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JOURNAL ARTICLE
Thanikul Srithunyarat, Supranee Jitpean, Piyasak Wipoosak, Chalermkwan Nonthakotr, Nitaya Boonbal, Panisara Kunkitti, Suvaluk Seesupa
BACKGROUND AND AIM: The Apgar score is a useful assessment of neonatal viability in dogs. The Apgar score in puppies born by cesarean section can be lower than vaginal delivery because all anesthetic drugs can cross the placenta. Therefore, anesthetic drugs with minimal cardiorespiratory effect and rapid elimination are recommended for cesarean section. The present study aimed to compare Apgar scores in puppies born after the induction of etomidate, alfaxalone or propofol, and those maintained with isoflurane inhalation during cesarean section...
March 2024: Veterinary World
#62
RANDOMIZED CONTROLLED TRIAL
Wenjuan Zhang, Jiao Liu, Xiaohui Li, Zhixia Bai, Yan Sun, Xuexin Chen
BACKGROUND: Anesthesia techniques and drug selection may influence tumor recurrence and metastasis. Neutrophil extracellular trapping (NETosis), an immunological process, has been linked to an increased susceptibility to metastasis in individuals with tumors. Furthermore, recurrence may be associated with vascular endothelial growth factor A (VEGF-A), a mediator of angiogenesis. This study investigates the impact of lidocaine (combined with sevoflurane or propofol anesthesia ) during breast cancer surgery inhibits the expression of biomarkers associated with metastasis and recurrence (specifically H3Cit, NE, MPO, MMP-9 and VEGF-A)...
April 27, 2024: BMC Anesthesiology
#63
REVIEW
Rohan Ameratunga, Anthony Jordan, Klaus Lehnert, Euphemia Leung, Emily R Mears, Russell Snell, Richard Steele, See-Tarn Woon
COVID-19 has caused calamitous health, economic and societal consequences. Although several COVID-19 vaccines have received full authorization for use, global deployment has faced political, financial and logistical challenges. The efficacy of first-generation COVID-19 vaccines is waning and breakthrough infections are allowing ongoing transmission and evolution of SARS-CoV-2. Furthermore, COVID-19 vaccine efficacy relies on a functional immune system. Despite receiving three primary doses and three or more heterologous boosters, some immunocompromised patients may not be adequately protected by COVID-19 vaccines and remain vulnerable to severe disease...
April 25, 2024: Antiviral Research
#64
REVIEW
Luc E Vanlinthout, Jacques J Driessen, Robert Jan Stolker, Emmanuel M Lesaffre, Johan M Berghmans, Lonneke M Staals
BACKGROUND: Age-related differences in the pharmacokinetics and pharmacodynamics of neuromuscular blocking agents (NMBAs) and the short duration of many surgical procedures put pediatric patients at risk of postoperative residual curarization (PORC). To date, the duration of neuromuscular blocking agent effect in children has not been analyzed in a quantitative review. The current meta-analysis aimed to compare spontaneous recovery following administration of various types and doses of neuromuscular blocking agents and to quantify the effect of prognostic variables associated with the recovery time in pediatric patients...
April 26, 2024: Paediatric Anaesthesia
#65
JOURNAL ARTICLE
María S Magi, Yanina de Lafuente, Eride Quarta, María C Palena, Perla Del R Ardiles, Paulina L Páez, Fabio Sonvico, Francesca Buttini, Alvaro F Jimenez-Kairuz
Polyelectrolyte-drug complexes are interesting alternatives to improve unfavorable drug properties. Vancomycin (VAN) is an antimicrobial used in the treatment of methicillin-resistant Staphylococcus aureus pulmonary infections in patients with cystic fibrosis. It is generally administered intravenously with a high incidence of adverse side effects, which could be reduced by intrapulmonary administration. Currently, there are no commercially available inhalable formulations containing VAN. Thus, the present work focuses on the preparation and characterization of an ionic complex between hyaluronic acid (HA) and VAN with potential use in inhalable formulations...
March 22, 2024: Pharmaceutics
#66
RANDOMIZED CONTROLLED TRIAL
Shuhui Li, Kairui Feng, Jieon Lee, Yuqing Gong, Fang Wu, Bryan Newman, Miyoung Yoon, Lanyan Fang, Liang Zhao, Jogarao V S Gobburu
Advair Diskus is an essential treatment for asthma and chronic obstructive pulmonary disease. It is a dry powder inhaler with a combination of fluticasone propionate (FP) and salmeterol xinafoate (SX). However, the pharmacokinetics (PK) batch-to-batch variability of the reference-listed drug (RLD) hindered its generic product development. This work developed the PK models for inhaled FP and SX that could represent potential batch variability. Two batches each of the reference and the test product (R1 , R2 , T1 , T2 ) of Advair Diskus (100 μg FP/50 μg SX inhalation) were administered to 60 healthy subjects in a 4-period, 4-sequence crossover study...
April 26, 2024: AAPS Journal
#67
JOURNAL ARTICLE
Lei Wang, Yinan Guo, Xiaozhou Sun, Dan Wang, Tianlong Xie, Liang Liu, Liping Sun, Lina Wei
This study investigates the molecular mechanism of Ma Huang-Ku Xing Ren, a traditional Chinese medicine formula, in treating pediatric pneumonia. The focus is on the regulation of caspase-3 activation and reduction of alveolar macrophage necrosis through network pharmacology and bioinformatics analyses of Ephedra and bitter almond components. Active compounds and targets from ephedrine and bitter almond were obtained using TCMSP, TCMID, and GeneCards databases, identifying pediatric pneumonia-related genes...
April 2024: Chemical Biology & Drug Design
#68
JOURNAL ARTICLE
Qinxiu Zhang, Genju Li, Guozhi Zhao, Chongzheng Yan, Huaiyou Lv, Yaqing Fu, Yuhan Li, Zhongxi Zhao
Orally marketed products nintedanib (NDNB) and pirfenidone (PFD) for pulmonary fibrosis (PF) are administered in high doses and have been shown to have serious toxic and side effects. NDNB can cause the elevation of galectin-3, which activates the NF-κB signaling pathway and causes the inflammatory response. S-allylmercapto-N-acetylcysteine (ASSNAC) can alleviate the inflammation response by inhibiting the TLR-4/NF-κB signaling pathway. Therefore, we designed and prepared inhalable ASSNAC and NDNB co-loaded liposomes for the treatment of pulmonary fibrosis...
April 24, 2024: European Journal of Pharmaceutical Sciences
#69
REVIEW
Danyang Zhang, Haimei Zhao, Ping Li, Xueqiong Wu, Yan Liang
Traditional vaccines have played an important role in the prevention and treatment of infectious diseases, but they still have problems such as low immunogenicity, poor stability, and difficulty in inducing lasting immune responses. In recent years, the nucleic acid vaccine has emerged as a relatively cheap and safe new vaccine. Compared with traditional vaccines, nucleic acid vaccine has some unique advantages, such as easy production and storage, scalability, and consistency between batches. However, the direct administration of naked nucleic acid vaccine is not ideal, and safer and more effective vaccine delivery systems are needed...
April 26, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
#70
REVIEW
Lal Dhar Mishra, Ankit Agarwal, Atul K Singh, Kamath Sriganesh
Health-care settings have an important responsibility toward environmental health and safety. The operating room is a major source of environmental pollution within a hospital. Inhalational agents and nitrous oxide are the commonly used gases during general anesthesia for surgeries, especially in the developing world. These greenhouse gases contribute adversely to the environmental health both inside the operating room and in the outside atmosphere. Impact of these anesthetic agents depends on the total consumption, characteristics of individual agents, and gas flows, with higher levels increasing the environmental adverse effects...
2024: Journal of Anaesthesiology, Clinical Pharmacology
#71
REVIEW
Dave Singh, MeiLan K Han, Nathaniel M Hawkins, John R Hurst, Janwillem W H Kocks, Neil Skolnik, Daiana Stolz, Jad El Khoury, Chris P Gale
Chronic obstructive pulmonary disease (COPD) constitutes a major global health burden and is the third leading cause of death worldwide. A high proportion of patients with COPD have cardiovascular disease, but there is also evidence that COPD is a risk factor for adverse outcomes in cardiovascular disease. Patients with COPD frequently die of respiratory and cardiovascular causes, yet the identification and management of cardiopulmonary risk remain suboptimal owing to limited awareness and clinical intervention...
