James W Pinkerton, Silvia Preite, Antonio Piras, Dimitrios Zervas, Thomais Markou, Mark S Freeman, Tobias Hofving, Emil Ivarsson, Sara J Bonvini, Wayne Brailsford, Linda Yrlid, Maria G Belvisi, Mark A Birrell
BACKGROUND: Two isoforms of Phosphoinositide 3-kinase (PI3K), p110γ and p110δ, are predominantly expressed in leukocytes and represent attractive therapeutic targets for the treatment of allergic asthma. The study aim was to assess the impact of administration of an inhaled PI3Kγδ inhibitor (AZD8154) in a rat model of asthma. METHODS: Firstly, we checked that the tool compound, AZD8154, inhibited rat PI3K γ & δ kinases using rat cell-based assays...
April 23, 2024: Respiratory Research