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JOURNAL ARTICLE
Anielle de Oliveira, Thaysa F M Moreira, Beatriz Paes Silva, Grazielle Oliveira, Valéria Maria C Teixeira, Lycio S Watanabe, Suzana Lucy Nixdorf, Luana Eloísa Leal, Luiz Gustavo A Pessoa, Flavio Augusto V Seixas, Odinei H Gonçalves, Ana Paula Peron, Anacharis B Sá-Nakanishi, Fernanda V Leimann, Adelar Bracht, Lívia Bracht, Jurandir F Comar
Coffee processing generates large amounts of residues of which a portion still has bioactive properties due to their richness in phenolic compounds. This study aimed to obtain a coffee husks extract (CHE) and to encapsulate it (ECHE) with polyvinylpyrrolidone using a one-step procedure of solid dispersion. The extraction and encapsulation yields were 9.1% and 92%, respectively. Thermal analyses revealed that the encapsulation increased the thermal stability of CHE and dynamic light scattering analyses showed a bimodal distribution of size with 81% of the ECHE particles measuring approximately 711 nm...
February 2024: Food Research International
#42
JOURNAL ARTICLE
W-L Gong, Y-N Zhang, J Zhang, X Jiang, W-J Xian
OBJECTIVE: The aim of the study was to analyze the apoptosis of neurons and the differences in expression of Bcl-2 and Bax protein in the neurons in the corresponding spinal cord segment after the repair of the tibial nerve (TN) and common peroneal nerve (CPN) in rats. MATERIALS AND METHODS: 126 healthy male Sprague-Dawley (SD) rats aged 7-8 weeks were randomly divided into group A (control group), group B (TN was cut and sutured), and group C (CPN was cut and sutured), with 42 rats in each group...
January 2024: European Review for Medical and Pharmacological Sciences
#43
Aysylu Murtazina, Artem Borovikov, Andrey Marakhonov, Artem Sharkov, Inna Sharkova, Alena Mirzoyan, Sviatlana Kulikova, Ralina Ganieva, Viktoriia Zabnenkova, Oksana Ryzhkova, Sergey Nikitin, Elena Dadali, Sergey Kutsev
Congenital myasthenic syndrome with episodic apnea is associated with pathogenic variants in the CHAT gene. While respiratory disorders and oculomotor findings are commonly reported in affected individuals, a subset of patients only present with muscle weakness and/or ptosis but not apneic crises. In this case series, we describe five individuals with exercise intolerance caused by single nucleotide variants in the CHAT gene. The age of onset ranged from 1 to 2.5 years, and all patients exhibited a fluctuating course of congenital myasthenic syndrome without disease progression over several years...
2024: Frontiers in Pediatrics
#44
JOURNAL ARTICLE
Serena Jasmine Aleo, Valentina Del Dotto, Martina Romagnoli, Claudio Fiorini, Giada Capirossi, Camille Peron, Alessandra Maresca, Leonardo Caporali, Mariantonietta Capristo, Concetta Valentina Tropeano, Claudia Zanna, Fred N Ross-Cisneros, Alfredo A Sadun, Maria Gemma Pignataro, Carla Giordano, Chiara Fasano, Andrea Cavaliere, Anna Maria Porcelli, Gaia Tioli, Francesco Musiani, Alessia Catania, Costanza Lamperti, Stefania Bianchi Marzoli, Annamaria De Negri, Maria Lucia Cascavilla, Marco Battista, Piero Barboni, Michele Carbonelli, Giulia Amore, Chiara La Morgia, Dmitrii Smirnov, Catalina Vasilescu, Aiman Farzeen, Beryll Blickhaeuser, Holger Prokisch, Claudia Priglinger, Bettina Livonius, Claudia B Catarino, Thomas Klopstock, Valeria Tiranti, Valerio Carelli, Anna Maria Ghelli
Idebenone, the only approved treatment for Leber hereditary optic neuropathy (LHON), promotes recovery of visual function in up to 50% of patients, but we can neither predict nor understand the non-responders. Idebenone is reduced by the cytosolic NAD(P)H oxidoreductase I (NQO1) and directly shuttles electrons to respiratory complex III, bypassing complex I affected in LHON. We show here that two polymorphic variants drastically reduce NQO1 protein levels when homozygous or compound heterozygous. This hampers idebenone reduction...
