keyword
https://read.qxmd.com/read/38453571/acute-heart-failure-an-efim-guideline-critical-appraisal-and-adaptation-for-internists
#41
JOURNAL ARTICLE
Valentin A Kokorin, Alvaro González-Franco, Antonio Cittadini, Oskars Kalejs, Vera N Larina, Alberto M Marra, Francisco J Medrano, Zdenek Monhart, Laura Morbidoni, Joana Pimenta, Wiktoria Lesniak
BACKGROUND: Over the past two decades, several studies have been conducted that have tried to answer questions on management of patients with acute heart failure (AHF) in terms of diagnosis and treatment. Updated international clinical practice guidelines (CPGs) have endorsed the findings of these studies. The aim of this document was to adapt recommendations of existing guidelines to help internists make decisions about specific and complex scenarios related to AHF. METHODS: The adaptation procedure was to identify firstly unresolved clinical problems in patients with AHF in accordance with the PICO (Population, Intervention, Comparison and Outcomes) process, then conduct a critical assessment of existing CPGs and choose recommendations that are most applicable to these specific scenarios...
March 6, 2024: European Journal of Internal Medicine
https://read.qxmd.com/read/38452888/identifying-and-mitigating-risk-of-post-cardiotomy-cardiogenic-shock-in-patients-with-ischemic-and-non-ischemic-cardiomyopathy
#42
JOURNAL ARTICLE
Michael J Javorski, Karolis Bauza, Fei Xiang, Edward Soltesz, Lin Chen, Faisal G Bakaeen, Lars Svensson, Lucy Thuita, Eugene H Blackstone, Michael Z Tong
OBJECTIVES: To identify preoperative predictors of post-cardiotomy cardiogenic shock in patients with ischemic and non-ischemic cardiomyopathy and evaluate trajectory of postoperative ventricular function. METHODS: From 1/2017-1/2020, 238 patients with ejection fraction <30% (206/238) or 30-34% with at least moderately severe mitral regurgitation (32/238) underwent conventional cardiac surgery at Cleveland Clinic, 125 with ischemic and 113 with non-ischemic cardiomyopathy...
March 5, 2024: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38447194/trends-and-outcomes-of-heart-transplantation-in-adults-with-congenital-heart-disease
#43
JOURNAL ARTICLE
Bahaaldin Alsoufi, Deborah Kozik, Melissa Perrotta, Sarah Wilkens, Andrea Nicole Lambert, Shriprassad Deshpande, Mark Slaughter, Jaimin Trivedi
OBJECTIVE: Heart transplantation for adult congenital heart disease is complicated and associated with challenging pretransplant support, long waiting, and high early post-transplant mortality. We explored if surgical and medical advances, and allocation system changes have affected outcomes. METHODS: From United Network for Organ Sharing database, adults with congenital heart disease listed for heart transplantation were queried. To explore practice and outcome trends, patients were divided into 4 eras (eras1-3: nearly 3 equal periods from 1992-2018, era-4: after 2018, corresponding with new allocation system)...
March 6, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38446873/in-vivo-evaluation-of-a-novel-integrated-pediatric-pump-lung-in-a-30-day-ovine-animal-model
#44
JOURNAL ARTICLE
Joshua L Leibowitz, Morcos A Awad, Dong Han, Aakash Shah, Wenji Sun, Jiafeng Zhang, Bartley P Griffith, Zhongjun J Wu
Recently there has been increased use of mechanical circulatory support in pediatric patients as a bridge to cardiopulmonary recovery or transplantation. However, there are few devices that are optimized and approved for use in pediatric patients. We designed and prototyped a novel integrated pediatric pump lung (PPL) that underwent 30 day in-vivo testing in seven juvenile Dorset Hybrid sheep. Devices were implanted in a right atrial to pulmonary artery configuration. Six of seven sheep survived with a device functioning for 25-35 days...
February 27, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38446842/percutaneous-venopulmonary-extracorporeal-membrane-oxygenation-as-bridge-to-lung-transplantation
#45
JOURNAL ARTICLE
Asad Ali Usman, Audrey Elizabeth Spelde, Wasim Lutfi, Jacob T Gutsche, William J Vernick, Omar Toubat, Salim E Olia, Edward Cantu, Andrew Courtright, Maria M Crespo, Joshua Diamond, Mauer Biscotti, Christian A Bermudez
Mechanical circulatory support (MCS) as a bridge to lung transplant is an infrequent but accepted pathway in patients who have refractory end-stage pulmonary failure. The American Association of Thoracic Surgeons Expert Consensus Guidelines, published in 2023, recommends venovenous (VV) extracorporeal membrane oxygenation (ECMO) as the initial configuration for those patients who have failed conventional medical therapy, including mechanical ventilation, while waiting for lung transplantation and needing MCS...
