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MULTICENTER STUDY
David García-Azorín, Cristina Martínez-Badillo, Javier Camiña Muñiz, Ana Beatriz Gago-Veiga, Noemi Morollón Sánchez, Vicente González-Quintanilla, Jesús Porta-Etessam, Alvaro Sierra-Mencía, Nuria González-García, Yésica González-Osorio, Marcos Polanco-Fernandez, Andrea Recio-García, Robert Belvis Nieto, Angel Luis Guerrero-Peral
INTRODUCTION: Effectiveness of candesartan in migraine prevention is supported by two randomized controlled trials. We aimed to assess the effectiveness, tolerability, and response predictors of candesartan in the preventive treatment of migraine. METHODS: Observational, multicenter, prospective cohort study. The 50%, 75% and 30% responder rates, between weeks 8-12 and 20-24, were compared with the baseline. Treatment emergent adverse effects were systematically evaluated...
April 2024: Cephalalgia: An International Journal of Headache
#2
JOURNAL ARTICLE
Niklas Klümper, Ngoc Khanh Tran, Stefanie Zschäbitz, Oliver Hahn, Thomas Büttner, Florian Roghmann, Christian Bolenz, Friedemann Zengerling, Constantin Schwab, Dora Nagy, Marieta Toma, Glen Kristiansen, Hendrik Heers, Philipp Ivanyi, Günter Niegisch, Camilla Marisa Grunewald, Christopher Darr, Arian Farid, Katrin Schlack, Mahmoud Abbas, Can Aydogdu, Jozefina Casuscelli, Theresa Mokry, Michael Mayr, Dora Niedersüß-Beke, Steffen Rausch, Dimo Dietrich, Jonas Saal, Jörg Ellinger, Manuel Ritter, Abdullah Alajati, Christoph Kuppe, Joshua Meeks, Francisco E Vera Badillo, J Alberto Nakauma-González, Joost Boormans, Kerstin Junker, Arndt Hartmann, Viktor Grünwald, Michael Hölzel, Markus Eckstein
PURPOSE: The anti-NECTIN4 antibody-drug conjugate enfortumab vedotin (EV) is approved for patients with metastatic urothelial cancer (mUC). However, durable benefit is only achieved in a small, yet uncharacterized patient subset. NECTIN4 is located on chromosome 1q23.3, and 1q23.3 gains represent frequent copy number variations (CNVs) in urothelial cancer. Here, we aimed to evaluate NECTIN4 amplifications as a genomic biomarker to predict EV response in patients with mUC. MATERIALS AND METHODS: We established a NECTIN4 -specific fluorescence in situ hybridization (FISH) assay to assess the predictive value of NECTIN4 CNVs in a multicenter EV-treated mUC patient cohort (mUC-EV, n = 108)...
April 24, 2024: Journal of Clinical Oncology
#3
JOURNAL ARTICLE
Brenda Patricia Garza Badillo, David Hernández Barajas, José Luis González Vela, Ileana Cecilia Reynosa Silva, Luis Andrés González Torres, Ana Patricia Sanchéz Fonseca
No abstract text is available yet for this article.
April 5, 2024: Journal of the National Comprehensive Cancer Network: JNCCN
#4
JOURNAL ARTICLE
Andrés Rojas-Jaramillo, Gustavo León-Sánchez, África Calvo-Lluch, Juan José González-Badillo, David Rodríguez-Rosell
The aim of this study was to compare the effects of two velocity-based resistance training (RT) programs using moderate loads (45-60% 1RM) but different magnitudes of velocity loss (VL) limits (10% vs. 30%) on the changes in physical performance in young soccer players. Twenty young soccer players were randomly allocated into two groups: VL10% (n = 10) and VL30% (n = 10). All participants were assessed before and after the 8-week RT program (twice a week) involving the following tests: 20 m running sprint (T20), countermovement jump (CMJ), kicking a ball (KB), and progressive loading test in the full squat (SQ) exercise...
