Jamir Pitton Rissardo, Ana Letícia Fornari Caprara
Central nervous system adverse effects are commonly reported with pregabalin (PGB). On the other hand, movement disorders (MDs) associated with this drug were rarely described. However, their occurrence could significantly affect the quality of life of PGB users. This literature review aims to evaluate the clinical epidemiological profile, pathological mechanisms, and management of PGB-associated MDs. Relevant reports in six databases were identified and assessed by two reviewers without language restriction...
April 2020: Brain Circulation
Chun-Chia Chang, Wei-Ting Yen, Yao-Tsung Lin, Li-Kai Wang, Kuo-Chuan Hung, Zhi-Fu Wu, Jen-Yin Chen
OBJECTIVES: Pregabalin is a drug for neuropathic pain. The antipronociceptive properties of pregabalin have led to its recent use as an adjuvant to the multimodal postoperative pain regimen. This meta-analysis was conducted to evaluate the efficacy of perioperative pregabalin on acute and chronic postsurgical pain(CPSP) after breast cancer surgery. METHODS: A meta-analysis including eight randomized controlled trials searched from MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials was conducted...
September 21, 2020: Clinical Journal of Pain
Romina Brignardello-Petersen
No abstract text is available yet for this article.
September 5, 2020: Journal of the American Dental Association
Mitra Eftekhariyazdi, Mojgan Ansari, Hadi Darvishi-Khezri, Roghayeh Zardosht
BACKGROUND: Laparoscopic cholecystectomy (LC) is the optimal approach for patients with symptomatic cholecystolithiasis. Although LC has some advantages, many patients experience postoperative pain. METHODS: In this review, we aimed to study the available information and meta-analyses of pharmacological methods of postoperative pain management in patients undergoing LC. Two researchers conducted a literature search in multiple databases (PubMed, Web of Science, Science Direct, Scopus, EMBASE, and Cochrane Library)...
August 31, 2020: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Staffan Hägg, Anna K Jönsson, Johan Ahlner
This review summarizes current evidence on the abuse and misuse of the gabapentinoids pregabalin and gabapentin. Pharmacovigilance studies, register-based studies, surveys, clinical toxicology studies, and forensic toxicology studies were identified and scrutinized with the goal to define the problem, identify risk factors, and discuss possible methods to reduce the potential for abuse and misuse. Studies found that gabapentinoids are abused and misused and that individuals with a history of psychiatric disorders or substance use disorder seem to be at high risk...
August 28, 2020: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Michael D Staudt, Tarun Prabhala, Breanna L Sheldon, Nicholas Quaranta, Michael Zakher, Ravneet Bhullar, Julie G Pilitsis, Charles E Argoff
The development of painful diabetic neuropathy (PDN) is a common complication of chronic diabetes that can be associated with significant disability and healthcare costs. Prompt symptom identification and aggressive glycemic control is essential in controlling the development of neuropathic complications; however, adequate pain relief remains challenging and there are considerable unmet needs in this patient population. Although guidelines have been established regarding the pharmacological management of PDN, pain control is inadequate or refractory in a high proportion of patients...
August 28, 2020: Journal of Diabetes Science and Technology
J Galindo-Ávalos, A Colin-Vázquez, J López-Valencia, J M Gómez-Gómez, L D Bernal-Fortich
OBJECTIVE: To assess the efficacy and safety of preemptive analgesia with gabapentinoids for patients undergoing arthroscopic shoulder surgery. MATERIAL AND METHODS: A PRISMA-compliant systematic review and meta-analysis was conducted in PubMed, Cochrane Library and ScienceDirect databases. Randomized Controlled Trials (RCTs) comparing gabapentinoids (gabapentin and pregabalin) with placebo in patients undergoing shoulder arthroscopic surgery were retrieved. The primary endpoint was the visual analogue scale (VAS) score at 24 hours and cumulative morphine consumption at 24 hours...
November 2019: Acta Ortopédica Mexicana
Heath McAnally, Udo Bonnet, Alan D Kaye
INTRODUCTION: Recent years have seen a dramatic escalation of off-label prescribing for gabapentin and pregabalin (gabapentinoids) owing in part to generic versions of each being released over the past two decades, but also in part as a response to increasing calls for multimodal and non-opioid pain management strategies. In this context, several recent articles have been published alleging widespread misuse, with speculations on the unappreciated addictive potential of the gabapentinoid class of drugs...