March 6, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38439661/platelet-function-testing-to-guide-cangrelor-dosing-in-patients-with-temporary-mechanical-circulatory-support-or-as-a-bridge-to-procedure
#46
JOURNAL ARTICLE
Margaret M Buck, Chelsea I Barry, Courtney A Montepara, Nathan J Verlinden
Cangrelor is a rapid-acting, intravenous P2Y12 inhibitor that can be used in patients after percutaneous coronary intervention who require mechanical circulatory support or as a bridge to procedure. We retrospectively reviewed adult patients who received platelet function testing (PFT) with the VerifyNow P2Y12 assay while on cangrelor from March 2021 through November 2022. All patients were initiated on 0.75 mcg/kg/min of cangrelor with P2Y12 reaction unit (PRU) values collected 12-24 h after initiation...
2024: Clinical and Applied Thrombosis/hemostasis
https://read.qxmd.com/read/38435796/influence-of-hematocrit-level-and-integrin-%C3%AE-iib-%C3%AE-iii-function-on-vwf-mediated-platelet-adhesion-and-shear-induced-platelet-aggregation-in-a-sudden-expansion
#47
JOURNAL ARTICLE
Connor T Watson, Shane C Ward, Stefano A Rizzo, Alberto Redaelli, Keefe B Manning
PURPOSE: Shear-mediated thrombosis is a clinically relevant phenomenon that underlies excessive arterial thrombosis and device-induced thrombosis. Red blood cells are known to mechanically contribute to physiological hemostasis through margination of platelets and vWF, facilitating the unfurling of vWF multimers, and increasing the fraction of thrombus-contacting platelets. Shear also plays a role in this phenomenon, increasing both the degree of margination and the near-wall forces experienced by vWF and platelets leading to unfurling and activation...
February 2024: Cellular and Molecular Bioengineering
https://read.qxmd.com/read/38433342/mtor-inhibition-within-the-first-days-after-pediatric-heart-transplantation-is-a-potentially-safe-option-to-prevent-cardiac-allograft-vasculopathy
#48
JOURNAL ARTICLE
Hannah Kreienbaum, Brigitte Stiller, Rouven Kubicki, Alexej Bobrowski, Johannes Kroll, Thilo Fleck
BACKGROUND: Immunosuppression after heart transplantation (HTX) with mammalian target of rapamycin (mTOR) inhibitors serves as a prophylaxis against rejection and to treat coronary vascular injury. However, there is little data on the early, preventive use of everolimus after pediatric HTX. METHODS: Retrospective study of 61 pediatric HTX patients (48 cardiomyopathy and 13 congenital heart disease), 28 females, median age 10.1 (range 0.1-17.9) years transplanted between 2008 and 2020...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38431362/optn-srtr-2022-annual-data-report-heart
#49
JOURNAL ARTICLE
Monica M Colvin, Jodi M Smith, Yoon Son Ahn, Dzhuliyana K Handarova, Alina C Martinez, Kelsi A Lindblad, Ajay K Israni, Jon J Snyder
The number of heart transplants in the United States has continued to increase. Since 2011, pediatric heart transplants have increased 31.7% to 494 and adult heart transplants have increased 85.8% to 3,668 in 2022. The numbers of new candidates for pediatric and adult heart transplants have also increased, with 703 new pediatric candidates and 4,446 new adult candidates in 2022. Adult heart transplant rates continue to rise, peaking at 122.5 transplants per 100 patient-years in 2022; however, the pediatric heart transplant rate decreased to its lowest rate in the past decade, 104...
February 2024: American Journal of Transplantation
https://read.qxmd.com/read/38431185/the-future-of-durable-mechanical-circulatory-support-emerging-technological-innovations-and-considerations-to-enable-evolution-of-the-field
#50
REVIEW
Seraina A Dual, Jennifer Cowger, Ellen Roche, Aditi Nayak
The field of durable mechanical circulatory support (MCS) has undergone an incredible evolution over the past few decades, resulting in significant improvements in longevity and quality of life for advanced heart failure patients. Despite these successes, substantial opportunities for further improvements remain, including in pump design and ancillary technology, peri- and post-operative management, and the overall patient experience. Ideally, durable MCS devices would be fully implantable, automatically controlled, and minimize need for anticoagulation...
