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JOURNAL ARTICLE
Mohammed Djemai, Maroua Jalouli, Mohamed Chahine
BACKGROUND: Variants of the SCN5A gene, which encodes the NaV 1.5 cardiac sodium channel, have been linked to arrhythmic disorders associated with dilated cardiomyopathy (DCM). However, the precise pathological mechanisms remain elusive. The present study aimed to elucidate the pathophysiological consequences of the DCM-linked Nav1.5/R219H variant, which is known to generate a gating pore current, using patient-specific human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) cultured in monolayers...
May 25, 2024: Biochemical and Biophysical Research Communications
#2
JOURNAL ARTICLE
Edward S Harake, John H Lee, Mark M Zaki, Rushikesh S Joshi, Joseph R Linzey, Rakesh D Patel, Paul Park, Yamaan S Saadeh
OBJECTIVE: Computed tomography is considered the gold-standard imaging tool to evaluate spinal implant accuracy. However, there are no studies that evaluate the accuracy of robotic sacroiliac joint (SIJ) implant placement using CT to date. The aim of this study was to compare the accuracy of implant placement on CT between robotic and fluoroscopic navigation for SIJ fusion and the subsequent complications and clinical outcomes of suboptimally placed screws. METHODS: A retrospective analysis of SIJ fusions utilizing either robotic or fluoroscopic guidance at a single institution was conducted from 2014 to 2023...
May 31, 2024: Journal of Neurosurgery. Spine
#3
JOURNAL ARTICLE
Zongze Li, Yang Zhao, Peixi Liu, Yuan Shi, Kai Quan, Hongfei Zhang, Mingjian Liu, Yingjun Liu, Yanlong Tian, Peiliang Li, Yuanli Zhao, Wei Zhu
OBJECTIVE: Craniocervical junction arteriovenous fistulas (CCJ-AVFs) are complex vascular shunts that present a challenge for treatment. The aim of this study was to compare the clinical outcomes of microsurgery and endovascular embolization for CCJ-AVFs and to determine whether the treatment approach affected the obliteration rate and neurological improvement. METHODS: The authors conducted a retrospective analysis of 64 patients who had undergone microsurgery or endovascular embolization for CCJ-AVF at one of two neurosurgical centers from January 2014 to February 2022...
May 31, 2024: Journal of Neurosurgery
#4
JOURNAL ARTICLE
Alejandro Enriquez-Marulanda, Jean Filo, Felipe Ramirez-Velandia, Thomas Fodor, Daniel Sconzo, Michael Young, Sandeep Muram, Max Shutran, Justin Granstein, Philipp Taussky, Christopher S Ogilvy
OBJECTIVE: Concern about thromboembolic events after flow diversion (FD) warrants dual antiplatelet therapy for 3 to 6 months. Platelet function tests are routinely performed prior to the procedure to detect clopidogrel responsiveness, as resistance is associated with CYP2C19 gene polymorphisms. This study aimed to identify optimal cutoff values in light transmission aggregometry (LTA) for clopidogrel and aspirin as predictive indicators of thromboembolic complications. METHODS: The authors conducted a retrospective analysis of aneurysms treated with FD between 2013 and 2023 at a single academic institution...
May 31, 2024: Journal of Neurosurgery
#5
JOURNAL ARTICLE
Nitin Agarwal, Andrew K Chan, Erica F Bisson, Steven D Glassman, Kevin T Foley, Christopher I Shaffrey, Oren N Gottfried, Luis M Tumialán, Eric A Potts, Mark E Shaffrey, Domagoj Coric, John J Knightly, Sufyan Ibrahim, Rida Mitha, Giorgos Michalopoulos, Paul Park, Michael Y Wang, Kai-Ming Fu, Jonathan R Slotkin, Anthony L Asher, Michael S Virk, Jian Guan, Regis W Haid, Dean Chou, Mohamad Bydon, Praveen V Mummaneni
OBJECTIVE: Deficiency in patient education has been correlated with increased disease-related morbidity and decreased access to care. However, the associations between educational level, preoperative disease severity, and postoperative outcomes in patients with lumbar spondylolisthesis have yet to be explored. METHODS: The spondylolisthesis dataset of the Quality Outcomes Database (QOD)-a cohort with prospectively collected data by the SpineCORe study team of the 12 highest enrolling sites with an 81% follow-up at 5 years -was utilized and stratified for educational level...
