Abnormal uterine

Toshinari Muramatsu, Taro Sugiyama, Yuki Kuriyama, Takatoshi Manabe, Ippei Oiwa, Rie Nakajima, Chisa Narayama, Tomoaki Narayama, Tetsuji Iida, Kenichi Goya, Hitomi Tsukada, Hironobu Maeda, Mikio Mikami
The patient was a 69-year-old multiparous female (gravida/para, 3/3) who had hypertension and arrhythmia. Her history included cerebral infarction treated with conservative therapy. She visited our hospital for atypical genital bleeding. She was diagnosed with atypical glandular cells (AGC) based on cervical cytology, atypical cells in endometrial cytology, and atypical endometrial hyperplasia on preoperative endometrial biopsy, and underwent total laparoscopic hysterectomy. However, in a postoperative pathologic examination, she was diagnosed with stage IB1 cervical adenocarcinoma without endometrial abnormality...
April 20, 2020: Tokai Journal of Experimental and Clinical Medicine
Priscila L Podratz, Eduardo Merlo, Julia F P de Araújo, Julia G M Ayub, Amanda F Z Pereira, Leandro C Freitas-Lima, Mércia B da Costa, Leandro Miranda-Alves, Sonara G S Cassa, Maria Tereza W D Carneiro, Gilberto Fillmann, Jones B Graceli
Early life exposure to endocrine-disrupting chemicals (EDCs) is an emerging risk factor for development of complications later in life and in subsequent generations. We previously demonstrated that exposure to the EDC organotin (OT), which is present in contaminated seafood, resulted in reproductive abnormalities in female rats. However, few studies have explored the effect of OT accumulation in seafood on pregnancy outcomes. This led us to consider the potential effects of the OT present in seafood on fertility, pregnancy, the placenta, and the offspring...
March 18, 2020: Science of the Total Environment
Nicole Robertson, Satomi Okano, Cameron Hurst, Sailesh Kumar
Objective: Excessive daytime sleepiness is a frequently described phenomenon in pregnant women. The Epworth Sleepiness Scale (ESS) is a self reported standardized method of assessing sleep propensity and has been used extensively within pregnant populations. An elevated score is associated with sleep disordered breathing, as well as adverse obstetric and neonatal outcomes which may be indicative of a degree of placental dysfunction. Thus the aim of this study was to prospectively assess women using the Epworth questionnaire in conjunction with an ultrasound in both the second and third trimesters to determine if there was a difference in ESS scores across gestation and if a mid or late gestation assessment was correlated with Doppler ultrasound measures of fetal well-being...
March 23, 2020: Journal of Maternal-fetal & Neonatal Medicine
Jon Frias-Gomez, Yolanda Benavente, Jordi Ponce, Joan Brunet, Raquel Ibáñez, Paula Peremiquel-Trillas, Nuria Baixeras, Alba Zanca, Josep Maria Piulats, Álvaro Aytés, Xavier Matias-Guiu, Francesc Xavier Bosch, Silvia de Sanjosé, Laia Alemany, Laura Costas
Cervico-vaginal cytology is primarily a cervical cancer screening test. The anatomical continuity of the uterine cavity with the cervix makes the Papanicolaou (Pap) test accessible to evaluate signs of disease shed from the endometrium. Our aim was to determine the sensitivity of routine Pap test in endometrial carcinoma detection and its relationship with clinico-pathologic factors. We performed a systematic review of studies reporting Pap test results prior to diagnosis of or surgery for endometrial carcinoma between 1990 and 2018 in PubMed or Web of Science...
March 23, 2020: Cancer Cytopathology
Chuanming Peng, Yanqin Lu, Xiuzhi Ren, Yanzhou Wang, Shie Zhang, Mei Chen, Junlong Liu, Fengling Fang, Tianyou Li, Jinxiang Han
Wnt1 is the first member of the Wnt family that was identified. It is phylogenetically conserved and essential for oncogenesis and multiple developmental processes. This study has summarized diseases and mutations related to Wnt1 . Wnt1 is involved in various cancers, genetic type XV osteogenesis imperfecta, osteoporosis, and neurological diseases. The expression of Wnt1 in normal tissues and different types of cancers and the potential survival of cancer were analyzed using experiment-based bioinformatic analysis...
February 2020: Intractable & Rare Diseases Research
Natasha de Alwis, Sally Beard, Yeukai T Mangwiro, Natalie K Binder, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Stephen Tong, Natalie J Hannan
OBJECTIVES: There is avid interest in pravastatin as a therapeutic intervention for pre-eclampsia, however little is known on statin action on endothelial dysfunction. This study aimed to evaluate the ability of pravastatin, simvastatin and rosuvastatin to reduce pre-eclampsia-associated markers of endothelial dysfunction in human endothelial cells. STUDY DESIGN: Primary human umbilical vein endothelial cells (HUVECs) and uterine microvascular cells (UtMVs) were isolated and treated with 0...
