Ninad S Chaudhary, Nicole D Armstrong, Bertha A Hidalgo, Orlando M Gutiérrez, Jacklyn N Hellwege, Nita A Limdi, Richard J Reynolds, Suzanne E Judd, Girish N Nadkarni, Leslie Lange, Cheryl A Winkler, Jeffrey B Kopp, Donna K Arnett, Hemant K Tiwari, Marguerite R Irvin
Background: Some but not all African-Americans (AA) who carry APOL1 nephropathy risk variants ( APOL1 ) develop kidney failure (end-stage kidney disease, ESKD). To identify genetic modifiers, we assessed gene-gene interactions in a large prospective cohort of the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. Methods: Genotypes from 8,074 AA participants were obtained from Illumina Infinium Multi-Ethnic AMR/AFR Extended BeadChip. We compared 388 incident ESKD cases with 7,686 non-ESKD controls, using a two-locus interaction approach...
2022: Frontiers in Medicine