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JOURNAL ARTICLE
Dorota Zarębska-Michaluk, Michał Brzdęk, Piotr Rzymski, Krystyna Dobrowolska, Robert Flisiak
INTRODUCTION: Hepatitis B virus (HBV) and hepatitis C virus (HCV) share a similar transmission route, increasing coinfection odds, which worsens clinical outcomes. Objectives: Therefore it is pivotal to study coinfected patients undergoing HCV treatment with direct-acting antivirals (DAAs) to understand their characteristics, risk of HBV reactivation, and effectiveness of therapy. Patients and methods: The present research included the complex analysis of 1118 patients with chronic HCV infection, divided into three subgroups based on HBV status...
January 2, 2024: Polish Archives of Internal Medicine
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JOURNAL ARTICLE
Jiangbo Liu, Xuejiao Qian, Xueyan Jie, Ping Jiang
OBJECTIVE: To analyze the effects of different types of inhalant allergens on the lung functions of adult patients with bronchial asthma. METHODS: This cross-sectional study included a total of 47 adults diagnosed with bronchial asthma at the Respiratory Outpatient Department of Tianjin First Central Hospital. Patients were divided into non-sensitized and sensitized groups based on the number of positive allergens detected and classified into four groups (the dust mite mixed group, animal dander mixed group, pollen-mixed group, and mold mixed group) based on the type of positive allergen detected...
December 2023: Immunity, Inflammation and Disease
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JOURNAL ARTICLE
L Lorente Ramos, B Rodriguez Lozano, M L Barroso Morales, D Rodríguez Perez, A Jiménez Sosa, N E Hernández Cabrera, M L Mora Quintero, M Rodríguez Gaspar, M S Bustabad Reyes, M M Cueto Serrano
BACKGROUND: Workplace aggressions on hospital workers is a very frequent and under-reported problem. OBJECTIVE: The novel objective of our study was to analyze the number of workplace aggressions per hospital worker. Other objectives of the study were to analyze the management knowledge and interest in receiving training on aggressions by hospital workers. METHODS: An anonymous survey was handed out among all professionals in a university hospital...
December 20, 2023: Work: a Journal of Prevention, Assessment, and Rehabilitation
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JOURNAL ARTICLE
Gary N Landis, Hans S Bell, Oscar Peng, Brett Bognar, Andy Tong, Tomás D Manea, Hanmei Bao, Xianlin Han, John Tower
Mating and receipt of male Sex Peptide hormone cause increased egg laying, increased midgut size and decreased life span in female Drosophila. Feeding mated females with the synthetic steroid mifepristone decreases egg production, reduces midgut size, and increases life span. Here, several gene mutations were assayed to investigate possible mechanisms for mifepristone action. Drosophila Dhr96 is a hormone receptor, and a key positive regulator of midgut lipid uptake and metabolism. Dhr96[1] null mutation increased female life span, and reduced the effects of mifepristone on life span, suggesting that Dhr96[1] mutation and mifepristone may act in part through the same mechanism...
2023: PloS One
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JOURNAL ARTICLE
Renáta Sütő, Marianna Pócsi, Zsolt Szabó, Zsolt Fejes, Gergely Ivády, György Kerekes, Miklós Fagyas, Attila Nagy, Zoltán Szentkereszty, János Kappelmayer, Béla Nagy
BACKGROUND: We retrospectively analyzed serum level of human epididymis protein 4 (HE4) as a pulmonary inflammatory biomarker in patients with COVID-19 pneumonia in association with disease severity and outcome. METHODS: Ninety-nine (40 critically ill, 40 severe and 19 mild) COVID-19 patients and as controls 25 age- and sex-matched non-COVID-19 bacterial sepsis subjects were included. Serum HE4 was measured by an immunoassay (Architect® i1000SR, Abbott) in the baseline samples of all study participants obtained at intensive care unit (ICU) admission or during outpatient clinic visit and follow-up sera were available in case of 30 COVID-19 subjects with life-threating conditions...
