Hyung-Jin Kim, Wa Cao, Gi-Su Oh, SeungHoon Lee, AiHua Shen, Dipendra Khadka, Su-Bin Lee, Subham Sharma, Seon Young Kim, Seong-Kyu Choe, Tae Hwan Kwak, Jin-Man Kim, Raekil Park, Hong-Seob So
Age-related hearing loss (ARHL) is a major neurodegenerative disorder and the leading cause of communication deficit in the elderly population, which remains largely untreated. The development of ARHL is a multifactorial event that includes both intrinsic and extrinsic factors. Recent studies suggest that NAD+ /NADH ratio may play a critical role in cellular senescence by regulating sirtuins, PARP-1, and PGC-1α. Nonetheless, the beneficial effect of direct modulation of cellular NAD+ levels on aging and age-related diseases has not been studied, and the underlying mechanisms remain obscure...
October 2019: Aging Cell