keyword
https://read.qxmd.com/read/33151336/estimating-glomerular-filtration-rate-in-patients-with-acute-kidney-injury-a-prospective-multicenter-study-of-diagnostic-accuracy
#1
Karyne Pelletier, Jean-Philippe Lafrance, Louise Roy, Mathieu Charest, Marie-Claire Bélanger, Jean-François Cailhier, Martin Albert, Anatolie Duca, Naoual Elftouh, Josée Bouchard
BACKGROUND: Estimating glomerular filtration rate (GFR) in acute kidney injury (AKI) is challenging, with limited data comparing estimated and gold standard methods to assess GFR. The objective of our study was to assess the performance of the kinetic estimated GFR (KeGFR) and Jelliffe equations to estimate GFR in AKI, using a radioisotopic method (technetium-diethylenetriaminepentaacetic acid) as a reference measure. METHODS: We conducted a prospective multicenter observational study in hospitalized patients with AKI...
November 1, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33136737/pre-exposure-prophylaxis-uptake-among-men-who-have-sex-with-men-who-used-npep-a-longitudinal-analysis-of-attendees-at-a-large-sexual-health-clinic-in-montr%C3%A3-al-canada
#2
Yiqing Xia, Zoë R Greenwald, Rachael M Milwid, Claire Trottier, Michel Boissonnault, Neil Gaul, Louise Charest, Gabrielle Landry, Navid N Zahedi, Jason Szabo, Réjean Thomas, Mathieu Maheu-Giroux
BACKGROUND: Reducing HIV transmission using pre-exposure prophylaxis (PrEP) requires focussing on individuals at high acquisition risk, such as men who have sex with men with a history of nonoccupational post-exposure prophylaxis (nPEP). This study aims to characterize longitudinal trends in PrEP uptake and its determinants among nPEP users in Montréal. METHODS: Eligible attendees at Clinique médicale l'Actuel were recruited prospectively starting in October 2000 (nPEP) and January 2013 (PrEP)...
December 1, 2020: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/32835887/mobilizing-crop-biodiversity
#3
Susan McCouch, Katy Navabi, Michael Abberton, Noelle L Anglin, Rosa Lia Barbieri, Michael Baum, Kirsten Bett, Helen Booker, Gerald L Brown, Glenn J Bryan, Luigi Cattivelli, David Charest, Kellye Eversole, Marcelo Freitas, Kioumars Ghamkhar, Dario Grattapaglia, Robert Henry, Maria Cleria Valadares Inglis, Tofazzal Islam, Zakaria Kehel, Paul J Kersey, Stephen Kresovich, Emily Marden, Sean Mayes, Marie Noelle Ndjiondjop, Henry T Nguyen, Samuel Paiva, Roberto Papa, Peter W B Phillips, Awais Rasheed, Christopher Richards, Mathieu Rouard, Maria Jose Amstalden Sampaio, Uwe Scholz, Paul D Shaw, Brad Sherman, S Evan Staton, Nils Stein, Jan Svensson, Mark Tester, Jose Francisco Montenegro Valls, Rajeev Varshney, Stephen Visscher, Eric von Wettberg, Robbie Waugh, Peter W B Wenzl, Loren H Rieseberg
No abstract text is available yet for this article.
August 21, 2020: Molecular Plant
https://read.qxmd.com/read/32826567/pre-exposure-prophylaxis-uptake-among-men-who-have-sex-with-men-who-used-non-occupational-post-exposure-prophylaxis-a-longitudinal-analysis-of-attendees-at-a-large-sexual-health-clinic-in-montr%C3%A3-al-canada
#4
Yiqing Xia, Zoë R Greenwald, Rachael M Milwid, Trottier Claire, Michel Boissonnault, Neil Gaul, Louise Charest, Gabrielle Landry, Zahedi N Navid, Jason Szabo, Réjean Thomas, Mathieu Maheu-Giroux
BACKGROUND: Reducing HIV transmission using pre-exposure prophylaxis (PrEP) requires targeting individuals at high acquisition risk, such as men who have sex with men (MSM) with a history of non-occupational post-exposure prophylaxis (nPEP). This study aims to characterize longitudinal trends in PrEP uptake and its determinants among nPEP users in Montréal. METHODS: Eligible attendees at Clinique médicale l'Actuel were recruited prospectively starting in October 2000 (nPEP) and January 2013 (PrEP)...
