Rehab M El-Gohary, Asmaa H Okasha, Alaa H Abd El-Azeem, Muhammad T Abdel Ghafar, Sarah Ibrahim, Islam I Hegab, Eman E Farghal, Soha Abdel Fattah Shalaby, Ola A Elshora, Aisha E ElMehy, Amany Nagy Barakat, Basma Saed Amer, Fatma G Sobeeh, Gehan H AboEl-Magd, Asmaa A Ghalwash
Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a life-threatening clinical issue with limited preventive approaches, posing a substantial challenge to cancer survivors. The anthraquinone diacerein (DCN) exhibits significant anti-inflammatory, anti-proliferative, and antioxidant actions. Its beneficial effects on DIC have yet to be clarified. Therefore, this study investigated DCN's cardioprotective potency and its conceivable molecular targets against DIC. Twenty-eight Wister rats were assigned to CON, DOX, DCN-L/DOX, and DCN-H/DOX groups...
April 20, 2024: Antioxidants (Basel, Switzerland)