Anna Nevalainen, Olli Nevalainen
BACKGROUND: Pharmacovigilance risk signals have proposed a relationship between the use of acid-suppressive medications and the development of certain autoimmune and immune-mediated inflammatory diseases. OBJECTIVE: A systematic review and a meta-analysis was performed. METHODS: We reviewed MEDLINE (Ovid) and Scopus for comparative observational studies between these diseases and previous exposure to proton-pump inhibitors (PPI), H2-receptor antagonists (H2RA), and antacids...
November 15, 2022: International Journal of Risk & Safety in Medicine
Cristina Cadenas-Sanchez, Rafael Cabeza, Fernando Idoate, Maddi Osés, María Medrano, Arantxa Villanueva, Lide Arenaza, Aritz Sanz, Francisco B Ortega, Jonatan R Ruiz, Idoia Labayen
IMPORTANCE: Excess abdominal fat is a major determinant in the development of insulin resistance and other metabolic disorders. Increased visceral adipose tissue (VAT) seems to precede the development of insulin resistance and is therefore a prime target of childhood lifestyle interventions aimed at preventing diabetes. OBJECTIVES: To examine the effect of added exercise to a family-based lifestyle intervention program designed to reduce VAT plus subcutaneous (ASAT), intermuscular (IMAAT), and pancreatic (PAT) adipose tissue in children with overweight or obesity and to explore the effect of changes in VAT on insulin resistance...
November 1, 2022: JAMA Network Open
Haiyang Lai, Ketong Wu, Yang Liu, Dan Li, Tao Peng, Bo Zhang
UNLABELLED: BACKGROUND AND GOALS: Gastric outlet obstruction (GOO) usually occurs at the pylorus or the duodenum through primary gastric, duodenal, or pancreatic tumors. However, metastatic GOO is relatively rare. Although self-expandable metal stent (SEMS) placement is often performed as an alternative and practical palliative approach for primary GOO, there are few reports of metastatic GOO treatment with SEMS. This study aimed to investigate the efficacy, safety, stent patency, and complications of SEMS for treating primary and metastatic GOO...
November 28, 2022: Irish Journal of Medical Science
Tomasz Draus, Daniel Ansari, Roland Andersson
BACKGROUND: Detecting pancreatic cancer at an earlier stage may contribute to an increased survival. Patients with stage I pancreatic cancer have a 5-year survival rate of 36%, while stage IV patients have a 5-year survival rate of 1% in Sweden. Research into novel blood-based biomarkers for pancreatic cancer is highly intensive and innovative, but has yet to result in any routine screening test. The aim of this study was to evaluate the specificity and sensitivity of a hypothetical blood test for pancreatic cancer used for screening purposes and the economic aspects of testing...
November 28, 2022: Scandinavian Journal of Gastroenterology
Han Xie, Xinmei Wang, Min Xue, Yudong Qiu, Weihong Ge
WHAT IS KNOWN AND OBJECTIVE: As the incidence of postoperative pain in patients with biliary and pancreatic diseases has gradually increased, how to control postoperative pain has received increasing research attention. By reading pain management guidelines and multidisciplinary communication and cooperation, clinical pharmacists designed multi-mode analgesia regimens based on surgical types, in order to provide strong evidence for the effectiveness and safety of postoperative analgesia regimens and better serve patients...
November 28, 2022: Journal of Clinical Pharmacy and Therapeutics
Yanan Xu, Zhaoqi Zhang, Yang Zhao, Chenxu Zhao, Mingpu Shi, Xue Dong, Jiayu Zhang, Liang Tan, Lianfeng Zhang, Yong Zhao
Myeloid cell development in bone marrow is essential for the maintenance of peripheral immune homeostasis. However, the role of intracellular protein trafficking pathways during myeloid cell differentiation is currently unknown. By mining bioinformatics data, we identify trafficking protein particle complex subunit 1 (TRAPPC1) as continuously upregulated during myeloid cell development. Using inducible ER-TRAPPC1 knockout mice and bone marrow chimeric mouse models, we demonstrate that TRAPPC1 deficiency causes severe monocyte and neutrophil defects, accompanied by a selective decrease in common myeloid progenitors (CMPs) and subsequent cell subsets in bone marrow...
November 28, 2022: EMBO Reports
Raphaelle D Vallera, Yanli Ding, Kimmo J Hatanpaa, Justin A Bishop, Sasan Mirfakhraee, Abdel A Alli, Sergei G Tevosian, Mouna Tabebi, Oliver Gimm, Peter Söderkvist, Cynthia Estrada-Zuniga, Patricia L M Dahia, Hans K Ghayee
Genetic testing has become the standard of care for many disease states. As a result, physicians treating patients who have tumors often rely on germline genetic testing results for making clinical decisions. Cases of two sisters carrying a germline CHEK2 variant are highlighted whereby possible other genetic drivers were discovered on tumor analysis . CHEK2 (also referred to as CHK2) loss of function has been firmly associated with breast cancer development. In this case report, two siblings with a germline CHEK2 mutation also had distinct endocrine tumors...