July 31, 2020: Pain and Therapy
Sascha R A Alles, Kimberly Gomez, Aubin Moutal, Rajesh Khanna
Large amino acid transporter 1 (LAT1), also known as SLC7A5, is an essential amino acid transporter that forms a heterodimeric complex with the glycoprotein cell-surface antigen heavy chain (4F2hc (CD98, SLC3A2)). Within nociceptive pathways, LAT1 is expressed in the dorsal root ganglia and spinal cord. Although LAT1 expression is upregulated following spinal cord injury, little is known about LAT1 in neuropathic pain. To date, only circumstantial evidence supports LAT1/4F2hc's role in pain. Notably, LAT1's expression and regulation link it to key cell types and pathways implicated in pain...
August 2020: Neurobiology of Pain
Kathleen E Wheeler, Ryan Grilli, John E Centofanti, Janet Martin, Celine Gelinas, Paul M Szumita, John W Devlin, Gerald Chanques, Waleed Alhazzani, Yoanna Skrobik, Michelle E Kho, Mark E Nunnally, Andre Gagarine, Begum A Ergan, Shannon Fernando, Carrie Price, John Lewin, Bram Rochwerg
This systematic review and meta-analysis addresses the efficacy and safety of nonopioid adjunctive analgesics for patients in the ICU. Data Sources: We searched PubMed, Embase, the Cochrane Library, CINAHL Plus, and Web of Science. Study Selection: Two independent reviewers screened citations. Eligible studies included randomized controlled trials comparing efficacy and safety of an adjuvant-plus-opioid regimen to opioids alone in adult ICU patients. Data Extraction: We conducted duplicate screening of citations and data abstraction...
July 2020: Critical care explorations
Edward J Wladis, Michael I Rothschild, Tal J Rubinstein
PURPOSE: Clinicians are becoming increasingly aware of the risks of opioid analgesics, and, consequently, are searching for alternatives to these agents. This review considers the existing literature regarding the management of pain after ophthalmic plastic surgery. METHODS: A literature search was performed through the PubMed database. Articles were assessed for relevance, and the appropriate data was extracted from the medical literature regarding pain management strategies after oculoplastic procedures...
July 16, 2020: Orbit
Michael Verret, François Lauzier, Ryan Zarychanski, Caroline Perron, Xavier Savard, Anne-Marie Pinard, Guillaume Leblanc, Marie-Joëlle Cossi, Xavier Neveu, Alexis F Turgeon
BACKGROUND: Widely used for acute pain management, the clinical benefit from perioperative use of gabapentinoids is uncertain. The aim of this systematic review was to assess the analgesic effect and adverse events with the perioperative use of gabapentinoids in adult patients. METHODS: Randomized controlled trials studying the use of gabapentinoids in adult patients undergoing surgery were included. The primary outcome was the intensity of postoperative acute pain...
August 2020: Anesthesiology
Ying-Chih Cheng, Yu-Chen Huang, Wei-Lieh Huang
OBJECTIVE: Gabapentin (GBP) and pregabalin (PGB) have been used to treat alcohol use disorder (AUD) and alcohol withdrawal, but with inconsistent results. In this meta-analysis, we explored the effects of GBP/PGB treatment on AUD and their effects on withdrawal, craving, depression, and sleep disturbance in AUD patients. METHODS: We carried out a systematic review and meta-analysis of randomized controlled trials comparing the effects of GBP/PGB on AUD with those of a placebo or control treatment...
July 15, 2020: Human Psychopharmacology
Lingzhi Ge, Ang Li, Ni Wang, Ping Li, Hongyan Xin, Wenfei Li
Herpes zoster is an acute, painful, herpes skin disease caused by varicella-zoster virus, which may cause viral meningitis. Pregabalin has been shown to be efficacious in the treatment of pain in patients with herpes zoster. However, it has the side effects of neurotoxicity. We describe a 68-year-old female patient with herpes zoster, and she was treated with pregabalin. The patient presented with stuttering and frequent blepharospasm after 3 days of pregabalin treatment. Pregabalin was discontinued, the symptoms of stuttering and frequent blepharospasm completely resolved without any special treatment after one week...