April 25, 2024: Advances in Therapy
#72
REVIEW
Kannan Sridharan, Gowri Sivaramakrishnan
BACKGROUND: Inhalational corticosteroids (ICS) were observed to increase the pneumonia risk in chronic obstructive pulmonary airway disorder (COPD). However, it is unknown whether any differences exist between the drugs within the ICS class. AIM: This study aimed to evaluate the risk of pneumonia associated with different ICS and identify factors that predict pneumonia in patients with moderate-to-severe COPD using a network meta-analysis. METHOD: Electronic databases (Medline, Cochrane CENTRAL and Google Scholar) were searched for trials comparing ICS in COPD patients...
April 25, 2024: International Journal of Clinical Pharmacy
#73
JOURNAL ARTICLE
Dazhao Gou, Qixuan Zhu, Hak-Kim Chan, Agisilaos Kourmatzis, Shaokoon Cheng, Runyu Yang
Aerosol drug delivery in the human airway is significantly affected by the morphology and size of the airway. This work developed a CFD-DEM model to simulate and analyze air flow and powder dynamics in combined inhaler-airway systems with different degrees of airway deformation (non-deformed, 50%, and 75% deformed) and sizes (adult, 0.80, and 0.62 scaled). The airways were generated based on a regular airway constructed from the MRI images through finite element method (for deformed airways) or scaling-down (for smaller airways)...
April 23, 2024: International Journal of Pharmaceutics
#74
JOURNAL ARTICLE
James W Pinkerton, Silvia Preite, Antonio Piras, Dimitrios Zervas, Thomais Markou, Mark S Freeman, Tobias Hofving, Emil Ivarsson, Sara J Bonvini, Wayne Brailsford, Linda Yrlid, Maria G Belvisi, Mark A Birrell
BACKGROUND: Two isoforms of Phosphoinositide 3-kinase (PI3K), p110γ and p110δ, are predominantly expressed in leukocytes and represent attractive therapeutic targets for the treatment of allergic asthma. The study aim was to assess the impact of administration of an inhaled PI3Kγδ inhibitor (AZD8154) in a rat model of asthma. METHODS: Firstly, we checked that the tool compound, AZD8154, inhibited rat PI3K γ & δ kinases using rat cell-based assays...
April 23, 2024: Respiratory Research
#75
JOURNAL ARTICLE
Chunjuan Zhai, Fen Wang, Ruie Xu, Xia Sun, Wenbin Ma, Li Wang
PURPOSE: Umeclidinium plus vilanterol (UMEC/VI) is an inhaled long-acting muscarinic antagonist/long-acting beta2-agonist (LAMA/LABA), recently approved as once-daily maintenance therapy for chronic obstructive pulmonary disease (COPD). This meta-analysis aims to assess the efficacy and safety of UMEC/VI compared with fluticasone propionate plus salmeterol (FP/SAL). METHODS: A systematic search was conducted by a trained medical research librarian across MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and Chinese Biomedical Literature Database (CBM) for randomized controlled trials comparing UMEC/VI with FP/SAL in COPD patients...
April 23, 2024: Postgraduate Medical Journal
#76
JOURNAL ARTICLE
Marek Niedoszytko, Aleksandra Gorska, Knut Brockow, Patrizia Bonadonna, Magdalena Lange, Hanneke Kluin-Nelemans, Hanneke Oude-Elberink, Vito Sabato, Khalid Shoumariyeh, Dagmar von Bubnoff, Sabine Müller, Anja Illerhaus, Michael Doubek, Irena Angelova-Fischer, Olivier Hermine, Michel Arock, Chiara Elena, Luca Malcovati, Akif Selim Yavuz, Tanja Daniela Schug, Anna Belloni Fortina, Várkonyi Judit, Jason Gotlib, Jens Panse, Vladan Vucinic, Andreas Reiter, Juliana Schwaab, Massimo Triggiani, Mattias Mattsson, Christine Breynaert, Jan Romantowski, Roberta Zanotti, Elisa Olivieri, Alexander Zink, Annick van de Ven, Alex Stefan, Stephane Barete, Francesca Caroppo, Cecelia Perkins, Vanessa Kennedy, Deborah Christen, Mohamad Jawhar, Johannes Luebke, Roberta Parente, Kerstin Levedahl, Emir Hadzijusufovic, Karin Hartmann, Boguslaw Nedoszytko, Wolfgang R Sperr, Peter Valent
BACKGROUND: Hypersensitivity reactions (HR) are common in mastocytosis. However, little is known about triggers and risk factors. The registry of the European Competence Network on Mastocytosis (ECNM) enables reliable studies in a larger cohort of mastocytosis patients. We assessed prevalence, triggers and risk factors of HR in adults with mastocytosis in the ECNM registry. METHODS: Data were collected in 27 ECNM centers. We analyzed potential triggers (Hymenoptera venoms, food, drug, inhalant and others) and risk factors at diagnosis and during follow-up...
