keyword
https://read.qxmd.com/read/38701495/exploring-definitions-and-predictors-of-severe-asthma-clinical-remission-post-biologic-in-adults
#1
JOURNAL ARTICLE
Luis Perez-de-Llano, Ghislaine Scelo, Trung N Tran, Tham T Le, Malin Faregås, Borja G Cosio, Matthew Peters, Paul E Pfeffer, Mona Al-Ahmad, Riyad O Al-Lehebi, Alan Altraja, Celine Bergeron, Leif H Bjermer, Anne S Bjerrum, Lakmini Bulathsinhala, John Busby, Diana J Cano Rosales, Giorgio W Canonica, Victoria A Carter, Jeremy Charriot, George C Christoff, Eve J Denton, Delbert R Dorscheid, Maria J Fernandez Sanchez, João A Fonseca, Peter G Gibson, Celine Y Y Goh, Liam G Heaney, Enrico Heffler, Mark Hew, Takashi Iwanaga, Rohit Katial, Mariko S Koh, Piotr Kuna, Désirée E S Larenas-Linnemann, Lauri Lehtimäki, Bassam Mahboub, Neil Martin, Hisako Matsumoto, Andrew N Menzies-Gow, Nikolaos G Papadopoulos, Todor A Popov, Celeste M Porsbjerg, Pujan Patel, Chin K Rhee, Mohsen Sadatsafavi, Camille Taillé, Carlos A Torres-Duque, Ming-Ju Tsai, Charlotte S Ulrik, John W Upham, Anna von Bülow, Eileen Wang, Michael E Wechsler, David B Price
RATIONALE: There is no consensus on criteria to include in an asthma remission definition in real-life. Factors associated with achieving remission post-biologic-initiation remain poorly understood. OBJECTIVES: To quantify the proportion of adults with severe asthma achieving multi-domain-defined remission post-biologic-initiation and identify pre-biologic characteristics associated with achieving remission which may be used to predict it. METHODS: This was a longitudinal cohort study using data from 23 countries from the International Severe Asthma Registry...
May 3, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38701292/resistant-ovary-syndrome-two-case-reports-and-a-literature-review-of-effective-controlled-ovarian-stimulation-in-ivf
#2
REVIEW
Shanfei Zhao, Wenling Zheng, Xinru Gu, Guanglin Liang, Guanyun Long
INTRODUCTION: Resistant ovary syndrome (ROS) represents a rare reproductive endocrine disorder that is predominantly associated with infertility, characterized by heightened endogenous gonadotropin levels in the presence of a normal ovarian reserve. Patients with ROS typically exhibit a poor response to exogenous gonadotropins during controlled ovarian stimulation (COS). Due to the absence of a universally accepted effective COS protocol, this study aims to contribute to the existing body of literature by detailing 2 successful pregnancies achieved through conventional in vitro fertilization (c-IVF) in patients with ROS, and through retrospective analysis, seeks to elucidate the factors contributing to the successful ovarian stimulation in these cases, with the ultimate goal of establishing clinical guidelines for ROS management...
May 3, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38701278/comparative-efficacy-and-safety-of-different-drugs-in-patients-with-systemic-juvenile-idiopathic-arthritis-a-systematic-review-and-network-meta-analysis
#3
COMPARATIVE STUDY
Baoquan Wang, Yushan Zhang, Zhenbiao Zhao, Juan Ping, Liming Zhou, Yining Wang, Yongzhou Zhang
BACKGROUND: The goal of this study was to estimate the relative efficacy and safety of different biological agents (infliximab, canakinumab, baricitinib, anakinra, adalimumab, tofacitinib, tocilizumab, and rilonacept) compared with placebo for systemic juvenile idiopathic arthritis (JIA) patients, through a network meta-analysis. METHODS: Pubmed, Embase, and Cochrane Library were searched from database inception to July 2023 for randomized controlled trials comparing different biological agents (infliximab, canakinumab, baricitinib, anakinra, adalimumab, tofacitinib, tocilizumab, and rilonacept) or placebo directly or indirectly in JIA...
May 3, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38701128/nexus-between-organizational-learning-capability-and-organization-age-on-corporate-environmental-citizenship
#4
JOURNAL ARTICLE
Tay Lee Chin, Tay Lee Chee
BACKGROUND: Many organizations around the world have prudently adopted corporate environmental citizenship. However, the corporate environmental citizenship implementation may vary from reality. Thus, this study examines corporate environmental citizenship to identify ultimate practices to create a strong premise of CEC. OBJECTIVE: The study examines the influence of organizational learning capability, organization age on corporate environmental citizenship. METHODS: The data were collected from 50 Malaysian construction firms using the survey questionnaire and analyzed by using Partial Least Square Structural Equation Modeling (PLS-SEM)...
