Megan A Files, Lauren Gentles, Leanne Kehoe, Amanda Adler, Kirsten Lacombe, Jane A Dickerson, Alexander Greninger, Alpana Waghmare, Tarayn Fairlie, Kimberly Pringle, Claire M Midgley, Melissa Briggs Hagen, Janet A Englund, Chetan Seshadri
BACKGROUND: The kinetics and durability of T-cell responses to SARS-CoV-2 in children are not well-characterized. We studied a cohort of children aged 6 months to 20 years with COVID-19 in whom peripheral blood mononuclear cells (PBMC) and sera were archived at approximately 1, 6, and 12 months post-symptom onset. METHODS: We compared antibody (N = 85) and T-cell responses (N = 26) to nucleocapsid (N) and spike (S) glycoprotein over time across four age strata: 6 months to 5 years, 5-9, 10-14, and 15-20 years...
June 5, 2024: Journal of Infectious Diseases