Zachary Finkel, Fatima Esteban, Brianna Rodriguez, Tanner Clifford, Adelina Joseph, Hani Alostaz, Mridul Dalmia, Juan Gutierrez, Matthew J Tamasi, Samuel Ming Zhang, Jonah Simone, Hafize Petekci, Susmita Nath, Miriam Escott, Shivam Kumar Garg, Adam J Gormley, Suneel Kumar, Sonia Gulati, Li Cai
Genomic screened homeobox 1 (Gsx1 or Gsh1) is a neurogenic transcription factor required for the generation of excitatory and inhibitory interneurons during spinal cord development. In the adult, lentivirus (LV) mediated Gsx1 expression promotes neural regeneration and functional locomotor recovery in a mouse model of lateral hemisection spinal cord injury (SCI). The LV delivery method is clinically unsafe due to insertional mutations to the host DNA. In addition, the most common clinical case of SCI is contusion/compression...
April 24, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics