Anthony M Vintzileos, John C Smulian
One of the most important challenges in obstetrics is to determine the appropriate time to deliver the fetus without exposing the mother to unnecessary operative interventions. The use of continuous cardiotocography (cCTG) during labor has resulted in dramatic reductions in intrapartum fetal deaths, but fetal central nervous system (CNS) injury and cerebral palsy (CP) rates have remain relatively unchanged as related to the use of cCTG . In our view, this is due to continuing inability to recognize progressive fetal deterioration and intervene promptly prior to the development of fetal CNS injury...
June 13, 2021: Journal of Maternal-fetal & Neonatal Medicine
Elizabeth Patberg, Matthew Wells, Sevan Vahanian, Jose Zavala, Sarmistha Bhattacharya, Diana Richmond, Meredith Akerman, Michael Demishev, Wendy Kinzler, Martin R Chavez, Anthony Vintzileos
OBJECTIVES: To develop standard cervical elastography nomograms for singleton pregnancies at 18-22 weeks gestation using the E-cervix ultrasound application; assess intra-observer reliability of the E-cervix elastography parameters; and determine if these cervical elastography measurements can be used in the prediction of spontaneous preterm birth. METHODS: This was a prospective cohort study of pregnant women undergoing cervical length screening assessment via transvaginal ultrasound examination at 18 - 22 weeks gestation...
May 26, 2021: American Journal of Obstetrics and Gynecology
Benjamin J F Huntley, Isabelle A Mulder, Daniele Di Mascio, William S Vintzileos, Anthony M Vintzileos, Vincenzo Berghella, Suneet P Chauhan
OBJECTIVE: To compare the risk of intrauterine fetal death (20 weeks of gestation or later) and neonatal death among individuals who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared with those who tested negative for SARS-CoV-2 on admission for delivery. DATA SOURCES: MEDLINE, Ovid, EMBASE, Cumulative Index to Nursing and Allied Health, and Cochrane Library were searched from their inception until July 17, 2020. Hand search for additional articles continued through September 24, 2020...
April 1, 2021: Obstetrics and Gynecology
William Vintzileos
No abstract text is available yet for this article.
February 9, 2021: Academic Medicine
Eva Hoffmann, William S Vintzileos, Meredith Akerman, Rosanne Vertichio, Genevieve B Sicuranza, Anthony M Vintzileos
OBJECTIVE: The objectives of our study were to: (1) evaluate the prevalence of cesarean delivery due to maternal request among nulliparous, term, singleton, vertex (NTSV) patients; (2) identify the clinical profile, if any, of these patients; and (3) compare the perinatal outcomes between NTSV patients who requested a cesarean delivery versus patients who did not request cesarean delivery. STUDY DESIGN: This was a retrospective case control study performed at a single institution between November 2018 and July 2019...
November 10, 2020: Journal of Maternal-fetal & Neonatal Medicine
Elizabeth T Patberg, Tracy Adams, Patricia Rekawek, Sevan A Vahanian, Meredith Akerman, Andrea Hernandez, Amy V Rapkiewicz, Louis Ragolia, Genevieve Sicuranza, Martin R Chavez, Anthony M Vintzileos, Poonam Khullar
BACKGROUND: There is a paucity of data describing the effects of coronavirus disease 2019 on placental pathology, especially in asymptomatic patients. Although the pathophysiology of coronavirus disease 2019 is not completely understood, there is emerging evidence that it causes a severe systemic inflammatory response and results in a hypercoagulable state with widespread microthrombi. We hypothesized that it is plausible that a similar disease process may occur in the fetal-maternal unit...
October 19, 2020: American Journal of Obstetrics and Gynecology
Bailey McGuinness, Farr Nezhat, Lauren Ursillo, Meredith Akerman, William Vintzileos, Michael White
OBJECTIVE: To determine the incidence of fallopian tube endometriosis in patients undergoing laparoscopic surgery with a preoperative diagnosis of endometriosis, pelvic pain, infertility, or cystic adnexal mass. DESIGN: Retrospective cross-sectional study. SETTING: Gynecologic oncology and minimally invasive surgery practice. PATIENT(S): All patients who underwent surgery for endometriosis from July 2015 to June 2018 were included...
November 2020: Fertility and Sterility
Mohammad M Sajadi, Parham Habibzadeh, Augustin Vintzileos, Shervin Shokouhi, Fernando Miralles-Wilhelm, Anthony Amoroso
BACKGROUND: A significant number of infectious diseases display seasonal patterns in their incidence, including human coronaviruses. Betacoronaviruses such as MERS-CoV and SARS-CoV are not thought to be seasonal. METHODS: We examined climate data from cities with significant community spread of COVID-19 using ERA-5 reanalysis, and compared to areas that are either not affected, or do not have significant community spread. FINDINGS: To date, Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, has established significant community spread in cities and regions along a narrow east west distribution roughly along the 30-50o N' corridor at consistently similar weather patterns consisting of average temperatures of 5-11oC, combined with low specific (3-6 g/kg) and absolute humidity (4-7 g/m3)...
March 9, 2020: SSRN
Mohammad M Sajadi, Parham Habibzadeh, Augustin Vintzileos, Shervin Shokouhi, Fernando Miralles-Wilhelm, Anthony Amoroso
Importance: Coronavirus disease 2019 (COVID-19) infection has resulted in a global crisis. Investigating the potential association of climate and seasonality with the spread of this infection could aid in preventive and surveillance strategies. Objective: To examine the association of climate with the spread of COVID-19 infection. Design, Setting, and Participants: This cohort study examined climate data from 50 cities worldwide with and without substantial community spread of COVID-19...