May 3, 2024: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://read.qxmd.com/read/38700964/maze-based-scalable-wireless-power-transmission-experimental-arena-for-freely-moving-small-animals-applications
#5
JOURNAL ARTICLE
Saeideh Pahlavan, Shahin Jafarabadi-Ashtiani, S Abdollah Mirbozorgi
This paper presents an innovative T/Y-maze-based wireless power transmission (WPT) system designed to monitor spatial reference memory and learning behavior in freely moving rats. The system facilitates uninterrupted optical/electrical stimulation and neural recording experiments through the integration of wireless headstages or implants in T/Y maze setups. Utilizing an array of resonators covering the entire underneath of the mazes, the wireless platform ensures scalability with various configurations. The array is designed to ensure a natural localization mechanism to localize the Tx power toward the location of the Rx coil...
May 3, 2024: IEEE Transactions on Biomedical Circuits and Systems
https://read.qxmd.com/read/38700683/the-anterior-interhemispheric-transcallosal-approach-to-the-ventricles-how-we-do-it
#6
REVIEW
Lydia J Bernhardt, Alan R Cohen
Intraventricular tumors of the lateral and third ventricles are relatively rare, accounting for 1-2% of all primary brain tumors in most large series [1-4]. They can be uniquely challenging to approach due to their deep location, propensity to become large before they are discovered, and association with hydrocephalus [5, 6]. The surgeon's goal is to develop a route to these deep lesions that will cause the least morbidity, provide adequate working space, and achieve a complete resection. This must be performed with minimal manipulation of the neural structures encircling the ventricles, avoiding functional cortical areas, and acquiring early control of feeding vessels [7, 8]...
2024: Advances and Technical Standards in Neurosurgery
https://read.qxmd.com/read/38700051/a-surgical-checklist-for-optimizing-the-quality-and-outcomes-of-transurethral-resection-of-bladder-tumors-a-literature-review
#7
REVIEW
Rikiya Taoka, Mikio Sugimoto
To preserve the bladder without compromising survival, further treatments need to be optimized to prevent the recurrence and progression of non-muscle invasive bladder cancer. In clinical practice, transurethral resection of bladder tumors is essential for bladder cancer management. The primary goal of surgery is to achieve accurate pathological evaluation and complete resection of bladder cancer; high resection quality is required for the procedure. A representative surrogate indicator of the resection quality is the presence of the detrusor muscle in the resection specimen...
May 3, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
https://read.qxmd.com/read/38699379/evaluating-the-impact-of-delayed-study-startup-on-accrual-in-cancer-studies
#8
Isuru Panduka Ratnayake, Anh-Tuan Do, Daniel Gajewski, Sam Pepper, Oluwatobiloba Ige, Natalie Streeter, Tara L Lin, Matthew McGuirk, Byron Gajewski, Dinesh Pal Mudaranthakam
Background : Drug development in cancer medicine depends on high-quality clinical trials, but these require large investments of time to design, operationalize, and complete; for oncology drugs, this can take 8-10 years. Long timelines are expensive and delay innovative therapies from reaching patients. Delays often arise from study startup, a process that can take 6 months or more. We assessed how study-specific factors affected the study startup duration and the resulting overall success of the study. Method: Data from The University of Kansas Cancer Center (KUCC) were used to analyze studies initiated from 2018 to 2022...
April 19, 2024: Research Square
https://read.qxmd.com/read/38699249/electrocatalytic-functional-group-conversion-based-carbon-resource-upgrading
#9
REVIEW
Di Si, Xue Teng, Bingyan Xiong, Lisong Chen, Jianlin Shi
The conversions of carbon resources, such as alcohols, aldehydes/ketones, and ethers, have been being one of the hottest topics most recently for the goal of carbon neutralization. The emerging electrocatalytic upgrading has been regarded as a promising strategy aiming to convert carbon resources into value-added chemicals. Although exciting progress has been made and reviewed recently in this area by mostly focusing on the explorations of valuable anodic oxidation or cathodic reduction reactions individually, however, the reaction rules of these reactions are still missing, and how to purposely find or rationally design novel but efficient reactions in batches is still challenging...
