keyword
https://read.qxmd.com/read/38539537/transforming-growth-factor-beta-2-tgfb2-mrna-levels-in-conjunction-with-interferon-gamma-receptor-activation-of-interferon-regulatory-factor-5-irf5-and-expression-of-cd276-b7-h3-are-therapeutically-targetable-negative-prognostic-markers-in-low-grade-gliomas
#1
JOURNAL ARTICLE
Vuong Trieu, Anthony E Maida, Sanjive Qazi
LGG tumors are characterized by a low infiltration of immune cells, requiring therapeutic interventions to boost the immune response. We conducted a study analyzing mRNA expression datasets from the UCSC Xena web platform. To screen for upregulated genes, we sought to compare normal brain tissue with LGG tumor samples. We also used cBioportal to determine the relationship between mRNA expression levels of 513 LGG patients and their overall survival (OS) outcomes. Three tumor-associated macrophage (TAM) markers, MSR1/CD204, CD86, and CD68, exhibited a 6-fold ( p < 0...
March 19, 2024: Cancers
https://read.qxmd.com/read/38537730/the-involvement-of-interferon-regulatory-factor-8-in-regulating-the-proliferation-of-haemocytes-in-oyster-crassostrea-gigas
#2
JOURNAL ARTICLE
Zhuo Yu, Xue Qiao, Simiao Yu, Xiaoyu Gu, Yuhao Jin, Chunyu Tang, Jixiang Niu, Lingling Wang, Linsheng Song
Interferon regulatory factor 8 (IRF8) is an important transcriptional regulatory factor involving in multiple biological process, such as the antiviral immune response, immune cell proliferation and differentiation. In the present study, the involvement of a previously identified IRF8 homologue (CgIRF8) in regulating haemocyte proliferation of oyster were further investigated. CgIRF8 mRNA transcripts were detectable in all the stages of C. gigas larvae with the highest level in D-veliger (1.76-fold of that in zygote, p < 0...
March 25, 2024: Developmental and Comparative Immunology
https://read.qxmd.com/read/38466881/berberine-alleviates-concanavalin-a-induced-autoimmune-hepatitis-in-mice-by-modulating-the-gut-microbiota
#3
JOURNAL ARTICLE
Hao Yang, Qingqing Liu, Haixia Liu, Xing Kang, Haixia Tian, Yongbo Kang, Lin Li, Xiaodan Yang, Peng Ren, Xiaoyu Kuang, Xiaohui Wang, Linzhi Guo, Mingwei Tong, Jieqiong Ma, Weiping Fan
BACKGROUND: Autoimmune hepatitis (AIH) is an immune-mediated liver disease of unknown etiology accompanied by intestinal dysbiosis and a damaged intestinal barrier. Berberine (BBR) is a traditional antibacterial medicine that has a variety of pharmacological properties. It has been reported that BBR alleviates AIH, but relevant mechanisms remain to be fully explored. METHODS: BBR was orally administered at doses of 100 mg⋅kg-1⋅d-1 for 7 days to mice before concanavalin A-induced AIH model establishment...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38452958/the-antiviral-role-of-largemouth-bass-sting-against-iridovirus-infection
#4
JOURNAL ARTICLE
Xinmei Yang, Yuyun Dong, Yu Wang, Shanxin Liu, Xiaohong Huang, Youhua Huang, Qiwei Qin
Stimulator of interferon gene (STING) plays a crucial role in the innate immune response against viral and bacterial pathogens. However, its function in largemouth bass iridovirus (LMBV) infection remains uncertain. Here, a STING homolog (MsSTING) from largemouth bass (Micropterus salmoides) was cloned and characterized. MsSTING encoded a 407-amino-acid polypeptide, which shared 84.08% and 41.45% identity with golden perch (Perca flavescens) and human (Homo sapiens) homologs, respectively. MsSTING contained four transmembrane domains and a conserved C-terminal domain...
