Tuo Zhang, Xinhua Du, Lihua Zhao, Meina He, Lin Lin, Chuanhui Guo, Xinran Zhang, Jun Han, Hao Yan, Kun Huang, Guanghong Sun, Lei Yan, Bo Zhou, Guoliang Xia, YingYing Qin, Chao Wang
In female mammals, the majority of primordial follicles (PFs) are physiologically quiescent, and only a few of them are activated and enter the growing follicle pool. Specific molecules, such as mammalian target of rapamycin (mTOR) and the serine/threonine kinase Akt (AKT), have been proven to be important for PF activation. However, how the transcription of these genes is regulated is not clear. Although activators of mTOR or AKT have been successfully used to rescue the fertility of patients with premature ovarian insufficiency, the low efficacy and unclear safety profile of these drugs hinder their clinical use in the in vitro activation (IVA) of PFs...
November 6, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology