Matthew Allison, Pablo Caramés-Méndez, Christopher M Pask, Roger M Phillips, Rianne M Lord, Patrick C McGowan
The synthesis and characterisation of new bis(bipyridine)ruthenium(II) ferrocenyl β-diketonate complexes, [(bpy)2Ru(Fc-acac)][PF6] (bpy = 2,2'-bipyridine; Fc-acac = functionalized ferrocenyl β-diketonate ligand) are reported. Alongside clinical platinum drugs, these bimetallic ruthenium-iron complexes have been screened for their cytotoxicity against MIA PaCa-2 (human pancreatic carcinoma), HCT116 p53+/+ (human colon carcinoma, p53-wild type) and ARPE-19 (human retinal pigment epithelial) cell lines. With the exception of one complex, the library exhibit nanomolar potency against cancerous cell lines, and their relative potencies are up to 40x, 400x and 72x more cytotoxic than cisplatin, carboplatin and oxaliplatin, respectively...
October 19, 2020: Chemistry: a European Journal
Rong Cao, Keqi Wang, Manmei Long, Miaomiao Guo, Lulu Sheng, Ming Zhan, Ruimeng Yang, Hui Wang, Linhua Yang
Pancreatic cancer (PC) is a leading cause of cancer mortality and is expected to continue increasing incidence. Abnormally expressed microRNAs have been demonstrated tightly correlated with the development and progression of PC. However, the molecular mechanisms remain largely unknown. In this study through combing both the TCGA database and our two verification PC cohorts, we found the consistent reduction of miR-3613-5p in PC tumors, which significantly correlated with reduced cumulative survival rate among PC patients...
October 19, 2020: Cell Cycle
Hongkai Zhuang, Zixuan Zhou, Zuyi Ma, Zhenchong Li, Chunsheng Liu, Shanzhou Huang, Chuanzhao Zhang, Baohua Hou
Integrin β (ITGB) superfamily members have been reported to play important roles in multiple biological functions in various cancers. However, the prognostic and oncologic values of ITGB superfamily members have not been systematically investigated in pancreatic cancer (PC). In this study, the mRNA expression and biological functions of ITGB superfamily members in PC were evaluated by bioinformatic analysis. Our results demonstrated that ITGB1, ITGB4, ITGB5 and ITGB6 overexpressions were significantly associated with advanced AJCC stage and histologic grade, and worse prognosis in PC...
October 18, 2020: Journal of Cellular and Molecular Medicine
Yuki Tanisaka, Shomei Ryozawa, Masafumi Mizuide, Ryuichiro Araki, Akashi Fujita, Tomoya Ogawa, Tomoaki Tashima, Tatsuya Noguchi, Masahiro Suzuki, Hiromune Katsuda
BACKGROUND AND AIMS: Endoscopic retrograde cholangiopancreatography (ERCP) in patients with surgically altered anatomy is still challenging. Usefulness of single-balloon enteroscopy (SBE)-assisted ERCP has been increasingly reported. Short SBE is considered beneficial with a 152-cm working length and a 3.2-mm working channel. This has increased the variety of devices that can be used during ERCP procedures. The aim of this pooled analysis was to evaluate the efficacy of SBE-assisted ERCP in patients with surgically altered anatomy and elucidate the current status...
October 18, 2020: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Hiroshi Kasamatsu, Noritaka Oyama, Minoru Hasegawa, Yohei Oku, Genki Inoue, Makiko Kimura, Masataka Kanno, Takumi Kawakami, Hajime Ohta, Manabu Yoneshima
Pancreatic panniculitis (PP) is a rare clinical variant of subcutaneous fat necrosis, developing in patients with a variety of pancreatic diseases such as acute or chronic pancreatitis, tumors and cysts. The tumor-associated PP represents a noteworthy skin manifestation of underlying internal malignancies, also known as dermadrome. Among causative pancreatic tumors, acinar cell carcinoma is the most frequent malignancy; however, little is known about how the origin of tumor cells and progression stage of pancreatic tumors potentially contribute to the establishment of panniculitis...
October 18, 2020: Journal of Dermatology
Dimitrios Schizas, Spyridon Peppas, Stefanos Giannopoulos, Vasiliki Lagopoulou, Konstantinos S Mylonas, Spyridon Giannopoulos, Dimitrios Moris, Evangelos Felekouras, Konstantinos Toutouzas
BACKGROUND: Cirrhosis has been considered a contraindication to major abdominal surgeries, due to increased risk for postoperative morbidity and mortality. The aim of this study was to assess the safety of pancreatectomy in cirrhotic versus non-cirrhotic patients. METHODS: The present systematic review and meta-analysis was performed according to the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines. All meta-analyses were performed using the random effects model...