January 17, 2024: Cell reports medicine
#45
JOURNAL ARTICLE
Rodrigo Simões Castilho, João Murilo Brandão Magalhães, Bruno Peliz Machado Veríssimo, Carlo Perisano, Tommaso Greco, Roberto Zambelli
Introduction: Peroneal disorders are a common cause of ankle pain and lateral instability and have been described in as much as 77% of patients with lateral ankle instability. Clicking, swelling, pain, and tenderness in the peroneal tendons track are frequent symptoms, but they can be confused with other causes of lateral ankle pain. The management of peroneal disorders can be conservative or surgical. When the conservative treatment fails, surgery is indicated, and open or tendoscopic synovectomy, tubularization, tenodesis or tendon transfers can be performed...
January 5, 2024: Medicina
#46
Alexander J Baldwin, Chane Kulenkampff, Dominic M Power
A complication of peripheral nerve injuries, of which there exists limited discourse, is the entrapment of the nerve as it regenerates from the site of injury to its end target, resulting in the arrest of axon regeneration and a consequent reduction of functional recovery. This proof-of-concept paper reports a review of the relevant literature alongside a case series of patients who presented with this phenomenon and who were treated with targeted peripheral nerve decompression. Three cases were identified prospectively...
December 2023: Curēus
#47
JOURNAL ARTICLE
Yucheng Huang, Jing Jiao, Junwen Wang, Fei Xiao, Ming Chen, Wen Xiong, Jialang Hu, Shilei Wu, Xuan Ma
PURPOSE: The present study was designed to investigate the precise procedure and effectiveness of percutaneous minimally invasive fixation assisted by TiRobot in managing AO/OTA type 41B2 tibial plateau fracture to provide an alternative solution for clinical application. METHODS: In total, 10 participants with AO/OTA type 41B2 tibial plateau fractures diagnosed by preoperative imaging examinations were enrolled in this study between May 2019 and May 2022. They were 5 males and 5 females, with an average age of 45...
January 9, 2024: Knee
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JOURNAL ARTICLE
Uri Gottlieb, Roee Hayek, Jay R Hoffman, Shmuel Springer
PURPOSE: To compare the short, medium, and long-term effects of balance exercises combined with either peroneal neuromuscular electrical stimulation (NMES) or peroneal transcutaneous electrical nerve stimulation (TENS) on dynamic postural control and patient reported outcome measures (PROMs) in patients with chronic ankle instability (CAI). METHODS: Thirty-four participants with CAI were randomly assigned to a 12-session home based exercise program combined with NMES (Ex-NMES) or TENS (Ex- TENS)...
December 30, 2023: Journal of Electromyography and Kinesiology
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JOURNAL ARTICLE
Swetalina Pradhan, Rashid Shahid, Suvesh Singh
BACKGROUND AND AIM: Geriatric populations are susceptible to leprosy infection with masked clinical signs due to lower immunity in them. Our aim was to analyze the clinicoepidemiologic profile of patients with geriatric leprosy and find out the reasons for delayed diagnosis and treatment. MATERIALS AND METHODS: A retrospective, record-based study was conducted in a tertiary care center from May 2019 to May 2022. The clinicodemographic data of biopsy-confirmed leprosy cases aged ≥60 years were obtained from the leprosy clinic record...
November 2023: Journal of Family Medicine and Primary Care
#50
JOURNAL ARTICLE
María Mercedes Reverté-Vinaixa, Enrique García-Albó, Ferran Blasco-Casado, Oriol Pujol, Bueno Joan Pijoan, Nayana Joshi-Jubert, Enric Castellet-Feliu, Irene Portas-Torres, José Vicente Andrés-Peiró, Joan Minguell-Monyart
PURPOSE: To describe our institutional experience and results in the surgical management of multiligament knee injuries (MLKI). MATERIALS AND METHODS: Retrospective series of MLKI consecutively operated on at a single, level I Trauma Center. Data on patients' baseline characteristics, injuries, treatments, and outcomes were recorded up to one-year follow-up. Recorded outcomes included the Tegner-Lysholm Knee Scoring Scale (TLKSS), return to work, and patient satisfaction...
