Thomas Heimbucher, Zheng Liu, Carine Bossard, Richard McCloskey, Andrea C Carrano, Christian G Riedel, Bogdan Tanasa, Christian Klammt, Bryan R Fonslow, Celine E Riera, Bjorn F Lillemeier, Kenneth Kemphues, John R Yates, Clodagh O'Shea, Tony Hunter, Andrew Dillin
FOXO family transcription factors are downstream effectors of Insulin/IGF-1 signaling (IIS) and major determinants of aging in organisms ranging from worms to man. The molecular mechanisms that actively promote DAF16/FOXO stability and function are unknown. Here we identify the deubiquitylating enzyme MATH-33 as an essential DAF-16 regulator in IIS, which stabilizes active DAF-16 protein levels and, as a consequence, influences DAF-16 functions, such as metabolism, stress response, and longevity in C. elegans...
July 7, 2015: Cell Metabolism