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https://read.qxmd.com/read/32219626/experience-of-clinical-management-for-pregnant-women-and-newborns-with-novel-coronavirus-pneumonia-in-tongji-hospital-china
#1
Shao-Shuai Wang, Xuan Zhou, Xing-Guang Lin, Yan-Yan Liu, Jian-Li Wu, Lali Mwamaka Sharifu, Xiao-Lin Hu, Zhi-Hui Rong, Wei Liu, Xiao-Ping Luo, Zhuo Chen, Wan-Jiang Zeng, Su-Hua Chen, Ding Ma, Ling Chen, Ling Feng
Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia (Trial Edition 5), combined with our current clinical treatment experience, we recently proposed a revision of the first edition of "Guidance for maternal and fetal management during pneumonia epidemics of novel coronavirus infection in the Wuhan Tongji Hospital". This article focused on the issues of greatest concern of pregnant women including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnostic criteria, inspection precautions, drug treatment options, indications and methods of termination of pregnancy, postpartum fever, breastfeeding considerations, mode of mother-to-child transmission, neonatal isolation and advice on neonatal nursing, to provide valuable experience for better management of SARS-CoV-2 infection in pregnant women and newborns...
March 26, 2020: Current Medical Science
https://read.qxmd.com/read/32219535/-highly-dosed-anderson-and-kestenbaum-operations-for-anomalous-head-posture-due-to-nystagmus
#2
Michael Gräf, Anja Hausmann, Dominik Kowanz, Birgit Lorenz
BACKGROUND: The correction of anomalous head posture associated with infantile nystagmus syndrome (INS) is carried out by the Kestenbaum procedure (KP) combining bilateral horizontal yoke muscle recession with resection of their antagonists or by the Anderson procedure (AP) which is confined to yoke muscle recession alone. AIM OF THE STUDY: To compare the results of highly dosed AP and KP for anomalous head turn (HT). PATIENTS AND METHODS: The AP (2013-2019) and KP (2003-2013) were used as the exclusive procedures during the respective time periods...
March 26, 2020: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://read.qxmd.com/read/32218512/synergistic-effects-of-depression-and-nr3c1-methylation-on-prognosis-of-acute-coronary-syndrome
#3
Hee-Ju Kang, Robert Stewart, Ju-Wan Kim, Sung-Wan Kim, Il-Seon Shin, Min-Chul Kim, Young Joon Hong, Youngkeun Ahn, Myung-Geun Shin, Myung Ho Jeong, Jin-Sang Yoon, Jae-Min Kim
High levels of methylation in the GR gene (nuclear receptor subfamily 3, group C, member 1; NR3C1) have been associated with depression and cardiovascular risk. This study aimed to investigate whether NR3C1 methylation status was associated with the long-term prognosis of acute coronary syndrome (ACS) considering depression and cardiovascular status at the early phase of ACS. A total of 969 patients with recent ACS were recruited at a tertiary university hospital in Korea. Baseline evaluations were made from 2007 to 2012, including DSM-IV depressive disorder, NR3C1 methylation, and various demographic and clinical characteristics such as cardiovascular risk markers...
March 26, 2020: Scientific Reports
https://read.qxmd.com/read/32216658/balance-markers-and-saccadic-eye-movement-measures-in-adolescents-with-postconcussion-syndrome
#4
Coralie Rochefort, Elizabeth Legace, Chadwick Boulay, Gail Macartney, Kristian Goulet, Roger Zemek, Heidi Sveistrup
CONTEXT: Deficits in both balance and oculomotor function, including impairments in saccadic eye movements, are observed in approximately 30% of patients postconcussion. Whereas balance and saccadic eye movements are routinely assessed separately, growing evidence suggests that they should be assessed concurrently. OBJECTIVE: To compare balance measures and saccades between adolescents 1 to 3 months postconcussion and healthy uninjured adolescents. DESIGN: Case-control study...
March 27, 2020: Journal of Athletic Training
https://read.qxmd.com/read/32216545/fat-on-a-chip-models-for-research-and-discovery-in-obesity-and-its-metabolic-co-morbidities
#5
Michelle McCarthy, Theodore Brown, Andrea Alarcon, Christopher Williams, Xiying Wu, Rosalyn Abbott, Jeffrey M Gimble, Trivia Frazier
The obesity epidemic and its associated co-morbidities present a looming challenge to health care delivery throughout the world. Obesity is characterized as a sterile inflammatory process within adipose tissues leading to dysregulated secretion of bio-active adipokines such as adiponectin and leptin as well as systemic metabolic dysfunction. The majority of current obesity research has focused primarily on pre-clinical animal models in vivo and two-dimensional (2D) cell culture models in vitro. Neither of these generalized approaches is optimal due to inter-species variability, insufficient accuracy with respect to predicting human outcomes, and failure to recapitulate the three-dimensional (3D) microenvironment...
