keyword
https://read.qxmd.com/read/36716050/defining-occult-high-risk-cysts-of-the-pineal-region-a-case-series
#21
JOURNAL ARTICLE
Sergio W Guadix, Neelan J Marianayagam, Elizabeth K Weidman, Melissa Yuan, Benjamin Liechty, Jeffrey P Greenfield, Mark M Souweidane
BACKGROUND: Absence of hydrocephalus on neuroimaging may impart a false sense of security for patients with pineal cysts. In this case series, we characterize a subset of patients with pineal cysts having an occult presentation. Unifying features of worsening paroxysmal headaches suggesting intermittent obstructive hydrocephalus and radiographic evidence of third ventricular invagination characterize these patients as high risk. OBJECTIVE: To define features of occult, high-risk pineal cysts and outcomes of endoscopic cyst fenestration...
January 19, 2023: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/36608790/the-minimally-invasive-lateral-occipital-infracortical-supra-transtentorial-approach-in-surgery-of-lesions-of-the-pineal-region-a-possible-alternative-to-the-standard-approaches
#22
JOURNAL ARTICLE
Guenther C Feigl, Gavin Britz, Daniel Staribacher, Dzmitry Kuzmin
OBJECTIVE: The pineal region is an anatomical region that is difficult to access surgically, especially when it comes to removing neoplasms. Four main surgical approaches to this region are used as standards nowadays: infratentorial supracerebellar, occipital supra-/transtentorial, interhemispheric, and transventricular approaches. All methods have both advantages and disadvantages and are associated to any extent with intra- and postoperative risks. We have developed a lateral minimally invasive occipital infracortical supra-/transtentorial (OICST) approach, which retains the advantages of the standard occipital transtentorial approach while improving tumor exposure and minimizing its disadvantages...
April 2023: World Neurosurgery
https://read.qxmd.com/read/36553250/cdkl5-deficiency-disorder-cdd-rare-presentation-in-male
#23
Małgorzata Rodak, Mariola Jonderko, Patrycja Rozwadowska, Magdalena Machnikowska-Sokołowska, Justyna Paprocka
CDKL5 deficiency disorder (CDD) is a developmental encephalopathy caused by pathogenic variants in the X-linked cyclin-dependent kinase 5 (CDKL5) gene. This rare disorder occurs more frequently in females than in males. The incidence is estimated to be approximately 1: 40,000-60,000 live births. So far, 50 cases have been described in boys. The clinical course in males tends to be more severe and is often associated with death in the first or second decade of life. The authors present an unreported 2.5-year-old male patient with drug-resistant epilepsy who was diagnosed with a de novo mutation in the CDKL5 gene...
November 24, 2022: Children
https://read.qxmd.com/read/36468221/spectrum-of-intracranial-and-spinal-epidermoids-including-unusual-locations-and-imaging-findings-a-pictorial-review
#24
REVIEW
Vendoti Nitheesha Reddy, Krishnan Nagarajan, Vendoti Midhusha Reddy, Mohan Amuthabharathi, Madhavan S Gopalakrishnan, Andi S Ramesh
Intracranial and spinal epidermoids are benign slow-growing congenital lesions. They are predominantly intradural, extra-axial in location, with intra-axial locations (intra-parenchymal and spinal intramedullary) being rare. The most common locations of intradural epidermoids are cerebellopontine angle cistern followed by supra- and para-sellar regions, and fourth ventricle. Less common locations include inter-hemispheric fissure, sylvian fissure, lateral ventricle, intracerebral, velum interpositum cistern, superior cerebellar cistern and pineal gland...
February 2023: Journal of Medical Imaging and Radiation Oncology
https://read.qxmd.com/read/36323954/intracranial-cysts-incidental-or-neurodevelopmental
#25
JOURNAL ARTICLE
Mehmet Alp Dirik, Burcin Sanlidag
OBJECTIVES: Intracranial cysts are fluid-filled sacs within the brain. There is a diversity of intracranial cysts with different incidences in addition to the growing awareness about comorbidities and the consequences. The present study aimed to evaluate cystic findings in children who were admitted to the department of pediatric neurology. METHODS: Children who were admitted to the Clinic of Pediatric Neurology and who had an MRI between 2016 and 2021 were evaluated...
