Daniil Spector, Anna Bubley, Anastasia Zharova, Vladislav Bykusov, Dmitry Skvortsov, Daria Ipatova, Alexander Erofeev, Petr Gorelkin, Alexander Vaneev, Dmitrii Mazur, Vita Nikitina, Mikhail Melnikov, Vladimir Pergushov, Dmitry Bunin, Vladimir Kuzmin, Alexey Kostyukov, Anton Egorov, Elena Beloglazkina, Roman Akasov, Olga Krasnovskaya
Light-induced release of cisplatin from Pt(IV) prodrugs represents a promising approach for precise control over the antiproliferative activity of Pt-based chemotherapeutic drugs. This method has the potential to overcome crucial drawbacks of conventional cisplatin therapy, such as high general toxicity toward healthy organs and tissues. Herein, we report two Pt(IV) prodrugs with BODIPY-based photoactive ligands Pt-1 and Pt-2 , which were designed using carbamate and triazole linkers, respectively. Both prodrugs demonstrated the ability to release cisplatin under blue light irradiation without the requirement of an external reducing agent...
May 2, 2024: ACS Applied Bio Materials