March 5, 2024: Fish & Shellfish Immunology
https://read.qxmd.com/read/38432572/inhibition-of-spinal-brd4-alleviates-pyroptosis-and-m1-microglia-polarization-via-sting-irf3-pathway-in-morphine-tolerant-rats
#5
JOURNAL ARTICLE
Xiaoqian Jia, Jie Ju, Zheng Li, Xiaoling Peng, Jihong Wang, Feng Gao
BACKGROUND: Morphine tolerance has been a challenging medical issue. Neuroinflammation is considered as a critical mechanism for the development of morphine tolerance. Bromodomain-containing protein 4 (BRD4), a key regulator in cell damage and inflammation, participates in the development of chronic pain. However, whether BRD4 is involved in morphine tolerance and the underlying mechanisms remain unknown. METHODS: The morphine-tolerant rat model was established by intrathecal administration of morphine twice daily for 7 days...
March 1, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38429584/biophysical-and-functional-characterization-of-n-terminal-domain-of-human-interferon-regulatory-factor-6
#6
JOURNAL ARTICLE
Binita Kumari Sinha, Devbrat Kumar, Priyabrata Meher, Shilpi Kumari, Krishna Prakash, Samudrala Gourinath, Tara Kashav
BACKGROUND: Interferon regulatory factor 6 (IRF6) has a key function in palate fusion during palatogenesis during embryonic development, and mutations in IRF6 cause orofacial clefting disorders. METHODS AND RESULTS: The in silico analysis of IRF6 is done to obtain leads for the domain boundaries and subsequently the sub-cloning of the N-terminal domain of IRF6 into the pGEX-2TK expression vector and successfully optimized the overexpression and purification of recombinant glutathione S-transferase-fused NTD-IRF6 protein under native conditions...
March 2, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38393946/serine-arginine-rich-splicing-factor-7-promotes-the-type-i-interferon-response-by-activating-irf7-transcription
#7
JOURNAL ARTICLE
Haley M Scott, Mackenzie H Smith, Aja K Coleman, Kaitlyn S Armijo, Morgan J Chapman, Summer L Apostalo, Allison R Wagner, Robert O Watson, Kristin L Patrick
Tight regulation of macrophage immune gene expression is required to fight infection without risking harmful inflammation. The contribution of RNA-binding proteins (RBPs) to shaping the macrophage response to pathogens remains poorly understood. Transcriptomic analysis reveals that a member of the serine/arginine-rich (SR) family of mRNA processing factors, SRSF7, is required for optimal expression of a cohort of interferon-stimulated genes in macrophages. Using genetic and biochemical assays, we discover that in addition to its canonical role in regulating alternative splicing, SRSF7 drives transcription of interferon regulatory transcription factor 7 (IRF7) to promote antiviral immunity...
February 22, 2024: Cell Reports
https://read.qxmd.com/read/38378697/plasticity-induced-repression-of-irf6-underlies-acquired-resistance-to-cancer-immunotherapy-in-pancreatic-ductal-adenocarcinoma
#8
JOURNAL ARTICLE
Il-Kyu Kim, Mark S Diamond, Salina Yuan, Samantha B Kemp, Benjamin M Kahn, Qinglan Li, Jeffrey H Lin, Jinyang Li, Robert J Norgard, Stacy K Thomas, Maria Merolle, Takeshi Katsuda, John W Tobias, Timour Baslan, Katerina Politi, Robert H Vonderheide, Ben Z Stanger
Acquired resistance to immunotherapy remains a critical yet incompletely understood biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma (PDAC) to study tumor relapse following immunotherapy-induced responses, we find that resistance is reproducibly associated with an epithelial-to-mesenchymal transition (EMT), with EMT-transcription factors ZEB1 and SNAIL functioning as master genetic and epigenetic regulators of this effect. Acquired resistance in this model is not due to immunosuppression in the tumor immune microenvironment, disruptions in the antigen presentation machinery, or altered expression of immune checkpoints...
February 20, 2024: Nature Communications
https://read.qxmd.com/read/38376283/histone-deacetylase-inhibitor-sodium-butyrate-regulates-the-activation-of-toll-like-receptor-4-interferon-regulatory-factor-3-signaling-pathways-in-prostate-cancer-cells
#9
JOURNAL ARTICLE
Asuman Deveci Ozkan, Gamze Guney Eskiler, Nur Kazan, Ozge Turna
CONTEXT: The covalent acetylation and deacetylation of histone proteins by the histone deacetylase (HDAC) enzymes can be considered a novel therapeutic target in prostate cancer (PCa) cells. Sodium butyrate (NaBu) is a HDAC inhibitor (HDACi) which is a promising potential anticancer drug. Toll-like receptor 4 (TLR4) expression is increased in PCa cells and HDACi alter TLR-inducible gene expressions. AIMS: We aimed to evaluate the effects of NaBu on TLR4 mediating signaling pathways in two different PCa cells (DU-145 and LNCaP) for the first time...
