Fit bit

Hybrid modeling, with an appropriate blend of the mechanistic and data-driven framework, is increasingly being adopted in bioprocess modeling, model-based experimental design (digital-twin), identification of critical process parameters, and optimization. However, the development of a hybrid model from experimental data is an inherently complex workflow, involving designed experiments, selection of the data-driven process, identification of model parameters, assessment fitness, and generalization capability...

This paper addresses the design of a hybrid beamforming system considering the circuit parameter of six-bit millimeter-wave phase shifters based on the process design kit. The phase shifter design adopts 45 nm CMOS silicon on insulator (SOI) technology at 28-GHz. Various circuit topologies are utilized, and in particular, a design is presented based on switched LC components, connected in a cascode manner. The phase shifter configuration is connected in a cascading manner to get the 6-bit phase controls. Six different phase shifters are obtained, which are 180°, 90°, 45°, 22...

OBJECTIVE: There is no validated Persian questionnaire to measure childbirth-related PTSD (CB-PTSD) symptoms. To cover this gap, the present study aimed to provide a Persian version of the City Birth Trauma Scale (CityBiTS-Pr) and to determine its psychometric properties. METHOD: Since this is a cross-sectional study, sampling was done using a convenient sampling method. In total, 300 Persian-speaking women took part in this study and completed the City Birth Trauma Scale (CityBiTS-Pr), the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5), the Edinburgh Postnatal Depression Scale (EPDS), the Anxiety Subscale of the Depression, and the Anxiety and Stress Scale (DASS-21)...

Use of lentiviral vectors (LVs) in clinical Cell and Gene Therapy applications is growing. However, functional product loss during capture chromatography, typically anion-exchange (AIEX), remains a significant unresolved challenge for the design of economic processes. Despite AIEX's extensive use, variable performance and generally low recovery is reported. This poor understanding of product loss mechanisms highlights a significant gap in our knowledge of LV adsorption and other types of vector delivery systems...

Underwater wireless optical communication (UWOC) is a critical technology for underwater communication, providing high speed, low latency, and security advantages. However, the strong attenuation in the water channel still limits the UWOC systems and their performances require further improvement. In this study, an orbital angular momentum (OAM) multiplexing UWOC system that uses photon-counting detection is experimentally demonstrated. By employing a single-photon counting module to receive photon signals, we analyze the bit error rate (BER) and photon-counting statistics by building a theoretical model that fits the real system, and demodulate the OAM states in single photon level and implement signal processing using field programmable gate array (FPGA) programming...

Avoiding overfitting is a central challenge in machine learning, yet many large neural networks readily achieve zero training loss. This puzzling contradiction necessitates new approaches to the study of overfitting. Here we quantify overfitting via residual information, defined as the bits in fitted models that encode noise in training data. Information efficient learning algorithms minimize residual information while maximizing the relevant bits, which are predictive of the unknown generative models. We solve this optimization to obtain the information content of optimal algorithms for a linear regression problem and compare it to that of randomized ridge regression...

Planet's SuperDove constellation is evaluated for remote sensing of water targets. SuperDoves are small satellites with on board eight band PlanetScope imagers that add four new bands compared to the previous generations of Doves. The Yellow (612 nm) and Red Edge (707 nm) bands are of particular interest to aquatic applications, for example in aiding the retrieval of pigment absorption. The dark spectrum fitting (DSF) algorithm is implemented in ACOLITE for processing of SuperDove data, and its outputs are compared to matchup data collected using an autonomous pan-and-tilt hyperspectral radiometer (PANTHYR) installed in the turbid waters of the Belgian Coastal Zone (BCZ)...

OBJECTIVE: To investigate the experience of remote outpatient menopause service delivery by clinicians and patients during the COVID-19 pandemic. METHODS: Two surveys explored the experiences of patients and clinicians separately. Patients attending menopause clinics in the UK were directed to an online survey which included questions on demographics and on their experience of their most recent appointment. A clinician survey was shared to members of the British Menopause Society (BMS) via email and was made available on the BMS website...

The growing demands of remote detection and an increasing amount of training data make distributed machine learning under communication constraints a critical issue. This work provides a communication-efficient quantum algorithm that tackles two traditional machine learning problems, the least-square fitting and softmax regression problems, in the scenario where the dataset is distributed across two parties. Our quantum algorithm finds the model parameters with a communication complexity of O(log_{2}(N)/ε), where N is the number of data points and ε is the bound on parameter errors...

Telemedicine is one of the safest methods to provide healthcare facilities to the remote patients with the help of digitization. In this paper, state-of-the-art session key has been proposed based on the priority oriented neural machines followed by its validation. State-of-the-art technique can be mentioned as newer scientific method. Soft computing has been extensively used and modified here under the ANN domain. Telemedicine facilitates secure data communication between the patients and the doctors regarding their treatments...

