I Jalo, E W Isaac, M P Raymond, M Amina, R Y Adeniji
BACKGROUND: Blood transfusion is a lifesaving procedure with varying indications. Neonates, especially the extremely preterm are among the most frequent recipients of blood products. The indications could be from anaemia of prematurity or pathological causes such as haemolysis from ABO or rhesus incompatibility, neonatal sepsis and acute haemorrhage, among others. OBJECTIVE: To determine the rate, indications and outcome of blood transfusion in neonates at Federal Teaching Hospital Gombe, Nigeria...
February 2021: West African Journal of Medicine
Angela Segler, Thorsten Braun, Hendrik Stefan Fischer, Ricarda Dukatz, Claire-Rachel Weiss, Alexander Schwickert, Carsten Jäger, Christoph Bührer, Wolfgang Henrich
Evidence for umbilical cord blood (UCB) cell therapies as a potential intervention for neurological diseases is emerging. To date, most existing trials worked with allogenic cells, as the collection of autologous UCB from high-risk patients is challenging. In obstetric emergencies the collection cannot be planned. In preterm infants, late cord clamping and anatomic conditions may reduce the availability. The aim of the present study was to assess the feasibility of UCB collection in neonates at increased risk of brain damage...
January 2021: Cell Transplantation
Emma Persad, Greta Sibrecht, Martin Ringsten, Simon Karlelid, Olga Romantsik, Tommy Ulinder, Israel Júnior Borges do Nascimento, Maria Björklund, Anneliese Arno, Matteo Bruschettini
Blood loss in the first days of life has been associated with increased morbidity and mortality in very preterm infants. In this systematic review we included randomized controlled trials comparing the effects of interventions to preserve blood volume in the infant from birth, reduce the need for sampling, or limit the blood sampled. Mortality and major neurodevelopmental disabilities were the primary outcomes. Included studies underwent risk of bias-assessment and data extraction by two review authors independently...
2021: PloS One
William Hellström, Tobias Martinsson, Eva Morsing, Lotta Gränse, David Ley, Ann Hellström
BACKGROUND: Blood loss and adult blood transfusions are common during the neonatal period in preterm infants. The objective of the study was to clarify if degree of loss of fetal haemoglobin (HbF) was associated with later retinopathy of prematurity (ROP). METHODS: Retrospective observational cohort study. In total, 452 infants born <30 gestational weeks at a tertiary level neonatal intensive care unit in Sweden in 2009-2015 were included, 385 of whom had final ROP outcome...
February 5, 2021: British Journal of Ophthalmology
Samuel J Offor, Chinna N Orish, Eze Chidi Eze, Chiara Frazzoli, Orish E Orisakwe
Long term health effects of heavy metal exposure from both occupational and environmental settings involve multi-organ toxicities including but not limited to disturbances of neurological, cognitive, and metabolic processes, immune system dysregulation, carcinogenesis and sometimes permanent disabilities. Humans are exposed to toxic metals through various sources and routes of entry. The risk of heavy metal poisoning from donor blood has been the subject of many scientific investigations. In this review we highlight how the access to a safe and adequate blood transfusion with minimal risk of toxic metals to recipients is a public health challenge, especially in developing nations...
January 29, 2021: Transfusion and Apheresis Science
Karol Acevedo Viales, Kathia Valverde Muñoz, Daniela Gutiérrez Valverde
Fibrinogen is a precursor of fibrin, which acts as a procoagulant plasma soluble protein. It is involved in blood viscosity and clot stability to help in the recovery of damaged blood vessels. We describe the case of a preterm newborn who presented with abdominal distension and manifestations of bleeding in venipuncture sites. In the initial laboratories, prolonged coagulation times were observed with a decreased concentration of fibrinogen. This newborn had transfusion support, with recovery in factor levels and a subsequent decrease in them...
December 31, 2020: Curēus
Patricia E Zerra, Cassandra D Josephson
Transfusion of red blood cells, platelets, and fresh frozen plasma in neonatal patients has not been well characterized in the literature, with guidelines varying greatly between institutions. However, anemia and thrombocytopenia are highly prevalent, especially in preterm neonates. When transfusing a neonatal patient, clinicians must take into consideration physiologic differences, gestational and postnatal age, congenital disorders, and maternal factors while weighing the risks and benefits of transfusion...
March 2021: Clinics in Laboratory Medicine
Johanes Edy Siswanto, Peter H Dijk, Arend F Bos, Rita S Sitorus, Asri C Adisasmita, Sudarto Ronoatmodjo, Pieter J J Sauer
Background and Aims: Retinopathy of prematurity (ROP) is a severe disease in preterm infants. It is seen more frequently in Low-Middle Income Countries (LMIC) like Indonesia compared to High-Income Countries (HIC). Risk factors for ROP development are -extreme- preterm birth, use of oxygen, neonatal infections, respiratory problems, inadequate nutrition, and blood and exchange transfusions. In this paper, we give an overview of steps that can be taken in LMIC to prevent ROP and provide guidelines for screening and treating ROP...