October 1, 2023: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/38367238/the-irak1-irf5-axis-initiates-il-12-response-by-dendritic-cells-and-control-of-toxoplasma-gondii-infection
#10
JOURNAL ARTICLE
Milton Pereira, Theresa Ramalho, Warrison A Andrade, Danielle F Durso, Maria C Souza, Katherine A Fitzgerald, Douglas T Golenbock, Neal Silverman, Ricardo T Gazzinelli
Activation of endosomal Toll-like receptor (TLR) 7, TLR9, and TLR11/12 is a key event in the resistance against the parasite Toxoplasma gondii. Endosomal TLR engagement leads to expression of interleukin (IL)-12 via the myddosome, a protein complex containing MyD88 and IL-1 receptor-associated kinase (IRAK) 4 in addition to IRAK1 or IRAK2. In murine macrophages, IRAK2 is essential for IL-12 production via endosomal TLRs but, surprisingly, Irak2-/- mice are only slightly susceptible to T. gondii infection, similar to Irak1-/- mice...
February 15, 2024: Cell Reports
https://read.qxmd.com/read/38341879/1-2-dichloroethane-induces-testicular-pyroptosis-by-activating-pir-mmu-1019957-irf7-pathway-and-the-protective-effects-of-melatonin
#11
JOURNAL ARTICLE
Bingli Zhang, Yizhou Zhong, Jiaxin Du, Rongyi Ye, Bingchi Fan, Yanhong Deng, Ruobing Bai, Yu Feng, Xiaohong Yang, Yuji Huang, Boxuan Liang, Jiewei Zheng, Weifeng Rong, Xingfen Yang, Zhenlie Huang
1,2-Dichloroethane (1,2-DCE) is a prevalent environmental contaminant, and our study revealed its induction of testicular toxicity in mice upon subacute exposure. Melatonin, a prominent secretory product of the pineal gland, has been shown to offer protection against pyroptosis in male reproductive toxicity. However, the exact mechanism underlying 1,2-DCE-induced testicular toxicity and the comprehensive extent of melatonin's protective effects in this regard remain largely unexplored. Therefore, we sequenced testis piRNAs in mice exposed to environmentally relevant concentrations of 1,2-DCE by 28-day dynamic inhalation, and investigated the role of key piRNAs using GC-2 spd cells...
February 9, 2024: Environment International
https://read.qxmd.com/read/38319963/dna-hypomethylation-ameliorates-erosive-inflammatory-arthritis-by-modulating-interferon-regulatory-factor-8
#12
JOURNAL ARTICLE
Gaurav Swarnkar, Nicholas P Semenkovich, Manoj Arra, Dorothy K Mims, Syeda Kanwal Naqvi, Timothy Peterson, Gabriel Mbalaviele, Chia-Lung Wu, Yousef Abu-Amer
Epigenetic regulation plays a crucial role in the pathogenesis of autoimmune diseases such as inflammatory arthritis. DNA hypomethylating agents, such as decitabine (DAC), have been shown to dampen inflammation and restore immune homeostasis. In the present study, we demonstrate that DAC elicits potent anti-inflammatory effects and attenuates disease symptoms in several animal models of arthritis. Transcriptomic and epigenomic profiling show that DAC-mediated hypomethylation regulates a wide range of cell types in arthritis, altering the differentiation trajectories of anti-inflammatory macrophage populations, regulatory T cells, and tissue-protective synovial fibroblasts (SFs)...
February 13, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38311277/a-bet-inhibitor-nhwd-870-can-downregulate-dendritic-cells-maturation-via-the-irf7-mediated-signaling-pathway-to-ameliorate-imiquimod-induced-psoriasis-like-murine-skin-inflammation
#13
JOURNAL ARTICLE
Liping Jin, Liang Dong, Shiyao Pei, Xiang Chen, Yehong Kuang, Wangqing Chen, Wu Zhu, Mingzhu Yin
Psoriasis is a chronic, recurrent, inflammatory dermatosis accompanied by excessive activation of dendritic cells (DCs), which are primarily responsible for initiating an immune response. The bromodomain and extraterminal domain (BET) family plays a pivotal role in the transcriptional regulation of inflammation and its inhibitors can downregulate DCs maturation and activation. Here we investigated the effect of NHWD-870, a potent BET inhibitor, on inflammation in an imiquimod (IMQ)-induced psoriasis-like mouse model and murine bone marrow-derived dendritic cells (BMDCs) stimulated by lipopolysaccharide (LPS) and IMQ...
February 2, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38295895/multi-omics-reveals-the-switch-role-of-abnormal-methylation-in-the-regulation-of-decidual-macrophages-function-in-recurrent-spontaneous-abortion
#14
JOURNAL ARTICLE
Qian Li, Lei Zhang, Hua Zou, Tingjia Chai, Yan Su, Yan Shen, Xiao He, Hongbo Qi, Chunli Li
RSA, recurrent spontaneous abortion, often causes serious physical damage and psychological pressure in reproductive women with unclarified pathogenesis. Abnormal function of decidual cells and aberrant DNA methylation have been reported to cause RSA, but their association remains unclear. Here, we integrated transcriptome, DNA methylome, and scRNA-seq to clarify the regulatory relationship between DNA methylation and decidual cells in RSA. We found that DNA methylation mainly influenced the function of decidual macrophages (DMs), of which four hub genes, HLA-A, HLA-F, SQSTM1/P62, and Interferon regulatory factor 7 (IRF7), related to 22 hypomethylated CpG sites, regulated 16 hub pathways to participate in RSA pathogenesis...
January 29, 2024: Cellular Signalling
https://read.qxmd.com/read/38289089/infectious-bursal-disease-virus-vp5-triggers-host-shutoff-in-a-transcription-dependent-manner
#15
JOURNAL ARTICLE
Xinxin Niu, Jinze Han, Mengmeng Huang, Guodong Wang, Yulong Zhang, Wenying Zhang, Hangbo Yu, Mengmeng Xu, Kai Li, Li Gao, Suyan Wang, Yuntong Chen, Hongyu Cui, Yanping Zhang, Changjun Liu, Xiaomei Wang, Yulong Gao, Xiaole Qi
Viruses have evolved intricate mechanisms to evade host antiviral responses and exploit cellular resources by manipulating the expression profile of host genes. During infection, viruses encode proteins with shutoff activity to globally inhibit host protein synthesis, which is an effective strategy for immune evasion. In this study, compelling evidence shows that infectious bursal disease virus (IBDV) infection triggers the suppression of host protein synthesis. Furthermore, using both in vitro and in vivo viral infection models, we have identified that IBDV specifically impedes the transcription of host genes via the shutoff activity of viral VP5, simultaneously conferring advantages to IBDV infection in these circumstances...
January 30, 2024: MBio
https://read.qxmd.com/read/38278042/inhibition-of-pseudorabies-virus-replication-via-upregulated-interferon-response-by-targeting-7-dehydrocholesterol-reductase
#16
JOURNAL ARTICLE
Zicheng Ma, Lei Guo, Mengjiao Pan, Chenlong Jiang, Depeng Liu, Yanni Gao, Juan Bai, Ping Jiang, Xing Liu
Pseudorabies virus (PRV) is an alpha-herpesvirus capable of infecting a range of animal species, particularly its natural host, pigs, resulting in substantial economic losses for the swine industry. Recent research has shed light on the significant role of cholesterol metabolism in the replication of various viruses. However, the specific role of cholesterol metabolism in PRV infection remains unknown. Here, we demonstrated that the expression of 7-dehydrocholesterol reductase (DHCR7) is upregulated following PRV infection, as evidenced by the proteomic analysis...
