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JOURNAL ARTICLE
C Pérez Lázaro, A López-Bravo, C Gómez-Escalonilla Escobar, C Aguirre, A de Felipe, P de la Riva, S Calleja, A Arjona, M Serrano Ponz, M P Navarro-Pérez, R Delgado-Mederos, S Bashir Viturro, L Llul, J Egido, S García Madrona, N Díez González, L Benavente-Fernández, J D de la Torre-Colmenero, H Tejada Meza, A Vesperinas-Castro, L Sánchez-Cirera, S Trillo
INTRODUCTION: Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that mainly affects young adults. Early, accurate diagnosis can reduce the rate and severity of complications. OBJECTIVE: The aim of this study was to analyse the clinical characteristics, management, and treatment of CVT in different centres in Spain. METHODS: We conducted a multicentre, retrospective, descriptive study of patients hospitalised due to CVT between 2008 and 2017 at 10 Spanish centres...
April 2024: Neurología
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REVIEW
Aura Ximena González-Cely, Camilo A R Diaz, Mauro Callejas-Cuervo, Teodiano Bastos-Filho
BACKGROUND: In the last ten years, the design and implementation of Optical Fiber Sensors (OFS) in biomedical applications have been discussed, with a focus on different subareas, such as body parameter monitoring and control of assistive devices. MATERIALS AND METHODS: A scoping review was performed including scientific literature (PubMed/Scopus, IEEE and Web of Science), patents (WIPO/Google Scholar), and commercial information. RESULTS: The main applications of OFS in the rehabilitation field for preventing future postural diseases and applying them in device controllers were discussed in this review...
July 13, 2023: Disability and Rehabilitation. Assistive Technology
#43
JOURNAL ARTICLE
P Martín-Jiménez, M Sánchez-Tornero, S Llamas-Velasco, M P Guerrero-Molina, M González-Sánchez, A Herrero-San Martín, V Blanco-Palmero, P Calleja-Castaño, J Francisco-Gonzalo, A Hilario, A Ramos, E Salvador, Ó Toldos, A Hernández-Lain, D A Pérez-Martínez, A Villarejo-Galende
INTRODUCTION: Cerebral amyloid angiopathy-related inflammation (CAA-ri) is an entity characterised by an inflammatory response to β-amyloid deposition in the walls of cerebral microvessels. METHODS: We conducted a retrospective review of a series of patients with a diagnosis of CAA-ri according to histopathological study findings or clinical-radiological diagnostic criteria. RESULTS: The study included 7 patients (5 men) with a mean age of 79 years...
July 10, 2023: Neurología
#44
JOURNAL ARTICLE
António Miguel Martins Pinto da Costa, Ana Perez González, Fernando Pons Renedo, Elena Santos Pérez, Ana Dotor, José Luis Calleja Panero
No abstract text is available yet for this article.
June 28, 2023: Gastrointestinal Endoscopy
#45
JOURNAL ARTICLE
Fátima Sánchez-Cabo, Valentín Fuster, Juan Carlos Silla-Castro, Gema González, Erika Lorenzo-Vivas, Rebeca Alvarez, Sergio Callejas, Alberto Benguría, Eduardo Gil, Estefanía Núñez, Belén Oliva, José María Mendiguren, Marta Cortes-Canteli, Héctor Bueno, Vicente Andrés, Jose María Ordovás, Leticia Fernández-Friera, Antonio J Quesada, Jose Manuel Garcia, Xavier Rossello, Jesús Vázquez, Ana Dopazo, Antonio Fernández-Ortiz, Borja Ibáñez, Jose Javier Fuster, Enrique Lara-Pezzi
AIMS: Epigenetic age is emerging as a personalized and accurate predictor of biological age. The aim of this article is to assess the association of subclinical atherosclerosis with accelerated epigenetic age and to investigate the underlying mechanisms mediating this association. METHODS AND RESULTS: Whole blood methylomics, transcriptomics, and plasma proteomics were obtained for 391 participants of the Progression of Early Subclinical Atherosclerosis study. Epigenetic age was calculated from methylomics data for each participant...
