Zijin Feng, Zhijing Hu, Lei Li, Minquan Yu, Yiting Zhang, Peng Jing, Xiangqing Xu, Jinhui Wu, Yiqiao Hu, Xiangyang Xu
Background: Schizophrenia is a serious psychiatric disorder that significantly affects the quality of life of patients. The objective of this study is to discover a novel antipsychotic candidate with highly antagonistic activity against both serotonin and dopamine receptors, demonstrating robust efficacy in animal models of positive, negative, and cognitive symptoms of schizophrenia. Methods: In the present study, we examined the activity of antipsychotic drug (NH300094) on 5-HT2A , 5-HT2C , 5-HT1A , 5-HT1B , 5-HT7 , H1 , M1 , Alpha1A , D2L , D2S , Alpha2A , D3 receptor functional assay in vitro ...
2024: Frontiers in Pharmacology