March 26, 2020: Tissue Engineering. Part B, Reviews
https://read.qxmd.com/read/32215546/safe-composite-calf-augmentation-a-staged-procedure
#6
Katarina Andjelkov, Tatjana C Atanasijevic, Vesna M Popovic, Milan Colic, Ramon Llull
BACKGROUND: Calf augmentation can be performed using fat grafting, calf implants, or with a combination of both methods (composite augmentation). For safety reasons, we have to be aware of important calf anatomical features, specific physiological considerations and some health conditions can hinder the outcome of each of these procedures. OBJECTIVES: The authors present their experience in performing composite calf augmentation, its indications, surgical technique and ways of performing it safely...
March 26, 2020: Aesthetic Surgery Journal
https://read.qxmd.com/read/32215457/creating-cartoons-to-represent-habitual-leg-movements
#7
Karla Carlos, Eleida Pereira Camargo, Mayara Menezes do Moinho, Amanda Moraes de Paula Souza, Melissa Haruka Kuroiwa, Gilmar Fernandes do Prado
BACKGROUND: Many people have a habit of moving their legs and believe that this behavior is due to the restless legs syndrome (RLS), a highly prevalent neurological condition that greatly impairs the quality of life of affected individuals. This behavioral pattern, characterized by the habit of moving one's legs and feet, may be an important confounding factor in the diagnosis of RLS. OBJECTIVE: To describe the main movements associated with this benign behavioral state to characterize a possible clinical condition that can contribute to the differential diagnosis of RLS...
March 16, 2020: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/32214866/antibiotic-therapy-for-children-with-diarrhea-in-a-low-resource-setting-a-syndromic-approach
#8
Subhashchandra Daga, Achla Daga, Sameer Mhatre
Objective: To compare age and protein-energy malnutrition (PEM) - the predispositions - and fever and abnormal leukocyte count (ALC) - the SIRS criteria - in hospitalized children with and without diarrhea. Design: A prospective case-control study. Setting: A pediatric ward of a general hospital in a low-resource setting. Participants: Totally, 445 consecutive admissions to the pediatric ward of a general hospital over a period of 1 year were included in this prospective case-control study; hemodynamically unstable subjects (11) were excluded...
2020: Pediatric Health, Medicine and Therapeutics
https://read.qxmd.com/read/32214286/expanded-umbilical-cord-mesenchymal-stem-cells-uc-mscs-as-a-therapeutic-strategy-in-managing-critically-ill-covid-19-patients-the-case-for-compassionate-use
#9
Sairam Atluri, Laxmaiah Manchikanti, Joshua A Hirsch
COVID-19 has affected the United States leading to a national emergency with health care and economic impact, propelling the country into a recession with disrupted lifestyles not seen in recent history. COVID-19 is a serious illness leading to multiple deaths in various countries including the United States. Several million Americans satisfy the Center for Disease Control and Prevention (CDC) criteria for being high risk. Unfortunately, the available supply of medical beds and equipment for mechanical ventilation are much less than is projected to be needed...
March 2020: Pain Physician
https://read.qxmd.com/read/32213337/temporal-profiles-of-viral-load-in-posterior-oropharyngeal-saliva-samples-and-serum-antibody-responses-during-infection-by-sars-cov-2-an-observational-cohort-study
#10
Kelvin Kai-Wang To, Owen Tak-Yin Tsang, Wai-Shing Leung, Anthony Raymond Tam, Tak-Chiu Wu, David Christopher Lung, Cyril Chik-Yan Yip, Jian-Piao Cai, Jacky Man-Chun Chan, Thomas Shiu-Hong Chik, Daphne Pui-Ling Lau, Chris Yau-Chung Choi, Lin-Lei Chen, Wan-Mui Chan, Kwok-Hung Chan, Jonathan Daniel Ip, Anthony Chin-Ki Ng, Rosana Wing-Shan Poon, Cui-Ting Luo, Vincent Chi-Chung Cheng, Jasper Fuk-Woo Chan, Ivan Fan-Ngai Hung, Zhiwei Chen, Honglin Chen, Kwok-Yung Yuen
BACKGROUND: Coronavirus disease 2019 (COVID-19) causes severe community and nosocomial outbreaks. Comprehensive data for serial respiratory viral load and serum antibody responses from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not yet available. Nasopharyngeal and throat swabs are usually obtained for serial viral load monitoring of respiratory infections but gathering these specimens can cause discomfort for patients and put health-care workers at risk...