May 31, 2024: Journal of Neurosurgery. Spine
#6
JOURNAL ARTICLE
Maryam Ibrar, Harleen Kaur Rai, Ashleigh Main, Haruno McCartney, Roma Maguire, Mario Alfredo Parra Rodriguez
BACKGROUND: Cancer-related cognitive impairment (CRCI) is commonly experienced by patients with cancer during treatment, and 35% of patients experience cognitive impairment after treatment completion. Impairments in memory, attention, executive functioning, and information processing speed are most reported and often negatively impact daily functioning and quality of life (QoL). Despite the large scale of reports, this adverse side effect is underinvestigated across common cancer types, and there is a lack of insight into the CRCI experience...
May 31, 2024: JMIR Research Protocols
#7
JOURNAL ARTICLE
Laura Altweck, Silke Schmidt, Samuel Tomczyk
BACKGROUND: The gender gap in time use and its impact on health and well-being are still prevalent. Women work longer hours than men when considering both paid and unpaid (eg, childcare and chores) work, and this gender disparity is particularly visible among parents. Less is known about factors that could potentially mediate or moderate this relationship (eg, work-family conflict and gender role beliefs). Ecological momentary assessment (EMA) allows for the documentation of changes in momentary internal states, such as time use, stress, or mood...
May 31, 2024: JMIR Research Protocols
#8
JOURNAL ARTICLE
Margaret T Berrigan, Brendin R Beaulieu-Jones, Rachel Baines, Seth Berkowitz, Heather Evans, Gabriel A Brat
Rib fractures commonly result from traumatic injury and often require hospitalization for pain control and supportive pulmonary care. Although the use of mobile health technology to share patient-generated health data has increased, it remains limited in patients with traumatic injuries. We sought to assess the feasibility of mobile health tracking in patients with rib fractures by using a smartphone app to monitor postdischarge recovery. We encountered patient, institutional, and process-related obstacles that limited app use...
May 31, 2024: JMIR Formative Research
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JOURNAL ARTICLE
Wenfeng Fang, Yuanyuan Zhao, Yongzhong Luo, Runxiang Yang, Yan Huang, Zhiyong He, Hui Zhao, Mingjun Li, Kai Li, Qibing Song, Xiaobo Du, Yulan Sun, Wei Li, Fei Xu, Zhiyu Wang, Kunning Yang, Yun Fan, Baogang Liu, Hongyun Zhao, Ying Hu, Li Jia, Shen Xu, Tienan Yi, Dongqing Lv, Haitao Lan, Mengxia Li, Wenhua Liang, Yongsheng Wang, Hui Yang, Yuming Jia, Yuan Chen, Junguo Lu, Jifeng Feng, Chunling Liu, Ming Zhou, Jianya Zhou, Xianling Liu, Ningning Zhou, Ming He, Xiaorong Dong, Hualin Chen, Yongxing Chen, Haichuan Su, Xiaoling Li, Zhihong Zhang, Lei Yang, Ying Cheng, Likun Chen, Xue Hou, Yu Zhang, Jun Guo, Zhen Wang, Hong Lu, Di Wu, Weineng Feng, Wen Li, Jianan Huang, Yan Wang, Xia Song, Jiewen Peng, Laiyu Liu, Yubiao Guo, Wenting Li, Dongmei Lu, Mingxiu Hu, Zhongmin Maxwell Wang, Baiyong Li, Michelle Xia, Li Zhang
IMPORTANCE: For patients with non-small cell lung cancer whose disease progressed while receiving EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy, particularly third-generation TKIs, optimal treatment options remain limited. OBJECTIVE: To compare the efficacy of ivonescimab plus chemotherapy with chemotherapy alone for patients with relapsed advanced or metastatic non-small cell lung cancer with the epidermal growth factor receptor (EGFR) variant. DESIGN, SETTING, AND PARTICIPANTS: Double-blind, placebo-controlled, randomized, phase 3 trial at 55 sites in China enrolled participants from January 2022 to November 2022; a total of 322 eligible patients were enrolled...
