Mohan Satish, Palanikumar Gunasekar, Juan A Asensio, Devendra K Agrawal
Intracoronary stenting is a common procedure in patients with coronary artery disease (CAD). Stent deployment stretches and denudes the endothelial layer, promoting a local inflammatory response, resulting in neointimal hyperplasia. Vitamin D deficiency associates with CAD. In this study, we examined the association of vitamin D status with high mobility group box 1 (HMGB1)-mediated pathways (HMGB1, receptor for advanced glycation end products [RAGE], and Toll-like receptor-2 and -4 [TLR2 and TLR4]) in neointimal hyperplasia in atherosclerotic swine following bare metal stenting...
August 1, 2020: Molecular and Cellular Biochemistry
Leila Sadat Bahrami, Golnaz Ranjbar, Abdolreza Norouzy, Seyyed Mostafa Arabi
In this systematic review and meta-analysis our aim was to assess the effect of vitamin D supplementation on cardiac outcomes in patients with coronary artery disease (CAD). The search terms were performed from January 2000 to January 2018, only randomized clinical trials (RCT) in human subjects were considered, with no language restrictions. The electronic databases used in this study were: PubMed; Cochran library; Embase; and Scopus. Two independent expert reviewers carried out data extraction according to Cochrane recommendations...
July 31, 2020: Scientific Reports
Mahsa Mehrdad, Farhad Vahid, Mohammad Hassan Eftekhari
BACKGROUND: Obesity and overweight are the most prevailing problem in most countries. Overweight people are very susceptible to diseases such as diabetes, hypertension, cardiovascular disease, metabolic syndrome, and cancers. Adequate intake of micronutrients along with a quality diet that is varied and balanced plays an important role regarding health and the immune system. Numerous studies have investigated the relationship between the quality of diet and different diseases. Genetics is a risk factor of great importance regarding obesity and overweight...
June 27, 2020: American Journal of the Medical Sciences
Hai-Ying Chen, Hong-Ping Zhang, Jie Yang, Zhi-Qiong Huang, Hai-Xia Xu, Jiang Jin, Kai Xu, Yu Tong, Qian-Qian Dong, Jian-Qiong Zheng
OBJECTIVE: Maternal vitamin D deficiency is associated with glucose and lipid metabolism in the mother and offspring. Meanwhile, it can also lead to adverse pregnancy outcomes. The aim of this case-control study was to document maternal, umbilical arterial glucose and lipid metabolic levels and correlations in pregnancies with or without vitamin D deficiency, while also investigating adverse pregnancy outcomes. DESIGN/PARTICIPANTS/MEASUREMENTS: A total of 425 pregnant women who received antenatal care and delivered at Wenzhou People's Hospital were enrolled...
July 26, 2020: Clinical Endocrinology
Oluwakamisi F Akinmoladun, Fabian N Fon, Conference T Mpendulo, Omobola Okoh
Water restriction in small ruminants is usually accompanied by a drop in feed intake, body weight, and disturbances in the normal internal milieu. However, attempts to lessen the burden of water stress with vitamin C (VC) supplementation have been greeted with conflicting reports. Therefore, this experiment was conducted to evaluate the effect of single and/or multiple VC supplementations in water-restricted Xhosa goats by evaluating their performance, heat tolerance, and blood metabolites. In total, 42 does, 12 mo old and with an average weight of 15...
April 2020: Translational Animal Science
Heeseung Lee, Heaji Lee, Yunsook Lim
Oxidative stress and abnormal lipid metabolism in diabetes can trigger renal lipotoxicity, extending to diabetic nephropathy. Vitamin D3 has been known to be involved in lipid metabolism as well as insulin secretion or inflammation. Therefore, we hypothesized that vitamin D3 supplementation attenuated hyperglycemia-induced renal damage in diabetic mice. Diabetes was induced by a 40% kJ high-fat diet with 30 mg/kg body weight of streptozotocin by intraperitoneal injection twice in male C57BL/6J mice. Among diabetic mice (fasting blood glucose > 140 mg/dL), mice were supplemented with 300 ng/kg body weight of vitamin D3 dissolved in olive oil for 12 weeks...
June 10, 2020: Nutrition Research
Tiara R Ahmad, Sei Higuchi, Enrico Bertaggia, Allison Hung, Niroshan Shanmugarajah, Nicole C Guilz, Jennifer R Gamarra, Rebecca A Haeusler
Bile acids (BAs) comprise heterogenous amphipathic cholesterol-derived molecules that carry out physicochemical and signaling functions. A major site of BA action is the terminal ileum, where enterocytes actively reuptake BAs and express high levels of BA-sensitive nuclear receptors. BA pool size and composition are affected by changes in metabolic health, and vice versa. One of several factors that differentiate BAs is the presence of a hydroxyl group on C12 of the steroid ring. 12α-hydroxylated BAs (12HBAs) are altered in multiple disease settings, but the consequences of 12HBA abundance are incompletely understood...
