Chang Xu, Jin-Feng Cao, Yue Pei, Yujin Kim, Huiyeon Moon, Chui-Qin Fan, Mao-Chuan Liao, Xing-Yu Wang, Fei Yao, Yu-Jun Zhang, Shao-Hui Zhang, Jian Zhang, Jian-Zhang Li, Jong Seung Kim, Lian Ma, Zhong-Jian Xie
Chronic skin wounds are a serious complication of diabetes with a high incidence rate, which can lead to disability or even death. Previous studies have shown that mesenchymal stem cells derived extracellular vesicles (EVs) have beneficial effects on wound healing. However, the human foreskin mesenchymal stem cell (FSMSCs)-derived extracellular vesicle (FM-EV) has not yet been isolated and characterized. Furthermore, the limited supply and short lifespan of EVs also hinder their practical use. In this study, we developed an injectable dual-physical cross-linking hydrogel (PSiW) with self-healing, adhesive, and antibacterial properties, using polyvinylpyrrolidone and silicotungstic acid to load FM-EV...
April 27, 2024: Journal of Controlled Release