January 30, 2024: Sports
#5
JOURNAL ARTICLE
Nathaniel L Matteson, Gabriel W Hassler, Ezra Kurzban, Madison A Schwab, Sarah A Perkins, Karthik Gangavarapu, Joshua I Levy, Edyth Parker, David Pride, Abbas Hakim, Peter De Hoff, Willi Cheung, Anelizze Castro-Martinez, Andrea Rivera, Anthony Veder, Ariana Rivera, Cassandra Wauer, Jacqueline Holmes, Jedediah Wilson, Shayla N Ngo, Ashley Plascencia, Elijah S Lawrence, Elizabeth W Smoot, Emily R Eisner, Rebecca Tsai, Marisol Chacón, Nathan A Baer, Phoebe Seaver, Rodolfo A Salido, Stefan Aigner, Toan T Ngo, Tom Barber, Tyler Ostrander, Rebecca Fielding-Miller, Elizabeth H Simmons, Oscar E Zazueta, Idanya Serafin-Higuera, Manuel Sanchez-Alavez, Jose L Moreno-Camacho, Abraham García-Gil, Ashleigh R Murphy Schafer, Eric McDonald, Jeremy Corrigan, John D Malone, Sarah Stous, Seema Shah, Niema Moshiri, Alana Weiss, Catelyn Anderson, Christine M Aceves, Emily G Spencer, Emory C Hufbauer, Justin J Lee, Alison J King, Karthik S Ramesh, Kelly N Nguyen, Kieran Saucedo, Refugio Robles-Sikisaka, Kathleen M Fisch, Steven L Gonias, Amanda Birmingham, Daniel McDonald, Smruthi Karthikeyan, Natasha K Martin, Robert T Schooley, Agustin J Negrete, Horacio J Reyna, Jose R Chavez, Maria L Garcia, Jose M Cornejo-Bravo, David Becker, Magnus Isaksson, Nicole L Washington, William Lee, Richard S Garfein, Marco A Luna-Ruiz Esparza, Jonathan Alcántar-Fernández, Benjamin Henson, Kristen Jepsen, Beatriz Olivares-Flores, Gisela Barrera-Badillo, Irma Lopez-Martínez, José E Ramírez-González, Rita Flores-León, Stephen F Kingsmore, Alison Sanders, Allorah Pradenas, Benjamin White, Gary Matthews, Matt Hale, Ronald W McLawhon, Sharon L Reed, Terri Winbush, Ian H McHardy, Russel A Fielding, Laura Nicholson, Michael M Quigley, Aaron Harding, Art Mendoza, Omid Bakhtar, Sara H Browne, Jocelyn Olivas Flores, Diana G Rincon Rodríguez, Martin Gonzalez Ibarra, Luis C Robles Ibarra, Betsy J Arellano Vera, Jonathan Gonzalez Garcia, Alicia Harvey-Vera, Rob Knight, Louise C Laurent, Gene W Yeo, Joel O Wertheim, Xiang Ji, Michael Worobey, Marc A Suchard, Kristian G Andersen, Abraham Campos-Romero, Shirlee Wohl, Mark Zeller
The maturation of genomic surveillance in the past decade has enabled tracking of the emergence and spread of epidemics at an unprecedented level. During the COVID-19 pandemic, for example, genomic data revealed that local epidemics varied considerably in the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage importation and persistence, likely due to a combination of COVID-19 restrictions and changing connectivity. Here, we show that local COVID-19 epidemics are driven by regional transmission, including across international boundaries, but can become increasingly connected to distant locations following the relaxation of public health interventions...
December 21, 2023: Cell
#6
RANDOMIZED CONTROLLED TRIAL
Pedro Jesús Cornejo-Daza, Antonio Villalba-Fernández, Juan José González-Badillo, Fernando Pareja-Blanco
Cornejo-Daza, PJ, Villalba-Fernández, A, González-Badillo, JJ, and Pareja-Blanco, F. Time course of recovery from different velocity loss thresholds and set configurations during full-squat training. J Strength Cond Res 38(2): 221-227, 2024-The aims of the research were to examine the effects of (a) velocity loss (VL) thresholds and (b) set configuration, traditional or cluster, on time-course recovery. A randomized cross-over research design was conducted, in which 15 resistance-trained men performed 4 protocols consisting of 3 sets of 70% 1RM in full squat (SQ), differing in the VL incurred during the set assessed with a linear velocity transducer: (a) 20% (70-20), (b) 30% (70-30), (c) 40% (70-40), and in the set configuration (d) 20% of VL using a cluster methodology (70-CLU)...