July 20, 2020: Journal of Biological Chemistry
Hossein Mohaddes Ardabili, Mohammad Sobhan Sheikh Andalibi, Mina Safari, Samaneh Khakpour, Maryam Tayefi, Seyed Reza Moallem, Mojtaba Fayaz, Ahmadreza Zarifian, Maryam Saberi-Karimian, Zahra Khorasanchi, Alireza Pasdar, Gordon A Ferns, Majid Ghayour-Mobarhan
INTRODUCTION: An imbalanced dietary pattern may result in a number of non-communicable disorders that include: obesity, diabetes, metabolic syndrome, cardiovascular diseases, and subsequently impaired quality of life (QOL). Micro- and macro-nutrients play some important roles in maintaining human health. The objective of this study was to compare dietary intake of employees of a gas processing company, who were provided with meals by their employee, with staff from other public employers from Mashhad, in northeastern Iran...
August 2020: Clinical Nutrition ESPEN
Salesa Barja, Catalina Le Roy, Cecilia Sepúlveda, Maria Luisa Guzmán, Marithza Olivarez, María José Figueroa
BACKGROUND: obesity and associated cardiometabolic complications are increasing among adults with cerebral palsy (CP). Information in children is scarce, and there is no consensus definition of obesity. OBJECTIVES: to describe the frequency of obesity and metabolic complications in children and adolescents with CP. METHODS: a descriptive, cross-sectional study performed in two outpatient pediatric special needs centers. Demographic, anthropometric (Brooks 2011), and motor function (GMFCS) data, as well as antiepileptic use, were recorded...
July 20, 2020: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Dan Jin, Dao-Min Zhu, Hong-Lin Hu, Meng-Nan Yao, Wan-Jun Yin, Rui-Xue Tao, Peng Zhu
Background: The biological pathways through which vitamin D is involved in the regulation of systemic inflammation remain largely unknown. Objective: The objective of this study was to evaluate the role of vitamin D status on the relationship between lipid profile and high-sensitivity C-reactive protein (hs-CRP) in pregnant women. Design: Serum 25-hydroxyvitamin D (25(OH)D), hs-CRP, and indicators of lipid profiles (total cholesterol, TC; triglyceride, TG; high-density lipoprotein cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C), were measured in 2479 pregnant women during the second trimester...
2020: Nutrition & Metabolism
Ammar Abdulrahman Jairoun, Moyad Jamal Shahwan, Mohammed Husham Khattab
OBJECTIVES: To determine the overall prevalence of metabolic syndrome using World health organization (WHO); National Cholesterol Education program (NCEP) and International diabetes federation (IDF) guidelines and to study its association with vitamin D and other biochemical parameters in patients with type 2 Diabetes mellitus, as well as to identify the set of biochemical parameters that jointly influence the metabolic syndrome using different diagnostic criteria. METHODS: A cross-sectional study was carried out at private health care center...
July 16, 2020: Current Diabetes Reviews
Obiajulu Christian Ezeigwe, Favour Amarachi Nzekwe, Ogechukwu Frances Nworji, Chidinma Felicia Ezennaya, Ebele Lauretta Iloanya, Kingsley Kelechi Asogwa
Background: Ficus capensis Moraceae and Cnidoscolus aconitifolius Euphorbiaceae leaves have been used separately in traditional medical practice to treat different ailments, of which anemia is one. This study aims to evaluate the effect of F. capensis and C. aconitifolius on hepatic, renal parameters and oxidative stress of phenylhydrazine-induced anemic rats. Methods: Thirty-five rats were randomized into seven groups (A-G) of five rats each. Groups A and B served as the normal control and anemic control, respectively, while Groups C, D, E, F, and G were treated with a standard drug (vitamin B12 ), 200mg/kg bw...
2020: Journal of Experimental Pharmacology
Woo Jin Kim, Young Rong Bang, Je-Wook Kang, Jae Ho Yoo, Seong Hwan Kim, Jae Hong Park
Objectives: It remains unclear whether methylphenidate (MPH) has yadverse effects on growth in children. This study aimed to investigate the association of MPH with serum biological markers of growth in children with attention-deficit/hyperactivity disorder (ADHD). Methods: The present study included 103 children with ADHD (64 drug-naive children, 39 MPH-treated children) and 112 control subjects. Children with ADHD were diagnosed on the basis of a semi-structured interview...
