Vasileios Alampanos, Abuzar Kabir, Kenneth G Furton, Željka Roje, Ivana Vinković Vrček, Victoria Samanidou
An improved pretreatment approach of human breast tissue is demonstrated for subsequent analysis of seven parabens including methyl paraben (MPB), ethyl paraben (EPB), propyl paraben (PPB), butyl paraben (BPB), isopropyl paraben (iPPB), isobutyl paraben (iBPB), and benzyl paraben (BzPB). Specifically, a well-designed homogenization procedure, conjugated with an optimized fabric phase sorptive extraction (FPSE) protocol, resulted in a carefully outlined sample preparation process as part of a green, simple, sensitive, economical and fast HPLC-PDA analytical method in agreement with Green Analytical Chemistry (GAC) demands...
September 12, 2020: Journal of Chromatography. A
Shikhar Shrestha, Cici X C Bauer, Brian Hendricks, Thomas J Stopka
Syndemics framework describes two or more co-occurring epidemics that synergistically interact with each other and the complex structural social forces that sustain them leading to excess disease burden. The term syndemic was first used to describe the interaction between substance abuse, violence, and AIDS by Merrill Singer. A broader range of syndemic studies has since emerged describing the framework's applicability to other public health scenarios. With syndemic theory garnering significant attention, the focus is shifting towards developing robust empirical analytical approaches...
September 10, 2020: Social Science & Medicine
Nitesh Tewari, Vijay Prakash Mathur, Amandeep Kaur, Divesh Sardana, Rahul Morankar, Rigzen Tamchos, Priyanshi Ritwik, Shubhi Goel, Julie Schiavo
BACKGROUND/AIMS: Evidence-mapping of systematic reviews (SRs) systematically and comprehensively identify, organize, and summarize the distribution of scientific-evidence in a field. The aims of this study were paper aimed to delineate domains in dental traumatology (DT), evaluate the existing SRs within the domains and identify the paucity of evidence for future research. METHODS: Domains and sub-domains of DT were established according to the methods of qualitative-research...
September 18, 2020: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Xiaonan Xue, Qibin Qi, Daniela Sotres-Alvarez, Scott C Roesch, Maria M Llabre, Sierra A Bainter, Yasmin Mossavar-Rahmani, Robert Kaplan, Tao Wang
Recently developed accelerometer devices have been used in large epidemiological studies for continuous and objective monitoring of physical activities. Typically, physical movements are summarized as minutes in light, moderate, and vigorous physical activities in each wearing day. Because of preponderance of zeros, zero-inflated distributions have been used for modeling the daily moderate or higher levels of physical activity. Yet, these models do not fully account for variations in daily physical activity and cannot be extended to model weekly physical activity explicitly, while the weekly physical activity is considered as an indicator for a subject's average level of physical activity...
September 18, 2020: Statistics in Medicine
Fekri Dureab, Kamran Ahmed, Claudia Beiersmann, Claire J Standley, Ali Alwaleedi, Albrecht Jahn
BACKGROUND: Diseases Surveillance is a continuous process of data collection, analysis interpretation and dissemination of information for swift public health action. Recent advances in health informatics have led to the implementation of electronic tools to facilitate such critical disease surveillance processes. This study aimed to assess the performance of the national electronic Disease Early Warning System in Yemen (eDEWS) using system attributes: data quality, timeliness, stability, simplicity, predictive value positive, sensitivity, acceptability, flexibility, and representativeness, based on the Centres for Disease Control & Prevention (US CDC) standard indicators...
September 18, 2020: BMC Public Health
Ling Tang, Wangjun Tang, Xiaofang Li, Chuanxia Hu, Di Wu, Tianhou Wang, Guimei He
From 2016 to 2018, surveillance of influenza A viruses in wild birds was conducted in Shanghai, located at the East Asian-Australian flyway, China. A total of 5112 samples from 51 species of wild birds were collected from three different wetlands. The total three-year prevalence of influenza A viruses among them was 8.8%, as assessed using real-time polymerase chain reaction (PCR) methods, and the total prevalence was higher in Anseriformes (26.3%) than in the Charadriiformes (2.3%) and the other orders (2...
September 16, 2020: Viruses
Esther Vaquero-Álvarez, Antonio Cubero-Atienza, Pilar Ruiz-Martínez, Manuel Vaquero-Abellán, María Dolores Redel Mecías, Pilar Aparicio-Martínez
Since the eighties, technological tools have modified how people interact in their environment. At the same time, occupational safety and health measures have been widely applied. The European Agency for Safety and Health at Work considers that information and communication technologies are the main methods to achieve the goals proposed to improve working life and the dissemination of good practices. The principal objective was to determine the trends of publications focused on these technologies and occupational safety in the healthcare sector during the last 30 years...