March 2021: Health Science Reports
Shahida Husain Tarar, Muhammad Afzal, Hamna Atta, Syed Muhammad Ali Shah
OBJECTIVE: To evaluate the pregnancy outcome of human immunodeficiency syndrome-positive mothers. METHODS: The prospective observational study was conducted at the Department of Gynaecology and Obstetrics, Aziz Bhatti Shaheed Teaching Hospital, Gujrat, Pakistan, from June 2011 to March 2018, and comprised pregnant women screened positive for human immunodeficiency syndrome. Risk factors and perinatal outcomes were noted on a predesigned proforma. Data was analysed using SPSS 20...
January 2021: JPMA. the Journal of the Pakistan Medical Association
Victoria Stokes, Azita Rajai, Devdeep Mukherjee, Arindam Mukherjee
OBJECTIVE: To compare the characteristics and short-term outcomes in extremely preterm infants, who developed necrotizing enterocolitis (NEC) following a packed red blood cell transfusion (pRBC) within 48 h (TANEC), with those who developed NEC beyond 48 h (non-TANEC). SETTING: A single-center retrospective cohort study in a Tertiary neonatal intensive care unit in the UK over a 5-year period. PATIENTS AND METHODS: Extremely premature infants (23-27 weeks gestation) were selected...
January 20, 2021: Journal of Maternal-fetal & Neonatal Medicine
Haribalakrishna Balasubramanian, Mukesh Atyalgade, Bhawandeep Garg, Lakshmi Srinivasan, Nandkishor S Kabra, Swati Khapekar
The majority of extremely low birth weight (ELBW) neonates receive red blood cell (RBC) transfusions; at least 50% receive multiple transfusions. Anemia care bundles could be the most effective approach to reduce transfusion rates. We conducted a quality improvement non-controlled before-and-after retrospective study involving 345 ELBW infants admitted over a 5-year period in two consecutive epochs before and after implementation of an anemia care bundle in January 2017. Bundle components included (a) prophylactic subcutaneous erythropoietin twice each week (600 IU/kg/week) from day 7 through 8 weeks of age and (b) blood sampling stewardship in the first five postnatal weeks...
January 19, 2021: European Journal of Pediatrics
Phuong T Vu, Robin K Ohls, Dennis E Mayock, Kendell R German, Bryan A Comstock, Patrick J Heagerty, Sandra E Juul
BACKGROUND: Outcomes of extremely low gestational age neonates (ELGANs) may be adversely impacted by packed red blood cell (pRBC) transfusions. We investigated the impact of transfusions on neurodevelopmental outcome in the Preterm Erythropoietin (Epo) Neuroprotection (PENUT) Trial population. METHODS: This is a post hoc analysis of 936 infants 24-0/6 to 27-6/7 weeks' gestation enrolled in the PENUT Trial. Epo 1000 U/kg or placebo was given every 48 h × 6 doses, followed by 400 U/kg or sham injections 3 times a week through 32 weeks postmenstrual age...
January 11, 2021: Pediatric Research
Olivia Janssen, Jing Lin
Congenital parvovirus B19 infection is a rare but serious condition that can result in hydrops fetalis and fetal death. Due to the virus' cytotoxic effect on fetal red blood cell precursors, postnatal infection can cause a neonatal viremia and secondary pure red cell aplasia. Here, we describe a case of congenital parvovirus infection in a preterm infant complicated by hydrops fetalis and chronic anaemia that responded to postnatal treatment with intravenous immunoglobulin administered on day of life 44. After treatment, the anaemia resolved as the neonate exhibited interval increases in haemoglobin, haematocrit and reticulocyte count with no subsequent need for red blood cell transfusions...
January 11, 2021: BMJ Case Reports
Elizabeth K Baker, Euan M Wallace, Peter G Davis, Atul Malhotra, Susan E Jacobs, Stuart B Hooper, Rebecca Lim
Cell therapies for neonatal morbidities are progressing to early phase clinical trials. However, protocols for intravenous (IV) delivery of cell therapies to infants have not been evaluated. It has been assumed the cell dose prescribed is the dose delivered. Early in our clinical trial of human amnion epithelial cells (hAECs), we observed cells settling in the syringe and IV tubing used to deliver the suspension. The effect on dose delivery was unknown. We aimed to quantify this observation and determine an optimal protocol for IV delivery of hAECs to extremely preterm infants...