June 1, 2020: JAMA Network Open
Gabriela N Algarroba, Patricia Rekawek, Sevan A Vahanian, Poonam Khullar, Thomas Palaia, Morgan R Peltier, Martin R Chavez, Anthony M Vintzileos
No abstract text is available yet for this article.
May 13, 2020: American Journal of Obstetrics and Gynecology
Agata Kantorowska, Cassandra J Heiselman, Tara A Halpern, Meredith B Akerman, Ashley Elsayad, Jolene C Muscat, Genevieve B Sicuranza, Anthony M Vintzileos, Hye J Heo
BACKGROUND: Obstetric hypertensive emergency is defined as having systolic blood pressure ≥160 mm Hg or diastolic blood pressure ≥110 mm Hg, confirmed 15 minutes apart. The American College of Obstetricians and Gynecologists recommends that acute-onset, severe hypertension be treated with first line-therapy (intravenous labetalol, intravenous hydralazine or oral nifedipine) within 60 minutes to reduce risk of maternal morbidity and death. OBJECTIVE: Our objective was to identify barriers that lead to delayed treatment of obstetric hypertensive emergency...
August 2020: American Journal of Obstetrics and Gynecology
Cheryl Dinglas, Nur Afsar, Elizabeth Cochrane, Jay Davis, Sara Kim, Meredith Akerman, Matthew Wells, Martin Chavez, Kimberly Herrera, Hye Heo, Anthony Vintzileos
BACKGROUND: While elevated second trimester maternal serum alpha fetoprotein (msAFP) has been associated with adverse pregnancy outcomes, the utility of first trimester msAFP in predicting these outcomes is limited. Some laboratories have been including msAFP as part of the first trimester analyte screening for aneuploidy and preeclampsia, offering its potential utility in predicting pregnancy outcomes. OBJECTIVE: Our primary objective was to determine the association between elevated first trimester msAFP and preeclampsia, as well as ischemic placental disease (a composite of preeclampsia, fetal growth restriction and/or placental abruption)...
November 30, 2019: American Journal of Obstetrics and Gynecology
Andrew P Rabenstein, Khaled F Salhab, Georgios Spentzouris, Vijayapraveena Paruchuri, George Hines, Anthony M Vintzileos, Scott L Schubach
We report a rare case of a 30-year-old female who had a long-standing history of middle aortic syndrome that was being managed nonsurgically. She presented with hypertension and buttock pain with plans to become pregnant. She underwent an aortoiliac bypass.
June 2019: Aorta (Stamford, Conn.)
Mariarosaria Di Tommaso, Serena Pinzauti, Silvia Bandinelli, Chiara Poli, Antonio Ragusa
BACKGROUND: All guidelines regarding electronic fetal heart monitoring (EFM) before 2008 were designed to avoid more hypoxia than acidosis. In addition, the results of the Cochrane meta-analysis of 2013 do not show a significant improvement in neonatal outcomes using EFM or intermittent auscultation (IA). OBJECTIVES: We retrospectively evaluated the results on delivery outcomes arising from a comparison between EFM and IA during labor of 2 specific and high-quality trials...
September 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Farr R Nezhat, Cande V Ananth, Anthony M Vintzileos
Randomized controlled trials of surgery are fundamentally different from randomized controlled trials of medications because it is difficult to blind or mask a surgical procedure or perform "sham" operations. An additional challenge is the variation in skills and surgical proficiency of participating centers and surgeons. Addressing heterogeneity in surgical proficiency remains of paramount importance, especially when randomized controlled trials involve a new or complex procedure such as minimally invasive radical surgery...
September 2019: American Journal of Obstetrics and Gynecology
Cande V Ananth, Justin S Brandt, Anthony M Vintzileos
No abstract text is available yet for this article.
April 2019: American Journal of Obstetrics and Gynecology
Sevan A Vahanian, Matthew K Hoffman, Cande V Ananth, Damien J Croft, Christina Duzyj Buniak, Karin M Fuchs, Cynthia Gyamfi-Bannerman, Wendy L Kinzler, Lauren A Plante, Angela C Ranzini, Todd J Rosen, Daniel W Skupski, John C Smulian, Anthony M Vintzileos
BACKGROUND: Prior studies have reported an increased risk for preterm delivery following a term cesarean delivery. However, these studies did not adjust for high risk conditions related to the first cesarean delivery and are known to recur. OBJECTIVE: To determine if there is an association between term cesarean delivery in the first pregnancy and subsequent spontaneous or indicated preterm delivery. STUDY DESIGN: This was a retrospective cohort study of women with the first two consecutive singleton deliveries (2007-2014) identified through a linked pregnancy database at a single institution...
February 22, 2019: American Journal of Obstetrics and Gynecology
Cheryl Dinglas, Martin Chavez, Anthony Vintzileos
No abstract text is available yet for this article.
August 2019: American Journal of Obstetrics and Gynecology
Cande V Ananth, Anthony M Vintzileos
No abstract text is available yet for this article.
October 15, 2018: JAMA Pediatrics
A M Vintzileos
No abstract text is available yet for this article.
January 2019: BJOG: An International Journal of Obstetrics and Gynaecology
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