing prevalence of antimicrobial resistance against zoonotic bacteria, including Streptococcus (S.) suis , highlights the need for new therapeutical strategies, including the repositioning of drugs. In this study, susceptibilities of bacterial isolates were tested toward ten different 3-amidinophenyalanine (Phe(3-Am)) derivatives via determination of minimum inhibitory concentration (MIC) values. Some of these protease inhibitors, like compounds MI-432, MI-471, and MI-476, showed excellent antibacterial effects against S...
April 2, 2024: Biomedicines
#9
JOURNAL ARTICLE
Eric Ducasse, Marc Sapoval, Jérôme Brunet, Philippe Commeau, Yann Goueffic, Jean Sabatier, Eric Steinmetz, Patrick Lermusiaux, Eugenio Rosset, Caroline Caradu
BACKGROUND: Despite improved patency with newer-generation nitinol stents, one-half of patients will require secondary interventions for in-stent restenosis (ISR). The best treatment strategy remains unclear. This study aimed to compare drug-coated balloons (DCBs) used alone or in association with excimer laser atherectomy (ELA) to simple percutaneous transluminal angioplasty (PTA) in the treatment of femoropopliteal-ISR. METHODS: The INTACT trial is a multicenter, prospective, triple-arm randomized trial conducted across 14 centers from December 2015 to November 2019...
April 24, 2024: Journal of Endovascular Therapy
#10
JOURNAL ARTICLE
Alexandre Pouhin, Eric Steinmetz
No abstract text is available yet for this article.
April 22, 2024: European Journal of Vascular and Endovascular Surgery
#11
JOURNAL ARTICLE
Calebe P Mendes, Wido R Albert, Zachary Amir, Marc Ancrenaz, Eric Ash, Badrul Azhar, Henry Bernard, Jedediah Brodie, Tom Bruce, Elliot Carr, Gopalasamy Reuben Clements, Glyn Davies, Nicolas J Deere, Yoan Dinata, Christl A Donnelly, Somphot Duangchantrasiri, Gabriella Fredriksson, Benoit Goossens, Alys Granados, Andrew Hearn, Jason Hon, Tom Hughes, Patrick Jansen, Kae Kawanishi, Margaret Kinnaird, Sharon Koh, Alice Latinne, Matthew Linkie, Federica Loi, Anthony J Lynam, Erik Meijaard, Jayasilan Mohd-Azlan, Jonathan H Moore, Senthilvel K S S Nathan, Dusit Ngoprasert, Wilson Novarino, Ilyas Nursamsi, Timothy O'Brien, Robert Ong, John Payne, Dolly Priatna, D Mark Rayan, Glen Reynolds, Rustam Rustam, Sasidhran Selvadurai, Amanda Shia, Muhammad Silmi, Pablo Sinovas, Kriangsak Sribuarod, Robert Steinmetz, Matthew J Struebig, Ronglarp Sukmasuang, Sunarto Sunarto, Tarmizi Tarmizi, Arjun Thapa, Carl Traeholt, Oliver R Wearn, Hariyo B Wibisono, Andreas Wilting, Seth Timothy Wong, Siew Te Wong, Jettie Word, Wen Xuan Chiok, Zainal Zahari Zainuddin, Matthew Scott Luskin
Information on tropical Asian vertebrates has traditionally been sparse, particularly when it comes to cryptic species inhabiting the dense forests of the region. Vertebrate populations are declining globally due to land-use change and hunting, the latter frequently referred as "defaunation." This is especially true in tropical Asia where there is extensive land-use change and high human densities. Robust monitoring requires that large volumes of vertebrate population data be made available for use by the scientific and applied communities...
April 22, 2024: Ecology
#12
JOURNAL ARTICLE
Tobit D Steinmetz, Jana Thomas, Lena Reimann, Ann-Kathrin Himmelreich, Sebastian R Schulz, Florian Golombek, Kathrin Castiglione, Hans-Martin Jäck, Susanne Brodesser, Bettina Warscheid, Dirk Mielenz
Autophagy supervises the proteostasis and survival of B lymphocytic cells. Trk-fused gene (TFG) promotes autophagosome-lysosome flux in murine CH12 B cells, as well as their survival. Hence, quantitative proteomics of CH12 tfg KO and WT B cells in combination with lysosomal inhibition should identify proteins that are prone to lysosomal degradation and contribute to autophagy and B cell survival. Lysosome inhibition via NH4 Cl unexpectedly reduced a number of proteins but increased a large cluster of translational, ribosomal, and mitochondrial proteins, independent of TFG...
April 22, 2024: Journal of Proteome Research
#13
JOURNAL ARTICLE
Keren Skalsky, Leor Perl, Tali Steinmetz, Benaya Rozen Zvi, Mohamad Atamna, Yaron Shapira, Ran Kornowski, Arthur Shiyovich, Ruth Rahamimov, Mordehay Vaturi
RATIONALE & OBJECTIVE: Kidney function can be adversely affected by significant tricuspid regurgitation (TR) owing to effects on cardiac output and systemic venous congestion. However, the impact of significant TR on short- and long-term kidney function following a kidney transplant remains uncertain. STUDY DESIGN: Retrospective observational cohort. SETTING & PARTICIPANTS: Kidney transplant recipients from a single center between 2016 and 2019...