August 19, 2020: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/32536524/beyond-fertilisation-how-the-paternal-environment-influences-future-generations
#5
REVIEW
Janice L Bailey, Mathieu Dalvai, Maryse Lessard, Pauline M Herst, Phanie L Charest, P Navarro
In light of the relatively ignored role of paternal influences on offspring development and increasing societal concerns regarding possible health consequences of chemical exposures, our team has addressed the overall hypothesis that environmentally-relevant levels of contaminants have long-lasting effects that are transmitted through the paternal lineage. This review focuses on our research examining the impact of developmental exposure to toxicants and nutrients on the phenotype and epigenome of the male and of his subsequent generations...
May 17, 2020: Animal Reproduction Science
https://read.qxmd.com/read/31554827/prenatal-exposure-to-environmentally-relevant-contaminants-perturbs-male-reproductive-parameters-across-multiple-generations-that-are-partially-protected-by-folic-acid-supplementation
#6
Maryse Lessard, Pauline M Herst, Phanie L Charest, Pauline Navarro, Charles Joly-Beauparlant, Arnaud Droit, Sarah Kimmins, Jacquetta Trasler, Marie-Odile Benoit-Biancamano, Amanda J MacFarlane, Mathieu Dalvai, Janice L Bailey
The paternal environment is thought to influence sperm quality and future progeny may also be impacted. We hypothesized that prenatal exposure to environmentally-relevant contaminants impairs male reproduction, altering embryo gene expression over multiple generations. Folic acid (FA) can improve sperm quality and pregnancy outcomes, thus we further hypothesized that FA mitigates the contaminants. Sprague-Dawley F0 female rats treated with persistent organic pollutants (POPs) or corn oil and fed basal or supplemented FA diets, then used to yield four generations of litters...
September 25, 2019: Scientific Reports
https://read.qxmd.com/read/31525320/maternal-folic-acid-supplementation-does-not-counteract-the-deleterious-impact-of-prenatal-exposure-to-environmental-pollutants-on-lipid-homeostasis-in-male-rat-descendants
#7
Pauline Navarro, Mathieu Dalvai, Phanie L Charest, Pauline M Herst, Maryse Lessard, Bruno Marcotte, Patricia L Mitchell, Nadine Leblanc, Sarah Kimmins, Jacquetta Trasler, Amanda J MacFarlane, André Marette, Janice L Bailey, Hélène Jacques
Prenatal exposure to persistent organic pollutants (POPs) has been associated with the development of metabolic syndrome-related diseases in offspring. According to epidemiological studies, father's transmission of environmental effects in addition to mother's can influence offspring health. Moreover, maternal prenatal dietary folic acid (FA) may beneficially impact offspring health. The objective is to investigate whether prenatal FA supplementation can overcome the deleterious effects of prenatal exposure to POPs on lipid homeostasis and inflammation in three generations of male rat descendants through the paternal lineage...
September 16, 2019: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/30077593/preoperative-imaging-of-a-malignant-cardiac-tumor
#8
Josephine Pressacco, Jaramie Thomas-Gittens, Mathieu Charest, Yoel Bitton, Mathieu Rousseau, Moishe Liberman
No abstract text is available yet for this article.
August 2, 2018: Annals of Thoracic Surgery
https://read.qxmd.com/read/29400254/histomorphologic-analysis-of-the-late-term-rat-fetus-and-placenta
#9
Phanie L Charest, Vanessa Vrolyk, Pauline Herst, Maryse Lessard, Deborah M Sloboda, Mathieu Dalvai, Julius Haruna, Janice L Bailey, Marie-Odile Benoit-Biancamano
Histological examination of the rat placenta and fetus is uncommon. Toxicological studies mainly rely on gross examination of the fetus and on fetal and placental weights. These are often insufficient to assess the fetal and placental toxicity of xenobiotics. The small size of the fetus makes its dissection labor-intensive. Thus, our objective was to develop a simple and accurate technique to evaluate the rat fetus and placenta. Sprague-Dawley rat fetuses at gestational day 19.5 ( n = 18) and their placentas ( n = 32) were fixed in formalin...
February 2018: Toxicologic Pathology
https://read.qxmd.com/read/29273698/effective-dose-in-nuclear-medicine-studies-and-spect-ct-dosimetry-survey-across-quebec-province
#10
Mathieu Charest, Chantal Asselin
The aims of the current study were to draw a portrait of the delivered dose in selected nuclear medicine studies in Québec province and to assess the degree of change between an earlier survey performed in 2010 and a later survey performed in 2014. Methods: Each surveyed nuclear medicine department had to complete 2 forms: the first, about the administered activity in selected nuclear medicine studies, and the second, about the CT parameters used in SPECT/CT imaging, if available. The administered activities were converted into effective doses using the most recent conversion factors...
