Jing Zhao, Saisai Tian, Dong Lu, Jian Yang, Huawu Zeng, Feng Zhang, Dongzhu Tu, Guangbo Ge, Yuejuan Zheng, Ting Shi, Xin Xu, Shiyi Zhao, Yili Yang, Weidong Zhang
BACKGROUND: The traditional Chinese medicine (TCM) formula Qing-Fei-Pai-Du decoction (QFPDD) was the most widely used prescription in China's campaign to contain COVID-19, which has exhibited positive effects. However, the underlying mode of action is largely unknown. PURPOSE: A systems pharmacology strategy was proposed to investigate the mechanisms of QFPDD against COVID-19 from molecule, pathway and network levels. STUDY DESIGN AND METHODS: The systems pharmacological approach consisted of text mining, target prediction, data integration, network study, bioinformatics analysis, molecular docking, and pharmacological validation...
September 9, 2020: Phytomedicine
Christopher E Mascio
The Fontan is the final common pathway for most single ventricle lesions. It is not a durable circulation and many Fontan patients eventually present for advanced heart failure therapies including mechanical circulatory support. While there have been advancements in available durable devices, many pediatric patients have size, anatomic, and physiologic constraints that make placement of adult ventricular assist devices challenging. And, Fontan failure comes in different varieties, including failure with preserved systolic function...
September 22, 2020: Seminars in Thoracic and Cardiovascular Surgery
Virginie Fouilloux, Fedoua El Louali, Célia Gran, Roland Henaine, François Roubertie, Caroline Chenu, Marion Fiorini, Stéphane Le Bel, Philippe Mauriat, Jean Neidecker, Loïc Macé, Bernard Kreitmann, Caroline Ovaert
BACKGROUND: Berlin Heart EXCOR (BH) ventricular assist devices provide mechanical long-term circulatory support in children with end-stage heart failure, as a bridge to transplantation or to recovery. Most studies are from large-volume paediatric cardiac centres. AIM: The aim of this study was to analyse the experiences of three French centres and to compare these with available published data. METHOD: We performed a retrospective observational study of three paediatric cardiac intensive care units...
September 21, 2020: Heart, Lung & Circulation
Hye Won Kwon
No abstract text is available yet for this article.
September 22, 2020: Clinical and experimental pediatrics
Markus W Ferrari, Katharina Ferrari-Kühne
Out-of-hospital circulatory arrest represents a challenging situation in emergency medicine even until today. Despite optimal emergency care and clinical treatment pathways, we are faced with a mortality rate above 90 %. It is possible to improve the survival rate to more than 40 % under ideal clinical and preclinical conditions. Thus, more people's life could be saved by standardized SOPs and networks in emergency medicine. About 14.000 preclinical resuscitation cases are reported in Germany per year. The prognosis out-of-hospital circulatory arrest patients is determined by best preclinical treatment including early resuscitation by bystanders...
September 2020: Deutsche Medizinische Wochenschrift
JeffersonL Vieira, Hector O Ventura, Mandeep R Mehra
Substantial progress in the field of mechanical circulatory support (MCS) has expanded the treatment options for patients with advanced-stage heart failure (HF). Currently available MCS devices can be implanted percutaneously or surgically. They can also be configured to support the left, right, or both ventricles, offering varying levels of circulatory support. Short-term temporary MCS devices are primarily used in high-risk percutaneous coronary intervention, cardiogenic shock, and post-cardiac arrest, while durable left ventricular assist systems (LVAS) are increasingly utilized either as a bridge-to-transplant, bridge to decision, or as a destination therapy...
September 21, 2020: Progress in Cardiovascular Diseases
Arafat Ali, David H Ballard, Waleed Althobaity, Andy Christensen, Mariah Geritano, Michelle Ho, Peter Liacouras, Jane Matsumoto, Jonathan Morris, Justin Ryan, Rami Shorti, Nicole Wake, Frank J Rybicki, Adnan Sheikh
BACKGROUND: Medical 3D printing as a component of care for adults with cardiovascular diseases has expanded dramatically. A writing group composed of the Radiological Society of North America (RSNA) Special Interest Group on 3D Printing (SIG) provides appropriateness criteria for adult cardiac 3D printing indications. METHODS: A structured literature search was conducted to identify all relevant articles using 3D printing technology associated with a number of adult cardiac indications, physiologic, and pathologic processes...