December 16, 2023: BMC Pulmonary Medicine
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JOURNAL ARTICLE
Chloé Lazeras, Marie Bonnet, Brice Laurens, Gilles Berrut, Éric Dumas, Philippe Dombret, Sylvie Bonin-Guillaume, Philippe Lauwick, Francis Abramovici, Maria Soto-Martin, Virginie Goutte
The publication of the decree on the care of people with neurocognitive disorders brought to the fore the Reisberg's Global Deterioration Scale, a scale that only few clinicians use in memory centers or in geriatric. This scale has a number of limitations, not least of which is that it is obsolete, since it does not take into account disease advances in scientific knowledge with biomarkers. Consequently, the stages evoked no longer correspond to current descriptions. Moreover, it only concerns Alzheimer's disease, whereas in our practice we encounter other neurodegenerative pathologies...
September 1, 2023: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
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JOURNAL ARTICLE
Alain Tremblay, Shainur Premji, Nguyen Xuan Thanh, Huiming Yang, Paul MacEachern, Erika Penz, Sonya Cressman, Eric L R Bedard
INTRODUCTION: Lung cancer screening (LCS) for high-risk populations has been firmly established to reduce lung cancer mortality, but concerns exist regarding unintended downstream costs. METHODS: Mean health care utilization and costs were compared in the Alberta Lung Cancer Screening Study in a cohort undergoing LCS versus a propensity-matched control group who did not. RESULTS: A cohort of 651 LCS participants was matched to 336 unscreened controls...
December 2023: JTO clinical and research reports
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JOURNAL ARTICLE
Yuhei Inoue, Daniel Lock, Mikihiro Sato, Kurumi Aizawa, Akane Mikura, Natsumi Kohno, Etsuko Ogasawara
OBJECTIVE: Physical activity in a social setting is said to be associated with well-being because it provides opportunities for participants to form social relationships. However, there are inconsistent findings regarding the well-being benefits of participating in physical activity with others. To address this inconclusive evidence, we draw on the social identity approach to health and well-being to examine whether (a) the frequency of physical activity participation in a social setting and (b) the degree of social identification associated with it, have different relationships with participants' well-being...
November 28, 2023: Social Science & Medicine
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REVIEW
Jianxing Song
FUS and TDP-43, two RNA-binding proteins from the heterogeneous nuclear ribonucleoprotein family, have gained significant attention in the field of neurodegenerative diseases due to their association with amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). They possess folded domains for binding ATP and various nucleic acids including DNA and RNA, as well as substantial intrinsically disordered regions (IDRs) including prion-like domains (PLDs) and RG-/RGG-rich regions. They play vital roles in various cellular processes, including transcription, splicing, microRNA maturation, RNA stability and transport and DNA repair...
November 17, 2023: Aging and Disease
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JOURNAL ARTICLE
Kervin O Evans, David L Compton, Christopher D Skory, Michael Appell
Water insoluble α -glucans that were enzymatically synthesized using glucansucrase that was cloned from Leuconostoc mesenteroides NRRL B-1118 were previously shown to form nanoparticles via high pressure homogenization. These α -glucan nanoparticles were previously shown capable of encapsulating a small hydrophobic molecule. This work demonstrates that the same α -glucan can be formed into nanoparticles that encapsulate feruloylated soy glycerides from modified soybean oil, a product of interest to the cosmetic and skin care industries because of the UV absorbance and antioxidant properties of the feruloyl moiety...
December 2023: Biotechnology Reports
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JOURNAL ARTICLE
Masaharu Masuda, Yasuhiro Matsuda, Hiroyuki Uematsu, Ayako Sugino, Hirotaka Ooka, Satoshi Kudo, Subaru Fujii, Mitsutoshi Asai, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takuya Tsujimura, Yosuke Hata, Naoko Higashino, Sho Nakao, Toshiaki Mano
INTRODUCTION: Atrial fibrillation (AF) is accompanied by various types of remodeling, including volumetric enlargement and histological degeneration. Electrical remodeling reportedly reflects histological degeneration. PURPOSE: To clarify the differences in determinants and clinical impacts among types of remodeling. METHODS: This observational study included 1118 consecutive patients undergoing initial ablation for AF. Patients were divided into four groups: minimal remodeling (left atrial volume index [LAVI] < mean value and no low-voltage area [LVA], n = 477); volumetric remodeling (LAVI ≥ mean value and no LVA, n = 361); electrical remodeling (LAVI < mean value and LVA presence, n = 96); and combined remodeling (LAVI ≥ mean value and LVA presence, n = 184)...