June 2018: Journal of Nuclear Medicine Technology
https://read.qxmd.com/read/29127250/malignant-peripheral-nerve-sheath-tumours-of-the-pericardium-in-a-patient-with-neurofibromatosis-type-1-the-diagnostic-value-of-18f-fdg-pet-ct-and-i-123-mibg-spect-ct
#11
Mathieu Charest, Josephine Pressacco, Jaramie Thomas-Gittens
A 25 year old female with known neurofibromatosis type 1 with a large anterior mediastinal mass was investigated. F18-FDG PET-CT revealed a radiotracer avid anterior mediastinal mass with SUVmax of 4.3 and demonstrating a hypoactive center. The Iodine-123 MIBG SPECT-CT study performed subsequently did not demonstrate any uptake, thereby excluding for the most part the diagnoses of paraganglioma or neuroblastoma. At final pathology, a malignant peripheral nerve sheath tumour (MPNST) of the pericardium with areas of chondrosarcomatous and angiosarcomatous differentiation was diagnosed...
November 10, 2017: Journal of Nuclear Medicine Technology
https://read.qxmd.com/read/27363446/detection-of-intrathoracic-bleeding-by-99mtc-labeled-red-blood-cell-spect-ct-after-wedge-biopsy-of-pulmonary-angiosarcoma
#12
Karine Provost, Mathieu Charest
A 52-y-old man presenting with dyspnea and a massive effusion in the right pleural cavity underwent wedge biopsies of pulmonary lesions found on thoracic CT, leading to a diagnosis of pleural angiosarcoma. Bleeding developed postoperatively and was investigated using pulmonary CT angiography, which failed to identify a site of active bleeding. (99m)Tc-labeled red blood cell (RBC) SPECT/CT of the chest was performed, and the site was rapidly located. To our knowledge, this is the first case reported in the literature of localization of intrathoracic bleeding using (99m)Tc-RBC SPECT/CT...
September 2016: Journal of Nuclear Medicine Technology
https://read.qxmd.com/read/27121902/infiltration-of-f98-glioma-cells-in-fischer-rat-brain-is-temporary-stimulated-by-radiation
#13
Guillaume Desmarais, Gabriel Charest, Hélène Therriault, Minghan Shi, David Fortin, Rachel Bujold, David Mathieu, Benoit Paquette
PURPOSE: Irradiation of brain stimulates the expression of inflammatory mediators, some of which can modify the ability of cancer cells to infiltrate the brain. In the present study, the time window during which this stimulation occurs was determined. MATERIALS AND METHODS: Brain of Fischer rat was irradiated (15 Gy) and expression of pro-inflammatory mediators IL-1β, IL-6 and TNF-α was measured from 4 h to 20 days post-irradiation. Level of the matrix metalloproteinase 2 (MMP-2) and prostaglandin E2 (PGE2) which can favor cancer cell infiltration were also measured...
August 2016: International Journal of Radiation Biology
https://read.qxmd.com/read/26302463/the-relative-value-of-18f-fdg-pet-interpretation-criteria-in-generating-a-probabilistic-approach-for-characterization-of-pulmonary-nodules
#14
Anna Danilenko, Mathieu Charest, Antoine Leblond
PURPOSE: The evaluation of pulmonary nodules constitutes a large part of PET-CT studies. In this study, we aimed to evaluate the different interpretation criteria in F-fluorodeoxyglucose PET attenuation-corrected and non-attenuation-corrected studies as individual predictors of malignancy in order to propose a useful combination of criteria that can be used in daily practice to classify nodules appropriately. PATIENTS AND METHODS: We performed a historical prospective survey of all consecutive patients referred to our service for the initial assessment of pulmonary nodules and sought the final characterization of these nodules either from tissue sampling or from radiological and clinical follow-up...
November 2015: Nuclear Medicine Communications
https://read.qxmd.com/read/25979025/gamma-knife-irradiation-method-based-on-dosimetric-controls-to-target-small-areas-in-rat-brains
#15
Julie Constanzo, Benoit Paquette, Gabriel Charest, Laurence Masson-Côté, Mathieu Guillot
PURPOSE: Targeted and whole-brain irradiation in humans can result in significant side effects causing decreased patient quality of life. To adequately investigate structural and functional alterations after stereotactic radiosurgery, preclinical studies are needed. The purpose of this work is to establish a robust standardized method of targeted irradiation on small regions of the rat brain. METHODS: Euthanized male Fischer rats were imaged in a stereotactic bed, by computed tomography (CT), to estimate positioning variations relative to the bregma skull reference point...
