Alan D Kaye, Dominique M Perilloux, Alison M Hawkins, Grace C Wester, Amanda R Ragaland, Sage V Hebert, Julian Kim, Michael Heisler, Rucha A Kelkar, Azem A Chami, Sahar Shekoohi, Adam M Kaye
Chronic pain, a complex and debilitating condition, involves intricate interactions between central and peripheral inflammatory processes. Cytokines, specifically tumor necrosis factor (TNF) and interleukins (IL), are key mediators in the initiation and maintenance of chronic pain states. Sensory neurons expressing receptors for cytokines like TNF, IL-1, and IL-6 are implicated in peripheral sensitization, contributing to increased signaling of painful sensations. The potential of targeting TNF and IL for therapeutic intervention in chronic pain states is the focus of this review, with preclinical and clinical evidence supporting the use of TNF and IL modulators for pain management...
May 9, 2024: Pain and Therapy