May 31, 2024: JAMA
#10
JOURNAL ARTICLE
Hong-Zheng Lu, Yu-Zhuang Xie, Chen Gao, Ying Wang, Ting-Ting Liu, Xing-Zhe Wu, Fang Dai, Duo-Quan Wang, Sheng-Qun Deng
BACKGROUND: Dengue fever (DF) and West Nile fever (WNF) have become endemic worldwide in the last two decades. Studies suggest that individuals with diabetes mellitus (DM) are at a higher risk of developing severe complications from these diseases. Identifying the factors associated with a severe clinical presentation is crucial, as prompt treatment is essential to prevent complications and fatalities. This article aims to summarize and assess the published evidence regarding the link between DM and the risk of severe clinical manifestations in cases of DF and WNF...
May 31, 2024: PLoS Neglected Tropical Diseases
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RANDOMIZED CONTROLLED TRIAL
Simona Spaccavento, Giulio Carraturo, Elvira Brattico, Benedetta Matarrelli, Davide Rivolta, Fabiana Montenegro, Emilia Picciola, Niels Trusbak Haumann, Kira Vibe Jespersen, Peter Vuust, Ernesto Losavio
BACKGROUND: Disorders of consciousness (DOC), i.e., unresponsive wakefulness syndrome (UWS) or vegetative state (VS) and minimally conscious state (MCS), are conditions that can arise from severe brain injury, inducing widespread functional changes. Given the damaging implications resulting from these conditions, there is an increasing need for rehabilitation treatments aimed at enhancing the level of consciousness, the quality of life, and creating new recovery perspectives for the patients...
2024: PloS One
#12
JOURNAL ARTICLE
Abirami Kugadas, Pietro Artoni, Wanida Ruangsiriluk, Meng Zhao, Natalia Boukharov, Rizwana Islam, Dmitri Volfson, Katayoun Derakhchan
Fabry disease (FD) is an X-linked disorder of glycosphingolipid metabolism caused by mutations in the GLA gene encoding alpha-galactosidase A (α-Gal). Loss of α-Gal activity leads to progressive lysosomal accumulation of α-Gal substrate, predominately globotriaosylceramide (Gb3) and its deacylated derivative globotriaosylsphingosine (lyso-Gb3). FD manifestations include early onset neuropathic pain, gastrointestinal symptoms, and later onset life-threatening renal, cardiovascular and cerebrovascular disorders...
2024: PloS One
#13
COMPARATIVE STUDY
Chaiho Jeong, Hansang Baek, Jaewoong Bae, Nakwon Hwang, Jeonghoon Ha, Young-Seok Cho, Dong-Jun Lim
While several studies have proposed a connection between the gut microbiome and the pathogenesis of Graves's disease (GD), there has been a lack of reports on alteration in microbiome following using anti-thyroid drug treatment (ATD) to treat GD. Stool samples were collected from newly diagnosed GD patients provided at baseline and after 6 months of ATD treatment. The analysis focused on investigating the association between the changes in the gut microbiome and parameter including thyroid function, thyroid-related antibodies, and the symptom used to assess hyperthyroidism before and after treatment...
2024: PloS One
#14
JOURNAL ARTICLE
Ian Carroll, Lichy Han, Niushen Zhang, Robert P Cowan, Bryan Lanzman, Syed Hashmi, Meredith J Barad, Addie Peretz, Leon Moskatel, Oyindamola Ogunlaja, Jennifer M Hah, Nada Hindiyeh, Carol Barch, Selene Bozkurt, Tina Hernandez-Boussard, Andrew L Callen
BACKGROUND AND OBJECTIVES: Spinal CSF leaks lead to spontaneous intracranial hypotension (SIH). While International Classification of Headache Disorders, Third Edition (ICHD-3) criteria necessitate imaging confirmation or low opening pressure (OP) for SIH diagnosis, their sensitivity may be limited. We offered epidural blood patches (EBPs) to patients with symptoms suggestive of SIH, with and without a documented low OP or confirmed leak on imaging. This study evaluates the efficacy of this strategy...