June 20, 2023: European Heart Journal
#46
JOURNAL ARTICLE
Macarena Hernández-Jiménez, Francisco Abad-Santos, Ian Cotgreave, Jaime Gallego, Bernd Jilma, Alan Flores, Tudor G Jovin, José Vivancos, María Hernández-Pérez, Carlos A Molina, Joan Montaner, Joaquín Casariego, Mads Dalsgaard, David S Liebeskind, Erik Cobo, Mar Castellanos, Pere Cardona Portela, Jaime Masjuán, Francisco Moniche, José Ignacio Tembl, Mikel Terceño Izaga, Juan F Arenillas, Patricia Callejas, Jean Marc Olivot, Lionel Calviere, Hilde Henon, Mikael Mazighi, David Piñeiro, Marco Pugliese, Victor M González, Maria Angeles Moro, Alvaro Garcia-Tornel, Ignacio Lizasoain, Marc Ribo
IMPORTANCE: ApTOLL is a TLR4 antagonist with proven preclinical neuroprotective effect and a safe profile in healthy volunteers. OBJECTIVE: To assess the safety and efficacy of ApTOLL in combination with endovascular treatment (EVT) for patients with ischemic stroke. DESIGN, SETTING, AND PARTICIPANTS: This phase 1b/2a, double-blind, randomized, placebo-controlled study was conducted at 15 sites in Spain and France from 2020 to 2022. Participants included patients aged 18 to 90 years who had ischemic stroke due to large vessel occlusion and were seen within 6 hours after stroke onset; other criteria were an Alberta Stroke Program Early CT Score of 6 to 10, estimated infarct core volume on baseline computed tomography perfusion of 5 to 70 mL, and the intention to undergo EVT...
August 1, 2023: JAMA Neurology
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JOURNAL ARTICLE
J L Calleja-Panero, R Esteban Mur, I Jarque, M Romero Gómez, L García Labrador, J González Calvo
No abstract text is available yet for this article.
May 24, 2023: Gastroenterología y Hepatología
#48
JOURNAL ARTICLE
Teresa Bernal, Ainhoa Fernández Moreno, Almudena de LaIglesia, Celina Benavente, Ana García-Noblejas, Daniel García Belmonte, Rosalía Riaza, Olga Salamero, Maria Angeles Foncillas, Alicia Roldán, Víctor Noriega Concepción, Laura Llorente González, Juan Miguel Bergua Burgués, Soraya Lorente de Uña, Gabriela Rodríguez-Macías, Adolfo de la Fuente Burguera, Maria José García Pérez, Jose Luis López-Lorenzo, Pilar Martínez, Concepción Aláez, Marta Callejas, Carmen Martínez-Chamorro, José Rifón Roca, Lourdes Amador Barciela, Armando V Mena Durán, Karoll Gómez Correcha, Esperanza Lavilla Rubira, María Luz Amigo, Ferran Vall-Llovera, Ana Garrido, María García-Fortes, Dunia de Miguel Llorente, Anastasia Aules Leonardo, Carlos Cervero, Rosa Coll Jordá, Manuel M Pérez-Encinas, Marta Polo Zarzuela, Angela Figuera, Guillermo Rad, David Martínez-Cuadrón, Pau Montesinos
BACKGROUND: CPX-351 is approved for the treatment of therapy related acute myeloid leukemia (t-AML) and AML with myelodysplastic related changes (MRC-AML). The benefits of this treatment over standard chemotherapy has not been addressed in well matched cohorts of real-life patients. METHODS: Retrospective analysis of AML patients treated with CPX-351 as per routine practice. A propensity score matching (PSM) was used to compare their main outcomes with those observed in a matched cohort among 765 historical patients receiving intensive chemotherapy (IC), all of them reported to the PETHEMA epidemiologic registry...
