Huijun Yuan, Shaoyi Chen, Matthew R Duncan, Juan Pablo de Rivero Vaccari, Robert W Keane, W Dalton Dietrich, Tsung-Han Chou, Merline Benny, Augusto F Schmidt, Karen Young, Kevin K Park, Vittorio Porciatti, M Elizabeth Hartnett, Shu Wu
BACKGROUND: Retinopathy of prematurity (ROP), which often presents with bronchopulmonary dysplasia (BPD), is among the most common morbidities affecting extremely premature infants and is a leading cause of severe vision impairment in children worldwide. Activations of the inflammasome cascade and microglia have been implicated in playing a role in the development of both ROP and BPD. Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is pivotal in inflammasome assembly...
May 6, 2024: Angiogenesis