January 6, 2021: Stem Cells Translational Medicine
G Kayem, A Seco, G Beucher, C Dupont, B Branger, C Crenn Hebert, C Huissoud, J Fresson, N Winer, B Langer, P Rozenberg, O Morel, M P Bonnet, F Perrotin, E Azria, L Carbillon, C Chiesa, P Raynal, R C Rudigoz, M Dreyfus, F Vendittelli, S Patrier, C Deneux-Tharaux, L Sentilhes
OBJECTIVE: To describe and compare the characteristics of women with placenta accreta spectrum (PAS) and their pregnancy outcomes according to the presence of placenta praevia and a prior caesarean section. DESIGN: Prospective population-based study. SETTING: All 176 maternity hospitals of eight French regions. POPULATION: Two hundred and forty-nine women with PAS, from a source population of 520 114 deliveries. METHODS: Women with PAS were classified into two risk-profile groups, with or without the high-risk combination of placenta praevia (or an anterior low-lying placenta) and at least one prior caesarean...
January 3, 2021: BJOG: An International Journal of Obstetrics and Gynaecology
Shilei Bi, Lizi Zhang, Zhijian Wang, Jingsi Chen, Jingman Tang, Jingjin Gong, Sushan Xie, Lin Lin, Luwen Ren, Shanshan Zeng, Lijun Huang, Shaoshuai Wang, Lili Du, Dunjin Chen
PURPOSE: Through this study, we aimed to evaluate the effects of different types of placenta previa (PP) on maternal and neonatal outcomes. METHODS: This study was conducted in The Third Affiliated Hospital of Guangzhou Medical University and Tongji Hospital between January 2009 and 2019. PP was traditionally classified into four types, namely low-lying placenta, marginal, partial, and complete PP. Previous studies have classified PP into two types, namely low-lying placenta and PP...
January 2, 2021: Archives of Gynecology and Obstetrics
Haresh Kirpalani, Edward F Bell, Susan R Hintz, Sylvia Tan, Barbara Schmidt, Aasma S Chaudhary, Karen J Johnson, Margaret M Crawford, Jamie E Newman, Betty R Vohr, Waldemar A Carlo, Carl T D'Angio, Kathleen A Kennedy, Robin K Ohls, Brenda B Poindexter, Kurt Schibler, Robin K Whyte, John A Widness, John A F Zupancic, Myra H Wyckoff, William E Truog, Michele C Walsh, Valerie Y Chock, Abbot R Laptook, Gregory M Sokol, Bradley A Yoder, Ravi M Patel, C Michael Cotten, Melissa F Carmen, Uday Devaskar, Sanjay Chawla, Ruth Seabrook, Rosemary D Higgins, Abhik Das
BACKGROUND: Limited data suggest that higher hemoglobin thresholds for red-cell transfusions may reduce the risk of cognitive delay among extremely-low-birth-weight infants with anemia. METHODS: We performed an open, multicenter trial in which infants with a birth weight of 1000 g or less and a gestational age between 22 weeks 0 days and 28 weeks 6 days were randomly assigned within 48 hours after delivery to receive red-cell transfusions at higher or lower hemoglobin thresholds until 36 weeks of postmenstrual age or discharge, whichever occurred first...
December 31, 2020: New England Journal of Medicine
Elsa García González, Miguel Alsina Casanova, Dinara Samarkanova, Victoria Aldecoa-Bilbao, Marta Teresa-Palacio, Elisenda Farssac Busquets, Josep Figueras-Aloy, MªDolors Salvia-Roigés, Sergi Querol
BACKGROUND: Preterm infants born earlier than 32 weeks of gestational age (GA) often need red blood cell (RBC) transfusions, which have been associated with an increased incidence of complications of prematurity, due to changes in tissue oxygenation. Transfusion of umbilical cord blood (UCB) could be beneficial for this group. The aims of this study were: (i) to determine the RBC transfusion needs in infants <32 weeks in Hospital Clinic of Barcelona; (ii) to identify the target GA group that would benefit most from UCB transfusion; and (iii) to assess the current availability of UCB as a potential source of RBC transfusion for these premature infants in our tertiary referral blood bank...
December 18, 2020: Blood Transfusion
Jessica A Peterson, Kirsten Sandgren, Lisa D Levine
BACKGROUND: Preeclampsia complicates 5% to 8% of all pregnancies. Previous studies have examined the maternal morbidity and mortality associated with preeclampsia and the expectant management of severe preterm preeclampsia. However, these studies either did not comment on outcomes by race or were primarily made up of nonblack participants. OBJECTIVE: This study aimed to determine whether maternal morbidity associated with the expectant management of severe preterm preeclampsia varied by race...
November 2020: American journal of obstetrics & gynecology MFM
Matthew P Romagano, Onajovwe Fofah, Joseph J Apuzzio, Shauna F Williams, Lisa Gittens-Williams
BACKGROUND: Previous research has focused mainly on neonatal outcomes associated with preterm and periviable delivery, but maternal outcomes with preterm delivery are less well described. OBJECTIVE: This study aimed to determine if early preterm delivery results in an increase in maternal morbidity. STUDY DESIGN: This is a retrospective cohort study conducted at a tertiary care center over a 5-year time period. Subjects were women identified by review of neonatal intensive care unit admission logs...
August 2020: American journal of obstetrics & gynecology MFM
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"