November 29, 2023: Journal of Cardiovascular Electrophysiology
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JOURNAL ARTICLE
Nada Soliman, Ruba Almishal, Basant Elsayed, Ayaaz Ahmed, Sara Al-Amri, Aisha Al-Kuwari, Shaikha Al-Muhannadi, Muhammed Nadeer, Tawanda Chivese
OBJECTIVE: The objectives of this study were to investigate associations between micronutrient levels and diabetes and to explore the association in individuals with controlled and uncontrolled diabetes. METHODS: A case-control study, matched on age and gender, was performed on participants with (cases) and without diabetes (controls), who were Qatari or long-term residents (≥15 years of residence). Participants with diabetes were divided into those with controlled and uncontrolled diabetes using an HbA1c cutoff of 7%...
November 14, 2023: Biomedicines
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JOURNAL ARTICLE
Nan Chen, Yao Xu, Chong Xu, Junying Duan, Ye Zhou, Mingfeng Jin, Hao Xia, Wei Yuan, Rui Chen
BACKGROUND AND AIM: Heart failure (HF) is an important complication of ST-elevation myocardial infarction (STEMI), including early- and late-onset HF. This study aimed to investigate the association between insulin resistance (IR)-related parameters triglyceride glucose (TyG) and TyG-body mass index (TyG-BMI) index and early-onset HF in STEMI between sexes. METHODS AND RESULTS: This cross-sectional study included patients with STEMI who underwent primary percutaneous coronary intervention (PCI) between January 2016 and September 2022...
October 4, 2023: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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JOURNAL ARTICLE
Tao Gao, Yinan Zheng, Brian T Joyce, Minjung Kho, James G Terry, Jun Wang, Drew Nannini, John Jeffrey Carr, Sangeeta Nair, Kai Zhang, Wei Zhao, David R Jacobs, Pamela J Schreiner, Philip Greenland, Donald Lloyd-Jones, Jennifer A Smith, Lifang Hou
BACKGROUND: GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with age-related diseases including cancer and cardiovascular diseases. However, the associations between GAA and muscle mass and function are unknown. METHODS: We estimated measures of GAA in 1118 Black and White participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study at exam years (Y) 15 (2000-01) and 20 (2005-06). Abdominal muscle composition was measured using CT scans at the year 25 (2010-11) visit...
November 13, 2023: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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JOURNAL ARTICLE
Eva Aizpurua, Francisco Caravaca-Sánchez, Nancy Wolff
BACKGROUND: Childhood trauma is highly prevalent among incarcerated individuals and contributes to a range of negative outcomes. Assessing traumatic childhood events in prison settings requires valid, reliable, and effective instruments. OBJECTIVES AND METHODS: This study evaluated the performance of the Childhood Trauma Questionnaire - Short Form (CTQ-SF), originally developed and validated in English, within a sample of incarcerated men and women (n = 1118 and n = 207, respectively) in six Spanish prisons...
November 9, 2023: Child Abuse & Neglect
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JOURNAL ARTICLE
Neil Sadick, Sukhmani Pannu, Zehara Abidi, Suleima Arruda
BACKGROUND: Dyschromia is one of the most common reasons for patients to seek dermatological care, especially among individuals with skin of color. Most cases present as melasma or post-inflammatory hyperpigmentation (PIH); both are chronic issues requiring long-term treatment. While many pharmaceutical (topical or systemic) or procedural (lasers/chemical peels) options are available, some treatments are not safe/tolerable for long-term use or can induce/exacerbate PIH. Methods: This qualitative review provides an overview of topical treatments for melasma and PIH, including recent data from an investigator-initiated trial of the retinoid tazarotene...