November 2, 2022: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/36174946/minimally-invasive-supine-lateral-supracerebellar-infratentorial-approach-for-resection-of-a-pineal-cyst
#26
Kaan Yağmurlu, M Yashar S Kalani
Most pineal cysts are not surgical lesions and should be conservatively managed. Select lesions, notably those that present with hydrocephalus and Parinaud syndrome and lesions presenting with symptoms consistent with intermittent blockage of cerebrospinal fluid pathways and/or neurovascular compression, however, can be considered for surgical intervention. Two workhorse surgical approaches to the pineal region include the occipital interhemispheric transtentorial and supracerebellar infratentorial approaches...
December 2022: World Neurosurgery
https://read.qxmd.com/read/36128100/pineal-cyst-management-a-single-institution-experience-spanning-two-decades
#27
JOURNAL ARTICLE
Alexander Konovalov, David Pitskhelauri, Natalia Serova, Lyudmila Shishkina, Irakliy Abramov
Background: Pineal cysts (PCs) are benign lesions commonly found on intracranial imaging. Despite their high prevalence, there is no clear consensus on the most appropriate management of patients with PCs, especially those with symptomatic nonhydrocephalic cysts. Methods: A retrospective analysis was performed on 142 patients with PCs (103 surgical cases and 39 conservatively managed cases). Data were examined, including clinical presentation, imaging findings, ophthalmological status, natural course, postoperative outcomes, and complications...
2022: Surgical Neurology International
https://read.qxmd.com/read/36081625/case-report-fluctuating-tumor-markers-in-a-boy-with-gonadotropin-releasing-hormone-independent-precocious-puberty-induced-by-a-pineal-germ-cell-tumor
#28
Alessandro Cattoni, Assunta Albanese
GnRH-independent precocious puberty (GIPP) can be the presenting clinical picture experienced by patients with secreting germ cell tumor (GCT). Indeed, as luteinizing hormone (LH) and human chorionic gonadotropin (hCG) share identical α-subunits and similar β-subunits, an increased secretion of β-hCG may result in a precocious activation of Leydig cells. Though the co-occurrence of raised β-hCG levels and signs of precocious virilization usually prompts a complete oncological work-up, the diagnostic and therapeutic management of GCT-induced GIPP may be challenging...
2022: Frontiers in Pediatrics
https://read.qxmd.com/read/36017961/spontaneous-involution-of-a-large-pineal-cyst-case-report-and-narrative-review
#29
REVIEW
Robin M Bouttelgier, Mariska Sie, Giorgio G Hallaert
OBJECTIVE: To illustrate the possibility of spontaneous involution of a pineal cyst, justifying an initial observation strategy in patients without evident mass effect. BACKGROUND: Pineal cysts are frequent radiological findings, with a reported overall prevalence from 0.6% to 40%. Historically, surgery has been reserved for patients with symptoms attributable to a mass effect of the cyst. Despite the high prevalence of pineal cysts, the clinical approach to patients with non-specific symptoms remains controversial...
September 2022: Headache
https://read.qxmd.com/read/35965931/pineal-cyst-apoplexy-and-memory-loss-a-novel-complication
#30
Areez Shafqat, Hanin Jaber AlGethami, Shameel Shafqat, Syed Shafqat Ul Islam
An 8-year-old boy presented to our hospital complaining of a bilateral headache associated with episodes of anterograde amnesia. He had a road traffic accident 3 years ago when a computed tomography (CT) scan revealed traumatic brain injury. In addition, a small pineal cyst (PC) was noted with minor intramural calcifications. A follow-up CT a day later demonstrated increased density in the pineal gland of 60 Hounsfield Units, suggestive of apoplectic changes in the PC. However, the patient was lost to follow-up and presented with memory loss a year and a half later, upon which CT and magnetic resonance imaging revealed enlargement of the PC...