2022: Frontiers in Endocrinology
Tian Fang, Gong Xue, Wu Jianjun, Long Wei, Zhang Xiaomeng, Yang Fan
BACKGROUND: Emerging evidence shows that exosomes play a crucial role in the occurrence and development of diabetes and its complications. The molecules in exosomes can be regarded as important markers for the diagnosis of diseases. However, it is presently unclear the pathological association mechanism between exosomes and diabetes. RESULTS: In this study, transcriptome data and lncRNA regulatory association data of human pancreatic islet-derived exosome were integrated to construct the ceRNA network...
2022: Frontiers in Endocrinology
Xiaoyu Yu, Yuan Xing, Yiyu Zhang, Pu Zhang, Yi He, Farid Ghamsari, Melur K Ramasubramanian, Yong Wang, Huiwang Ai, Jose Oberholzer
Smartphone technology has been recently applied for biomedical image acquisition and data analysis due to its high-quality imaging capability, and flexibility to customize multi-purpose apps. In this work, we developed and characterized a smartphone-microfluidic fluorescence imaging system for studying the physiology of pancreatic islets. We further evaluated the system capability by performing real-time fluorescence imaging on mouse islets labeled with either chemical fluorescence dyes or genetically encoded fluorescent protein indicators (GEFPIs)...
2022: Frontiers in Endocrinology
Tomonori Okita, Shunbun Kita, Shiro Fukuda, Keita Fukuoka, Emi Kawada-Horitani, Masahito Iioka, Yuto Nakamura, Yuya Fujishima, Hitoshi Nishizawa, Dan Kawamori, Taka-Aki Matsuoka, Maeda Norikazu, Iichiro Shimomura
Endogenous humoral factors that link systemic and/or local insulin demand to pancreatic β-cells have not been identified. Here, we demonstrated that T-cadherin, a unique glycosylphosphatidylinositol-anchored cadherin primarily expressed in vascular endothelial cells and cardiac and skeletal muscle cells, but not in pancreatic β-cells, was secreted as soluble forms and was important for β-cell proliferation. Cdh13 (T-cadherin) knockout mice exhibited impaired glucose handling due to attenuated β-cell proliferation under high-fat diet conditions...
November 18, 2022: IScience
Jane Yu, Elizabeth Jenkins, Juan M Podadera, Nicholas Proschogo, Ringo Chan, Lara Boland
CASE SUMMARY: A 3-year-old female neutered domestic shorthair cat was presented for vomiting, inappetence and weight loss. The cat developed moderately regenerative anaemia, moderately increased alanine transaminase and alkaline phosphatase activities, hyperbilirubinaemia and prolonged activated partial thromboplastin time. Abdominal ultrasound identified gastric wall thickening and changes suggestive of pancreatitis. Gastroduodenoscopy identified a metal screw nut in the pylorus, which was removed with rat tooth forceps...
2022: JFMS Open Reports
Bharadwaj Adithya Sateesh, Nicole Gousy, Yogesh Prajapati, Girma M Ayele, Miriam B Michael
Dysphagia lusoria (DL) occurs due to an aberrant right subclavian artery (ARSA) compressing the esophagus resulting in dysphagia, odynophagia, and/or reflux symptoms. It is diagnosed by barium esophagram followed by a CT scan or MRI. In this case report, there is a 44-year-old male with a chronic history of reflux and a cough that presents after a meal. The case was complicated due to the history of the patient's alcoholism with recurrent pancreatitis. A CT scan was obtained during his admission, which showed pleural effusion, atelectasis, aspiration pneumonia, and an incidental aberrant RCA...
October 2022: Curēus
Jimm Grimm, Shiva F Naidoo, Kristena Yossef, Gaurav Shukla, Carla J Scofield, Abby C Searfoss, Madison A Zulkoski, James A Tanyi, Heath B Mackley, Anand Mahadevan
PURPOSE: Utilization of breathhold scans with live tracking has a long track record of good published outcomes for stereotactic body radiation therapy (SBRT) and is recommended by the manufacturer of the Synchrony tracking system. However, the popularity of four-dimensional computed tomography (4DCT) scans challenges the validity of the breathhold scan with live tracking technique. Although this study is not intended to prove the superiority of either method, we demonstrate the feasibility of using the breathhold scans with a phantom test and clinical examples...