February 1, 2024: Journal of Strength and Conditioning Research
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JOURNAL ARTICLE
A González-Celestino, Y González-Osorio, C García-Iglesias, A Echavarría-Iñiguez, A Sierra-Mencía, A Recio-García, J Trigo-López, A Planchuelo-Gómez, M L Hurtado, L Sierra-Martínez, M Ruiz, M Rojas-Hernández, C Pérez-Almendro, M Paniagua, G Núñez, M Mora, C Montilla, C Martínez-Badillo, A G Lozano, A Gil, M Cubero, A Cornejo, I Calcerrada, M Blanco, A Alberdí-Iglesias, C Fernández-de-Las-Peñas, A L Guerrero-Peral, D García-Azorín
INTRODUCTION: Headache is a frequent symptom at the acute phase of coronavirus disease 2019 (COVID-19) and also one of the most frequent adverse effects following vaccination. In both cases, headache pathophysiology seems linked to the host immune response and could have similarities. We aimed to compare the clinical phenotype and the frequency and associated onset symptoms in patients with COVID-19 related-headache and COVID-19 vaccine related-headache. SUBJECTS AND METHODS: A case-control study was conducted...
November 16, 2023: Revista de Neurologia
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JOURNAL ARTICLE
Nalini Ranjit, David J Badillo, Deanna M Hoelscher, Sarah Macias, Alejandra Gonzalez, Anna V Wilkinson
INTRODUCTION: National data reveal that the age-adjusted prevalence of leisure-time physical inactivity is higher among Blacks and Hispanics compared with Whites. However, these estimates do not consider nonleisure physical activity (PA). Also, race/ethnicity in these findings may by confounded by socioeconomic status disparities in PA. Here, we examine racial/ethnic differences in multiple measures of PA within a lower socioeconomic status sample. METHODS: Participants in the current cross-sectional study (n = 1526 adults, aged ≥ 18 y) were recruited from Supplemental Nutrition Assistance Program-Education classes (nutrition education classes that target low-income people) in Texas...
October 10, 2023: Journal of Physical Activity & Health
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JOURNAL ARTICLE
Manuel Jiménez-Lozano, Juan Manuel Yáñez-García, Ricardo Mora-Custodio, Adrián Valle-Salguero, David M Díez-Fernández, Felipe Franco-Márquez, Juan José González-Badillo, David Rodríguez-Rosell
Jiménez-Lozano, M, Yáñez-García, JM, Mora-Custodio, R, Valle-Salguero, A, Díez-Fernández, DM, Franco-Márquez, F, González-Badillo, JJ, and Rodríguez-Rosell, D. Load-time and load-speed relationship in the resisted sled sprint exercise: what independent variable most accurately determines the relative load? J Strength Cond Res 37(11): 2167-2177, 2023-The aims of this study were to analyze the load-speed and load-time relationships in the resisted sled sprint exercise using different variables as relative load and to estimate the decrement of speed sprint and the increase of sprint time across different loads...
November 1, 2023: Journal of Strength and Conditioning Research
#10
JOURNAL ARTICLE
Nikole A Bonillas Félix, Daisy T Noriega, Sofia Fabrega, Alex Leonardo Badillo Cabrera, Crystal Castillo, Diana Munera, Jairo E Martinez, Averi Giudicessi, Liliana Ramirez-Gomez, Clara Vila-Castelar, Marta Gonzalez Catalan, Yakeel T Quiroz
OBJECTIVE: Cardiovascular risk factors and depression are prevalent in Latino populations and have been associated with an increased risk of cognitive decline and dementia. Adults with depressive symptoms also have an increased risk of cardiovascular disease. Understanding the link between these factors and how they impact dementia risk among Latino cohorts is critical for the development of preventative interventions. We examined the associations among cardiovascular risk factors, depression, and cognitive status in older Latinos living in Massachusetts...
October 8, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
#11
JOURNAL ARTICLE
Cristina García-Iglesias, Ana González-Celestino, Álvaro Sierra Mencía, Yésica González Osorio, Andrea Recio García, Cristina Martínez-Badillo, Ana Echavarría Íñiguez, Berta Varona-Galán, David García-Azorín, Ángel Luis Guerrero-Peral
BACKGROUND: Since the first description of nummular headache (NH), more than 500 cases have been described, delineating its clinical phenotype and response to treatment. However, data on the natural history of NH and outcomes during long-term follow-up are not currently available. The present study aimed to describe the long-term outcomes and follow-up of a large series of patients with NH. METHODS: A descriptive observational ambisective study with a series of cases was conducted...