May 2024: Kidney medicine
#14
JOURNAL ARTICLE
Camil-Cassien Bamdé, Eric Steinmetz
No abstract text is available yet for this article.
April 5, 2024: European Journal of Vascular and Endovascular Surgery
#15
JOURNAL ARTICLE
Franziska Roeder, Tina Röpke, Lara-Kristin Steinmetz, Martin Kolb, Ulrich A Maus, Bradford J Smith, Lars Knudsen
Pre-injured lungs are prone to injury progression in response to mechanical ventilation. Heterogeneous ventilation due to (micro)atelectases imparts injurious strains on open alveoli (known as volutrauma). Hence, recruitment of (micro)atelectases by positive end-expiratory pressure (PEEP) is necessary to interrupt this vicious circle of injury but needs to be balanced against acinar overdistension. In this study, the lung-protective potential of alveolar recruitment was investigated and balanced against overdistension in pre-injured lungs...
April 6, 2024: Scientific Reports
#16
REVIEW
Laura Walthert, Michael Ris, Kevin Moerenhout, Sébastien Déglise, Pietro Giovanni Di Summa, Sylvain Steinmetz
Major amputations of the lower extremity may be required after trauma and a variety of underlying diseases such as peripheral vascular disease, diabetes, and malignancies. The goal of any major amputation is an optimal functional result with a maximum limb length in combination with optimal wound healing. The preservation of the knee joint is essential for successful rehabilitation, and this is best achieved by the Burgess below-knee amputation (BKA). Whenever a BKA is not possible, the Gritti-Stokes amputation is our first choice...
April 4, 2024: EFORT Open Reviews
#17
JOURNAL ARTICLE
Asya Drenkova-Tuhtan, Caleb Stewart Inskeep, Leoni Luthardt, Sara Li Deuso, Thomas Ballweg, Doris Hanselmann, Zoé Béalu, Carsten Meyer, Benedikt Schug, Heidrun Steinmetz, Karl Mandel
This work introduces a new sustainable alternative of powdered activated carbon (PAC) - magnetically harvestable and reusable after regeneration via inductive heating - for the adsorptive removal of organic micropollutants (OMP) from secondary wastewater effluents. For this purpose, two commercial PACs - lignite "L" (1187 m2 /g) and coconut "C"-based (1524 m2 /g) - were modified with magnetic iron oxide following two different synthesis approaches: infiltration ("infiltr") and surface deposition ("depos") route...
March 26, 2024: Water Research
#18
REVIEW
Yuncong Mao, Arpan A Patel, Seth Meade, Edward Benzel, Michael P Steinmetz, Thomas Mroz, Ghaith Habboub
INTRODUCTION: Expandable devices such as interbody cages, vertebral body reconstruction cages, and intravertebral body expansion devices are frequently utilized in spine surgery. Since the introduction of expandable implants in the early 2000s, the variety of mechanisms that drive expansion and implant materials have steadily increased. By examining expandable devices that have achieved commercial success and exploring emerging innovations, we aim to offer an in-depth evaluation of the different types of expandable cages used in spine surgery and the underlying mechanisms that drive their functionality...
April 1, 2024: Expert Review of Medical Devices
#19
JOURNAL ARTICLE
Nir Levi, Rafael Wolff, Rami Jubeh, Mony Shuvy, Yoed Steinmetz, Nimrod Perel, Tomer Maller, Itshak Amsalem, Rafael Hitter, Elad Asher, Anna Turyan, Mohammad Karmi, Amir Orlev, Dmitry Dratva, Zahi Khoury, Tal Hasin, Arik Wolak, Michael Glikson, Danny Dvir
IMPORTANCE: Rapid reperfusion during primary percutaneous coronary intervention (PCI) is associated with improved outcomes among patients with ST-elevation myocardial infarction (STEMI). Although attempts at reducing the time from STEMI diagnosis to arrival at the catheterization laboratory have been widely investigated, intraprocedural strategies aimed at reducing the time to reperfusion are lacking. OBJECTIVE: To evaluate the effect of culprit lesion PCI before complete diagnostic coronary angiography (CAG) vs complete CAG followed by culprit lesion PCI on reperfusion times among patients with STEMI...
March 4, 2024: JAMA Network Open
#20
JOURNAL ARTICLE
Jacob K Greenberg, Madelyn Frumkin, Ziqi Xu, Jingwen Zhang, Saad Javeed, Justin K Zhang, Braeden Benedict, Kathleen Botterbush, Salim Yakdan, Camilo A Molina, Brenton H Pennicooke, Daniel Hafez, John I Ogunlade, Nicholas Pallotta, Munish C Gupta, Jacob M Buchowski, Brian Neuman, Michael Steinmetz, Zoher Ghogawala, Michael P Kelly, Burel R Goodin, Jay F Piccirillo, Thomas L Rodebaugh, Chenyang Lu, Wilson Z Ray
BACKGROUND AND OBJECTIVES: Neurosurgeons and hospitals devote tremendous resources to improving recovery from lumbar spine surgery. Current efforts to predict surgical recovery rely on one-time patient report and health record information. However, longitudinal mobile health (mHealth) assessments integrating symptom dynamics from ecological momentary assessment (EMA) and wearable biometric data may capture important influences on recovery. Our objective was to evaluate whether a preoperative mHealth assessment integrating EMA with Fitbit monitoring improved predictions of spine surgery recovery...
March 29, 2024: Neurosurgery
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