October 2022: Curēus
Shreshtha Singh, Harshdeep Tyagi, Archana Khanduri, Nalini Bansal, Rahul Gupta
Clinical practice frequently involves the discovery of perineal lesions. The human papillomavirus, molluscum contagiosum, and herpes simplex virus are to blame for the majority of these anogenital lesions. In the majority of cases, these lesions may be identified by their distinctive appearance. It is challenging to make a clinical diagnosis in immunocompromised people since these lesions might be large and have uncommon appearances. Verrucous perianal herpes is a rare type of herpes that resembles squamous cell carcinoma in gross appearance...
October 2022: Curēus
Colin M Krueger, Melanie Langheinrich, Esther A Biesel, Lena Kundel, Karsten Krueger, Ulrich Adam, Hartwig Riediger
BACKGROUND: Postoperative pancreatic fistula (POPF) is the most critical complication after pancreatoduodenectomy (PD). Preoperative identification of high-risk patients and optimal pancreatic reconstruction technique can be a way to reduce postoperative complications. METHODS: A series of 386 patients underwent PD over a 10-year period (2009-2019). On routinely performed preoperative computed tomography (CT) images, the ventro-dorsal diameters of duct (D) and parenchyma (P) were measured in the cutting plane at the superior mesenteric vein...
2022: Frontiers in Surgery
Xuan Xu, Lulu Guan, Yao Wu, Huajing Ke, Yuanbin Zhao, Pi Liu
BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) has developed over the past few decades into a reliable technology for diagnostic and therapeutic purposes. Through a bibliometric analysis, this research attempted to evaluate the characteristics of the top 100 articles on ERCP that had the most citations. METHODS: We extracted pertinent publications from the Web of Science Core Collection (WoSCC) on July 9, 2022. The top 100 ERCP articles with the most citations were identified and analyzed...
2022: Frontiers in Surgery
Huijun Lei, Min Zhang, Luyao Zhang, Kari Hemminki, Xiao-Jia Wang, Tianhui Chen
Carriers with BRCA1/2 germline pathogenic variants are associated with a high risk of breast and ovarian cancers (also pancreatic and prostate cancers). While the spectrum on germline BRCA mutations among the Chinese population shows ethnic specificity, the identification of carriers with germline BRCA mutation before cancer onset is the most effective approach to protect them. This review focused on the current status of BRCA1/2 screening, the surveillance and prevention measures, and discussed the issues and potential impact of BRCA1/2 population screening in China...
2022: Frontiers in Oncology
Sehrish Javed, Touseef Ahmad Qureshi, Srinivas Gaddam, Lixia Wang, Linda Azab, Ashley Max Wachsman, Wansu Chen, Vahid Asadpour, Christie Younghae Jeon, Beichien Wu, Yibin Xie, Stephen Jacob Pandol, Debiao Li
Early detection of Pancreatic Ductal Adenocarcinoma (PDAC) is complicated as PDAC remains asymptomatic until cancer advances to late stages when treatment is mostly ineffective. Stratifying the risk of developing PDAC can improve early detection as subsequent screening of high-risk individuals through specialized surveillance systems reduces the chance of misdiagnosis at the initial stage of cancer. Risk stratification is however challenging as PDAC lacks specific predictive biomarkers. Studies reported that the pancreas undergoes local morphological changes in response to underlying biological evolution associated with PDAC development...
2022: Frontiers in Oncology
Dong Wang, Huajun Lin, Chengjian Guan, Xiaodong Zhang, Peixin Li, Chenglin Xin, Xiaobao Yang, Zhewen Feng, Yiyang Min, Xiaozhe Gu, Wei Guo
BACKGROUND AND OBJECTIVES: Obstructive jaundice is common in patients with pancreaticobiliary malignancies. Preoperative biliary drainage (PBD) can alleviate cholestasis; however, no consensus has been reached on the impact of PBD on the incidence of surgery-related complications and patient survival. This study aimed to evaluate the effect among patients treated with PBD. METHODS: This retrospective study examined the clinical and follow-up prognostic data of 160 patients with pancreaticobiliary malignancies who underwent pancreaticoduodenectomy (PD) at Beijing Friendship Hospital, Capital Medical University, from January 2016 to July 2020...
2022: Frontiers in Oncology
Jia Yan, Huang Yilin, Wu Di, Wang Jie, Wang Hanyue, Liu Ya, Peng Jie
OBJECTIVE: Gram-negative bacilli (GNB) are common pathogens of infection in severe acute pancreatitis (SAP), and their occurrence increases the mortality of SAP. Early identification of SAP severity and prognosis is of great significance to SAP treatment. This study explored risk factors for mortality in patients with SAP and GNB infection and established a model for early prediction of the risk of death in GNB-infected SAP patients. METHODS: Patients diagnosed with SAP from January 1, 2016, to March 31, 2022, were included, and their baseline clinical characteristics were collected...
2022: Frontiers in Cellular and Infection Microbiology
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