May 1, 2024: Chemical Science
https://read.qxmd.com/read/38699149/pediatric-tuberculosis-in-mexico-a-retrospective-analysis-of-100-patients
#10
JOURNAL ARTICLE
Enrique G Villarreal, Emilia Ramos-Barrera, Ricardo J Estrada-Mendizabal, Pablo D Treviño-Valdez, Oscar Tamez-Rivera
BACKGROUND: Analyzing the epidemiology and clinical manifestations of pediatric tuberculosis in endemic regions is crucial to meet the goal of ending tuberculosis. The objective was to assess the various clinical scenarios of tuberculosis in a large pediatric cohort in Mexico. METHODS: This retrospective study from a pediatric referral center in Mexico included patients diagnosed with tuberculosis from 2012 to 2021. We analyzed clinical data and diagnostic study results, including demographic characteristics, underlying medical conditions, BCG vaccination, clinical presentation, imaging findings, microbiologic data, treatment, and clinical outcomes...
August 2024: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
https://read.qxmd.com/read/38699040/investigating-the-role-of-nuclear-power-and-battery-storage-in-hungary-s-energy-transition-using-hourly-resolution-electricity-market-simulations
#11
JOURNAL ARTICLE
Bence Biró, Attila Aszódi
Electricity supply in European countries faces a number of challenges, such as achieving carbon neutrality, tackling rising prices, reducing dependence on fossil fuels, including fossil fuel imports. To achieve these goals, the electricity systems of all European countries will have to undergo major changes, while taking into account technical, environmental, economic and social objectives. Our simulations provide essential data for this transition by analyzing different power plant portfolios and electricity consumption scenarios...
May 15, 2024: Heliyon
https://read.qxmd.com/read/38699030/from-spear-to-trident-upgrading-arsenal-of-car-t-cells-in-the-treatment-of-multiple-myeloma
#12
REVIEW
Jin Zhao, Meijing Zheng, Li Ma, Tao Guan, Liping Su
Multiple myeloma (MM), marked by abnormal proliferation of plasma cells and production of monoclonal immunoglobulin heavy or light chains in the majority of patients, has traditionally been associated with poor survival, despite improvements achieved in median survival in all age groups since the introduction of novel agents. Survival has significantly improved with the development of new drugs and new treatment options, such as chimeric antigen receptor T-cell therapy (CAR-T), which have shown promise and given new hope in MM therapy...
May 15, 2024: Heliyon
https://read.qxmd.com/read/38699008/analysis-of-the-spatiotemporal-evolution-and-influencing-factors-of-green-development-level-in-the-manufacturing-industry
#13
JOURNAL ARTICLE
Weiwei Zhu, Guozhuo Yang
The manufacturing sector is the main battlefield of energy saving and carbon reduction in China, and vigorously promoting energy saving and carbon reduction in manufacturing and enhancing the green development level are the key links to support China's realization of the dual-carbon goal. The article adopts the SBM-GML model to measure the level of green development of the manufacturing industry in China. Based on this, it analyzes the spatio-temporal characteristics and the evolution law of the level of green development of the manufacturing industry by using the Dagum Gini Coefficient and Kernel Density Estimation...
May 15, 2024: Heliyon
https://read.qxmd.com/read/38698989/ecosystem-based-management-approaches-for-watershed-conservation-and-geosustainability
#14
JOURNAL ARTICLE
Junjun Liu, Yifan Zhao, Xi Chen, Sunila Akarsha
When contributors' goals and legislative and political structures vary, as they often do in the case of worldwide fish populations, it becomes more challenging to implement ethical fishing tactics. Canada, the United States, and Mexico all fish from Pacific regions anchovies in the California Modern. Climate-driven numbers and geographic dynamics may pollute the waters of collaborative aquaculture and lead to overloading. This research expands upon prior works using a game theoretic model of Tran's boundary sardine fisheries in different climatic conditions to account for ecological links...
May 15, 2024: Heliyon
https://read.qxmd.com/read/38698970/towards-net-zero-a-technological-review-on-the-potential-of-space-based-solar-power-and-wireless-power-transmission
#15
REVIEW
Khandoker Shahjahan Alam, A M A Daiyan Kaif, Sajal K Das, Sarafat H Abhi, S M Muyeen, Md Firoj Ali, Zinat Tasneem, Md Manirul Islam, Md Robiul Islam, Md Faisal R Badal, Md Hafiz Ahamed, Subrata K Sarker, Prangon Das, Md Mehedi Hasan
The global need for energy is increasing at a high rate and is expected to double or increase by 50%, according to some studies, in 30 years. As a result, it is essential to look into alternative methods of producing power. Solar photovoltaic (PV) power plants utilize the sun's clean energy, but they're not always dependable since they depend on weather patterns and requires vast amount of land. Space-based solar power (SBSP) has emerged as the potential solution to this issue. SBSP can provide 24/7 baseload carbon-free electricity with power density over 10 times greater than terrestrial alternatives while requiring far less land...