March 23, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32213332/interventions-to-mitigate-early-spread-of-sars-cov-2-in-singapore-a-modelling-study
#11
Joel R Koo, Alex R Cook, Minah Park, Yinxiaohe Sun, Haoyang Sun, Jue Tao Lim, Clarence Tam, Borame L Dickens
BACKGROUND: Since the coronavirus disease 2019 outbreak began in the Chinese city of Wuhan on Dec 31, 2019, 68 imported cases and 175 locally acquired infections have been reported in Singapore. We aimed to investigate options for early intervention in Singapore should local containment (eg, preventing disease spread through contact tracing efforts) be unsuccessful. METHODS: We adapted an influenza epidemic simulation model to estimate the likelihood of human-to-human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a simulated Singaporean population...
March 23, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32212852/everolimus-rescues-the-phenotype-of-elastin-insufficiency-in-patient-induced-pluripotent-stem-cell-derived-vascular-smooth-muscle-cells
#12
Caroline Kinnear, Rahul Agrawal, Caitlin Loo, Aric Pahnke, Deivid Carvalho Rodrigues, Tadeo Thompson, Oyediran Akinrinade, Samad Ahadian, Fred Keeley, Milica Radisic, Seema Mital, James Ellis
OBJECTIVE: Elastin gene deletion or mutation leads to arterial stenoses due to vascular smooth muscle cell (SMC) proliferation. Human induced pluripotent stem cells-derived SMCs can model the elastin insufficiency phenotype in vitro but show only partial rescue with rapamycin. Our objective was to identify drug candidates with superior efficacy in rescuing the SMC phenotype in elastin insufficiency patients. Approach and Results: SMCs generated from induced pluripotent stem cells from 5 elastin insufficiency patients with severe recurrent vascular stenoses (3 Williams syndrome and 2 elastin mutations) were phenotypically immature, hyperproliferative, poorly responsive to endothelin, and exerted reduced tension in 3-dimensional smooth muscle biowires...
March 26, 2020: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/32212788/chromosomal-abnormalities-in-myelodysplastic-syndrome-patients-in-upper-northern-thailand
#13
Suphitcha Phrommin, Adisak Tantiworawit, Thanawat Rattanathammethee, Chaniporn Puaninta, Nathaporn Pangjaidee, Sirinda Aungsuchawan, Kanokkan Bumroongkit
OBJECTIVE: Chromosome detection is important in the diagnosis and prognosis of Myelodysplastic syndrome (MDS) patients. About 50% of MDS patients have chromosomal abnormalities. Moreover, chromosome 5 and 7 are common genetic abnormalities in MDS patients and use to identify prognosis risk group and the proper treatment in MDS patients. The objective of this study was to evaluate chromosomal abnormalities and clinical features of MDS patients in upper northern Thailand. METHODS: Fifty bone marrow (BM) specimens were examined by conventional cytogenetic (CC) technique and fluorescence in situ hybridization (FISH) technique for detected chromosome 5 and 7 abnormalities...
March 1, 2020: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/32212350/kcnn2-mutation-in-autosomal-dominant-tremulous-myoclonus-dystonia
#14
Bettina Balint, Rita Guerreiro, Susana Carmona, Nadia Dehghani, Anna Latorre, Carla Cordivari, Kailash P Bhatia, Jose Bras
BACKGROUND: Despite recent advances in neurogenetics which have facilitated the identification of a number of dystonia genes, many familial dystonia syndromes remain without known cause. OBJECTIVE: To identify the cause of autosomal dominant tremulous myoclonus-dystonia in a UK kindred with affected individuals in three generations. METHODS: Known genetic causes of myoclonus-dystonia were excluded. We combined clinical and electrophysiological phenotyping with whole-exome sequencing and Sanger sequencing to identify candidate causal variants in a family with tremulous myoclonus-dystonia...
March 25, 2020: European Journal of Neurology
https://read.qxmd.com/read/32212061/real-world-dual-antiplatelet-therapy-following-polymer-free-sirolimus-eluting-stent-implantations-to-treat-coronary-artery-disease
#15
Florian Krackhardt, Matthias Waliszewski, Viktor Kočka, Petr Toušek, Bronislav Janek, Martin Hudec, Fernando Lozano, Koldobika Garcia-San Roman, Bruno Garcia Del Blanco, Josepa Mauri, Tay Mok Heang, Tae Hoon Ahn, Myung Ho Jeong, Denny Herberger, Vjekoslav Tomulic, Gilles Levy, Laurent Sebagh, Jérôme Rischner, Michel Pansieri
OBJECTIVES: The objective of this post hoc analysis was to analyze real-world dual antiplatelet therapy (DAPT) regimens following polymer-free sirolimus-eluting stent (PF-SES) implantations in an unselected patient population. METHODS: Patient-level data from two all-comers observational studies (ClinicalTrials.gov Identifiers: NCT02629575 and NCT02905214) were pooled and analyzed in terms of their primary endpoint. During the data verification process, we observed substantial deviations from DAPT guideline recommendations...