January 19, 2024: Veterinary Microbiology
https://read.qxmd.com/read/38257840/retinoic-acid-mediated-inhibition-of-mouse-coronavirus-replication-is-dependent-on-irf3-and-camkk
#17
JOURNAL ARTICLE
Justin H Franco, Ryan A Harris, William G Ryan, Roger Travis Taylor, Robert E McCullumsmith, Saurabh Chattopadhyay, Zhixing K Pan
The ongoing COVID-19 pandemic has revealed the shortfalls in our understanding of how to treat coronavirus infections. With almost 7 million case fatalities of COVID-19 globally, the catalog of FDA-approved antiviral therapeutics is limited compared to other medications, such as antibiotics. All-trans retinoic acid (RA), or activated vitamin A, has been studied as a potential therapeutic against coronavirus infection because of its antiviral properties. Due to its impact on different signaling pathways, RA's mechanism of action during coronavirus infection has not been thoroughly described...
January 18, 2024: Viruses
https://read.qxmd.com/read/38227268/evolutionary-and-functional-conservation-of-irf7-in-the-tibetan-frog-nanorana-parkeri
#18
JOURNAL ARTICLE
Qing Wang, Bo Li, Xin Na Sun, Zhen Gan
BACKGROUND: The production of interferons (IFNs) is essential for the control of viral infections, and interferon regulatory factor 7 (IRF7) is considered as a vital regulator for the transcription of type I IFNs. Amphibians appear to possess a highly expanded type I IFN repertoire, consisting of intron-containing genes as observed in fish, and intronless genes as in other higher vertebrates. However, the knowledge on transcriptional regulatory mechanism of these two types of type I IFN genes is rather scarce in amphibians...
January 16, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38216766/repeated-peripheral-infusions-of-anti-egfrviii-car-t-cells-in-combination-with-pembrolizumab-show-no-efficacy-in-glioblastoma-a-phase-1-trial
#19
JOURNAL ARTICLE
Stephen J Bagley, Zev A Binder, Lamia Lamrani, Eliana Marinari, Arati S Desai, MacLean P Nasrallah, Eileen Maloney, Steven Brem, Robert A Lustig, Goldie Kurtz, Michelle Alonso-Basanta, Pierre-Emmanuel Bonté, Christel Goudot, Wilfrid Richer, Eliane Piaggio, Shawn Kothari, Lea Guyonnet, Coralie L Guerin, Joshua J Waterfall, Suyash Mohan, Wei-Ting Hwang, Oliver Y Tang, Meghan Logun, Meghna Bhattacharyya, Kelly Markowitz, Devora Delman, Amy Marshall, E John Wherry, Sebastian Amigorena, Gregory L Beatty, Jennifer L Brogdon, Elizabeth Hexner, Denis Migliorini, Cecile Alanio, Donald M O'Rourke
We previously showed that chimeric antigen receptor (CAR) T-cell therapy targeting epidermal growth factor receptor variant III (EGFRvIII) produces upregulation of programmed death-ligand 1 (PD-L1) in the tumor microenvironment (TME). Here we conducted a phase 1 trial (NCT03726515) of CAR T-EGFRvIII cells administered concomitantly with the anti-PD1 (aPD1) monoclonal antibody pembrolizumab in patients with newly diagnosed, EGFRvIII+ glioblastoma (GBM) (n = 7). The primary outcome was safety, and no dose-limiting toxicity was observed...
January 12, 2024: Nature Cancer
https://read.qxmd.com/read/38211750/the-neuroprotective-effect-of-near-infrared-light-therapy-in-aged-mice-with-postoperative-neurocognitive-disorder-by-upregulating-irf7
#20
JOURNAL ARTICLE
Xiao-Jun Zhang, Zhi Wang, Jia-Wei Chen, Shang-Yan Yuan, Le Zhao, Jun-Ying Zhong, Jun-Jun Chen, Wei-Jye Lin, Wen-Si Wu
BACKGROUND: Postoperative neurocognitive disorder (PND) is a common central nervous system complication after undergoing surgery and anesthesia especially in elderly patients, while the therapeutic options are very limited. This study was carried out to investigate the beneficial effects of transcranial near infrared light (NIRL) which was employed to the treatment of PND and propose the involved mechanisms. METHODS: The PND mice were established through left carotid artery exposure under isoflurane anesthesia and received transcranial NIRL treatment...
January 9, 2024: Journal of Affective Disorders
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