July 1, 2020: Soa--chʻŏngsonyŏn chŏngsin ŭihak, Journal of child & adolescent psychiatry
Hassan Vatanparast, Naorin Islam, Mojtaba Shafiee, D Dan Ramdath
Current evidence suggests a link between red and processed meat consumption and the risk of various cancers and other health outcomes. Using national survey data from the Canadian Community Health Survey (CCHS)-Nutrition 2015, we aimed to model a dietary scenario to assess the potential effects of increasing the intake of currently consumed plant-based meat alternatives by 100% and decreasing the consumption of red and processed meat by 50% on the diet quality and nutrient intakes of Canadians (≥1 year). This dietary scenario had no significant impact on dietary energy intake ( p > 0...
July 9, 2020: Nutrients
Jinbao Chen, Weisong Zhao, Xuejing Yue, Ping Zhang
Background and Purpose: The lifetime prevalence of benign paroxysmal positional vertigo (BPPV) is high, especially in the elderly. Patients with BPPV are more susceptible to ischemic stroke, dementia, and fractures, severely reducing quality of life of patients. Many studies have analyzed risk factors for the occurrence of BPPV. However, the results of these studies are not identical. We performed this meta-analysis to determine potential risk factors associated with the occurrence of BPPV. Methods: PubMed, EMBASE, and the Cochrane Library (January 2000 through March 2020) were systematically searched for eligible studies analyzing risk factors for the occurrence of BPPV...
2020: Frontiers in Neurology
Suyan Duan, Jiajia Chen, Lin Wu, Guangyan Nie, Lianqin Sun, Chengning Zhang, Zhimin Huang, Changying Xing, Bo Zhang, Yanggang Yuan
OBJECTIVE: Chronic kidney disease (CKD) related to diabetes has become more common than glomerulonephritis in recent years. Given the inefficient and difficult identification of diabetic kidney disease (DKD) from non-diabetic kidney disease (NDKD) as well as a result of emerging evidence supporting a role for tubular involvement in DKD, we aimed to investigate the utility of urinary neutrophil gelatinase-associated lipocalin (uNGAL) in the differential diagnosis and predictive value of DKD from NDKD...
June 26, 2020: Journal of Diabetes and its Complications
Omid Sadeghi, Alireza Sadeghi, Hassan Mozaffari-Khosravi, Azad Shokri
OBJECTIVE: To assess the association between patterns of nutrient intake and metabolic syndrome (MetS) in a large sample of Iranian adults. DESIGN: Baseline data from the Shahedieh cohort study were used in the current cross-sectional study. Dietary intakes were assessed through the use of a validated semi-quantitative FFQ. Nutrient patterns (NP) were derived using factor analysis. The MetS was defined according to criteria introduced from the National Cholesterol Education Program Adult Treatment Panel III, modified for Iranian adults...
July 9, 2020: Public Health Nutrition
Dwiyati Pujimulyani, Umar Santoso, Sri Luwihana D, Ali Maruf
This research focused on studying the effects of orally administered pressure-blanched white saffron on the antioxidative properties and lipid profiles of wistar rats. White saffron was blanched in autoclave for 2.5, 5, 7.5, and 10 min at 100, 105, 110, 115, and 120 °C, which are equivalent to 14.71, 17.53, 20.79, 24.54, and 28.81 psia, respectively. A total of 30 male wistar rats aged four weeks were fed with a standard diet (N), oxidized peanut oil diet + unblanched white saffron (A), oxidized peanut oil diet + blanched white saffron (B), oxidized peanut oil diet + pressure-blanched white saffron (C), and oxidized peanut oil diet + aquadest (NC), for two weeks after pre-treatment with the standard diet for a week...
June 2020: Heliyon
Justyna Kikut, Anna Jasińska, Jakub Pobłocki, Jacek Brodowski, Szczuko Małgorzata
INTRODUCTION: In recent decades, the number of gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) cases, associated with coexisting metabolic disorders, has been continuously increasing. Patients with progressing neoplastic disease are at a risk of malnutrition. To improve the quality of life of neuroendocrine neoplasms (NEN) patients, the therapeutic approach should be supported by a well-balanced diet. The aim of the study was to analyze the nutritional errors and deficits in a group of GEP-NET patients...
June 30, 2020: Nutrients
B Sági, A Peti, O Lakatos, T Gyimesi, E Sulyok, I Wittmann, Botond Csiky
Objective: In this observational study we addressed accelerated arteriosclerosis (AS) in patients with chronic renal failure (CRF) on hemodialysis (HD) by measuring vascular stiffness (VS) parameters and attempted to relate them to pro-inflammatory and protective factors. Patients: 96 consecutive patients receiving regular HD were included. 20 adult patients without major renal, cardiovascular or metabolic morbidities served as controls. Methods: AS parameters (carotid-femoral pulse wave velocity - PWV, aortic augmentation index - Aix) were measured by using applanation tonometry (SphygmoCor, AtCor Medical, Sidney)...
July 2, 2020: Physiology International
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