November 1, 2023: Journal of Drugs in Dermatology: JDD
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JOURNAL ARTICLE
Luise Ernst, Hanna Offermann, Annemarie Werner, Daniel Wefers
Several lactic acid bacteria are able to produce water-soluble and water-insoluble homoexopolysaccharides (HoEPS) from sucrose. In this study, structures of all HoEPS which were fermentatively produced by Leuconostoc mesenteroides subsp. dextranicum NRRL B-1121 and B-1144, Leuconostoc mesenteroides subsp. mesenteroides NRRL B-1149, B-1438 and B-1118, Leuconostoc suionicum DSM 20241, and Liquorilactobacillus satsumensis DSM 16230 were systematically analyzed. Monosaccharide analysis, methylation analysis, NMR spectroscopy, size-exclusion chromatography, and different enzymatic fingerprinting methods were used to obtain detailed structural information...
January 1, 2024: Carbohydrate Polymers
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JOURNAL ARTICLE
Carolina Ayelen Isnardi, Deshire Alpizar-Rodriguez, Débora Cerqueira Calderaro, Claudia Diniz Lopes Marques, Guillermo Javier Pons-Estel, Ricardo Machado Xavier, Verónica Saurit, Cecilia Nora Pisoni, Yohana Soledad Tissera, Maria Eugenia D'Angelo Exeni, Paula Alba, Dora Pereira, Carla Andrea Gobbi, Maria Julieta Gamba, María Agustina Alfaro, Belén María Virasoro, Iris Jazmín Colunga-Pedraza, Fedra Irazoque-Palazuelos, Greta Reyes-Cordero, Tatiana S Rodriguez-Reyna, Jose Antonio Veloz-Aranda, Cassandra Michele Skinner-Taylor, Ingrid Maribel Juárez-Mora, Luis H Silveira, Cesar Francisco Pacheco Tena, Daniel Xavier Xibille-Friedmann, Gilda Aparecida Ferreira, Adriana Maria Kakehasi, Marcelo Medeiros Pinheiro, Ana Paula Monteiro Gomides, Gecilmara Cristina Salviato Pileggi, Licia Maria Henrique da Mota, Edgard Torres Dos Reis-Neto, Sandra Lúcia Euzébio Ribeiro, Lilian David de Azevedo Valadares, Marco Ulises Martínez-Martínez
OBJECTIVE: To describe characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with rheumatic immune-mediated inflammatory diseases (IMIDs) from Argentina, Mexico and Brazil, and to assess factors associated with mortality in this population. METHODS: Data from 3 national registries, SAR-COVID (Argentina), CMR-COVID (Mexico), and ReumaCoV-Brasil (Brazil), were combined. Adult patients with IMIDs and SARS-CoV-2 infection were recruited...
November 14, 2023: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
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JOURNAL ARTICLE
Cuiying Mo, Xufen Huang, Xiaohua Lu, Yan Zhou, Yingyi Su, Huanhua Zhang
PURPOSE: To investigate the knowledge, attitude, and practice (KAP) on insulin pump among non-endocrinology nurses in Southern China. METHODS: This multicenter cross-sectional study enrolled non-endocrinology nurses in Southern China between November 2020 and December 2020. A structured questionnaire about insulin pumps was designed and used to collect data. RESULTS: A total of 1118 nurses from 29 hospitals participated in the study. The majority of them were female (98...
2023: Diabetes, Metabolic Syndrome and Obesity
#60
JOURNAL ARTICLE
H L Maggard, G G Habing, D L Renaud, K L Proudfoot, Z A England, T-Y Cheng, D J Wilson, M Moran, J A Pempek
In North America, surplus dairy calves are sold soon after birth and often marketed through a third party (e.g., live auction, livestock dealer) before entering veal or dairy beef production. Previous work has demonstrated that a percentage of calves have failed transfer of passive immunity (FTPI) and clinical signs of disease on arrival at calf-raising facilities, but little is known regarding calf condition during marketing. The objectives of this cross-sectional study were to (1) estimate the prevalence of FTPI and poor health outcomes in surplus calves on arrival at livestock dealers, and (2) investigate the association between calf-level variables (body weight, sex, source) and health outcomes...
November 1, 2023: Journal of Dairy Science
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