February 22, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38429850/two-dimensional-speckle-tracking-echocardiography-in-chemotherapy-induced-cardiotoxicity-in-females-with-breast-cancer
#51
JOURNAL ARTICLE
Ahmed A Fawzy, Khaled A El-Menyawi, Walid M Sallam, Mohamed E Zahran
BACKGROUND: Cancer and cardiovascular diseases are the main causes of mortality worldwide. Although the incidence of cancer is rising, modern comprehensive management including surgery, chemotherapy, and radiotherapy led to decreased mortality, but also different cardiovascular complications. Conventional EF measurement fails to detect subtle changes in LV function, so a more sensitive tool is needed. METHODS: The study included 101 asymptomatic female patients with newly diagnosed breast cancer who received anthracycline ± trastuzumab-based chemotherapy regimen...
March 1, 2024: Cardio-Oncology
https://read.qxmd.com/read/38420763/kidney-function-trajectories-and-right-heart-failure-following-lvad-implantation
#52
JOURNAL ARTICLE
Carl P Walther, Andrew B Civitello, Harveen K Lamba, Nandan K Mondal, Sankar D Navaneethan
BACKGROUND: Preoperative kidney dysfunction is a risk factor for right heart failure (RHF) after implantation of a left ventricular assist device (LVAD). However, characteristic kidney function trajectories before and after post-LVAD RHF are uncertain, so we investigated this. METHODS AND RESULTS: We identified individuals who received primary continuous-flow LVAD implantation from July 1, 2014 to December 31, 2017 in the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) data set...
February 29, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38418055/association-between-clinical-trial-participation-status-and-outcomes-with%C3%A2-mitral-transcatheter-edge-to-edge-repair
#53
JOURNAL ARTICLE
Amro Aglan, Ahmed Maraey, Ayman R Fath, Hadeer Elsharnoby, Wael Abdelmottaleb, Ahmed M Elzanaty, Mahmoud Khalil, Sourbha S Dani, Marwan Saad, Islam Y Elgendy
BACKGROUND: Clinical trials have demonstrated the efficacy and safety of mitral transcatheter edge-to-edge repair (M-TEER) for selected patients with severe mitral regurgitation. However, the generalizability of trial results to real-world patients remains uncertain. OBJECTIVES: The authors aimed to compare baseline characteristics and in-hospital outcomes among trial participants with nonparticipants undergoing M-TEER. METHODS: Using the National Inpatient Sample database years 2016-2020, M-TEER admissions were identified and categorized into trial participants vs none...
February 26, 2024: JACC. Cardiovascular Interventions
https://read.qxmd.com/read/38410944/percutaneous-left-ventricular-unloading-during-high-risk-coronary-intervention-rationale-and-design-of-the-chip-bcis3-randomized-controlled-trial
#54
JOURNAL ARTICLE
Matthew Ryan, Saad M Ezad, Ian Webb, Peter D O'Kane, Matthew Dodd, Richard Evans, Lynn Laidlaw, Sohail Q Khan, Roshan Weerackody, Alan Bagnall, Vasileios F Panoulas, Haseeb Rahman, Julian W Strange, Farzin Fath-Ordoubadi, Stephen P Hoole, Rod H Stables, Nick Curzen, Tim Clayton, Divaka Perera
INTRODUCTION: Percutaneous coronary intervention for complex coronary disease is associated with a high risk of cardiogenic shock. This can cause harm and limit the quality of revascularization achieved, especially when left ventricular function is impaired at the outset. Elective percutaneous left ventricular unloading is increasingly used to mitigate adverse events in patients undergoing high-risk percutaneous coronary intervention, but this strategy has fiscal and clinical costs and is not supported by robust evidence...
February 27, 2024: Circulation. Cardiovascular Interventions
https://read.qxmd.com/read/38410296/urgent-transcatheter-mitral-valve-in-valve-replacement-with-venoarterial-extracorporeal-membrane-oxygenation-support-case-report-and-review-of-the-literature
#55
Mohammad Abdel Jawad, Cyrus M Munguti, Abdullah Abu Kar, Venkata Boppana, Zaher Fanari
Critical mitral valve stenosis due to a failed bioprosthetic valve is associated with significant morbidity and mortality, with the transcatheter Valve-in-Valve (ViV) approach becoming a popular treatment option. We present a case of cardiogenic shock secondary to a stenotic mitral bio-prosthetic valve. The Heart team was consulted; the patient was a high-risk surgical candidate for valve replacement. He required venoarterial extracorporeal membrane oxygenation as a bridge to definitive therapy. The patient underwent a successful urgent transcatheter mitral ViV procedure with a trans-septal approach...