September 2023: Cephalalgia: An International Journal of Headache
#12
JOURNAL ARTICLE
Rodríguez Badillo-Paulina, Rodríguez-Aldama Juan Carlos, Gabián-Fortes Lucía Del Carmen, Sifuentes-Rentería Sergio, Valdez-González María Teresa, Pérez-Flores Brian Eduardo, Velasco-Ramos Regina, Fernández-Vizcaya Oscar, Crabtree-Ramírez Brenda, Pérez-Barragán Edgar
Mpox-related ophthalmic disease has been reported as infrequent in the current outbreak. We retrospectively describe cases of patients with confirmed mpox. Out of 100 cases of confirmed mpox, 11 (11%) had ocular manifestations, of these 9 (81.8%) were people with HIV. We suggest that in moderate and severe mpox disease an ophthalmological evaluation should be performed.
September 8, 2023: Journal of Infectious Diseases
#13
JOURNAL ARTICLE
Esperanza Milagros García-Oropesa, Adriana L Perales-Torres, Yoscelina Estrella Martínez-López, Claudia X Munguía-Cisneros, Edna J Nava-González, Monserrat Pérez-Navarro, Marisol Rosas-Díaz, Neyla Baltazar, América Arroyo-Valerio, Alvaro Diaz-Badillo, Octelina Castillo-Ruiz, Joselín Hernández-Ruiz, Srinivas Mummidi, Laura Y Ramírez-Quintanilla, Alejandra Bustamante, Carlos Ramirez-Pfeiffer, Leonel Vela, Beatriz Tapia, Juan C Lopez-Alvarenga
AIM: Evaluate insulin resistance (IR) as a mediator of the effect of body fat distribution on liver fat infiltration and stiffness (LSt) in young adults using structural equation modeling (SEM). METHODS: We invited 500 first year students from two universities and evaluated their family history to determine the risk for cardiometabolic disease. Of these, 174 students (age 19 ± 1 years) were assessed for total body fat percentage (BF%), LSt, fat infiltration (Coefficient attenuated parameter CAP), and serum biochemical analysis...
September 1, 2023: Archives of Medical Research
#14
JOURNAL ARTICLE
Sergio Emilio Sifuentes Rentería, Paulina Rodríguez Badillo, Teresa Valdez González
OBJECTIVE: To analyze the frequent multimodal imaging features in posterior syphilitic uveitis. PURPOSE: Syphilis infection has re-emerged as a global health problem. Multimodal imaging approach has been proposed for diagnosis and follow-up; there are not previous reports dedicated to the anatomic and visual outcomes in patients diagnosed with ocular syphilis and concomitant HIV infection. METHODS: All demographic information was recovered; a complete ophthalmological examination and multimodal imaging evaluation (retinal fluorescein angiography (FA), autofluorescence (AF), optical coherence tomography (OCT)) were performed on initial visit and 1 month after antibiotic therapy...
August 17, 2023: Ocular Immunology and Inflammation
#15
JOURNAL ARTICLE
Valente Fernandez-Badillo, Javier Serrano-Roman, Neftali Eduardo Antonio-Villa, Aldo Cabello-Ganem, Adrian Espejel-Guzman, Laura Victoria Torres-Araujo, Alberto Aranda-Fraustro, Roberto Cano-Zarate, Enrique Solorzano-Pinot, Candace Keirns, Aloha Meave-Gonzalez, Erick Alexanderson-Rosas, Nilda Espinola-Zavaleta
BACKGROUND: The association between Ebstein anomaly and myocardial fibrosis, particularly in the left ventricle, has been controversial. We aimed to assess the prevalence of replacement fibrosis with a focus on the left ventricle (LV) using cardiac magnetic resonance (CMR), make a histopathological association between LV fibrosis and CMR findings, and explore whether LV fibrosis is an independent risk factor for cardiovascular disease mortality using a derived risk score. METHODS: We performed a 12-year (2009-2021) retrospective cohort of adult patients with Ebstein anomaly who underwent CMR...
May 8, 2023: Circulation. Cardiovascular Imaging
#16
JOURNAL ARTICLE
Pavel Iša, Blanca Taboada, Rodrigo García-López, Celia Boukadida, José Ernesto Ramírez-González, Joel Armando Vázquez-Pérez, Alejandra Hernández-Terán, José Ángel Romero-Espinoza, José Esteban Muñoz-Medina, Concepción Grajales-Muñiz, Alma Rincón-Rubio, Margarita Matías-Florentino, Alejandro Sanchez-Flores, Edgar Mendieta-Condado, Gisela Barrera-Badillo, Susana López, Lucía Hernández-Rivas, Irma López-Martínez, Santiago Ávila-Ríos, Carlos F Arias
BACKGROUND: SARS-CoV-2 infections have a wide spectrum of clinical manifestations whose causes are not completely understood. Some human conditions predispose to severe outcome, like old age or the presence of comorbidities, but many other facets, including coinfections with other viruses, remain poorly characterized. METHODS: In this study, the eukaryotic fraction of the respiratory virome of 120 COVID-19 patients was characterized through whole metagenomic sequencing...
