Cheima Djehiche, Nadia Benzidane, Hanene Djeghim, Mehdi Tebboub, Saad Mebrek, Katia Abedelouhab, Abderrahmane Baghiani, Noureddine Charef, Mohammed Messaoudi, Chawki Bensouici, Rabah Lebsir, Talha Bin Emran, Ali Alsalme, David Cornu, Mikhael Bechelany, Lekhmici Arrar, Ahmed Barhoum
This study assessed the efficacy of an Ammodaucus leucotrichus seed extract to treat rheumatoid arthritis in rat models of this disease. Rheumatoid arthritis was induced in rats using two methods: immunization with 100 µL of Complete Freund Adjuvant (CFA) and immunization with 100 µL of a 3 mg/ml solution of type II collagen (CII) from chicken cartilage. The therapeutic potential of the extract was assessed at different doses (150, 300, and 600 mg/kg/day for 21 days in the CII-induced arthritis model and for 14 days in the CFA-induced arthritis model) and compared with methotrexate (MTX; 0...
May 3, 2024: Applied Biochemistry and Biotechnology