Xiaoqing Luo, Sixi Wen, Junling Zeng, Jing Liu, Wenting Ye, Jiangpeng Wu, Songyu Huang, Wuwei Xie, Haiping Wen, Yan Sun, Jing Cai, Daidi Mo, Qianxia Lin, Mingwei Chen, Siyu Xia, Yali Song
Epithelial-mesenchymal transition (EMT) is known to play a crucial role in the development of endometriosis (EMs). However, the exact mechanisms involved in EMT regulation in EMs are not well understood. In this study, we performed comprehensive research using clinical samples, single-cell sequencing, and in vivo/in vitro models to investigate the effects of advanced oxidation protein products (AOPPs) on EMT and the underlying mechanisms in EMs. Combining bioinformatics analysis with experimental validation, our results show that AOPPs accumulate in EMs tissues, and their levels positively correlate with the expression of EMT markers in fibrotic lesions of EMs patients...
September 5, 2024: Reproductive Biology