September 16, 2020: International Journal of Environmental Research and Public Health
Hong-Fei Gao, Wei-Ping Li, Teng Zhu, Ci-Qiu Yang, Mei Yang, Liu-Lu Zhang, Fei Ji, Min-Yi Cheng, Jie-Qing Li, Kun Wang
PURPOSE: The aim of this study was to explore the value of adjuvant chemotherapy in patients with early-stage ER/PR-positive mucinous carcinoma. METHODS: We identified early-stage ER/PR-positive mucinous carcinoma patients in the Surveillance, Epidemiology, and End Results (SEER) database. We used propensity-score matching (PSM) analysis to eliminate selection bias and differences in baseline characteristics. Univariate and multivariate analyses were performed to identify significant prognostic factors...
September 9, 2020: Breast: Official Journal of the European Society of Mastology
Reiko Shimbashi, Motoi Suzuki, Bin Chang, Hiroshi Watanabe, Yoshinari Tanabe, Koji Kuronuma, Kengo Oshima, Takaya Maruyama, Hiroaki Takeda, Kei Kasahara, Jiro Fujita, Junichiro Nishi, Tetsuya Kubota, Keiko Tanaka-Taya, Tamano Matsui, Tomimasa Sunagawa, Kazunori Oishi
The decline in the proportion of pneumococcal conjugate vaccine (PCV)-covered serotypes among adult invasive pneumococcal disease (IPD) patients might change the overall effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) because its effectiveness differs according to serotype. Using the indirect cohort method, we calculated the effectiveness of PPSV23 against IPD among adults in Japan to assess the impact of the national pediatric PCV program. Clinical and epidemiologic information and pneumococcal isolates were collected from IPD patients >20 years of age through enhanced IPD surveillance during April 2013-December 2017...
October 2020: Emerging Infectious Diseases
Karsten Weller, Ana Giménez-Arnau, Clive Grattan, Riccardo Asero, Pascale Mathelier-Fusade, Mojca Bizjak, Michael Hanna, Marcus Maurer
BACKGROUND: Chronic urticaria (CU) is a common disease, characterized by the recurrent appearance of wheals, angioedema, or both for more than 6 weeks. Its underlying biology is not well understood, and many patients do not obtain sufficient relief from recommended treatments. Patient registries are rapidly growing as a form of research, because they can provide powerful, data-driven insights about the epidemiology of diseases, real-world effectiveness of treatments, rare patient types, safety monitoring, healthcare costs, and opportunities for quality improvement of healthcare delivery...
September 18, 2020: Journal of the European Academy of Dermatology and Venereology: JEADV
Julie Crabtree, Jennifer L Hudson, Toby Newton-John
Objective : The association between creativity and psychopathology has intrigued researchers and recent studies have affirmed genetic and epidemiological links. In particular, epidemiological research highlights the need to study what aspects of the creative individual protect or provide risk for transition to psychosis. Two factors, associated with transition to psychosis, will be investigated, namely anxiety and adverse life events. Method : A diverse sample of 110 participants (18-35 years) was examined, including early psychosis (EP), creative professionals who are clinically vulnerable or "at-risk" (ARCC), those with no psychotic symptoms (CC), and non-creative (NCC) participants...
September 18, 2020: Psychiatry
Andrea Ticinesi, Nicoletta Cerundolo, Alberto Parise, Antonio Nouvenne, Beatrice Prati, Angela Guerra, Fulvio Lauretani, Marcello Maggio, Tiziana Meschi
BACKGROUND: Delirium incidence and clinical correlates in coronavirus disease-19 (COVID-19) pneumonia are still poorly investigated. AIM: To describe the epidemiology of delirium in patients hospitalized for suspect COVID-19 pneumonia during the pandemic peak in an academic hospital of Northern Italy, identify its clinical correlations and evaluate the association with mortality. METHODS: The clinical records of 852 patients admitted for suspect COVID-19 pneumonia, defined as respiratory symptoms or fever or certain history of contact with COVID-19 patients, plus chest CT imaging compatible with alveolar-interstitial pneumonia, were retrospectively analyzed...
September 18, 2020: Aging Clinical and Experimental Research
Teng Wang, Haonan Li, Yiqun Han, Yanwen Wang, Jicheng Gong, Ke Gao, Weiju Li, Hongyin Zhang, Junxia Wang, Xinghua Qiu, Tong Zhu
Oxylipins are highly bioactive lipid mediators derived from polyunsaturated fatty acids (PUFAs) and have fundamental roles in a diverse set of homeostatic and inflammatory processes. Current targeted methods of analyzing oxylipins require long runtimes and laborious sample preparation, limiting their application to epidemiological studies. Here, we report the development of an online solid-phase extraction-liquid chromatography-triple quadrupole mass spectrometry (online SPE-LC-MS/MS) method to quantify 49 non-esterified oxylipins and PUFAs, including prostanoids, leukotrienes, lipoxins, resolvins, hydroxy PUFAs, epoxy PUFAs, and their PUFA precursors, in 50-μL samples of human serum...
