Inna Bukreeva, Olga Junemann, Alessia Cedola, Francesca Palermo, Laura Maugeri, Ginevra Begani Provinciali, Nicola Pieroni, Alessia Sanna, Dmitry A Otlyga, Alexey Buzmakov, Yuri Krivonosov, Denis Zolotov, Marina Chukalina, Anna Ivanova, Sergey Saveliev, Victor Asadchikov, Michela Fratini
Pineal gland (PG) is a part of the human brain epithalamus that plays an important role in sleep, circadian rhythm, immunity, and reproduction. The calcium deposits and lesions in PG interfere with normal function of the organ and can be associated with different health disorders including serious neurological diseases. At the moment, the detailed mechanisms of PG calcifications and PG lesions formation as well as their involvement in pathological processes are not fully understood. The deep and comprehensive study of the structure of the uncut human PG with histological details, poses a stiff challenge to most imaging techniques, due to low spatial resolution, low visibility or to exceedingly aggressive sample preparation...
October 24, 2020: Journal of Structural Biology