January 2024: Curēus
https://read.qxmd.com/read/38409825/longitudinal-cardiac-dimensions-in-patients-undergoing-lvad-implantation
#56
JOURNAL ARTICLE
Florian Meissner, Sophie Szvetics, Michelle Costa Galbas, Maximilian Russe, David Schibilsky, Klaus Kaier, Martin Czerny, Wolfgang Bothe
BACKGROUND: In conventional left ventricular assist devices (LVAD), a separate outflow graft is sutured to the ascending aorta. Novel device designs may include a transventricular outflow cannula crossing the aortic valve (AV). While transversal ventricular dimensions are well investigated in patients with severe heart failure, little is known about the longitudinal dimensions. These dimensions are, however, particularly critical for the design and development of mechanical circulatory support (MCS) devices with transaortic outflow cannula...
February 26, 2024: Artificial Organs
https://read.qxmd.com/read/38409476/circulating-proteome-analysis-identifies-reduced-inflammation-after-initiation-of-hemodynamic-support-with-either-veno-arterial-extracorporeal-membrane-oxygenation-or-impella-in-patients-with-cardiogenic-shock
#57
JOURNAL ARTICLE
Nikolaos A Diakos, Lija Swain, Shreyas Bhave, Xiaoying Qiao, Towia Libermann, Jillian Haywood, Siya Goel, Shiva Annamalai, Michele Esposito, Haval Chweich, Anthony Faugno, Navin K Kapur
In-hospital mortality associated with cardiogenic shock (CS) remains high despite the use of percutaneous assist devices. We sought to determine whether support with VA-ECMO or Impella in patients with CS alters specific components of the plasma proteome. Plasma samples were collected before device implantation and 72 h after initiation of support in 11 CS patients receiving ECMO or Impella. SOMAscan was used to detect 1305 circulating proteins. Sixty-seven proteins were changed after ECMO (18 upregulated and 49 downregulated, p < 0...
February 26, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38407792/mechanical-circulatory-support-for-high-risk-percutaneous-coronary-intervention
#58
REVIEW
Silvia Moscardelli, Reza Masoomi, Pedro Villablanca, Ahmad Jabri, Ankitkumar K Patel, Francesco Moroni, Lorenzo Azzalini
PURPOSE OF REVIEW: This review will focus on the indications of mechanical circulatory support (MCS) for high-risk percutaneous coronary intervention (PCI) and then analyze in detail all MCS devices available to the operator, evaluating their mechanisms of action, pros and cons, contraindications, and clinical data supporting their use. RECENT FINDINGS: Over the last decade, the interventional cardiology arena has witnessed an increase in the complexity profile of the patients and lesions treated in the catheterization laboratory...
February 26, 2024: Current Cardiology Reports
https://read.qxmd.com/read/38400638/outcomes-of-impella-5-0-and-5-5-for-cardiogenic-shock-a-single-center-137-patient-experience
#59
JOURNAL ARTICLE
Yeahwa Hong, Nishant Agrawal, Nicholas R Hess, Luke A Ziegler, McKenzie M Sicke, Gavin W Hickey, Raj Ramanan, Jeffrey A Fowler, Danny Chu, Pyongsoo D Yoon, Johannes O Bonatti, David J Kaczorowski
BACKGROUND: This study evaluated the outcomes of patients with cardiogenic shock (CS) supported with Impella 5.0 or 5.5 and identified risk factors for in-hospital mortality. METHODS: Adults with CS who were supported with Impella 5.0 or 5.5 at a single institution were included. Patients were stratified into three groups according to their CS etiology: (1) acute myocardial infarction (AMI), (2) acute decompensated heart failure (ADHF), and (3) postcardiotomy (PC)...
February 23, 2024: Artificial Organs
https://read.qxmd.com/read/38398478/complications-and-outcomes-in-39-864-patients-receiving-standard-care-plus-mechanical-circulatory-support-or-standard-care-alone-for-infarct-associated-cardiogenic-shock
#60
JOURNAL ARTICLE
Jan-Sören Padberg, Jannik Feld, Leonie Padberg, Jeanette Köppe, Lena Makowski, Joachim Gerß, Patrik Dröge, Thomas Ruhnke, Christian Günster, Stefan Andreas Lange, Holger Reinecke
BACKGROUND: Temporary mechanical circulatory support devices (tMCS) are increasingly being used in patients with infarct-associated cardiogenic shock (AMICS). Evidence on patient selection, complications and long-term outcomes is lacking. We aim to investigate differences in clinical characteristics, complications and outcomes between patients receiving no tMCS or either intra-aortic balloon pump (IABP), veno-arterial extracorporeal membrane oxygenation (V-A ECMO) or Impella® for AMICS, with a particular focus on long-term outcomes...
February 19, 2024: Journal of Clinical Medicine
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