October 19, 2022: BMC Infectious Diseases
#17
REVIEW
Juan José González-Badillo, Luis Sánchez-Medina, Juan Ribas-Serna, David Rodríguez-Rosell
For more than a century, many concepts and several theories and principles pertaining to the goals, organization, methodology and evaluation of the effects of resistance training (RT) have been developed and discussed between coaches and scientists. This cumulative body of knowledge and practices has contributed substantially to the evolution of RT methodology. However, a detailed and rigorous examination of the existing literature reveals many inconsistencies that, unless resolved, could seriously hinder further progress in our field...
September 16, 2022: Sports Medicine—Open
#18
JOURNAL ARTICLE
Maria A Nieves-Colón, Keyla M Badillo Rivera, Karla Sandoval, Vanessa Villanueva Dávalos, Luis E Enriquez Lencinas, Javier Mendoza-Revilla, Kaustubh Adhikari, Ram González-Buenfil, Jessica W Chen, Elisa T Zhang, Alexandra Sockell, Patricia Ortiz-Tello, Gloria Malena Hurtado, Ramiro Condori Salas, Ricardo Cebrecos, José C Manzaneda Choque, Franz P Manzaneda Choque, Germán P Yábar Pilco, Erin Rawls, Celeste Eng, Scott Huntsman, Esteban Burchard, Andrés Ruiz-Linares, Rolando González-José, Gabriel Bedoya, Francisco Rothhammer, Maria Cátira Bortolini, Giovanni Poletti, Carla Gallo, Carlos D Bustamante, Julie C Baker, Christopher R Gignoux, Genevieve L Wojcik, Andrés Moreno-Estrada
Preeclampsia is a multi-organ complication of pregnancy characterized by sudden hypertension and proteinuria that is among the leading causes of preterm delivery and maternal morbidity and mortality worldwide. The heterogeneity of preeclampsia poses a challenge for understanding its etiology and molecular basis. Intriguingly, risk for the condition increases in high-altitude regions such as the Peruvian Andes. To investigate the genetic basis of preeclampsia in a population living at high altitude, we characterized genome-wide variation in a cohort of preeclamptic and healthy Andean families (n = 883) from Puno, Peru, a city located above 3,800 meters of altitude...
May 13, 2022: American Journal of Human Genetics
#19
JOURNAL ARTICLE
Juan Manuel Yáñez García, Ricardo Mora-Custodio, Juan Ribas-Serna, Juan José González-Badillo, David Rodríguez-Rosell
This study aimed to analyze the acute mechanical, metabolic and EMG response to five resistance exercise protocols (REP) in the full squat (SQ) exercise performed with 2 velocity conditions: maximal intended velocity (MaxV) vs. half-maximal velocity (HalfV). Eleven resistance-trained men performed 10 REP (5 with each velocity conditions) in random order (72-96 h apart). The REP consisted of 3 sets of 8-3 repetitions against 45-65% 1RM. The percent change in countermovement jump (CMJ) height, velocity attained with the load that elicited a ~1...
April 25, 2022: International Journal of Sports Medicine
#20
JOURNAL ARTICLE
Javier Mendoza-Revilla, J Camilo Chacón-Duque, Macarena Fuentes-Guajardo, Louise Ormond, Ke Wang, Malena Hurtado, Valeria Villegas, Vanessa Granja, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Rodrigo Barquera, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Caio C Silva de Cerqueira, Keyla M Badillo Rivera, Maria A Nieves-Colón, Christopher R Gignoux, Genevieve L Wojcik, Andrés Moreno-Estrada, Tábita Hünemeier, Virginia Ramallo, Lavinia Schuler-Faccini, Rolando Gonzalez-José, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Giovanni Poletti, Gabriel Bedoya, Francisco Rothhammer, David Balding, Matteo Fumagalli, Kaustubh Adhikari, Andrés Ruiz-Linares, Garrett Hellenthal
Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separated human groups. Although classical and recent work have shown that studying admixture can yield novel historical insights, the extent to which this process contributed to adaptation remains underexplored. Here, we introduce a novel statistical model, specific to admixed populations, that identifies loci under selection while determining whether the selection likely occurred post-admixture or prior to admixture in one of the ancestral source populations...
April 11, 2022: Molecular Biology and Evolution
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