October 18, 2020: World Journal of Surgery
Ravneet Vohra, Matthew D Campbell, Joshua Park, Stella Whang, Kayla Gravelle, Yak-Nam Wang, Joo-Ha Hwang, David J Marcinek, Donghoon Lee
Background: Cancer cachexia is a multifactorial wasting syndrome that is characterized by the loss of skeletal muscle mass and weakness, which compromises physical function, reduces quality of life, and ultimately can lead to mortality. Experimental models of cancer cachexia have recapitulated this skeletal muscle atrophy and consequent decline in muscle force generating capacity. We address these issues in a novel transgenic mouse model Kras, Trp53 and Pdx-1-Cre ( KPC ) of pancreatic ductal adenocarcinoma (PDA) using multi-parametric magnetic resonance (mp-MR) measures...
July 2020: JCSM Rapid Communications
Aubrey L Miller, Patrick L Garcia, Tracy L Gamblin, Rebecca B Vance, Karina J Yoon
Aim: Gemcitabine is a frontline agent for locally-advanced and metastatic pancreatic ductal adenocarcinoma (PDAC), but neither gemcitabine alone nor in combination produces durable remissions of this tumor type. We developed three PDAC patient-derived xenograft (PDX) models with gemcitabine resistance (gemR) acquired in vivo , with which to identify mechanisms of resistance relevant to drug exposure in vivo and to evaluate novel therapies. Methods: Mice bearing independently-derived PDXs received 100 mg/kg gemcitabine once or twice weekly...
2020: Cancer Drug Resistance
Olaf Sommerburg, Jutta Hammermann
There are currently four countries and one local region in Europe that use PAP in their newborn screening programme. The first country to employ PAP at a national level was the Netherlands, which started using IRT/PAP/DNA/EGA in 2011. Germany followed in 2016 with a slightly different IRT/PAP/DNA strategy. Portugal also started in 2016, but with an IRT/PAP/IRT programme, and in 2017, Austria changed its IRT/IRT protocol to an IRT/PAP/IRT program. In 2018, Catalonia started to use an IRT/PAP/IRT/DNA strategy...
June 2020: International Journal of Neonatal Screening
Cheng-Peng Li, Zhen Wang, Bo-Nan Liu, Ang Lv, Dao-Ning Liu, Jian-Hui Wu, Hui Qiu, Chun-Yi Hao
Background: En bloc resection of retroperitoneal sarcoma (RPS) with adjacent organs such as pancreatic head and duodenum is challenging for surgeons. This mono-institutional study aims to evaluate the feasibility, safety, and outcome of performing pancreaticoduodenectomy (PD) during RPS resection. Methods: The clinical data of RPS patients who underwent PD at the Sarcoma Center of Peking University Cancer Hospital from January 2011 to December 2019 was collected and analyzed...
2020: Frontiers in Oncology
Xin Zhou, Wei Gao, Huanhuan Hua, Zhimin Ji
Objective: To investigate the role of lncRNA-BLACAT1 in promoting H3K27 trimethylation of CDKN1C gene by recruiting EZH2 to regulate CCNE on glycolysis and mitochondrial oxidative phosphorylation of pancreatic cancer (PC) cells. Methods: Following bioinformatic prediction, EZH2 and BLACAT1 in PC cells were interfered, and cells proliferation, migration and invasion in each group were detected. Western blotting detected the expression of key proteins of mitochondrial complex...
2020: Frontiers in Oncology
Francesca Tavano, Andrea Fontana, Tommaso Mazza, Domenica Gioffreda, Tommaso Biagini, Orazio Palumbo, Massimo Carella, Angelo Andriulli
The high prevalence of early-diabetes in patients with pancreatic cancer (PanC) implies that its recognition could help identify people at high risk of developing PanC. Candidate microRNAs (miRNAs) associated with recent diabetes were screened from our previous miRNA expression profiling on 10 pools of plasma from PanC patients and non-PanC controls, both including also subjects with early- and late-diabetes. The droplet digital PCR (ddPCR) was used to re-test candidate miRNAs in a new independent cohort of 69 subjects (40 PanC, 29 non-PanC) with early- (17 PanC, 13 non-PanC) or late-diabetes (23 PanC, 16 non-PanC), and in 100 non-diabetic healthy subjects (HS)...
2020: Frontiers in Oncology
Ibrahim Almafreji, Sathyaprakash Ranganath
An 83-year-old man presented to the emergency department (ED) during the peak of the first wave of the SARS CoV-2 (COVID-19) pandemic with severe abdominal pain, mimicking a severe abdominal pathology. He was found to have features suggestive of COVID-19 infection radiologically, with no leaking aortic aneurysm, bowel ischemia, pancreatitis, or perforation. With worsening symptoms, a repeat computer tomography (CT) scan four days later showed features of bowel ischemia, and he underwent a laparotomy and right hemicolectomy...