April 23, 2024: Allergy
#77
JOURNAL ARTICLE
Tetsuri Kondo, Toshimori Tanigaki, Makoto Hibino, Shigeto Horiuchi, Kazunari Maeda, Shunichi Tobe, Riko Kamada, Shigehiro Watanabe
Background : The combined use of a pressurized metered-dose inhaler and valved holding chamber (pMDI+VHC) is recommended to improve efficiency and safety; however, aerosol release is likely to vary with the inhalation maneuver. This in vitro study investigated the aerodynamic characteristics and aerosol release features of pMDI+VHC (Aerochamber, Trudell Medical International). Methods : The static and dynamic changes in the airway resistance ( R aw ) during inhalation (withdrawal) through pMDI+VHC were measured...
April 22, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
#78
JOURNAL ARTICLE
Toyoshi Yanagihara, Hiroaki Ogata, Asami Mori, Masako Kadowaki, Yuki Moriuchi, Akiko Ishimatsu, Junji Otsuka, Kazuhito Taguchi, Atushi Moriwaki, Makoto Yoshida
The increasing prevalence of Mycobacterium avium complex (MAC) pulmonary disease poses a significant therapeutic challenge, particularly due to the limited efficacy and systemic toxicity associated with conventional guideline-based therapy. Amikacin liposome inhalation suspension (ALIS) has been developed, yet its real-world application remains underreported. This retrospective analysis, conducted from March 2021 to February 2024, examined ALIS's clinical use in patients aged 20 years or older with refractory MAC pulmonary disease at our institution...
March 2024: Curēus
#79
JOURNAL ARTICLE
Tiantian Zhang, Yiyang Wang, Youliang Sun, Meiyue Song, Junling Pang, Mingyao Wang, Zhe Zhang, Peiran Yang, Yiling Chen, Xianmei Qi, Huan Zhou, Zhenzong Han, Yanjiang Xing, Ying Liu, Baicun Li, Jiangfeng Liu, Juntao Yang, Jing Wang
Inhalation of crystalline silica dust induces incurable lung damage, silicosis and pulmonary fibrosis. However, the mechanisms of the lung injury remain poorly understood, with limited therapeutic options aside from lung transplantation. Post-translational modifications can regulate the function of proteins and play an important role in studying disease mechanisms. To investigate changes in post-translational modifications of proteins in silicosis, combined quantitative proteome, acetylome, and succinylome analyses were performed with lung tissues from silica-injured and healthy mice using liquid chromatography-mass spectrometry...
April 17, 2024: Molecular & Cellular Proteomics: MCP
#80
JOURNAL ARTICLE
Sagun Poudel, Ehsan Kaffash, Long Zhao, Rudra Pangeni, Woon Nam Chow, Qingguo Xu
Nitrogen mustard (NM) is a potent vesicating chemical warfare agent that is primarily absorbed through skin, inhalation, or ocular surface. Ocular exposure of NM can cause acute to chronic keratopathy which can eventually lead to blindness. There is a current lack of effective countermeasures against ocular exposure of NM despite their imperative need. Herein, we aim to explore the sustained effect of Dexamethasone sodium phosphate (DSP)-loaded polymeric nanoparticles (PLGA-DSP-NP) following a single subconjunctival injection in the management and prevention of corneal injury progression upon exposure to NM...
April 17, 2024: Experimental Eye Research
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