December 26, 2023: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
#51
Bogdan Anglitoiu, Ahmed Abu-Awwad, Jenel-Marain Patrascu, Simona-Alina Abu-Awwad, Anca Raluca Dinu, Alina-Daniela Totorean, Dan Cojocaru, Mihai-Alexandru Sandesc
Osteomyelitis of the tibia is a challenging condition, particularly when it occurs as a result of trauma. This abstract presents a case study detailing the successful staged treatment of posttraumatic tibial osteomyelitis utilizing a unique combination of rib graft and serratus anterior muscle. This medical abstract presents a case study of a 52-year-old male with a history of heavy smoking and obliterating arteriopathy of the lower limbs. The patient sustained a traumatic open fracture classified as Type IIIA Gustilo Anderson involving one-third of the distal right tibia diaphysis, with an associated right fibular malleolus fracture...
November 27, 2023: Journal of Personalized Medicine
#52
JOURNAL ARTICLE
Vanessa Matias Souza Duarte, Dinorá Simone Santi Bonazza, Adriana Lino-Dos-Santos-Franco, Cor Jesus Fernandes Fontes, Amílcar Sabino Damazo
Leprosy is a chronic infectious disease characterized by acute inflammatory episodes that affect the skin and peripheral nerves and can develop progressive and irreversible disabilities and deformities. In addition, drug therapy and physiotherapy offer resources and techniques capable of mitigating the consequences of neural lesions, but neural lesions can occur before, during, and even after drug treatment. Thus, new treatments are needed. Photobiomodulation (PBM) might be a promissor therapy since it aims to reduce the inflammatory process and restore motor and sensory functions in the affected area...
December 22, 2023: Lasers in Medical Science
#53
JOURNAL ARTICLE
Pierre Bichet, Rémi Moskwa, Christophe Goetz, Yinka Zevering, Jean-Charles Vermion, Jean-Marc Perone
PURPOSE: The long-term clinical outcomes, postoperative complications, and graft survival of Descemet-membrane endothelial keratoplasty (DMEK) remain poorly understood. We retrospectively assessed these variables in all consecutive eyes that underwent DMEK for any indication in 2014-2018. The findings were compared to the long-term DMEK studies of five other groups (3-10-year follow-up). METHODS: Patients underwent ophthalmological tests preoperatively, at 1, 3, 6, and 12 postoperative months, and then annually...
2023: PloS One
#54
JOURNAL ARTICLE
Yan Li, Yukun Jia
For investigating the impact of miR-146a rs2910164 polymorphism on the therapeutic efficacy of lipoic acid therapy in patients with type 2 diabetes mellitus (T2DM) peripheral neuropathy (DPN). 106 T2DM-DPN patients in our hospital from Jan. 2020- 2022 were selected. The probe detection method was utilized to determine the polymorphism of the miR-146a rs2910164 gene in peripheral blood. All patients were treated with zinc sulfate for 3 weeks period. According to the treatment effect, 37 patients who were ineffective in treatment will be divided into an ineffective group, and 79 patients who were effective in treatment will be divided into an effective group...
November 30, 2023: Cellular and Molecular Biology
#55
JOURNAL ARTICLE
Ana G Starcevich, Leah R F Demetri, Michelle A James, Joel A Lerman
INTRODUCTION: Constriction band syndrome (CBS) is a congenital limb anomaly frequently associated with clubfoot. Clubfeet in CBS patients may be associated with peroneal nerve dysfunction in the involved lower extremity; however, the etiology of this neuromuscular dysfunction is not clear. We sought to characterize the distribution of constriction bands on lower extremities with clubfoot and determine if neuromuscular deficit (NMD), defined here as having absent ankle dorsiflexion, was associated with ipsilateral proximal bands...