July 6, 2020: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Yuangui Zhang, Xiaoqian Wang, Guimin Dong
BACKGROUND: Only few studies have yet investigated whether perioperative administration of pregabalin can reduce the incidence of postoperative chronic neuropathic pain after total hip arthroplasty (THA). This prospective, randomized study compared placebo with pregabalin in the hope that a lower pregabalin dose would improve analgesia without increasing side-effects after THA. METHODS: This study was a prospective randomized blinded study, with a parallel design and an allocation ratio of 1:1 for the treatment groups...
July 2, 2020: Medicine (Baltimore)
Mohammed A M Farooqi, Vicky Cheng, Mustafaa Wahab, Izza Shahid, Paul M O'Byrne, Imran Satia
Chronic cough affects approximately 10% of general population, is highest amongst people aged 50-60, and is twice as common in women than men. It is described to last 8 weeks or longer in adults and not treated effectively with most over-the-counter medications. This is a debilitating condition with physical, social, and psychological consequences. The purpose of this review is to highlight the key messages from the task force commissioned by The European Respiratory Society on the management of chronic cough...
July 6, 2020: Polish Archives of Internal Medicine
Casey Evans, Deanna McCullough, Kelly Best, Brian K Yorkgitis
Context: The number of deaths due to opioid overdose has steadily increased in the United States since the early 2000s. The US opioid epidemic calls for an urgent need to evaluate physician prescribing habits. Objective: To educate obstetrics and gynecology residents about opioid abuse, the quantity typically prescribed postoperatively, and strategies to decrease adverse outcomes. Methods: Obstetrics and gynecology residents at an urban safety-net hospital were given a preintervention evaluation to understand their opioid prescribing patterns and use of resources like prescription drug monitoring programs and opioid risk tool...
July 1, 2020: Journal of the American Osteopathic Association
Michael Khazaka, Jeanne Laverdière, Audrey Bouchard, Victor Ferreira, Alexandre Mathieu
PURPOSE: To present the pharmacological evaluation process in a case of a polymedicated patient presenting with toxic epidermal necrolysis (TEN). SUMMARY: A 75-year-old Caucasian polymedicated woman had been treated for hip pain with nonsteroidal anti-inflammatory drugs and pregabalin in the months preceding the apparition of an expanding papulo-erythematous rash. She had also started using new medicated eye drops for glaucoma. She presented to the emergency department of a regional hospital where all of her medications were stopped...
June 26, 2020: Journal of Pharmacy Practice
Charles P Hannon, Yale A Fillingham, James A Browne, Emil H Schemitsch, Kyle Mullen, Francisco Casambre, Vidya Visvabharathy, William G Hamilton, Craig J Della Valle
BACKGROUND: Gabapentinoids are commonly used as an adjunct to traditional pain management strategies after total joint arthroplasty (TJA). The purpose of this study is to evaluate the efficacy and safety of gabapentinoids in primary TJA to support the combined clinical practice guidelines of the American Association of Hip and Knee Surgeons, American Academy of Orthopedic Surgeons, Hip Society, Knee Society, and the American Society of Regional Anesthesia and Pain Management. METHODS: The MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were searched for studies published prior to September 2019 on gabapentinoids in TJA...
May 26, 2020: Journal of Arthroplasty
Bo Young Chung, Han Bi Kim, Min Je Jung, Seok Young Kang, In-Suk Kwak, Chun Wook Park, Hye One Kim
Post-burn pruritus is the pruritus that occurs after burn during the rehabilitation and healing process of burn wounds. The post-burn pruritus is a common and serious complication of burn injury, which severely lowers the quality of life of the patient. Many potential treatments are available for pruritus but there is no consensus of the best single treatment yet. The precise mechanism of post-burn pruritus has not been elucidated, but it appears to have pruritogenic and neuropathic aspects. Clinically, post-burn pruritus tends to be intractable to conventional treatment but rather responds to neuroleptic agents, such as gabapentin and pregabalin...
May 29, 2020: International Journal of Molecular Sciences
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