May 22, 2023: Cancer Medicine
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JOURNAL ARTICLE
Verónica Reyes-Galindo, Juan Pablo Jaramillo-Correa, Karina Carrasco Nava, Alejandra Elizabeth De la Rosa González, David Flores Flores, Mauricio Martínez, Luis Alberto Monroy de la Rosa, Miguel Ángel Morelos Zamora, Billy Emmanuel Ramírez Morales, Oliver Tanui Ramírez Morales, María Del Pilar Rodríguez, Maurilio Salazar Zamora, Claudio Zamora Callejas, Rafael Zamora Callejas, César Zamora, Tonatiuh Zamora, Victor Alejandro González Camacho, Erick Rebollo, Ricardo Torres-Jardón, Ana Wegier-Brioulo, Alicia Mastretta-Yanes
Peri-urban forest monitoring requires indicators of vegetation damage. An example is the sacred fir (Abies religiosa) forests surrounding Mexico City, which have been heavily exposed to tropospheric ozone, a harmful pollutant, for over 4 decades. We developed a participatory monitoring system with which local community members and scientists generated data on ozone tree damage. Santa Rosa Xochiac rangers (13) used the digital tool KoboToolBox to record ozone damage to trees, tree height, tree ages, tree condition, tree position, and whether the tree had been planted...
May 19, 2023: Conservation Biology
#50
REVIEW
Javier Espasa-Labrador, Azahara Fort-Vanmeerhaeghe, Alicia M Montalvo, Marta Carrasco-Marginet, Alfredo Irurtia, Julio Calleja-González
The monitoring of internal load in basketball can be used to understand the effects and potential physiological adaptations caused by external load. The main aim of this systematic review was to identify the methods and variables used to quantify internal load in female basketball. The studies included different populations and events: youth athletes, elite, and amateur players. Subjective methods included using the rating of perceived exertion (RPE) method, and sensor-based methods included monitoring the cardiac response to exercise, using heart rate (HR) as the primary metric...
May 2, 2023: Sensors
#51
REVIEW
E Sanjuan, O Pancorbo, K Santana, O Miñarro, V Sala, M Muchada, S Boned, J M Juega, J Pagola, Á García-Tornel, M Requena, N Rodríguez-Villatoro, D Rodríguez-Luna, M Deck, M Ribo, C A Molina, P Meler, V Romero, G Dalmases, M T Rodríguez-Samaniego, L Calleja, T Gutierrez, L Peña, J C Gallego, E Lorenzo, Y Gonzalez, R Moreno, M Rubiera
OBJECTIVE: This study provides a series of updated, evidence-based recommendations for the management of acute stroke. We aim to lay a foundation for the development of individual centres' internal protocols, serving as a reference for nursing care. METHODS: We review the available evidence on acute stroke care. The most recent national and international guidelines were consulted. Levels of evidence and degrees of recommendation are based on the Oxford Centre for Evidence-Based Medicine classification...
April 27, 2023: Neurología
#52
REVIEW
Cristina Hidalgo Calleja, María Dolores Sánchez González, Julio Medina Luezas, Lucía López Corral
BACKGROUND AND OBJECTIVE: Chronic graft-versus-host disease (cGVRD) is a systemic immune-mediated complication that occurs in approximately half of the patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HCT) and, although it is associated with beneficial graft versus tumour effects and lower relapse rates, it remains the leading cause of late morbidity and mortality in these patients. The aim of this systematic review of the literature is to provide a current overview on the diagnostic musculoskeletal manifestations of cGVRD, its clinical evaluation, and therapeutic possibilities...