December 8, 2023: Journal of Pediatric Orthopedics
#56
JOURNAL ARTICLE
Fengshi Zhang, Qicheng Li, Bo Ma, Meng Zhang, Yuhui Kou
BACKGROUND: Severe peripheral nerve injuries, such as deficits over long distances or proximal nerve trunk injuries, pose complex reconstruction challenges that often result in unfavorable outcomes. An innovative approach to repairing severe peripheral nerve damage involves using conduit suturing for nerve transposition repair. Cylindrical nerve guides are typically unsuitable for nerve transposition repair. Moreover, postsurgical adjuvant treatment is essential to promote the development of axonal lateral sprouts, proximal growth, and the restoration of neurostructure and function...
November 24, 2023: Frontiers in Bioscience (Landmark Edition)
#57
JOURNAL ARTICLE
Ruth Willis, Chaza Akik, Zeinab El-Dirani, Claudia Truppa, Carla Zmeter, Fabrizio Fleri, Sigiriya Aebischer Perone, Roberta Paci, Signe Frederiksen, Celine Abi Haidar, Randa S Hamadeh, Fouad M Fouad, Pablo Perel, Bayard Roberts, Éimhín Ansbro
Humanitarian health care models increasingly incorporate care for non-communicable diseases (NCDs). Current research evidence focuses on burden of disease, service provision and access to care, and less is known about patient's experience of the continuum of care in humanitarian settings. To address this gap, this study explored experiences of displaced Syrian and vulnerable Lebanese patients receiving care for hypertension and/or diabetes at four health facilities supported by humanitarian organisations in Lebanon...
2023: PLOS Glob Public Health
#58
JOURNAL ARTICLE
Karsten Heusser, Jens Tank, André Diedrich, Annelie Fischer, Tim Heise, Jens Jordan
INTRODUCTION: Reductions in sympathetic nervous system activity may contribute to beneficial effects of sodium glucose cotransporter 2 (SGLT2) inhibition on cardiovascular outcomes. Therefore, we tested the hypothesis that SGLT2 inhibition with empagliflozin (Empa) lowers muscle sympathetic nerve activity (MSNA) in patients with type 2 diabetes mellitus (T2DM) compared with hydrochlorothiazide (HCT) to discern SGLT2-specific actions from responses to increased natriuresis. METHODS: We randomized patients with T2DM on metformin monotherapy to either 25 mg/d Empa ( n = 20) or 25 mg/d HCT ( n = 21) for 6 weeks in a parallel, double-blind fashion...
November 2023: KI Reports
#59
JOURNAL ARTICLE
Gerardo de Jesús Franco-Ramírez, Francisco Cabrales-García, Francisco Godínez-García
BACKGROUND: The anterior cervical discectomy and fusion (ACDF) is the gold standard in the treatment of cervical compression pathology and the titanium cage for fusion represents the most used procedure at an institutional level. A technique using fibular autograft has been described, with good results, lower morbidity and lower cost. OBJECTIVE: To compare the rate of fusion, subsidence and functional clinical results after discectomy with titanium cage and fibular autograft...
September 18, 2023: Revista Médica del Instituto Mexicano del Seguro Social
#60
JOURNAL ARTICLE
Andrei-Daniel Bolovan, Roxana-Ramona Onofrei, Gheorghe-Bogdan Hogea, Ahmed Abu-Awwad, Emil-Adrian Lazarescu, Simona-Alina Abu-Awwad, Alexandra-Roxana Tapardea, Madalina-Ianca Suba, Elena-Constanta Amaricai
The management of tibial pilon fractures is challenging and often leads to complications and limitations in ankle function. The study aims to investigate myotonometric parameters and muscle strength of ankle muscles, as well as gait pattern and balance among patients following surgical treatment of pilon fractures. The randomized controlled study will analyze the differences between the patients who will follow a 3-month physical exercise program and will wear customized foot orthoses (i.e., customized orthotic arch support insoles) versus patients who will attend only the physical exercise program...
November 10, 2023: Life
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