March 4, 2020: Pregnancy Hypertension
Yishai Sompolinsky, Simcha Yagel, Drorith Hochner-Celniker, Zion Tal
Placenta accrete spectrum (PAS) is a complicated obstetrical condition arising from abnormal implantation of the placenta into the myometrium. The placenta might partially or completely adhere to the myometrium and in rare cases invade adjacent organs (placenta percreta). The abnormal placentation might cause life-threatening hemorrhages during pregnancy and birth, increasing maternal and neonatal mortality and morbidity. Detachment of the placenta after delivery in PAS might be difficult and requires manual removal of the placenta as well as advanced surgical procedures in more serious cases...
March 2020: Harefuah
Kamran Hessami, Maryam Kasraeian, Nasrin Asadi, Homeira Vafaei, Leila Foroughinia
Purpose: There is a growing evidence suggesting that hypertensive disorders of pregnancy (HDP), especially preeclampsia, are associated with an increased risk of cardiometabolic disease for both mother and child later in life. The objective of this study was to determine the association of maternal and umbilical cord blood (UCB) lipid profiles with uterine and fetal-placental blood flow at the third trimester of pregnancy. Patients and Methods: A total of 1,135 women were prospectively followed through pregnancy and data for 812 mother-newborn pairs, including 170 HDP ‎developed subjects and ‎642 ‎normotensive subjects were analyzed at the end of the study...
2020: International Journal of Women's Health
Qing Feng, Bingsi Gao, Huan Huang, Jeffrey Je-Chuen Woo, Lingxiao Zou, Xingping Zhao, Chunxia Cheng, Dabao Xu
Background: Intrauterine adhesion (IUA) is caused by adhesion of the uterine cavity due to the damage of endometrium. Hysteroscopic adhesiolysis (HA) is the main treatment. The objective of the study was to investigate the obstetrical outcome in the third trimester of women who previously underwent HA. Methods: We performed a retrospective cohort study in the university-affiliated hospital. A total of 146 women with a history of HA who had given birth in their third trimester from May 2012 to May 2019 were enrolled (study group), while 292 women with a negative history of HA were matched for maternal age, gravidity, parity, and delivery year...
February 2020: Annals of Translational Medicine
Nahid Tajeddin, Ali Mohammad Ahadi, Gholamreza Javadi, Hoda Ayat
Background: There are numerous couples worldwide currently suffering from infertility. Several factors, including genetic abnormalities are involved in infertility. In this study, we investigated the expression of myc gene in uterine tissue of infertile women. The protein encoded by this gene is one of the important transcription factors involved in the expression of many genes in the embryonic growth, and development pathways. Methods: There are about 45 samples of uterine tissue from women with primary and secondary infertility were involved in this study...
2020: International Journal of Preventive Medicine
Olga Kuźmycz, Paweł Stączek
Many types of cancers, including endometrial cancer, were found to have cyclooxygenase-2 (COX-2) overexpression. Because this enzyme belongs to the group of pro-inflammatory enzymes, so-called NSAIDs (non-steroidal anti-inflammatory drugs) directly inhibit its activity. An increasing number of reports on COX-2 involvement in cancer, as well as on the role of microbiota in abnormal metabolism and signaling of cells, forces the development of new NSAID types. Besides, NSAIDs can affect some bacteria, which are vaginal/endometrial microbiome members...
March 15, 2020: Cancer Biology & Therapy
Edinson Dante Meregildo Rodriguez, Miguel Villegas Chiroque, Juan Roberto Rodriguez Llanos, Halbert Christian Sánchez Carrillo, Stalin Vílchez Rivera, Marcela Cecilia Delgado Sánchez
Tuberculous meningitis (TBM) is a medical emergency: it is the most severe, lethal and disabling clinical form of tuberculosis. We report the case of a 44-year-old woman who had undergone a clandestine abortion six weeks before admission. One week later, she had abnormal vaginal discharge. Three weeks prior to admission, headache, hyperpyrexia and mental alteration were added. At admission, a transvaginal ultrasound showed abnormalities of the uterine cavity. Sepsis and endometritis were diagnosed, and a hysterectomy was scheduled...
March 1, 2020: Le Infezioni in Medicina
Frank T Spradley, Ying Ge, Joey P Granger, Alejandro R Chade
BACKGROUND: Remodeling of the uterine spiral arteries and blood vessels within the placenta allows delivery of nutrients to the growing utero-fetal-placental unit. While abnormal remodeling of these vessels is thought to play an important role in syndromes including intrauterine growth restriction and preeclampsia, there are a lack of studies that have quantified vascular remodeling in normal pregnant rats. Thus, the purpose of this study was to quantify time-dependent remodeling of the utero-placental vasculature during late gestation in normal pregnant rats...