September 23, 2020: 3D Printing in Medicine
Elian F Giordanino
No abstract text is available yet for this article.
September 22, 2020: Clinical Transplantation
Şerife Bektaş, Mine Çavuş, Sema Turan
Background: We aimed to investigate the efficacy and safety of percutaneous dilatational tracheostomy procedure following cardiac surgery in patients receiving extracorporeal membrane oxygenation and/or left ventricular assist device. Methods: A total of 42 patients (10 males, 32 females; mean age 51±14.6 years; range, 18 to 77 years) who underwent percutaneous dilatational tracheostomy procedure under extracorporeal membrane oxygenation and/or left ventricular assist device support between January 2017 and January 2019 were retrospectively analyzed...
July 2020: Türk Göğüs Kalp Damar Cerrahisi Dergisi
Arda Akoluk, Usman Mazahir, Steven Douedi, Adel Aziz, Aref Obagi, Daniel Kiss, Daniel Flynn, Eric Costanzo, Sinan A Simsir, Matthew D Saybolt
Background: Novel coronavirus 2019 (COVID-19) has been the focus of the medical world since being declared a pandemic in March 2020. While the pathogenesis and heterogeneity of COVID-19 manifestations is still not fully understood, viral evasion of cellular immune responses and inflammatory dysregulation are believed to play essential roles in disease progression and severity. Case Presentation: We present the first case of a patient with COVID-19 with massive pulmonary embolism treated successfully with systemic thrombolysis, VA-ECLS, and bail out catheter directed thrombolysis...
2020: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
Enrico Ammirati, Michela Brambatti, Oscar Ö Braun, Palak Shah, Manlio Cipriani, Quan M Bui, Jesse Veenis, Euyhyun Lee, Ronghui Xu, Kimberly N Hong, Caroline M Van de Heyning, Enrico Perna, Philippe Timmermans, Maja Cikes, Jasper J Brugts, Giacomo Veronese, Jonathan Minto, Saige Smith, Grunde Gjesdal, Yan K Gernhofer, Cynthia Partida, Luciano Potena, Marco Masetti, Silvia Boschi, Antonio Loforte, Nina Jakus, Davor Milicic, Johan Nilsson, Dina De Bock, Caroline Sterken, Klaartje Van den Bossche, Filip Rega, Hao Tran, Ramesh Singh, Jonathan Montomoli, Michele Mondino, Barry Greenberg, Claudio F Russo, Victor Pretorius, Klein Liviu, Maria Frigerio, Eric D Adler
BACKGROUND: Geographic variations in management and outcomes of individuals supported by continuous-flow left ventricular assist devices (CF-LVAD) between the United States (US) and Europe (EU) is largely unknown. METHODS: We created a retrospective, multinational registry of 524 patients who received a CF-LVAD (either HVAD or Heartmate II) between January 2008 and April 2017. Follow up spanned from date of CF-LVAD implant to post-HTx period with a median follow up of 44...
September 17, 2020: International Journal of Cardiology
Cumaraswamy Sivathasan, Christopher Hayward, Paul Jansz, Amul Kumar Sibal, ChenChen, Ho Ka Lai Cally, Komarakshi Rajagopalan Balakrishnan, Yang Hyun Cho, Mohd Nazeri Nordin, Joseph B Barril, Feras Khaliel, Mandeep R Mehra
No abstract text is available yet for this article.
September 3, 2020: Journal of Heart and Lung Transplantation
Anubodh S Varshney, Sameer A Hirji, Michael M Givertz
The United Network for Organ Sharing (UNOS) implemented a revised donor heart allocation system on October 18, 2018 with principle aims to reduce waitlist mortality, enhance geographic organ sharing, and improve organ distribution equity. Five recently published analyses compared outcomes of heart transplant (HT) recipients transplanted under the revised versus previous system. All demonstrated increased pre-transplant temporary mechanical circulatory support use and graft ischemic times under the revised system...
August 26, 2020: Journal of Heart and Lung Transplantation
Douglas Farmer, Ernesto Jimenez
PURPOSE OF REVIEW: The use of coronary artery bypass grafting (CABG) in patients with acute coronary syndrome (ACS) has markedly declined during the past decade, with an increase in the use of percutaneous coronary intervention (PCI). However, long-term data continues to show survival advantages for patients undergoing CABG over PCI. We describe the current indications for and outcomes of CABG in patients who present with ACS. RECENT FINDINGS: Real-world studies demonstrate better long-term outcomes with CABG than with PCI after NSTE-ACS...