September 18, 2020: Analytical and Bioanalytical Chemistry
Christina L Faust, Kirstyn Brunker, Diana Ajambo, Mary Ryan, Arinaitwe Moses, Candia Rowel, Robert Mandela Wangoola, Eddie M Wampande, Andrew Guma, Moses Adriko, Poppy H L Lamberton, Edridah M Tukahebwa, Albert Mugenyi, Charles Waiswa
Improvements in genetic and genomic technology have enabled field-deployable molecular laboratories and these have been deployed in a variety of epidemics that capture headlines. In this editorial, we highlight the importance of building physical and personnel capacity in low and middle income countries to deploy these technologies to improve diagnostics, understand transmission dynamics and provide feedback to endemic communities on actionable timelines. We describe our experiences with molecular field research on schistosomiasis, trypanosomiasis and rabies and urge the wider tropical medicine community to embrace these methods and help build capacity to benefit communities affected by endemic infectious diseases...
September 18, 2020: Transactions of the Royal Society of Tropical Medicine and Hygiene
Jing Zhou, Lili Huang, Jin Chen, Xiaowei Yuan, Qinhua Shen, Su Dong, Bei Cheng, Tang-Meng Guo
Background : Since December 2019, the cumulative number of coronavirus disease-2019 (COVID-19) deaths in worldwide has reached 612,876 and continues to increase as of writing. Of the deaths, more than 90% are people ages 60 and older. However, an easy-to-use clinically predictive tool for predicting the mortality risk in older individuals with COVID-19 is limited. Objective : To explore an easy-to-use clinically predictive tool that may be utilized in predicting mortality risk in older patients with COVID-19...
September 18, 2020: Current Medical Research and Opinion
Hongyun Gong, Yuxin Chu, Qinyong Hu, Qibin Song
OBJECTIVE: To explore the clinical and pathological features of gastric signet ring cell carcinoma, and evaluate the survival impact of preoperative radiotherapy on these patients. METHODS: The Surveillance, Epidemiology, and End Results database was used to extract eligible patients from 2004 to 2015. The patients were divided into those with and without preoperative radiotherapy. The categorical variables were described by chi-square tests. The patients' survival was compared between the 2 groups by Kaplan-Meier method with log-rank tests...
January 2020: Technology in Cancer Research & Treatment
J García-Cruces, R López Izquierdo, M Domínguez-Gil, L López-Urrutia, M de Frutos, B Lorenzo, B Nogueira, A Puerta, M Fernández-Esgueva, I Merino, M C Ramos Sanchez, J M Eiros
OBJECTIVE: Since the discovery of the SARS-CoV-2 virus, the polymerase chain reaction technique (RT-PCR) has become the fundamental method for diagnosing the disease in its acute phase. The objective is to describe the demand-based series of RT-PCR determinations received at a Microbiology Service at a third-level reference hospital for a health area for three months spanning from the onset of the epidemic by SARS-CoV-2. METHODS: A retrospective analysis of the total of the RT-PCR requested in the Microbiology Service analyzed from 02/25/2020 to 05/26/2020 (90 days) has been carried out...
September 16, 2020: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Yan Li, Ming-Xi Zhu, Bing Zhang
Background: The impact of insurance status on renal cell carcinoma (RCC) patient survival is unclear. In this study, we investigated the effects of insurance status on the survival outcomes of RCC patients in the United States of America. Methods: Data of patients diagnosed with RCC between 2007 and 2014 were obtained from the Surveillance, Epidemiology and End Results (SEER) database, a large national database including statistics on cancer patients. The Kaplan-Meier method and Cox regression analysis were used to determine the influence of insurance status on cancer-specific survival (CSS)...
August 2020: Translational Andrology and Urology
Kyungmoo Heo, Daejoong Lee, Yongseok Seo, Hyeseung Choi
Background: Korea has achieved health policy objectives in pandemic management so far, namely minimizing mortality, flattening the epidemic curve, and limiting the socio-economic burden of its measures. The key to the Korean government's success in combating COVID-19 lies with the latest digital technologies (DTs). The prompt and effective application of DTs facilitates both containment as well as mitigation strategies and their sub-policy measures. Methods: This article uses an experiential analysis based on an exploratory case study - analysis on field applications of the government's interventions...
August 31, 2020: Annals of Global Health
Danming You, Zuyu Zhang, Mingzhu Cao
BACKGROUND We developed a nomogram for prognostic prediction of overall survival (OS) in postoperative ovarian sex cord-stromal tumor (SCST) patients and discuss the effect of chemotherapy at various FIGO stages. MATERIAL AND METHODS SCST patients after surgery from 2004 to 2015 were enrolled from the Surveillance, Epidemiology and End-Results (SEER) database, matched into pairs by propensity score matching (PSM), and divided into a training set and a validation set. Univariate and multivariate Cox analyses were conducted to identify significant variables for the development of the nomogram...
September 18, 2020: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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