March 3, 2020: Pregnancy Hypertension
H Zhang, G Ning, C Fu, L Bao, Y Guo
AIM: To evaluate the diverse presentations of Herlyn-Werner-Wunderlich (HWW) syndrome on magnetic resonance imaging (MRI) and its surgical correlations. MATERIALS AND METHODS: From 2014 to 2019, a total of 40 patients with HWW syndrome underwent pelvic MRI. All MRI images were reviewed by two experienced radiologists in consensus. Uterine anomalies, obstruction sites, laterality and communications, urinary anomalies, and other abnormal findings were recorded. MRI findings were correlated with ultrasonography and surgical results...
March 11, 2020: Clinical Radiology
John V Groth, Sanjiv Prabhu, Ramayee Periakaruppan, Samuel Ohlander, Rajyasree Emmadi, Rajul Kothari
Lynch syndrome is an autosomal dominant disorder, caused by an abnormality in DNA mismatch repair genes and characterized by the development of a variety of cancers. Upper urinary tract urothelial carcinoma is well characterized in Lynch syndrome; however, support for the inclusion of bladder urothelial carcinoma is limited, except for MSH2 mutation carriers. Urologic adenocarcinoma has not been documented in Lynch syndrome. Here we report, to the best of our knowledge, the first case of bladder adenocarcinoma, synchronous with uterine endometrioid dedifferentiated endometrioid adenocarcinoma in a patient with Lynch syndrome...
March 2020: Applied Immunohistochemistry & Molecular Morphology: AIMM
Monica W Rosen, Emma Giuliani, Erica E Marsh, Elisabeth H Quint, Yolanda R Smith
STUDY OBJECTIVE: To explore trends over time in the utilization of the Emergency Department (ED) for adolescents with abnormal uterine bleeding (AUB). DESIGN: Retrospective cross-sectional study. SETTING: Nationwide Emergency Department Sample database (Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality, Rockville, MD). PARTICIPANTS: Subset of adolescents aged 10-19 from overall cohort of females aged 10-49...
March 9, 2020: Journal of Pediatric and Adolescent Gynecology
Sangjoon Choi, Jin Woo Joo, Sung-Im Do, Hyun-Soo Kim
Malignancies of extragenital origin very rarely metastasize to the uterine body. Endometrium-limited metastases may pose diagnostic challenges in endometrial curettage specimens as they may be misdiagnosed as primary endometrial tumors. We investigated the clinicopathological characteristics of seven cases with endometrial-limited metastases from carcinomas of the nasopharynx ( n = 1), breast ( n = 2), colon ( n = 2), stomach ( n = 1), and appendix ( n = 1). The patients' ages ranged from 36 to 71 (mean: 55...
March 10, 2020: Diagnostics
Itaru Sonoda, Tsuyoshi Chiku, Kimio Shinoda, Takahiro Hashiba, Wataru Sano, Yasuhiro Togawa, Akihiko Toyoda
In September 2013, a 50-year-old woman presented to our hospital with right abdominal pain as the main complaint. Careful examinations led to the diagnosis of ascending colon cancer. In October 2013, resection of the right half colon and removal of the D3 lymph nodes were performed. As postoperative adjunctive chemotherapy, 6 courses of CAPOX therapy were initiated. PET-CT conducted 17 months after the surgery revealed an enlarged right para-aoric lymph nodes and abnormal FDG accumulation. Lymph node recurrence was diagnosed...
December 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Zengshu Huang, Jing Zhou, Wing Ting Leung, Hans Jürgen Gober, Xinyao Pan, Chuyu Li, Lisha Li, Ling Wang
The Hippo-Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ), originally identified as a regulator of tissue generation and tumorigenesis, has been proven to have a pivotal position in immunity. Its multi-faceted roles in regulating immunity cover both intrinsic mechanism of immune cells and the crosstalk with non-immune cells. Survival of the allogeneic embryo in the maternal uterine environment depends on immune tolerance, supported by the highly orchestrated cooperation between decidual immune cells, decidual stromal cells and trophoblasts at the maternal-fetal interface...
March 4, 2020: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Shafat Ali, Sabhiya Majid, Md Niamat Ali, Shahnaz Taing
Recurrent miscarriage (RM) is defined as two or more consecutive pregnancy losses that affect approximately 5% of conceived women worldwide. RM is a multi-factorial reproductive problem and has been associated with parental chromosomal abnormalities, embryonic chromosomal rearrangements, uterine anomalies, autoimmune disorders, endocrine dysfunction, thrombophilia, life style factors, and maternal infections. However, the exact cause is still undecided in remaining 50% of cases. Immunological rejection of the embryo due to exacerbated maternal immune reaction against paternal embryonic antigens has been set forth as one of the significant reason for RM...
March 3, 2020: International Immunopharmacology
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