October 2022: Radiology Case Reports
https://read.qxmd.com/read/35855169/exclusively-endoscopic-management-of-complicated-pineal-cysts-in-young-children-definitive-treatment-through-single-burr-hole-technique
#31
JOURNAL ARTICLE
Baher Hanna, Michael W Robinson, Jesse Skoch
Background: The management of complicated symptomatic pineal cysts in the pediatric population is challenging and variable. Surgical management may include treatment of hydrocephalus alone, or direct treatment of the cyst with or without direct hydrocephalus management. This is typically done through craniotomy-based microsurgical approaches to the pineal region or an endoscopic transventricular approach. Methods: We present a stepwise minimally invasive technique to treat complicated pineal cysts in young children associated with an obstructive hydrocephalus in a single procedure through third ventriculostomy combined with an intraventricular marsupialization of the pineal cyst through a single burr-hole using stereotactic navigation...
2022: Surgical Neurology International
https://read.qxmd.com/read/35855119/pineal-region-neuroenteric-cyst-in-a-13-year-old-girl-a-rare-localization-with-postoperative-recurrence-and-local-dissemination
#32
Ilya O Nosov, Alexei N Kislyakov, Matvey I Livshits, Pavel V Lobankin, Gennady E Chmutin, Gerald Musa
Background: Neuroenteric cysts are rare cystic benign neoplasms of the central nervous system most often located in the spinal cord and rarely, intracranially. The nonspecific neuroimaging features make management planning potentially challenging. We present a case of a radiologically misdiagnosed neurenteric cyst with a complicated course. Case Description: A 13-year-old girl presented with a 6-month history of headache, tinnitus, and dizziness. Initial magnetic resonance images (MRIs) were indistinguishable from a pineal arachnoid cyst with aqueductal stenosis and hydrocephalus...
2022: Surgical Neurology International
https://read.qxmd.com/read/35832948/a-surgical-perspective-on-the-association-between-cystic-lesions-of-the-pineal-gland-descartes-seat-of-the-soul-and-the-pituitary-the-master-gland
#33
JOURNAL ARTICLE
Alaa S Montaser, Elise Y Cho, Michael P Catalino, Jack Hanna, Timothy R Smith, Edward R Laws
Introduction  Rene Descartes (1596-1650), the famous philosopher and scientist, identified the pineal gland as the only cerebral structure not represented bilaterally, the "seat of the soul"; and the source of rational thought. Pineal cysts (PCs) are often incidentally identified in MRI studies, with a reported prevalence of 1 to 4.3%. Rathke cleft cysts (RCCs) are pituitary lesions accounting for <1% of intracranial masses. There are scant data in the literature addressing any association between these two midline cystic lesions...
June 2022: Journal of Neurological Surgery. Part B, Skull Base
https://read.qxmd.com/read/35829978/pineal-cysts-without-hydrocephalus-microsurgical-resection-via-an-infratentorial-supracerebellar-approach-surgical-strategies-complications-and-their-avoidance
#34
JOURNAL ARTICLE
Steffen Fleck, Ahmed El Damaty, Ina Lange, Marc Matthes, Ehab El Rafaee, Sascha Marx, Jörg Baldauf, Henry W S Schroeder
Indications for surgery of pineal cysts without ventriculomegaly are still under debate. In view of the limited data for pineal cyst resection in the absence of hydrocephalus, and the potential risk of this approach, we have analyzed our patient cohort focusing on strategies to avoid complications according to our experience in a series of 73 pineal cyst patients. From 2003 to 2015, we reviewed our database retrospectively for all patients operated on a pineal cyst. Furthermore, we prospectively collected patients from 2016 to 2020...
October 2022: Neurosurgical Review
https://read.qxmd.com/read/35778719/population-pharmacokinetic-modeling-of-csf-to-blood-clearance-prospective-tracer-study-of-161-patients-under-work-up-for-csf-disorders
#35
JOURNAL ARTICLE
Markus Herberg Hovd, Espen Mariussen, Hilde Uggerud, Aslan Lashkarivand, Hege Christensen, Geir Ringstad, Per Kristian Eide
BACKGROUND: Quantitative measurements of cerebrospinal fluid to blood clearance has previously not been established for neurological diseases. Possibly, variability in cerebrospinal fluid clearance may affect the underlying disease process and may possibly be a source of under- or over-dosage of intrathecally administered drugs. The aim of this study was to characterize the cerebrospinal fluid to blood clearance of the intrathecally administered magnetic resonance imaging contrast agent gadobutrol (Gadovist, Bayer Pharma AG, GE)...