Despite reduced resting lung volumes and D LCO , patients with long COVID and dyspnoea have similar physiological response to exercise to healthy subjects. D LCO impairment can marginally explain heterogeneity of complex syndromes such as long COVID. https://bit.ly/40j4aX6.

Autologous cell therapy has proven to be an effective treatment for hematological malignancies. Cell therapies for solid tumors are on the horizon, however the high cost and complexity of manufacturing these therapies remain a challenge. Routinely used open steps to transfer cells and reagents through unit operations further burden the workflow reducing efficiency and increasing the chance for human error. Here we describe a fully closed, autologous bioprocess generating engineered TCR-T cells. This bioprocess yielded 5-12 × 10e9 TCR-expressing T cells, transduced at low multiplicity of infections, within 7-10 days, and cells exhibited an enriched memory T-cell phenotype and enhanced metabolic fitness...

The paper presents for the first time a pill-based ingestible electronics with CMOS integrated multiplexed fluorescence bio-molecular sensor arrays, bi-directional wireless communication and packaged optics in a FDA-approved capsule for in-vivo bio-molecular sensing. The silicon chip integrates both the sensor array, and the ultra-low-power (ULP) wireless system that allows offloading sensor computing to an external base station that can reconfigure the sensor measurement time, and its dynamic range, allowing optimized high sensitivity measurement under low power consumption...

Healthcare technology is evolving from a conventional hub-based system to a personalized healthcare system accelerated by rapid advancements in smart fitness trackers. Modern fitness trackers are mostly lightweight wearables and can monitor the user's health round the clock, supporting ubiquitous connectivity and real-time tracking. However, prolonged skin contact with wearable trackers can cause discomfort. They are susceptible to false results and breach of privacy due to the exchange of user's personal data over the internet...

OBJECTIVE: City Birth Trauma Scale (City BiTS) is an instrument designed to evaluate and diagnose postpartum posttraumatic stress disorder (PTSD) according to the 5th edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-5). No validated Swedish instrument exists to measure postpartum PTSD according to DSM-5. Therefore, the primary aim of this study was to assess the psychometric properties of the Swedish version of the City BiTS (City BiTS-Swe) and to examine the latent factor structure of postpartum PTSD...

In this work, we present power and quality measurements of four transmissions using different emission technologies in an indoor environment, specifically a corridor, at the frequency of 868 MHz under two non-line-of-sight (NLOS) conditions. A narrowband (NB) continuous wave (CW) signal has been transmitted, and its received power has been measured with a spectrum analyzer, LoRa and Zigbee signals have also been transmitted, and their Received Signal Strength Indicator (RSSI) and bit error rate (BER) have been measured using the transceivers themselves; finally, a 20 MHz bandwidth 5G QPSK signal has also been transmitted and their quality parameters, such as SS-RSRP, SS-RSRQ and SS-RINR, have been measured using a SA...

INTRODUCTION: Fatigue is a prevalent symptom among both cancer survivors and older adults. Negative consequences of fatigue include increased sedentary behavior, decreased physical activity and function, and lower quality of life. Few pharmacologic interventions improve fatigue. Our preclinical and clinical data show promising effects of a muscadine grape extract supplement (MGES) on oxidative stress, mitochondrial bioenergetics, the microbiome, and the symptom of fatigue. This pilot study seeks to translate these observations to cancer survivorship by testing the preliminary effect of MGE supplementation on older adult cancer survivors with self-reported fatigue...

Next generation manufacturing (NGM) has evolved over the past decade to a point where large biopharmaceutical organizations are making large investments in the technology and considering implementation in clinical and commercial processes. There are many well-considered reasons to implement NGM. For the most part, organizations will not fund NGM unless the implementation benefits the funding organization by providing reduced costs, reduced time or additional needed capabilities. Productivity improvements gained from continuous purification are shown in this work, which used a new system that fully integrates and automates several downstream unit operations of a biopharmaceutical process to provide flexibility and easy implementation of NGM...

ERS/ATS D LCO standards recommend acceptability ranges for weekly D LCO simulation testing performed with a 3-L syringe. On some devices, the ERS/ATS limits may exceed or not fit a 3-sd range, in which case, simulation ranges based on 3 sd may be appropriate. https://bit.ly/3Z0YoZL.

INTRODUCTION: Osteotomy around proximal femur provides excellent exposure and helps in revision of both cemented and uncemented femoral stem. Hereby, describing our case report on wedge episiotomy, a new surgical technique for removal of distal fitting cemented or uncemented femoral stem in conditions were extended trochanteric osteotomy (ETO) becomes inappropriate and episiotomy becomes inadequate. CASE REPORT: A 35-year-old lady presented with painful right hip and difficulty in walking...