June 25, 2024: Neurology
#15
REVIEW
Krisstina Gowin, Meri Muminovic, Suzanna M Zick, Richard T Lee, Christina Lacchetti, Ashwin Mehta
INTRODUCTION: ASCO and the Society for Integrative Oncology have collaborated to develop guidelines for the application of integrative approaches in the management of anxiety, depression, fatigue and use of cannabinoids and cannabis in patients with cancer. These guidelines provide evidence-based recommendations to improve outcomes and quality of life by enhancing conventional cancer treatment with integrative modalities. METHODS: All studies that informed the guideline recommendations were reviewed by an Expert Panel which was made up of a patient advocate, an ASCO methodologist, oncology providers, and integrative medicine experts...
June 2024: American Society of Clinical Oncology Educational Book
#16
JOURNAL ARTICLE
Fasil Bayafers Tamene, Endalamaw Aschale Mihiretie, Akalu Fetene Desalew, Fasika Argaw Tafesse, Samuel Agegnew Wondm
BACKGROUND: Providing care for individuals dealing with long-term illnesses like cancer demands significant amounts of time, energy, and emotional investment, potentially resulting in a challenging and overwhelming quality of life for those providing the care. OBJECTIVE: The purpose of this study was to assess the level of health-related quality of life (HRQoL) and associated factors among family caregivers of patients with cancer in oncologic centers of Northwest Ethiopia...
2024: PloS One
#17
JOURNAL ARTICLE
Ruxue Gong, Rebecca W Roth, Allen J Chang, Nishant Sinha, Alexandra Parashos, Kathryn A Davis, Ruben Kuzniecky, Leonardo Bonilha, Ezequiel Gleichgerrcht
BACKGROUND AND OBJECTIVES: Postoperative seizure control in drug-resistant temporal lobe epilepsy (TLE) remains variable, and the causes for this variability are not well understood. One contributing factor could be the extensive spread of synchronized ictal activity across networks. Our study used novel quantifiable assessments from intracranial EEG (iEEG) to test this hypothesis and investigated how the spread of seizures is determined by underlying structural network topological properties...
June 25, 2024: Neurology
#18
JOURNAL ARTICLE
Gabiana Rodrigues Freitas, Bárbara Luzia Capitanio, Theodoro Weissheimer, Bruna Barcelos Só, Emmanuel João Silva, Manoela Domingues Martins, Ricardo Abreu Da Rosa, Marcus Vinicius Reis So
Assessing scientific literature about prevalence of periapical lesions in individuals with osteoporosis in comparison to those without osteoporosis. Systematic searches were conducted up to November 24th, 2023 in Cochrane Library, EMBASE, MEDLINE/PubMed, SCOPUS, Web of Science and Grey Literature Reports databases. Only observational studies were included. The ROBINS-E tool, a revised Cochrane instrument for assessing bias in nonrandomized exposure studies, was employed. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool was utilized to evaluate the certainty of the evidence...
May 30, 2024: European Endodontic Journal
#19
JOURNAL ARTICLE
Mohammad Arifur Rahman, Sanjida Tasnim, Md Forhad Hossain
OBJECTIVES: This study aims to observe the associated risk factors of lower back pain and the factors that increase the pain severity. So, the main objective of this research is to identify the factors which may cause the lower back pain and the causal effect on the pain severity and respective treatment. This study also tries to determine the demographical characteristics of the low back pain patients and determine the inter relationship of psychological health, work stress and treatment effect with the pain disability index...
2024: PloS One
#20
JOURNAL ARTICLE
Hasan Sawan, Chenyang Li, Sagar Buch, Evanthia Bernitsas, E Mark Haacke, Yulin Ge, Yongsheng Chen
Studying the relationship between cerebral oxygen utilization and cognitive impairment is essential to understanding neuronal functional changes in the disease progression of multiple sclerosis (MS). This study explores the potential of using venous susceptibility in internal cerebral veins (ICVs) as an imaging biomarker for cognitive impairment in relapsing-remitting MS (RRMS) patients. Quantitative susceptibility mapping derived from fully flow-compensated MRI phase data was employed to directly measure venous blood oxygen saturation levels (Sv O2 ) in the ICVs...
May 31, 2024: Journal of Cerebral Blood Flow and Metabolism
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