September 17, 2020: Current Cardiology Reports
Sonal Sharma, Abraham Sonny, Adam A Dalia, Kunal Karamchandani
Acute heart failure (AHF) is an under recognized yet potentially lethal complication after liver transplantation (LT) surgery. The increase in incidence of liver transplantation amongst high risk patients and the leniency in the criteria for transplantation, predisposes these patients to postoperative AHF and the antecedent morbidity and mortality. The inability of conventional pre-operative cardiovascular testing to accurately identify patients at risk for post-LT AHF poses a considerable challenge to clinicians caring for these patients...
September 17, 2020: Clinical Transplantation
Stacey Chen, Darien Paone, Lilly Spellman, Neel K Ranganath, Julius A Carillo, Claudia G Gidea, Alex Reyentovich, Craig A Thompson, Louai Razzouk, Zachary N Kon, Nader Moazami, Deane E Smith
BACKGROUND: The Impella (Abiomed) ventricular support system is a family of temporary mechanical circulatory support (MCS) devices used to treat patients with cardiogenic shock, acute cardiogenic decompensation, and for high-risk percutaneous or surgical revascularization. These devices include the percutaneously implanted 2.5/cardiac power (CP) and the surgically implanted 5.0/left direct (LD). Despite the beneficial effects and increased usage of these devices, data to assess adverse outcomes and guide clinician decision-making between the Impella CP and 5...
September 16, 2020: Journal of Cardiac Surgery
María Monteagudo-Vela, Vasileios Panoulas, Diana García-Saez, Fabio de Robertis, Ulrich Stock, Andre Simon
INTRODUCTION: The Impella® (Abiomed, Danvers, MA) has become an important adjunct treatment modality in bridging patients with end stage heart failure to recovery or orthotopic heart transplantation (HTx). We compared the outcome of patients directly bridged to HTx with the Impella 5.0 versus patients without mechanical circulatory support (MCS). METHODS: Patients with no previous sternotomy or MCS, who were transplanted between September 2014 and March 2019 were included in this retrospective analysis...
September 16, 2020: Artificial Organs
Ahmed Seliem, Shelley A Hall
PURPOSE OF REVIEW: In recent decades, multiple left and right ventricular assist devices (VAD) have been developed, and the utilization of these devices has grown exponentially. We discuss the most common temporary mechanical circulatory support (tMCS) devices used for patients in cardiogenic shock, including the intra-aortic balloon pump (IABP), transvalvular axial flow support systems (Impella®), the Tandem™ collection, and extracorporeal membrane oxygenation (ECMO). RECENT FINDINGS: In 2018 the United Network for Organ Sharing (UNOS) introduced new listing criteria for candidates awaiting heart transplantation in the USA...
September 16, 2020: Current Heart Failure Reports
Nili Schamroth Pravda, Ran Kornowski
The use of VA-ECMO for patients with cardiac arrest or cardiogenic shock in the cardiac catheterization laboratory may be associated with improved survival. Clinicians should be aware of a high complication rate of this therapy. Further data is needed to best select the appropriate form of mechanical circulatory support in this clinical context.
September 1, 2020: Catheterization and Cardiovascular Interventions
Anirudh Kumar, Chetan P Huded, Leon Zhou, Chayakrit Krittanawong, Laura D Young, Amar Krishnaswamy, Venu Menon, A Michael Lincoff, Stephen G Ellis, Grant W Reed, Samir R Kapadia, Umesh N Khot
Mortality in patients with STEMI-associated cardiogenic shock (CS) is increasing. Whether a comprehensive ST-elevation myocardial infarction (STEMI) protocol (CSP) can improve their care delivery and mortality is unknown. We evaluated the impact of a CSP on incidence and outcomes in patients with STEMI-associated CS. We implemented a 4-step CSP including: (1) Emergency Department catheterization lab activation; (2) STEMI Safe Handoff Checklist; (3) immediate catheterization lab transfer; (4) and radial-first percutaneous coronary intervention (PCI)...
August 15, 2020: American Journal of Cardiology
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