May 15, 2024: Heliyon
https://read.qxmd.com/read/38698590/statistical-experimental-designs-for-cltb-syn-vaccine-production-using-daucus-carota-cell-suspension-cultures
#16
JOURNAL ARTICLE
Christian Carreño-Campos, Elba Villegas, María Luisa Villarreal, Mónica Morales-Aguilar, Dania Govea-Alonso, Andrea Romero-Maldonado, María E Jimenez-Capdeville, Sergio Rosales-Mendoza, Anabel Ortiz-Caltempa
The carrot-made LTB-Syn antigen (cLTB-Syn) is a vaccine candidate against synucleinopathies based on carrot cells expressing the target antigen LTB and syn epitopes. Therefore, the development of an efficient production process is required with media culture optimization to increase the production yields as the main goal. In this study, the effect of two nitrogen sources (urea and glutamate) on callus cultures producing cLTB-Syn was studied, observing that the addition of 17 mM urea to MS medium favored the biomass yield...
May 2, 2024: Planta Medica
https://read.qxmd.com/read/38698564/male-elephant-management-in-aza-institutions-current-status-and-priorities-for-the-future
#17
JOURNAL ARTICLE
Chase A LaDue, Maura Davis, Rachel Emory, Rebecca J Snyder
Asian elephant (Elephas maximus) and African savanna elephant (Loxodonta africana) populations collectively managed by ex-situ facilities accredited by the Association of Zoos and Aquariums (AZA) face sustainability challenges. Among the priorities to strengthen animal wellbeing and population sustainability is male elephant management. We conducted a survey of AZA facilities currently housing male elephants to assess the status, challenges, and priorities in three areas of male elephant management: musth, socialization, and semen collection...
May 2, 2024: Zoo Biology
https://read.qxmd.com/read/38698456/association-of-child-marriage-and-nutritional-status-of-mothers-and-their-under-five-children-in-bangladesh-a-cross-sectional-study-with-a-nationally-representative-sample
#18
JOURNAL ARTICLE
Shanta Akter Mim, Abu Sayed Md Al Mamun, Md Abu Sayem, Md Abdul Wadood, Md Golam Hossain
BACKGROUND: Child marriage remains an important problem around the world with young mothers and their under-five children often experiencing under-nutrition. The problem is rarely studied in the Bangladeshi population. This paper was designed to identify the association between child marriage and nutritional status of mothers and their under-five children in Bangladesh. METHODS: Nationally representative secondary data was used for this study, data was extracted from the Bangladesh Demographic and Health Survey (BDHS) 2017-18...
May 2, 2024: BMC Nutrition
https://read.qxmd.com/read/38698381/barriers-and-facilitators-to-implementing-a-canadian-shared-care-adhd-program-in-pediatric-settings-in-shanghai-a-consolidated-framework-for-implementation-research-approach
#19
JOURNAL ARTICLE
Sayna Bahraini, Alexander R Maisonneuve, Danping Wu, Minhui Huang, Mingyu Xu, Li Yang, Fei Li, André Samson, Feng Li, Philippe Robaey
OBJECTIVES: The vast majority of children with Attention-Deficit Hyperactivity Disorder (ADHD) do not have access to proper diagnosis and treatment in China. The goal of this project is to identify the challenges and facilitators in implementing a Canadian ADHD Shared Care Pathways program in pediatric settings in Shanghai region. METHODS: Purposive semi-structured focus groups were conducted on a total of 13 healthcare practitioners from the Shanghai Xinuha, Ninghai and Chongming hospitals...
May 2, 2024: BMC Health Services Research
https://read.qxmd.com/read/38698356/association-between-early-childhood-caries-and-parental-education-and-the-link-to-the-sustainable-development-goal-4-a-scoping-review
#20
REVIEW
Morenike Oluwatoyin Folayan, Elisa Maria Rosa de Barros Coelho, Imen Ayouni, Arthemon Nguweneza, Ola Barakat Al-Batayneh, Hamideh Daryanavard, Duangporn Duangthip, Ivy Guofang Sun, Arheiam Arheiam, Jorma I Virtanen, Balgis Gaffar, Maha El Tantawi, Robert J Schroth, Carlos Alberto Feldens
BACKGROUND: The goal of the United Nations Sustainable Development Goal (SDG) 4 is to ensure inclusive and equitable quality education and promote lifelong learning opportunities for all. The aim of this scoping review was to map the current evidence on the association between the prevalence of early childhood caries (ECC) and parental education; and to identify possible pathways by which parental education may protect against ECC. METHODS: The two questions that guided this review were: what is the existing evidence on the association between maternal and paternal education and ECC; and what are the pathways by which parental education protects against ECC? The initial search was conducted in January 2023 in PubMed, Web of Science and Scopus...
May 2, 2024: BMC Oral Health
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