April 20, 2023: Reumatología clinica
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JOURNAL ARTICLE
Tomás Urrego-Callejas, Alejandro Hernández, Sebastián Ruiz Giraldo, Beatriz Frade-Sosa, Adriana L Vanegas-García, Carlos H Muñoz, Carolina Rua, Julieta Duque Botero, Luis A González, Gloria Vásquez, José A Gómez-Puerta
BACKGROUND: There is an increasing interest in the study of non-criteria antiphospholipid antibodies (aPL) including antibodies targeting domain 1 of the B2 glycoprotein 1 (anti-D1 B2GP1) and antibodies anti phosphatidylserine/ prothrombin (PS/PT). OBJECTIVES: Our aim was to analyze a panel of conventional and non-criteria aPL in a cohort of patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS), to describe if there are differences in aPL titers among groups, to evaluate clinical associations including risk of recurrent events of novel aPL...
April 2023: Reumatología clinica
#54
JOURNAL ARTICLE
Antonio Muñoz-Callejas, Elena González-Sánchez, Javier Silván, Esther San Antonio, Rafael González-Tajuelo, Alejandra Ramos-Manzano, Inés Sánchez-Abad, Isidoro González-Alvaro, Javier García-Pérez, Eva G Tomero, Rosario García de Vicuña, Esther F Vicente-Rabaneda, Santos Castañeda, Ana Urzainqui
Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the generation of anti-DNA autoantibodies due to exposure of immune cells to excessive amounts of extracellular DNA. Lack of P-selectin in mice induces the development of a lupus-like syndrome and patients with cutaneous lupus have reduced P-selectin expression in skin vessels. Using flow cytometry we analyzed in healthy donors and patients the expression of P-selectin Glycoprotein Ligand-1 (PSGL-1) in circulating neutrophils and the implication of PSGL-1/P-selectin interaction in neutrophil extracellular traps (NETs) generation...
March 24, 2023: International Journal of Molecular Sciences
#55
JOURNAL ARTICLE
Marco Pernigoni, Julio Calleja-González, Inga Lukonaitienė, Antonio Tessitore, Jūratė Stanislovaitienė, Paulius Kamarauskas, Daniele Conte
Purpose : To compare the effectiveness of active recovery (AR) versus static stretching (SS) during post-exercise recovery in basketball. Methods : Using a counterbalanced crossover design, 17 elite youth male players completed two 90-min training sessions, followed by either AR or SS. Differences in jump height (CMJ), heart rate variability (Ln-rMSSD), muscle soreness (VAS), perceived recovery (TQR) and hormonal biomarkers (cortisol, testosterone, testosterone:cortisol ratio) between interventions were assessed at pre-session, post-session (except hormonal biomarkers), post-recovery and 24 h post-session...
April 11, 2023: Research Quarterly for Exercise and Sport
#56
JOURNAL ARTICLE
Jorge Luis Vélez-Páez, Santiago Xavier Aguayo-Moscoso, Christian Castro-Bustamante, Mario Montalvo-Villagómez, Fernando Jara-González, Lucy Baldeón-Rojas, Natalia Zubieta-DeUrioste, Denise Battaglini, Gustavo R Zubieta-Calleja
BACKGROUND: Obesity is a common chronic comorbidity of patients with COVID-19, that has been associated with disease severity and mortality. COVID-19 at high altitude seems to be associated with increased rate of ICU discharge and hospital survival than at sea-level, despite higher immune levels and inflammation. The primary aim of this study was to investigate the survival rate of critically ill obese patients with COVID-19 at altitude in comparison with overweight and normal patients...
April 6, 2023: BMC Pulmonary Medicine
#57
REVIEW
Jeffrey V Lazarus, Marcela Villota-Rivas, Carolina Jiménez-González, Alvaro Santos-Laso, Paula Iruzubieta, María Teresa Arias-Loste, Lisa Rice-Duek, Simon Leigh, Christopher J Kopka, Juan Turnes, José Luis Calleja, Javier Crespo
Globally, the use of digital health interventions (DHIs) is expanding, along with growing scientific evidence of their effectiveness. Given the high and increasing prevalence of noncommunicable liver disease, we surveyed 295 physicians across Spain about their knowledge, beliefs, attitudes, practices, and access with regard to DHIs for patient care and in particular for liver diseases, including nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Physicians reported high familiarity with DHIs, although most had not recommended them in patient care...