July 1, 2022: Fluids and Barriers of the CNS
https://read.qxmd.com/read/35623363/pineal-cyst-results-of-long-term-mri-surveillance-and-analysis-of-growth-and-shrinkage-rates
#36
JOURNAL ARTICLE
Hirotaka Hasegawa, Akitoshi Inoue, Ahmed Helal, Kosuke Kashiwabara, Fredric B Meyer
OBJECTIVE: Pineal cyst (PC) is a relatively common true cyst in the pineal gland. Its long-term natural course remains ill defined. This study aims to evaluate the long-term natural history of PC and examine MRI risk factors for cyst growth and shrinkage to help better define which patients might benefit from surgical intervention. METHODS: The records and MRI of 409 consecutive patients with PC were retrospectively examined (nonsurgical cohort). Cyst growth and shrinkage were defined as a ≥ 2-mm increase and decrease in cyst diameter in any direction, respectively...
January 1, 2023: Journal of Neurosurgery
https://read.qxmd.com/read/35525892/prevalence-of-incidental-intracranial-findings-on-magnetic-resonance-imaging-a-systematic-review-and-meta-analysis
#37
REVIEW
Divya Elizabeth Sunny, Michael Amoo, Maryam Al Breiki, Elite Dong Wen Teng, Jack Henry, Mohsen Javadpour
BACKGROUND: As the volume and fidelity of magnetic resonance imaging (MRI) of the brain increase, observation of incidental findings may also increase. We performed a systematic review and meta-analysis to determine the prevalence of various incidental findings. METHODS: PubMed/MEDLINE, EMBASE and SCOPUS were searched from inception to May 24, 2021. We identified 6536 citations and included 35 reports of 34 studies, comprising 40,777 participants. A meta-analysis of proportions was performed, and age-stratified estimates for each finding were derived from age-adjusted non-linear models...
October 2022: Acta Neurochirurgica
https://read.qxmd.com/read/35509728/diagnostic-difficulties-and-treatment-challenges-of-a-young-patient-with-severe-acute-psychosis-and-complete-recovery
#38
Jagoda Siembida, Saaduddin Mohammed, Mariam Chishty, Luba Leontieva
First break psychosis in young adults is sometimes presented as a dichotomous model of organic or substance-induced etiology or a primary psychiatric disorder on the schizophrenia spectrum and related disorders. In this case of a young adult with a typical age of onset for psychotic symptoms also presenting with cannabis use, excessive vaping, history of COVID-19 illness, pineal cyst, and extreme elevation of blood pressure, the diagnostic certainty decreases. Increased risk of progression to schizophrenia in individuals with cannabis use disorder and genetic loading has been extensively reported in the literature...
April 2022: Curēus
https://read.qxmd.com/read/35487129/pineal-morphology-of-the-clinical-high-risk-state-for-psychosis-and-different-psychotic-disorders
#39
JOURNAL ARTICLE
Tsutomu Takahashi, Stephen J Wood, Alison R Yung, Barnaby Nelson, Ashleigh Lin, Hok Pan Yuen, Lisa J Phillips, Michio Suzuki, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis
BACKGROUND: Pineal volume reductions have been reported in schizophrenia and clinical high-risk states for the development of psychosis, supporting the role of melatonin dysregulation in the pathophysiology of psychosis. However, it remains unclear whether pineal volume is associated with the later onset of psychosis in individuals at clinical high-risk (CHR) of psychosis or if pineal atrophy is specific to schizophrenia among different psychotic disorders. METHODS: This magnetic resonance imaging study examined the volume of and cyst prevalence in the pineal gland in 135 individuals at CHR of psychosis [52 (38...
June 2022: Schizophrenia Research
https://read.qxmd.com/read/35455578/supratentorial-pediatric-midline-tumors-and-tumor-like-lesions-clinical-spectrum-natural-history-and-treatment-options
#40
REVIEW
Luca Paun, Alexandre Lavé, Gildas Patet, Andrea Bartoli
Childhood Central Nervous System tumors account for 25% of all pediatric tumors. Large availability and broadening of indications to imaging has made incidental findings more common. Among these, midline lesions have different clinical relevance depending on their intrinsic pattern of behaviour and on their specific location. In this narrative review we describe the natural history and treatment options of midline lesions in children.
April 9, 2022: Children
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