March 24, 2020: Cardiovascular Drugs and Therapy
https://read.qxmd.com/read/32210970/the-landscape-and-prognosis-potential-of-the-t-cell-repertoire-in-membranous-nephropathy
#16
Yu Zhang, Yabin Jin, Zhanwen Guan, Huishi Li, Zuhui Su, Chao Xie, Xiangping Chen, Xiaofen Liu, Yingming Pan, Peiyi Ye, Lifang Zhang, Yaozhong Kong, Wei Luo
Membranous nephropathy (MN), a common pathological type of adult nephrotic syndrome, is an antibody-mediated kidney disease. It is widely accepted now that MN is an immune-related disease that involves the whole immune system. In this study, we analyzed the T-cell receptor beta chain (TCRβ) repertoire of the circulating T lymphocytes of MN patients and healthy controls using high-throughput sequencing. We compared multiple aspects of the TCRβ repertoire, including diversity and the Vβ and Jβ genes between MN patients and healthy controls, and we found that the diversities within the VJ cassette combination in the peripheral blood of MN patients were lower than in the healthy controls...
2020: Frontiers in Immunology
https://read.qxmd.com/read/32210965/advances-in-developing-car-t-cell-therapy-for-hiv-cure
#17
REVIEW
Jinxin Qi, Chengchao Ding, Xian Jiang, Yong Gao
Acquired immune deficiency syndrome (AIDS), which is caused by HIV infection, is an epidemic disease that has killed millions of people in the last several decades. Although combination antiretroviral therapy (cART) has enabled tremendous progress in suppressing HIV replication, it fails to eliminate HIV latently infected cells, and infected individuals remain HIV positive for life. Lifelong antiretroviral therapy is required to maintain control of virus replication, which may result in significant problems, including long-term toxicity, high cost, and stigma...
2020: Frontiers in Immunology
https://read.qxmd.com/read/32210562/tempo-oxidized-sacchachitin-nanofibers-toscnfs-combined-with-platelet-rich-plasma-prp-for-management-of-dry-eye-syndrome
#18
Hong-Liang Lin, Ting-Huan Wu, Hsiu-O Ho, Fang-Ching Chao, Meng-Huang Wu, Der-Zen Liu, Ling-Chun Chen, Ming-Thau Sheu
Introduction: In this study, the combination of TEMPO-oxidized sacchachitin nanofibers (TOSCNFs) with chitosan-activated platelet-rich plasma (cPRP) was evaluated for remedying dry eye syndrome (DES). Methods: TOSCNFs, designated T050SC, were generated. T050SC combined with chitosan-activated ( c PRP) was formulated as eye drops for application for severe DES. To evaluate the effects of cPRP and TOSCNFs on the repair of corneal injury, in vitro studies were conducted using Statens Seruminstitut rabbit corneal (SIRC) epithelial cells for cell proliferation and cell migration assays, and a severe DES animal model using rabbits was established with benzalkonium chloride (BAC) treatment for the evaluation...
2020: International Journal of Nanomedicine
https://read.qxmd.com/read/32209819/update-on-primary-micronodular-bilateral-adrenocortical-diseases
#19
Michel Maillet, Isabelle Bourdeau, André Lacroix
PURPOSE OF REVIEW: Primary micronodular bilateral adrenocortical hyperplasias (MiBAH) are rare challenging diseases. Important progress in understanding its pathophysiology and genetics occurred in the last two decades. We summarize those progress and recent data on investigation and therapy of MiBAH focusing on primary pigmented nodular adrenocortical disease (PPNAD). RECENT FINDINGS: Larger recent cohorts of PPNAD patients from various countries have confirmed their variable Cushing's syndrome phenotypes...
March 23, 2020: Current Opinion in Endocrinology, Diabetes, and Obesity
https://read.qxmd.com/read/32208488/interferon-complement-loop-in-transplant-associated-thrombotic-microangiopathy
#20
Sonata Jodele, Mario Medvedovic, Nathan Luebbering, Jenny Chen, Christopher E Dandoy, Benjamin L Laskin, Stella M Davies
Transplant-associated thrombotic microangiopathy (TA-TMA) is an important cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). The complement inhibitor eculizumab improves TA-TMA, but not all patients respond to therapy, prompting a search for additional targetable pathways of endothelial injury. TA-TMA is relatively common after HSCT and can serve as a model to study mechanisms of tissue injury in other thrombotic microangiopathies. In this work, we performed transcriptome analyses of peripheral blood mononuclear cells collected before HSCT, at onset of TA-TMA, and after resolution of TA-TMA in children with and without TA-TMA after HSCT...
March 24, 2020: Blood Advances
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