September 14, 2020: Curēus
Shehriyar Mehershahi, Asim Haider, Danial Shaikh, Hafsa Abbas, Ariyo Ihimoyan
The list of drugs associated with acute pancreatitis is increasing with each passing year. Nevertheless, knowledge of drug-induced pancreatitis (DIP) are often curtailed by the limited availability of evidence needed to implicate given agents, especially for non-prescription medications. Indeed, the majority of available data are derived from case reports, case series, or case-control studies. We present a case chemically and radiologically proven pancreatitis in a 43-year-old female who was on sulfasalazine as a maintenance therapy for ulcerative colitis...
September 14, 2020: Curēus
Junare Parmeshwar Ramesh, Chandnani Sanjay, Suhas Udgirkar, Nair Sujit, Debnath Prasanta, Modi Ammar, Debnath Partha, Jain Shubham, Ravi Thanage, Rathi Pravin, Contractor Qais
Acute pancreatitis (AP) is an acute inflammatory process of the pancreas with variable clinical presentations. Splanchnic venous thrombosis is a well-known vascular complication of AP and commonly present as thrombosis of the splanchnic venous system: splenic vein (SplV), portal vein (PV) and superior mesenteric vein (SMV), either separately or in combinations. Involvement of extra-splanchnic vessels is rare and associated with morbidity and mortality. Vascular complications are late phenomena and usually associated with local complications of AP, namely acute fluid collections, necrotizing pancreatitis and walled-off pancreatic necrosis...
September 4, 2020: Clinics and Practice
Mehdi Razavi, Rosita Primavera, Bhavesh D Kevadiya, Jing Wang, Peter Buchwald, Avnesh S Thakor
The aim of this work was to develop, characterize and test a novel 3D bioscaffold matrix which can accommodate pancreatic islets and provide them with a continuous, controlled and steady source of oxygen to prevent hypoxia-induced damage following transplantation. Hence, we made a collagen based cryogel bioscaffold which incorporated calcium peroxide (CPO) into its matrix. The optimal concentration of CPO integrated into bioscaffolds was 0.25wt.% and this generated oxygen at 0.21±0.02mM/day (day 1), 0.19±0...
April 14, 2020: Advanced Functional Materials
Christian Schneeweis, Zonera Hassan, Markus Schick, Ulrich Keller, Günter Schneider
An urgent medical need to develop novel treatment strategies for patients with pancreatic ductal adenocarcinoma (PDAC) exists. However, despite various efforts in the histopathological and molecular subtyping of PDAC, novel targeted or specific therapies have not been established. Posttranslational modifications (PTMs) with ubiquitin-like proteins, including small ubiquitin-like modifiers (SUMOs), mediate numerous processes that can contribute to the fitness and survival of cancer cells. The contribution of SUMOylation to transcriptional control, DNA repair pathways, mitotic progression, and oncogenic signalling has been described...
October 19, 2020: British Journal of Cancer
Pukar Khanal, Basanagouda M Patil
OBJECTIVE: Duranta repens is reported to contain a wide array of secondary metabolites, including α-amylase and α-glucosidase inhibitors, and - has potent antioxidant activity. The present study evaluated the network pharmacology of D. repens (whole plant) with targets related to diabetes mellitus and assessed its outcome by evaluating the effects of the hydroalcoholic extract of D. repens in streptozotocin-nicotinamide-induced diabetes mellitus in rats. METHODS: Phytoconstituents of D...
October 7, 2020: Journal of Integrative Medicine
Marina M Bellet, Monica Borghi, Marilena Pariano, Giorgia Renga, Claudia Stincardini, Fiorella D'Onofrio, Stefano Brancorsini, Enrico Garaci, Claudio Costantini, Luigina Romani
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the gene encoding for the ion channel Cystic Fibrosis Transmembrane conductance Regulator (CFTR). Long considered a lung disease for the devastating impact on the respiratory function, the recent diagnostic and therapeutic advances have shed the light on the extra-pulmonary manifestations of CF, including gastrointestinal, hepatobiliary and pancreatic symptoms. We have previously demonstrated that thymosin alpha1 (Tα1), a naturally occurring immunomodulatory peptide, displays multi-sided beneficial effects in CF that concur in ameliorating the lung inflammatory pathology...
October 9, 2020: European Journal of Medicinal Chemistry
Jenni Perrin, Bathiya Ratnayake, Cameron Wells, John A Windsor, Benjamin P T Loveday, Neil MacLennan, Helen Lindsay, Sanjay Pandanaboyana
BACKGROUND: This study compared epidural analgesia with local anesthetic administration via transabdominal wall catheters (TAWC), to determine the effect on perioperative outcomes in pancreatic surgery. MATERIALS AND METHODS: A retrospective review of patients undergoing open pancreatic surgery at Auckland City Hospital from 2015 to 2018 was undertaken. Data collected included patient demographics, type of perioperative analgesia, intravenous fluid and vasopressor use, length of high dependency unit stay, postoperative complications, and length of hospital stay...
October 15, 2020: Journal of Surgical Research
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