May 2023: Clinics in Liver Disease
#58
JOURNAL ARTICLE
Emmanuel M Gonzalez, Ariyan Zarei, Nathanial Hendler, Travis Simmons, Arman Zarei, Jeffrey Demieville, Robert Strand, Bruno Rozzi, Sebastian Calleja, Holly Ellingson, Michele Cosi, Sean Davey, Dean O Lavelle, Maria José Truco, Tyson L Swetnam, Nirav Merchant, Richard W Michelmore, Eric Lyons, Duke Pauli
As phenomics data volume and dimensionality increase due to advancements in sensor technology, there is an urgent need to develop and implement scalable data processing pipelines. Current phenomics data processing pipelines lack modularity, extensibility, and processing distribution across sensor modalities and phenotyping platforms. To address these challenges, we developed PhytoOracle (PO), a suite of modular, scalable pipelines for processing large volumes of field phenomics RGB, thermal, PSII chlorophyll fluorescence 2D images, and 3D point clouds...
2023: Frontiers in Plant Science
#59
JOURNAL ARTICLE
Seifeddine Brini, Daniel Boullosa, Julio Calleja-González, Rodrigo Ramirez-Campillo, Hadi Nobari, Carlo Castagna, Filipe Manuel Clemente, Luca Paolo Ardigò
Multidirectional jumping and repeated sprint ability are crucial performance factors in basketball. The main aim of this investigation was to examine the neuromuscular performance and body balance adaptations following basketball-specific combined training programs based on drop jump and multidirectional repeated sprint versus multidirectional plyometric training. Forty-two professional basketball male players participated in the current investigation and were randomly assigned to three groups: a combined group (COMB; n = 14), a multidirectional jump group (MJG; n = 14) and an active control group (CON; n = 14)...
2023: PloS One
#60
JOURNAL ARTICLE
Joaquín Martínez-López, Javier De la Cruz, Rodrigo Gil-Manso, Adrián Alegre, Javier Ortiz, Pilar Llamas, Yolanda Martínez, José-Ángel Hernández-Rivas, Isabel González-Gascón, Celina Benavente, Pablo Estival Monteliu, Víctor Jiménez-Yuste, Miguel Canales, Mariana Bastos, Mi Kwon, Susana Valenciano, Marta Callejas-Charavia, Javier López-Jiménez, Pilar Herrera, Rafael Duarte, Lucía Núñez Martín-Buitrago, Pedro Sanchez Godoy, Cristina Jacome Yerovi, Pilar Martínez-Barranco, María García Roa, Cristian Escolano Escobar, Arturo Matilla, Belén Rosado Sierra, María Concepción Aláez-Usón, Keina Quiroz-Cervantes, Carmen Martínez-Chamorro, Jaime Pérez-Oteyza, Rafael Martos-Martinez, Regina Herráez, Clara González-Santillana, Juan Francisco Del Campo, Arancha Alonso, Adolfo de la Fuente, Adriana Pascual, Rosalía Bustelos-Rodriguez, Ana Sebrango, Elena Ruiz, Eriel Alexis Marcheco-Pupo, Carlos Grande, Ángel Cedillo, Carlos Lumbreras, Andrés Arroyo Barea, José Manuel Casas-Rojo, Maria Calbacho, José Luis Diez-Martín, Julio García-Suárez
Mortality rates for COVID-19 have declined over time in the general population, but data in patients with hematologic malignancies are contradictory. We identified independent prognostic factors for COVID-19 severity and survival in unvaccinated patients with hematologic malignancies, compared mortality rates over time and versus non-cancer inpatients, and investigated post COVID-19 condition. Data were analyzed from 1166 consecutive, eligible patients with hematologic malignancies from the population-based HEMATO-MADRID registry, Spain, with COVID-19 prior to vaccination roll-out, stratified into early (February-June 2020; n = 769 (66%)) and later (July 2020-February 2021; n = 397 (34%)) cohorts...
February 27, 2023: Cancers
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