May 2015: Medical Physics
https://read.qxmd.com/read/25912457/cyclooxygenase-2-inhibitor-prevents-radiation-enhanced-infiltration-of-f98-glioma-cells-in-brain-of-fischer-rat
#16
Guillaume Desmarais, Gabriel Charest, David Fortin, Rachel Bujold, David Mathieu, Benoit Paquette
PURPOSE: Radiation induces a neuro-inflammation that is characterized by the expression of genes known to increase the invasion of cancer cells. In Fischer rats, brain irradiation increases the infiltration of cancer cells and reduced the median survival of the animals. In this study, we have determined whether these adverse effects of radiation can be prevented with the cyclooxygenase-2 (COX-2) inhibitor meloxicam. MATERIALS AND METHODS: Brain of Fischer rats treated or not with meloxicam were irradiated (15 Gy) and then implanted with the F98 glioma cells...
August 2015: International Journal of Radiation Biology
https://read.qxmd.com/read/24310279/metabolic-activity-measured-on-pet-ct-correlates-with-clinical-outcomes-in-patients-with-limb-and-girdle-sarcomas
#17
Sonia R Skamene, Rajan Rakheja, Kristina R Dahlstrom, Kristina R Dalhstrom, David Roberge, Ayoub Nahal, Mathieu Charest, Robert Turcotte, Marc Hickeson, Carolyn Freeman
OBJECTIVE: To explore the relationship between metabolic activity and outcome in patients with extremity sarcomas. METHODS: Between June 2004 and December 2011, 120 patients with newly diagnosed limb and girdle sarcomas underwent FDG-PET/CT for disease staging prior to curative intent treatment. The maximum standardized uptake value (SUV(max)) was measured for each primary tumor and correlated with outcome. Progression-free survival and overall survival (OS) were analyzed using the Kaplan-Meier method...
April 2014: Journal of Surgical Oncology
https://read.qxmd.com/read/24026531/optimization-of-the-route-of-platinum-drugs-administration-to-optimize-the-concomitant-treatment-with-radiotherapy-for-glioblastoma-implanted-in-the-fischer-rat-brain
#18
Gabriel Charest, Léon Sanche, David Fortin, David Mathieu, Benoit Paquette
Treatment of glioblastoma with platinum compounds modestly improves progression-free survival and may cause toxic effects which prevent use at higher dose that would otherwise improve the antineoplastic effect. To reduce toxicity, we propose to encapsulate the platinum drug in a liposome. We have also tested three methods of drug administration (intra-venous, intra-arterial and intra-arterial combined with blood brain barrier disruption) to determine which one optimizes the tumor cell uptake, limits the toxicity and delivers the best concomitance effect with radiotherapy...
December 2013: Journal of Neuro-oncology
https://read.qxmd.com/read/22284691/glioblastoma-treatment-bypassing-the-toxicity-of-platinum-compounds-by-using-liposomal-formulation-and-increasing-treatment-efficiency-with-concomitant-radiotherapy
#19
Gabriel Charest, Léon Sanche, David Fortin, David Mathieu, Benoit Paquette
PURPOSE: Treatments of glioblastoma with cisplatin or oxaliplatin only marginally improve the overall survival of patients and cause important side effects. To prevent adverse effects, improve delivery, and optimize the tumor response to treatment in combination with radiotherapy, a potential approach consists of incorporating the platinum agent in a liposome. METHODS AND MATERIALS: In this study, cisplatin, oxaliplatin, carboplatin, Lipoplatin (the liposomal formulation of cisplatin), and Lipoxal (the liposomal formulation of oxaliplatin) were tested on F98 glioma orthotopically implanted in Fischer rats...
September 1, 2012: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/22172684/prognostic-implication-of-the-lymphangitic-carcinomatosis-pattern-on-perfusion-lung-scan
#20
REVIEW
Mathieu Charest, Shadia Armanious
PURPOSE: Findings not associated with thromboembolic disease on routine perfusion lung scan may sometimes have particular clinical significance. We wanted to assess the clinical importance and overall survival after the recognition of a lymphangitic carcinomatosis pattern on perfusion lung scan. CASE REPORT: We report a case of lymphangitic carcinomatosis pattern on perfusion lung scan performed in a previously healthy patient who had rapid progressive course and died the next day...
November 2012: Canadian Association of Radiologists Journal
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